Identifying a potential dietary non-pharmacological treatment to prevent cerebrovascular damage in Alzheimer's disease is crucial for alleviating cognitive decline in older adults and enhancing quality of life.Thi...Identifying a potential dietary non-pharmacological treatment to prevent cerebrovascular damage in Alzheimer's disease is crucial for alleviating cognitive decline in older adults and enhancing quality of life.This study featured the combined supplementation of soy lecithin(SL)and soy isoflavones(SIF),using in vivo animal models,in vitro vascular ring preparation,and cell studies to investigate the potential advantages and mechanisms of SL combined with SIF on cognitive function and cerebrovascular health from multiple perspectives.The results show that Aβcan significantly induce learning and memory impairment in rats,as well as pathological changes in brain blood vessels,exacerbating damage to cerebral vasodilation function and subsequently reducing cerebral blood flow in the brain.The above-mentioned phenomena induced by Aβcan be significantly improved by the combined intervention of SL and SIF.Further research has revealed that the combined intervention of SL and SIF can reverse the downregulation of the PI3K/PIP3/PDK-1/Akt/eNOS signaling pathway and phosphorylated protein expression induced by Aβin rat brain vascular tissues and bEND.3 cells.Silencing PDK-1 expression in bEND.3 cells showed that the upregulation effect of SL and SIF on Akt and eNOS disappeared.Here we find that prophylactically supplementation with SL in conjunction with SIF appears to effectively activate the PI3K/PIP3/PDK-1/Akt/e NOS pathway within cerebral vascular.This activation improves cerebrovascular vasodilation,offering potential protective effects for both cerebral vascular health and cognitive function.展开更多
Background and Objectives:To explore the nutritional challenges and its influencing factors of adults aged 40-69 living in Chinese cities.Methods and Study Design:This cross-sectional study involved 300 subjects from ...Background and Objectives:To explore the nutritional challenges and its influencing factors of adults aged 40-69 living in Chinese cities.Methods and Study Design:This cross-sectional study involved 300 subjects from 29 cities in China.Questionnaires were used to collect demographic information,presence of chronic disease,and the use of nutritional supplements and fortified foods.24-hour food intake was recorded using the Eat-Right Assistant,a validated digital service.Results:Fiber(56.7%),calcium(66.3%)and selenium(67.0%)were the nutrients with the highest insufficient intake.The foods with the highest inadequate consumption were dairy products(91%),fruits(84.3%),tubers(76.3%),soybeans and nuts(70%),and whole grains(65%).Even though 95.7%of the study population showed medium-high level of dietary diversity,dietary imbalance was present among 99%of the subjects.Higher socioeconomic status,passive health awareness,or the use of nutritional supplements or fortified foods showed positive influence on nutrient intake and dietary quality.Conclusions:This research provided insights into the dietary intake status and its influencing factors of 300 urban residents aged 40-69.The adult population still face a challenge of inadequate nutrient intake and imbalanced diet.In addition,this study supported the feasibility of using a digital service in research.Further studies with a larger sample size are needed to confirm current findings.This will help to clarify the unmet nutritional needs of adults in China and thus help to achieve healthy aging.展开更多
Background and Objectives:To investigate the relationship between sodium(Na)and potassium(K)nutritional condition and body compositions in youth aiming to give target population reasonable diet recommendations.Methods...Background and Objectives:To investigate the relationship between sodium(Na)and potassium(K)nutritional condition and body compositions in youth aiming to give target population reasonable diet recommendations.Methods and Study Design:The cross-sectional study was conducted involving 512 healthy youth aged 18 to 31 years from universities in Beijing.Food frequency questionnaire(FFQ)and bioelectrical impedance analyzer(BIA)were used to collect dietary intake information and body compositions.Results:There was an increasing tendency in fat-related indicators and muscle-related indicators of the dietary Na tertile group(p<0.05).Additionally,Weight,body