The shop scheduling problem with limited buffers has broad applications in real-world production scenarios,so this research direction is of great practical significance.However,there is currently little research on th...The shop scheduling problem with limited buffers has broad applications in real-world production scenarios,so this research direction is of great practical significance.However,there is currently little research on the hybrid flow shop scheduling problem with limited buffers(LBHFSP).This paper deeply investigates the LBHFSP to optimize the goal of the total completion time.To better solve the LBHFSP,a multi-level subpopulation-based particle swarm optimization algorithm(MLPSO)is proposed,which is founded on the attributes of the LBHFSP and the shortcomings of the basic PSO(particle swarm optimization)algorithm.In MLPSO,firstly,considering the impact of the limited buffers on the process of subsequent operations,a specific circular decoding strategy is developed to accommodate the characteristics of limited buffers.Secondly,an initialization strategy based on blocking time is designed to enhance the quality and diversity of the initial population.Afterward,a multi-level subpopulation collaborative search is developed to prevent being trapped in a local optimum and improve the global exploration capability.Additionally,a local search strategy based on the first blocked job is designed to enhance the MLPSO algorithm’s exploitation capability.Lastly,numerous experiments are carried out to test the performance of the proposed MLPSO by comparing it with classical intelligent optimization and popular algorithms in recent years.The results confirm that the proposed MLPSO has an outstanding performance when compared to other algorithms when solving LBHFSP.展开更多
Leading national space exploration agencies and private enterprises are actively engaged in lunar exploration initiatives to accomplish manned lunar landings and establish permanent lunar bases in the forthcoming year...Leading national space exploration agencies and private enterprises are actively engaged in lunar exploration initiatives to accomplish manned lunar landings and establish permanent lunar bases in the forthcoming years.With limited access to lunar surface materials on Earth,lunar regolith simulants are crucial for lunar exploration research.The Chang’e-5(CE-5)samples have been characterized by state-of-the-art laboratory equipment,providing a unique opportunity to develop a high-quality lunar regolith simulant.We have prepared a high-fidelity PolyU-1 simulant by pulverizing,desiccating,sieving,and blending natural mineral materials on Earth based on key physical,mineral,and chemical characteristics of CE-5 samples.The results showed that the simulant has a high degree of consistency with the CE-5 samples in terms of the particle morphology,mineral and chemical composition.Direct shear tests were conducted on the simulant,and the measured internal friction angle and cohesion values can serve as references for determining the mechanical properties of CE-5 lunar regolith.The PolyU-1 simulant can contribute to experimental studies involving lunar regolith,including the assessment of interaction between rovers and lunar regolith,as well as the development of in-situ resource utilization(ISRU)technologies.展开更多
A cloud computing based optimal driving method is proposed and its feasibility is validated through a real-world scenario simulation.Based on principles of vehicle dynamics,the driving optimization problem has been fo...A cloud computing based optimal driving method is proposed and its feasibility is validated through a real-world scenario simulation.Based on principles of vehicle dynamics,the driving optimization problem has been formulated into an optimal control problem constrained by traffic rules,directed at achieving lower equivalent fuel consumption and shorter travel time.In order to conveniently specify the constraints and facilitate the application of the dynamic programming(DP)algorithm,the driving optimization problem is transformed into spatial domain and discretized properly.Considering the heavy computational costs of the DP algorithm,a cloud computing based platform structure is proposed to solve the optimal driving problem in real-time.A case study is simulated based on a real-world traffic scenario in Matlab.Simulation results demonstrate that the cloud computing framework is promising toward realizing the real-time energy management for hybrid electric vehicles.展开更多
