This study aimed to determine the effectiveness of comprehensive rehabilitation for patients with aneurysmal subarachnoid hemorrhage (aSAH) and to explore the factors influencing the prognosis of rehabilitation. This ...This study aimed to determine the effectiveness of comprehensive rehabilitation for patients with aneurysmal subarachnoid hemorrhage (aSAH) and to explore the factors influencing the prognosis of rehabilitation. This was a retrospective study. Twenty-five patients with aSAH were treated with physical therapy, occupational therapy, speech therapy, cognitive therapy, music therapy, Chinese acupuncture, hyperbaric oxygen, and transcranial magnetic stimulation. The general data of all patients were collected, and the functional scores at admission were compared with those at discharge. The Mini Mental State Examination, Fugl-Meyer Assessment Scale (FMAS) for motor and balance assessment, Holden Functional Ambulation Classification (FAC), modified Rankin Scale, National Institute of Health Stroke Scale, Modified Barthel Index for activities of daily living (ADL), and Glasgow Outcome Scale were significantly improved among 25 patients with aSAH after 1 month of comprehensive rehabilitation training. Hydrocephalus was an independent factor of the ability to perform ADLs (odds ratio, 0.29;95% confidence interval, 2.03. 3.15;p = 0.000). The improvement of ADLs in aSAH patients was not related to sex, surgical method, aneurysm location, age, or smoking status. Comprehensive and professional rehabilitation is effective for the cognition, movement, walking, ADLs, and functional prognosis of patients with aSAH, while early hydrocephalus may be a risk factor for poor ADLs.展开更多
1.INTRODUCTION Thrombocytopenia,including immune thrombocytopenia(ITP),aplastic anemia,myelodysplastic syndrome,hereditary thrombocytopenia,and isolated thrombocytopenia after hema-topoietic stem cell transplantation(...1.INTRODUCTION Thrombocytopenia,including immune thrombocytopenia(ITP),aplastic anemia,myelodysplastic syndrome,hereditary thrombocytopenia,and isolated thrombocytopenia after hema-topoietic stem cell transplantation(HSCT),is defined as a plate-let count of<150×10^(9)/L and may lead to spontaneous bleeding,prolonged bleeding,and menorrhagia.1-3 The induction of thrombopoiesis and elevation of platelet count using throm-bopoietin(THPO)receptor agonists(THPO-RAs)are critical treatments for thrombocytopenia.展开更多
Generating intense ultrashort pulses with high-quality spatial modes is crucial for ultrafast and strong-field science and can be achieved by nonlinear supercontinuum generation(SCG)and pulse compression.In this work,...Generating intense ultrashort pulses with high-quality spatial modes is crucial for ultrafast and strong-field science and can be achieved by nonlinear supercontinuum generation(SCG)and pulse compression.In this work,we propose that the generation of quasi-stationary solitons in periodic layered Kerr media can greatly enhance the nonlinear lightmatter interaction and fundamentally improve the performance of SCG and pulse compression in condensed media.With both experimental and theoretical studies,we successfully identify these solitary modes and reveal their unified condition for stability.Space-time coupling is shown to strongly influence the stability of solitons,leading to variations in the spectral,spatial and temporal profiles of femtosecond pulses.Taking advantage of the unique characteristics of these solitary modes,we first demonstrate single-stage SCG and the compression of femtosecond pulses from 170 to 22 fs with an efficiency>85%.The high spatiotemporal quality of the compressed pulses is further confirmed by highharmonic generation.We also provide evidence of efficient mode self-cleaning,which suggests rich spatiotemporal self-organization of the laser beams in a nonlinear resonator This work offers a route towards highly efficient,simple,stable and highly flexible SCG and pulse compression solutions for state-of-the-art ytterbium laser technology.展开更多
Nonadiabatic phase matching of high-harmonic generation(HHG)driven by few-cycle laser pulses is essential for extending harmonic energy and generating isolated attosecond pulses.However,understanding nonadiabatic HHG ...Nonadiabatic phase matching of high-harmonic generation(HHG)driven by few-cycle laser pulses is essential for extending harmonic energy and generating isolated attosecond pulses.However,understanding nonadiabatic HHG is challenging due to the complex interplay of various optical phases driven by temporally and spatially varying laser fields.Theoretical calculations typically rely on computationally demanding 3-dimensional simulations,which can make it difficult to extract the essential features of nonadiabatic HHG.In this work,we develop a computationally efficient 2-dimensional model that directly considers various phase contributions of HHG.Our model can well explain the experimentally observed pressure-and intensity-dependent behaviors of different harmonic orders.By appropriately parameterizing the single-atom response,our model can also estimate the variation of HHG spectra under different driving conditions.Our model can provide an efficient tool for the design and optimization of HHG-based applications.展开更多