mass index(BMI),waist circumference(WC),and muscle-related indicators increased with the dietary K tertile group(p<0.05).Across increasing tertiles of dietary Na intake,the odds ratio(OR)was increased significantly(p<0.05)in fat-related indicators.On the contrary,with the increased dietary Na intake,the OR decreased(p<0.05)in appendicular skeletal muscle mass index(ASMI)and body lean mass.As tertiles of dietary K intake increased,the OR in both skeletal muscle mass index(SMMI)and lean mass index(LMI)decreased.Conclusions:High dietary Na is a risk factor for abnormal lipid distribution in college students.High dietary K can maintain skeletal muscle mass and reduce the risk of obesity.Na in the diet has a greater impact on the body composition of young people than K.Low dietary Na and high dietary K still need to be strengthened in science popularization and practice among more college students.展开更多
Background and Objectives:To elucidate the role of dietary fats on the relationship between mild cognitive impairment and sarcopenia and help identifying and preventing the decline of cognitive and muscle function in ...Background and Objectives:To elucidate the role of dietary fats on the relationship between mild cognitive impairment and sarcopenia and help identifying and preventing the decline of cognitive and muscle function in elderly individuals.Methods and Study Design:The study conducted involving a group of 1812 individuals between the ages of 61 and 92.Body composition and BMR were assessed by bioelectrical impedance analysis.Cognitive function and dietary nutrition were evaluated by neuropsychological assessments and questionnaire of food intake frequency.Lipidomics analysis was performed using UHPLC-Qtrap-MS/MS.Results:MCI and SA are mutual influencing factors,lower intake of MUFA,PUFA and higher intake of fat was associated with cognitive dysfunction and/or SA(p<0.05).PUFA was important for MCI combined with SA(Compared with Q1,Q4 OR:0.176,95%CI:0.058,0.533).Lipidomics analysis revealed that triacylglycerol(TAG)contain more carbon chains with saturated double bonds may be closely related to cognitive impairment and the progression of SA(p<0.05).While,DAG with carbon chains of unsaturated double bonds is opposite.Conclusions:Insufficient intake of unsaturated fatty acids was associated with the development of cognitive decline and the progression of SA.MUFA affecting muscle health,fats and PUFA has a greater impact on MCI combined with SA.Less MUFA intake and increasing saturated double-bonded fatty acid intake might be the key factors on promoting cognitive impairment and SA in the elderly.They have the potential to serve as prospective biomarkers indicating a higher risk of cognitive decline and/or SA in the elderly population.展开更多
基金supported by the National Natural Science Foundation of China(82273620,81302427)。
文摘Identifying a potential dietary non-pharmacological treatment to prevent cerebrovascular damage in Alzheimer's disease is crucial for alleviating cognitive decline in older adults and enhancing quality of life.This study featured the combined supplementation of soy lecithin(SL)and soy isoflavones(SIF),using in vivo animal models,in vitro vascular ring preparation,and cell studies to investigate the potential advantages and mechanisms of SL combined with SIF on cognitive function and cerebrovascular health from multiple perspectives.The results show that Aβcan significantly induce learning and memory impairment in rats,as well as pathological changes in brain blood vessels,exacerbating damage to cerebral vasodilation function and subsequently reducing cerebral blood flow in the brain.The above-mentioned phenomena induced by Aβcan be significantly improved by the combined intervention of SL and SIF.Further research has revealed that the combined intervention of SL and SIF can reverse the downregulation of the PI3K/PIP3/PDK-1/Akt/eNOS signaling pathway and phosphorylated protein expression induced by Aβin rat brain vascular tissues and bEND.3 cells.Silencing PDK-1 expression in bEND.3 cells showed that the upregulation effect of SL and SIF on Akt and eNOS disappeared.Here we find that prophylactically supplementation with SL in conjunction with SIF appears to effectively activate the PI3K/PIP3/PDK-1/Akt/e NOS pathway within cerebral vascular.This activation improves cerebrovascular vasodilation,offering potential protective effects for both cerebral vascular health and cognitive function.