In this study,we propose a drainage pipe pile under vacuum consolidation to integrate foundation treatment and pile foundation engineering in soft soil areas.To study its bearing capacity characteristics and foundatio...In this study,we propose a drainage pipe pile under vacuum consolidation to integrate foundation treatment and pile foundation engineering in soft soil areas.To study its bearing capacity characteristics and foundation treatment performance,single pile static load tests,vane shear tests,and water content tests were carried out for ordinary piles,perforated piles,and drainage pipe piles under conditions of static and vacuum consolidation.Based on the results,the concept of strong and weak reinforcement areas was proposed and used for bearing capacity prediction.The results showed that the drainage pipe pile did not become silted under vacuum consolidation.The single pile bearing capacity was much higher than that of an ordinary pile,and the pile side friction was exerted mainly in the middle and lower parts.Good results were achieved using the shear strength at the junction of the strong and weak reinforcement areas to estimate the ultimate bearing capacity of a single pile.This study provided important insights into the design and construction of drainage pipe piles in a soft soil foundation.展开更多
Ergothioneine is a natural amino acid with powerful antioxidant activity.Previous studies have demonstrated that ergothioneine can increase the lifespan of Drosophila melanogaster and Caenorhabditis elegans,and enhanc...Ergothioneine is a natural amino acid with powerful antioxidant activity.Previous studies have demonstrated that ergothioneine can increase the lifespan of Drosophila melanogaster and Caenorhabditis elegans,and enhance telomerase activity.In present study,the metagenomics sequencing and quantitative real-time polymerase chain reaction analysis were employed to characterize the composition and diversity of gut microbiome in aging flies.And the alterations in the gut barrier,gut morphology,and other gut physiological indicators of aging flies were evaluated.Here,the results showed that ergothioneine induced little variations in gut microbiota composition in flies at mid-life,and significant alterations in the gut microbiota populations were only observed in flies at late-life.And ergothioneine attenuated age-related gut injuries,including decreasing reactive oxygen species levels in intestinal enterocytes,reduction of intestinal cells death,and preservation of gut integrity in aging flies.Ergothioneine also improved the gut morphology by preserving the structure and shape of cell organelles and inducing the intestinal autophagy.And activation of intestinal autophagy also contributed to the longevity effect mediated by ergothioneine in an unidentified mechanism.展开更多
Objective:To investigate the effects of butylphthalide on reducing neuronal apoptosis in rats with cerebral infarction by inhibiting the JNK/P38 MAPK signaling pathway.Methods:Forty-eight SD male rats were divided int...Objective:To investigate the effects of butylphthalide on reducing neuronal apoptosis in rats with cerebral infarction by inhibiting the JNK/P38 MAPK signaling pathway.Methods:Forty-eight SD male rats were divided into DZ group(control group),CI group(model group)and NBP group(butylphthalide group).Rats in CI group and NBP group were used to establish cerebral infarction models.NBP group used NBP.The solution(80 mg/(kg?d))was administered orally,and the remaining two groups were administered with the same volume of peanut oil.After 14 consecutive days of treatment,the Zea Longa score was used to evaluate the neurological function of DZ,CI and NBP rats.Scoring,TTC staining was used to observe the cerebral infarction volume of rats in DZ group,CI group and NBP group,HE staining was used to observe the pathological morphology of brain tissue in DZ group,CI group and NBP group.Neuronal apoptosis,Western blot was used to detect the expression of p-JNK and p-p38MAPK in brain tissues of DZ group,CI group and NBP group.Results:The neurological function of the rats in the CI group was higher than that in the DZ group,and the difference was statistically significant(P<0.05).The neurological function score of the rats in the NBP group was reduced compared with the CI group,and the difference was statistically significant(P<0.05).The cerebral infarction volume in the group was 35.56%higher than that in the DZ group,and the difference was statistically significant(P<0.05).The minor infarct volume in the NBP group was 21.59%,which was less than that in the CI group,and the difference was statistically significant(P<0.05).Nerve cells are neatly sorted,with a large number.The gap between blood vessels and interstitial tissue in the CI group is enlarged,the cells are severely contracted,and the neuron structure is incomplete.Compared with the CI group,the NBP group has reduced neuron contraction and increased number;The dead nerve cells were brown.The apoptosis rate of nerve cells in the CI group was 79.65%higher than that in the DZ group was 5.82%.The difference was statistically significant(P<0.05).The nerve cell apoptosis rate in the NBP group was 30.23%.Compared with CI group,the difference was statistically significant(P<0.05);Western blot results showed that p-JNK and p-p38MAPK protein expression in CI group was higher than that in DZ group,and the difference was statistically significant(P<0.05).The levels of p-JNK and p-p38MAPK proteins in the NBP group were lower than those in the CI group.There was statistically significant(P<0.05).Conclusion:Butylphthalide can improve neurological damage,reduce apoptotic nerve cells,and reduce infarct volume in rats with cerebral infarction,which is related to the inhibition of JNK/P38 MAPK pathway expression.展开更多