High-quality ultrafast light sources are critical for developing advanced time-and angle-resolved photoemission spectroscopy(TrARPES).While the application of high harmonic generation(HHG)light sources in TrARPES has ...High-quality ultrafast light sources are critical for developing advanced time-and angle-resolved photoemission spectroscopy(TrARPES).While the application of high harmonic generation(HHG)light sources in TrARPES has increased substantially over the past decade,the optimization of the HHG probe beam size and selective control of the light polarization,which are important for TrARPES measurements,have been rarely explored.In this work,we report the implementation of high-quality HHG probe source with an optimum beam size down to 57μm×90μm and selective light polarization control,together with mid-infrared(MIR)pumping source for TrARPES measurements using a 10-kHz amplifier laser.The selective polarization control of the HHG probe source allows to enhance bands with different orbital contributions or symmetries,as demonstrated by experimental data measured on a few representative transition metal dichalcogenide materials as well as topological insulator Bi2Se3.Furthermore,by combining the HHG probe source with MIR pumping at 2-μm wavelength,TrARPES on a bilayer graphene shows a time resolution of 140 fs,allowing to distinguish 2 different relaxation processes in graphene.Such high-quality HHG probe source together with the MIR pumping expands the capability of TrARPES in revealing the ultrafast dynamics and light-induced emerging phenomena in quantum materials.展开更多
文摘This study aimed to determine the effectiveness of comprehensive rehabilitation for patients with aneurysmal subarachnoid hemorrhage (aSAH) and to explore the factors influencing the prognosis of rehabilitation. This was a retrospective study. Twenty-five patients with aSAH were treated with physical therapy, occupational therapy, speech therapy, cognitive therapy, music therapy, Chinese acupuncture, hyperbaric oxygen, and transcranial magnetic stimulation. The general data of all patients were collected, and the functional scores at admission were compared with those at discharge. The Mini Mental State Examination, Fugl-Meyer Assessment Scale (FMAS) for motor and balance assessment, Holden Functional Ambulation Classification (FAC), modified Rankin Scale, National Institute of Health Stroke Scale, Modified Barthel Index for activities of daily living (ADL), and Glasgow Outcome Scale were significantly improved among 25 patients with aSAH after 1 month of comprehensive rehabilitation training. Hydrocephalus was an independent factor of the ability to perform ADLs (odds ratio, 0.29;95% confidence interval, 2.03. 3.15;p = 0.000). The improvement of ADLs in aSAH patients was not related to sex, surgical method, aneurysm location, age, or smoking status. Comprehensive and professional rehabilitation is effective for the cognition, movement, walking, ADLs, and functional prognosis of patients with aSAH, while early hydrocephalus may be a risk factor for poor ADLs.
基金supported by The National Nature Science Foundation of China(32270875 and 32370874)the Guangzhou General Science and Technology Project of Health and Family Planning(20241A011012)the Guangzhou Municipal Science and Technology Project(2024A03J1021).
文摘1.INTRODUCTION Thrombocytopenia,including immune thrombocytopenia(ITP),aplastic anemia,myelodysplastic syndrome,hereditary thrombocytopenia,and isolated thrombocytopenia after hema-topoietic stem cell transplantation(HSCT),is defined as a plate-let count of<150×10^(9)/L and may lead to spontaneous bleeding,prolonged bleeding,and menorrhagia.1-3 The induction of thrombopoiesis and elevation of platelet count using throm-bopoietin(THPO)receptor agonists(THPO-RAs)are critical treatments for thrombocytopenia.
基金the National Natural Science Foundation of China(Grant No.11874121)the Shanghai Municipal Science and Technology Basic Research Project(Grant No.19JC1410900).C.S.T.acknowledges support from the National Natural Science Foundation of China(No.11874123)the National Key Research and Development Program of China(No.2016YFA0300902).C J.acknowledges support from the National Natural Science Foundation of China(No.11774175 and No.91950102).A.B.acknowledges support from Austrian Science Fund(Grant No.I 4566).Z.T.is thankful for the support from the Alexander-von-Humboldt foundation.
