Cardiovascular diseases remain a leading global cause of mortality,underscoring the urgent need for intelligent diagnostic tools to enhance early detection,prediction,diagnosis,prevention,treatment,and recovery.This d...Cardiovascular diseases remain a leading global cause of mortality,underscoring the urgent need for intelligent diagnostic tools to enhance early detection,prediction,diagnosis,prevention,treatment,and recovery.This demand has spurred the advancement of wearable and flexible technologies,revolutionizing continuous,noninvasive,and remote heart sound(HS)monitoring—a vital avenue for assessing heart activity.The conventional stethoscope,used to listen to HSs,has limitations in terms of its physical structure,as it is inflexible and bulky,which restricts its prospective applications.Recently,mechanoacoustic sensors have made remarkable advancements,evolving from primitive forms to soft,flexible,and wearable designs.This article provides an in-depth review of the latest scientific and technological advancements by addressing various topics,including different types of sensors,sensing materials,design principles,denoising techniques,and clinical applications of flexible and wearable HS sensors.This transformative potential lies in the capacity for ongoing,remote,and personalized monitoring,promising enhanced patient outcomes,amplified remote monitoring capabilities,and timely diagnoses.Last,the article highlights current challenges and prospects for the future,suggesting techniques to advance HS sensing technologies for exciting real‐time applications.展开更多
Cardiovascular diseases(CVDs)are fatal chronic diseases,where electrocardiography(ECG)monitoring could be a prominent solution for early diagnosis.In spite of available commercialized,multilead ECG devices,bulky forma...Cardiovascular diseases(CVDs)are fatal chronic diseases,where electrocardiography(ECG)monitoring could be a prominent solution for early diagnosis.In spite of available commercialized,multilead ECG devices,bulky formats,discontinuous monitoring,and no safety alarm system significantly limit their practical applications.Herein,we present a soft,and stretchable,three-lead ECG device allowing continuous monitoring and wireless transmission of ECG signals.A newly developed organohydrogel patch with a strong adhesive ability(~9.9 kPa)and higher conductivity(~6.5 kΩ)is applied for high-quality ECG signals collection.With a long operation duration(6.5 h)and wireless transmission distance(20.9 m),it could fulfill most of the daily applications.Machine learning algorithms and the graphical user interface are used for real-time ECG monitoring and cardiac abnormalities diagnosis.The vibratory flexible actuator,which is triggered by cardiac abnormalities that need immediate medical treatment,is also integrated as a warning system for the user.As a newly reported stretchable multi-lead ECG device for long-term ECG signal monitoring,there is a high potential for improving users'life quality with the high-risk population of CVDs.展开更多
基金supported by the City University of Hong Kong and funded by the Research Grants Council(RGC)partly supported by the InnoHK Project on Project 1.2-Novel Drug Delivery Systems to Achieve Precision Medicine for Acute CVD Patients(a closed-loop CVD control system)at the Hong Kong Center for Cerebrocardiovascular Health Engineering(COCHE).City University of Hong Kong(9610430,7006082,9678292,7020073,9609332,9609333),funded by the Research Grants Council(RGC)+2 种基金Innovation and Technology Commission(ITC)(9667220)-Research Talent Hub(RTH)1-5University Grant Committee(UGC)Innovation and Technology Fund(ITF).
文摘Cardiovascular diseases remain a leading global cause of mortality,underscoring the urgent need for intelligent diagnostic tools to enhance early detection,prediction,diagnosis,prevention,treatment,and recovery.This demand has spurred the advancement of wearable and flexible technologies,revolutionizing continuous,noninvasive,and remote heart sound(HS)monitoring—a vital avenue for assessing heart activity.The conventional stethoscope,used to listen to HSs,has limitations in terms of its physical structure,as it is inflexible and bulky,which restricts its prospective applications.Recently,mechanoacoustic sensors have made remarkable advancements,evolving from primitive forms to soft,flexible,and wearable designs.This article provides an in-depth review of the latest scientific and technological advancements by addressing various topics,including different types of sensors,sensing materials,design principles,denoising techniques,and clinical applications of flexible and wearable HS sensors.This transformative potential lies in the capacity for ongoing,remote,and personalized monitoring,promising enhanced patient outcomes,amplified remote monitoring capabilities,and timely diagnoses.Last,the article highlights current challenges and prospects for the future,suggesting techniques to advance HS sensing technologies for exciting real‐time applications.
基金supported by Hong Kong Center for Cerebra-Cardiovascular Health Engineering,City University of Hong Kong(Grants No.9667221,9680322)Research Grants Council of the Hong Kong Special Administrative Region(Nos.21210820,11213721)National Natural Science Foundation of China(No.62122002).
文摘Cardiovascular diseases(CVDs)are fatal chronic diseases,where electrocardiography(ECG)monitoring could be a prominent solution for early diagnosis.In spite of available commercialized,multilead ECG devices,bulky formats,discontinuous monitoring,and no safety alarm system significantly limit their practical applications.Herein,we present a soft,and stretchable,three-lead ECG device allowing continuous monitoring and wireless transmission of ECG signals.A newly developed organohydrogel patch with a strong adhesive ability(~9.9 kPa)and higher conductivity(~6.5 kΩ)is applied for high-quality ECG signals collection.With a long operation duration(6.5 h)and wireless transmission distance(20.9 m),it could fulfill most of the daily applications.Machine learning algorithms and the graphical user interface are used for real-time ECG monitoring and cardiac abnormalities diagnosis.The vibratory flexible actuator,which is triggered by cardiac abnormalities that need immediate medical treatment,is also integrated as a warning system for the user.As a newly reported stretchable multi-lead ECG device for long-term ECG signal monitoring,there is a high potential for improving users'life quality with the high-risk population of CVDs.