SET domain-containing 2(SETD2)is a methyltransferase that catalyzes trimethylation of lysine 36 on H3(H3K36me3)in mammals,an epigenetic mark associated with actively transcribed regions.SETD2 is implicated in multiple...SET domain-containing 2(SETD2)is a methyltransferase that catalyzes trimethylation of lysine 36 on H3(H3K36me3)in mammals,an epigenetic mark associated with actively transcribed regions.SETD2 is implicated in multiple chromatin biological processes,such as alternative splicing,transcriptional regulation,DNA damage repair,and maintenance of genomic integrity.Extensive studies have demonstrated that SETD2-inactivating mutations and resultant dysregulation of these functions may result in tumorigenesis.However,the role of SETD2 in the development and function of immune cells receives relatively limited attention.In this review,we seek to summarize current knowledge of the biological function and underlying mechanisms of SETD2 and highlight its important role in immune cell biology.By influencing the biological processes of immune cells,SETD2 participates in the pathogenesis of immune-related diseases,including infection,cancers,autoimmune diseases,and inflammatory diseases.Finally,we discuss challenges and prospects for targeting SETD2 in immune cells to provide guidance for treating those diseases in clinical practice.展开更多
A novel real-time predictive control strategy is proposed for path following(PF)and vehicle stability of autonomous electric vehicles under extreme drive conditions.The investigated vehicle configuration is a distribu...A novel real-time predictive control strategy is proposed for path following(PF)and vehicle stability of autonomous electric vehicles under extreme drive conditions.The investigated vehicle configuration is a distributed drive electric vehicle,which allows to independently control the torques of each in-wheel motor(IWM)for superior stability,but bringing control com-plexities.The control-oriented model is established by the Magic Formula tire function and the single-track vehicle model.For PF and direct yaw moment control,the nonlinear model predictive control(NMPC)strategy is developed to minimize PF tracking error and stabilize vehicle,outputting front tires’lateral force and external yaw moment.To mitigate the calcu-lation burdens,the continuation/general minimal residual algorithm is proposed for real-time optimization in NMPC.The relaxation function method is adopted to handle the inequality constraints.To prevent vehicle instability and improve steering capacity,the lateral velocity differential of the vehicle is considered in phase plane analysis,and the novel stable bounds of lateral forces are developed and online applied in the proposed NMPC controller.Additionally,the Lyapunov-based constraint is proposed to guarantee the closed-loop stability for the PF issue,and sufficient conditions regarding recursive feasibility and closed-loop stability are provided analytically.The target lateral force is transformed as front steering angle command by the inversive tire model,and the external yaw moment and total traction torque are distributed as the torque commands of IWMs by optimization.The validations prove the effectiveness of the proposed strategy in improved steering capacity,desirable PF effects,vehicle stabilization,and real-time applicability.展开更多
Discovery and development of new sustainable photothermal materials with tunable light absorption spectra play a key role in solar energy harvesting and conversion.One possible solution to this quest is to check natur...Discovery and development of new sustainable photothermal materials with tunable light absorption spectra play a key role in solar energy harvesting and conversion.One possible solution to this quest is to check nature as a source of matters or inspiration.Inspired by the formation of tea stains,a unique class of dark stain materials generated by the interfacial reaction between tea polyphenols and metal substance,we reported the facile preparation and screening of a series of photothermal nanocoating layers via the metal ion(i.e.C u(ll)>Fe(lll),Ni(ll),Zn(ll))promoted in situ polymerization of typical phenolic moieties of tea polyphenols(i.e.,catechol and pyrogallol).It was found that those resulting metal-polyphenolic nanocoatings showed various promising features,such as high blackness and strong adhesion,excellent and tunable light absorption properties,good hydrophilicity and long-term stability.We further fabricated the photothermal composite devices by/n s/'fty formation of meta卜polyphenolic nanocoatings on pristine silks for solar desalination,which demonstrated promising durable evaporation behaviors with excellent evaporation rates and steam generation efficiencies.We believe that this work could provide more opportunities towards new types of bio-inspired and sustainable photothermal nanomaterials for solar energy harvesting applications such as water desalination.展开更多