基金funded by Danone Open Science Research Center,Shanghai,China。
文摘Background and Objectives:To explore the nutritional challenges and its influencing factors of adults aged 40-69 living in Chinese cities.Methods and Study Design:This cross-sectional study involved 300 subjects from 29 cities in China.Questionnaires were used to collect demographic information,presence of chronic disease,and the use of nutritional supplements and fortified foods.24-hour food intake was recorded using the Eat-Right Assistant,a validated digital service.Results:Fiber(56.7%),calcium(66.3%)and selenium(67.0%)were the nutrients with the highest insufficient intake.The foods with the highest inadequate consumption were dairy products(91%),fruits(84.3%),tubers(76.3%),soybeans and nuts(70%),and whole grains(65%).Even though 95.7%of the study population showed medium-high level of dietary diversity,dietary imbalance was present among 99%of the subjects.Higher socioeconomic status,passive health awareness,or the use of nutritional supplements or fortified foods showed positive influence on nutrient intake and dietary quality.Conclusions:This research provided insights into the dietary intake status and its influencing factors of 300 urban residents aged 40-69.The adult population still face a challenge of inadequate nutrient intake and imbalanced diet.In addition,this study supported the feasibility of using a digital service in research.Further studies with a larger sample size are needed to confirm current findings.This will help to clarify the unmet nutritional needs of adults in China and thus help to achieve healthy aging.
基金supported by National Natural Science Foundation of China(82003459)the Key Laboratory of Trace Element and Nutrition,National Health Commission of China(WLKFZ202201)The Nutrition Research Foundation Fund of the Chinese Nutrition Society,and the Yum Brands Health Fund(CNS-YUM2020-98).
文摘Background and Objectives:To investigate the relationship between sodium(Na)and potassium(K)nutritional condition and body compositions in youth aiming to give target population reasonable diet recommendations.Methods and Study Design:The cross-sectional study was conducted involving 512 healthy youth aged 18 to 31 years from universities in Beijing.Food frequency questionnaire(FFQ)and bioelectrical impedance analyzer(BIA)were used to collect dietary intake information and body compositions.Results:There was an increasing tendency in fat-related indicators and muscle-related indicators of the dietary Na tertile group(p<0.05).Additionally,Weight,body mass index(BMI),waist circumference(WC),and muscle-related indicators increased with the dietary K tertile group(p<0.05).Across increasing tertiles of dietary Na intake,the odds ratio(OR)was increased significantly(p<0.05)in fat-related indicators.On the contrary,with the increased dietary Na intake,the OR decreased(p<0.05)in appendicular skeletal muscle mass index(ASMI)and body lean mass.As tertiles of dietary K intake increased,the OR in both skeletal muscle mass index(SMMI)and lean mass index(LMI)decreased.Conclusions:High dietary Na is a risk factor for abnormal lipid distribution in college students.High dietary K can maintain skeletal muscle mass and reduce the risk of obesity.Na in the diet has a greater impact on the body composition of young people than K.Low dietary Na and high dietary K still need to be strengthened in science popularization and practice among more college students.
基金funded by the National Natural Science Foundation of China(82273620 and 81973018).
文摘Background and Objectives:To elucidate the role of dietary fats on the relationship between mild cognitive impairment and sarcopenia and help identifying and preventing the decline of cognitive and muscle function in elderly individuals.Methods and Study Design:The study conducted involving a group of 1812 individuals between the ages of 61 and 92.Body composition and BMR were assessed by bioelectrical impedance analysis.Cognitive function and dietary nutrition were evaluated by neuropsychological assessments and questionnaire of food intake frequency.Lipidomics analysis was performed using UHPLC-Qtrap-MS/MS.Results:MCI and SA are mutual influencing factors,lower intake of MUFA,PUFA and higher intake of fat was associated with cognitive dysfunction and/or SA(p<0.05).PUFA was important for MCI combined with SA(Compared with Q1,Q4 OR:0.176,95%CI:0.058,0.533).Lipidomics analysis revealed that triacylglycerol(TAG)contain more carbon chains with saturated double bonds may be closely related to cognitive impairment and the progression of SA(p<0.05).While,DAG with carbon chains of unsaturated double bonds is opposite.Conclusions:Insufficient intake of unsaturated fatty acids was associated with the development of cognitive decline and the progression of SA.MUFA affecting muscle health,fats and PUFA has a greater impact on MCI combined with SA.Less MUFA intake and increasing saturated double-bonded fatty acid intake might be the key factors on promoting cognitive impairment and SA in the elderly.They have the potential to serve as prospective biomarkers indicating a higher risk of cognitive decline and/or SA in the elderly population.