文摘Generating intense ultrashort pulses with high-quality spatial modes is crucial for ultrafast and strong-field science and can be achieved by nonlinear supercontinuum generation(SCG)and pulse compression.In this work,we propose that the generation of quasi-stationary solitons in periodic layered Kerr media can greatly enhance the nonlinear lightmatter interaction and fundamentally improve the performance of SCG and pulse compression in condensed media.With both experimental and theoretical studies,we successfully identify these solitary modes and reveal their unified condition for stability.Space-time coupling is shown to strongly influence the stability of solitons,leading to variations in the spectral,spatial and temporal profiles of femtosecond pulses.Taking advantage of the unique characteristics of these solitary modes,we first demonstrate single-stage SCG and the compression of femtosecond pulses from 170 to 22 fs with an efficiency>85%.The high spatiotemporal quality of the compressed pulses is further confirmed by highharmonic generation.We also provide evidence of efficient mode self-cleaning,which suggests rich spatiotemporal self-organization of the laser beams in a nonlinear resonator This work offers a route towards highly efficient,simple,stable and highly flexible SCG and pulse compression solutions for state-of-the-art ytterbium laser technology.
基金Z.T.gratefully acknowledges support from the National Key Research and Development Program of China(Grant Nos.2021YFA1400200 and 2022YFA1404700)National Natural Science Foundation of China(Grant No.12221004)+4 种基金Shanghai Municipal Science and Technology Basic Research Project(Grant No.19JC1410900)B.L.and C.Jj.were supported by the National Natural Science Foundation of China(Grant No.12274230)Funding of NJUST(Grant No.TSXK2022D005)Y.L.acknowledges support from the National Natural Science Foundation of China(Grant No.12034013)G.F.acknowledges support from the National Natural Science Foundation of China(Grant No.12374318).
文摘Nonadiabatic phase matching of high-harmonic generation(HHG)driven by few-cycle laser pulses is essential for extending harmonic energy and generating isolated attosecond pulses.However,understanding nonadiabatic HHG is challenging due to the complex interplay of various optical phases driven by temporally and spatially varying laser fields.Theoretical calculations typically rely on computationally demanding 3-dimensional simulations,which can make it difficult to extract the essential features of nonadiabatic HHG.In this work,we develop a computationally efficient 2-dimensional model that directly considers various phase contributions of HHG.Our model can well explain the experimentally observed pressure-and intensity-dependent behaviors of different harmonic orders.By appropriately parameterizing the single-atom response,our model can also estimate the variation of HHG spectra under different driving conditions.Our model can provide an efficient tool for the design and optimization of HHG-based applications.
基金supported by the National Natural Science Foundation of China(Grant Nos.12327805,12234011,92250305,52388201,11725418,and 11427903)the National Key R&D Program of China(Nos.2021YFA1400100 and 2020YFA0308800)+3 种基金C.B.is supported by a project funded by China Postdoctoral Science Foundation(Nos.2022M721886 and BX20230187)the Shuimu Tsinghua Scholar Program.Z.T.acknowledges the support from the National Key Research and Development Program of China(Grant No.2021YFA1400200)the National Natural Science Foundation of China(No.12274091)the Shanghai Municipal Science and Technology Basic Research Project(Grant No.22JC1400200).
文摘High-quality ultrafast light sources are critical for developing advanced time-and angle-resolved photoemission spectroscopy(TrARPES).While the application of high harmonic generation(HHG)light sources in TrARPES has increased substantially over the past decade,the optimization of the HHG probe beam size and selective control of the light polarization,which are important for TrARPES measurements,have been rarely explored.In this work,we report the implementation of high-quality HHG probe source with an optimum beam size down to 57μm×90μm and selective light polarization control,together with mid-infrared(MIR)pumping source for TrARPES measurements using a 10-kHz amplifier laser.The selective polarization control of the HHG probe source allows to enhance bands with different orbital contributions or symmetries,as demonstrated by experimental data measured on a few representative transition metal dichalcogenide materials as well as topological insulator Bi2Se3.Furthermore,by combining the HHG probe source with MIR pumping at 2-μm wavelength,TrARPES on a bilayer graphene shows a time resolution of 140 fs,allowing to distinguish 2 different relaxation processes in graphene.Such high-quality HHG probe source together with the MIR pumping expands the capability of TrARPES in revealing the ultrafast dynamics and light-induced emerging phenomena in quantum materials.