Type 1 diabetes(T1D)is an autoimmune disease that resulted from the severe destruction of the insulin-producingβcells in the pancreases of individuals with a genetic predisposition.Genome-wide studies have identified...Type 1 diabetes(T1D)is an autoimmune disease that resulted from the severe destruction of the insulin-producingβcells in the pancreases of individuals with a genetic predisposition.Genome-wide studies have identified HLA and other risk genes associated with T1D susceptibility in humans.However,evidence obtained from the incomplete concordance of diabetes incidence among monozygotic twins suggests that environmental factors also play critical roles in T1D pathogenesis.Epigenetics is a rapidly growing field that serves as a bridge to link T1D risk genes and environmental exposures,thereby modulating the expression of critical genes relevant to T1D development beyond the changes of DNA sequences.Indeed,there is compelling evidence that epigenetic changes induced by environmental insults are implicated in T1D pathogenesis.Herein,we sought to summarize the recent progress in terms of epigenetic mechanisms in T1D initiation and progression,and discuss their potential as biomarkers and therapeutic targets in the T1D setting.展开更多
To support power grid operators to detect and evaluate potential power grid congestions due to the electrification of urban private cars,accurate models are needed to determine the charging energy and power demand of ...To support power grid operators to detect and evaluate potential power grid congestions due to the electrification of urban private cars,accurate models are needed to determine the charging energy and power demand of battery electric vehicles(BEVs)with high spatial and temporal resolution.Typically,e-mobility traffic simulations are used for this purpose.In particular,activity-based mobility models are used because they individually model the activity and travel patterns of each person in the considered geographical area.In addition to inaccuracies in determining the spatial distribution of BEV charging demand,one main limitation of the activity-based models proposed in the literature is that they rely on data describing traffic flow in the considered area.However,these data are not available for most places in the world.Therefore,this paper proposes a novel approach to develop an activity-based model that overcomes the spatial limitations and does not require traffic flow data as an input parameter.Instead,a route assignment procedure assigns a destination to each BEV trip based on the evaluation of all possible destinations.The basis of this evaluation is the travel distance and speed between the origin of the trip and the destination,as well as the car-access attractiveness and the availability of parking spots at the destinations.The applicability of this model is demonstrated for the urban area of Berlin,Germany,and its 448 sub-districts.For each district in Berlin,both the required daily BEV charging energy demand and the power demand are determined.In addition,the load shifting potential is investigated for an exemplary district.The results show that peak power demand can be reduced by up to 31.7%in comparison to uncontrolled charging.展开更多
The development of ultrafine particles provided a new way to solve problems in the fields of energy,environment,and medicine,and had become one of the most promising technologies.Therefore,the application of ultrafine...The development of ultrafine particles provided a new way to solve problems in the fields of energy,environment,and medicine,and had become one of the most promising technologies.Therefore,the application of ultrafine particles required the development of cleaner,greener,and more efficient preparation methods.The new freeze-dissolving technology has been applied in manufacturing of KHCO_(3)ultrafine particles,with an aqueous solution of 0.02-0.1 g KHCO_(3)/g water.Frozen ice particles were formed after dripping the solution into liquid nitrogen.The antisolvent ethanol was used to dissolve the ice spherical template at a temperature below 273.15 K,and the pre-formed KHCO_(3)ultrafine particles inside the ice template remained in the ethanol aqueous solution.The ice particles were put into the freeze dryer to isolate the ultrafine KHCO_(3)particles.Compared with the particles produced with traditional freeze-drying technology,the ultrafine powder/particles produced by the freeze-dissolving technology were smaller with narrower size distribution.The freeze-dissolving technology has demonstrated a much more sustainable and efficient manufacturing process than the traditional freeze-drying process.In addition,the influence of the concentrations of KHCO_(3)and the sizes of ice particles were investigated with the discussions of mechanisms.展开更多
基金supported in part by the National Natural Science Foundation of China under Grant No.52175490.
文摘The shop scheduling problem with limited buffers has broad applications in real-world production scenarios,so this research direction is of great practical significance.However,there is currently little research on the hybrid flow shop scheduling problem with limited buffers(LBHFSP).This paper deeply investigates the LBHFSP to optimize the goal of the total completion time.To better solve the LBHFSP,a multi-level subpopulation-based particle swarm optimization algorithm(MLPSO)is proposed,which is founded on the attributes of the LBHFSP and the shortcomings of the basic PSO(particle swarm optimization)algorithm.In MLPSO,firstly,considering the impact of the limited buffers on the process of subsequent operations,a specific circular decoding strategy is developed to accommodate the characteristics of limited buffers.Secondly,an initialization strategy based on blocking time is designed to enhance the quality and diversity of the initial population.Afterward,a multi-level subpopulation collaborative search is developed to prevent being trapped in a local optimum and improve the global exploration capability.Additionally,a local search strategy based on the first blocked job is designed to enhance the MLPSO algorithm’s exploitation capability.Lastly,numerous experiments are carried out to test the performance of the proposed MLPSO by comparing it with classical intelligent optimization and popular algorithms in recent years.The results confirm that the proposed MLPSO has an outstanding performance when compared to other algorithms when solving LBHFSP.
基金supported by the PolyU RCDSE projects(Nos.P0049221 and P0041304)We would like to express our sincere gratitude to Prof.Feng Li and Dr.Siqi Zhou from Beihang University for providing us with the BH-1 simulant,which served as the crucial reference for the PolyU-1 simulant.We would like to thank the support from the National Natural Science Foundation of China(No.42241103)the Key Research Program of the Institute of Geology and Geophysics,Chinese Academy of Sciences(No.IGGCAS-202101)。
文摘Leading national space exploration agencies and private enterprises are actively engaged in lunar exploration initiatives to accomplish manned lunar landings and establish permanent lunar bases in the forthcoming years.With limited access to lunar surface materials on Earth,lunar regolith simulants are crucial for lunar exploration research.The Chang’e-5(CE-5)samples have been characterized by state-of-the-art laboratory equipment,providing a unique opportunity to develop a high-quality lunar regolith simulant.We have prepared a high-fidelity PolyU-1 simulant by pulverizing,desiccating,sieving,and blending natural mineral materials on Earth based on key physical,mineral,and chemical characteristics of CE-5 samples.The results showed that the simulant has a high degree of consistency with the CE-5 samples in terms of the particle morphology,mineral and chemical composition.Direct shear tests were conducted on the simulant,and the measured internal friction angle and cohesion values can serve as references for determining the mechanical properties of CE-5 lunar regolith.The PolyU-1 simulant can contribute to experimental studies involving lunar regolith,including the assessment of interaction between rovers and lunar regolith,as well as the development of in-situ resource utilization(ISRU)technologies.
基金Supported by the National Nature Science Foundation of China(5177503951861135301)
文摘A cloud computing based optimal driving method is proposed and its feasibility is validated through a real-world scenario simulation.Based on principles of vehicle dynamics,the driving optimization problem has been formulated into an optimal control problem constrained by traffic rules,directed at achieving lower equivalent fuel consumption and shorter travel time.In order to conveniently specify the constraints and facilitate the application of the dynamic programming(DP)algorithm,the driving optimization problem is transformed into spatial domain and discretized properly.Considering the heavy computational costs of the DP algorithm,a cloud computing based platform structure is proposed to solve the optimal driving problem in real-time.A case study is simulated based on a real-world traffic scenario in Matlab.Simulation results demonstrate that the cloud computing framework is promising toward realizing the real-time energy management for hybrid electric vehicles.
基金supported by the Key Water Science and Technology Project of Zhejiang Province(No.RB2027)the Zhejiang Provincial Public Welfare Technology Application Research Project(No.LGG22E080002),China。
文摘In this study,we propose a drainage pipe pile under vacuum consolidation to integrate foundation treatment and pile foundation engineering in soft soil areas.To study its bearing capacity characteristics and foundation treatment performance,single pile static load tests,vane shear tests,and water content tests were carried out for ordinary piles,perforated piles,and drainage pipe piles under conditions of static and vacuum consolidation.Based on the results,the concept of strong and weak reinforcement areas was proposed and used for bearing capacity prediction.The results showed that the drainage pipe pile did not become silted under vacuum consolidation.The single pile bearing capacity was much higher than that of an ordinary pile,and the pile side friction was exerted mainly in the middle and lower parts.Good results were achieved using the shear strength at the junction of the strong and weak reinforcement areas to estimate the ultimate bearing capacity of a single pile.This study provided important insights into the design and construction of drainage pipe piles in a soft soil foundation.
基金supported by the National Natural Science Foundation of China(32072646,31772373,and 32001832).
文摘Ergothioneine is a natural amino acid with powerful antioxidant activity.Previous studies have demonstrated that ergothioneine can increase the lifespan of Drosophila melanogaster and Caenorhabditis elegans,and enhance telomerase activity.In present study,the metagenomics sequencing and quantitative real-time polymerase chain reaction analysis were employed to characterize the composition and diversity of gut microbiome in aging flies.And the alterations in the gut barrier,gut morphology,and other gut physiological indicators of aging flies were evaluated.Here,the results showed that ergothioneine induced little variations in gut microbiota composition in flies at mid-life,and significant alterations in the gut microbiota populations were only observed in flies at late-life.And ergothioneine attenuated age-related gut injuries,including decreasing reactive oxygen species levels in intestinal enterocytes,reduction of intestinal cells death,and preservation of gut integrity in aging flies.Ergothioneine also improved the gut morphology by preserving the structure and shape of cell organelles and inducing the intestinal autophagy.And activation of intestinal autophagy also contributed to the longevity effect mediated by ergothioneine in an unidentified mechanism.
基金Key research project of medical science of Hubei province
文摘Objective:To investigate the effects of butylphthalide on reducing neuronal apoptosis in rats with cerebral infarction by inhibiting the JNK/P38 MAPK signaling pathway.Methods:Forty-eight SD male rats were divided into DZ group(control group),CI group(model group)and NBP group(butylphthalide group).Rats in CI group and NBP group were used to establish cerebral infarction models.NBP group used NBP.The solution(80 mg/(kg?d))was administered orally,and the remaining two groups were administered with the same volume of peanut oil.After 14 consecutive days of treatment,the Zea Longa score was used to evaluate the neurological function of DZ,CI and NBP rats.Scoring,TTC staining was used to observe the cerebral infarction volume of rats in DZ group,CI group and NBP group,HE staining was used to observe the pathological morphology of brain tissue in DZ group,CI group and NBP group.Neuronal apoptosis,Western blot was used to detect the expression of p-JNK and p-p38MAPK in brain tissues of DZ group,CI group and NBP group.Results:The neurological function of the rats in the CI group was higher than that in the DZ group,and the difference was statistically significant(P<0.05).The neurological function score of the rats in the NBP group was reduced compared with the CI group,and the difference was statistically significant(P<0.05).The cerebral infarction volume in the group was 35.56%higher than that in the DZ group,and the difference was statistically significant(P<0.05).The minor infarct volume in the NBP group was 21.59%,which was less than that in the CI group,and the difference was statistically significant(P<0.05).Nerve cells are neatly sorted,with a large number.The gap between blood vessels and interstitial tissue in the CI group is enlarged,the cells are severely contracted,and the neuron structure is incomplete.Compared with the CI group,the NBP group has reduced neuron contraction and increased number;The dead nerve cells were brown.The apoptosis rate of nerve cells in the CI group was 79.65%higher than that in the DZ group was 5.82%.The difference was statistically significant(P<0.05).The nerve cell apoptosis rate in the NBP group was 30.23%.Compared with CI group,the difference was statistically significant(P<0.05);Western blot results showed that p-JNK and p-p38MAPK protein expression in CI group was higher than that in DZ group,and the difference was statistically significant(P<0.05).The levels of p-JNK and p-p38MAPK proteins in the NBP group were lower than those in the CI group.There was statistically significant(P<0.05).Conclusion:Butylphthalide can improve neurological damage,reduce apoptotic nerve cells,and reduce infarct volume in rats with cerebral infarction,which is related to the inhibition of JNK/P38 MAPK pathway expression.
基金supported by the National Natural Science Foundation of China(No.82300929,82470877,82100892)the Department of Science and Technology of Hubei Province Program Project(China)(No.2022CFB739)+1 种基金the Intramural Research Program of the Central Hospital of Wuhan,Hubei,China(No.23YJ14,21YJ01)Wuhan Talent Project(China).
文摘SET domain-containing 2(SETD2)is a methyltransferase that catalyzes trimethylation of lysine 36 on H3(H3K36me3)in mammals,an epigenetic mark associated with actively transcribed regions.SETD2 is implicated in multiple chromatin biological processes,such as alternative splicing,transcriptional regulation,DNA damage repair,and maintenance of genomic integrity.Extensive studies have demonstrated that SETD2-inactivating mutations and resultant dysregulation of these functions may result in tumorigenesis.However,the role of SETD2 in the development and function of immune cells receives relatively limited attention.In this review,we seek to summarize current knowledge of the biological function and underlying mechanisms of SETD2 and highlight its important role in immune cell biology.By influencing the biological processes of immune cells,SETD2 participates in the pathogenesis of immune-related diseases,including infection,cancers,autoimmune diseases,and inflammatory diseases.Finally,we discuss challenges and prospects for targeting SETD2 in immune cells to provide guidance for treating those diseases in clinical practice.
基金supported by the Natural Science Foundation of Beijing(Grant No.3212013)by the National Natural Science Foundation of China(Grant No.51805030)in part by the National Natural Science Foundation of China(Grant No.51775039).
文摘A novel real-time predictive control strategy is proposed for path following(PF)and vehicle stability of autonomous electric vehicles under extreme drive conditions.The investigated vehicle configuration is a distributed drive electric vehicle,which allows to independently control the torques of each in-wheel motor(IWM)for superior stability,but bringing control com-plexities.The control-oriented model is established by the Magic Formula tire function and the single-track vehicle model.For PF and direct yaw moment control,the nonlinear model predictive control(NMPC)strategy is developed to minimize PF tracking error and stabilize vehicle,outputting front tires’lateral force and external yaw moment.To mitigate the calcu-lation burdens,the continuation/general minimal residual algorithm is proposed for real-time optimization in NMPC.The relaxation function method is adopted to handle the inequality constraints.To prevent vehicle instability and improve steering capacity,the lateral velocity differential of the vehicle is considered in phase plane analysis,and the novel stable bounds of lateral forces are developed and online applied in the proposed NMPC controller.Additionally,the Lyapunov-based constraint is proposed to guarantee the closed-loop stability for the PF issue,and sufficient conditions regarding recursive feasibility and closed-loop stability are provided analytically.The target lateral force is transformed as front steering angle command by the inversive tire model,and the external yaw moment and total traction torque are distributed as the torque commands of IWMs by optimization.The validations prove the effectiveness of the proposed strategy in improved steering capacity,desirable PF effects,vehicle stabilization,and real-time applicability.
基金the National Natural Science Foundation of China(Nos.21975167,21774079)the Program of the Science&Technology Department of Guangzhou,China(No.201803020039)the Fundamental Research Funds for Central Universities.
文摘Discovery and development of new sustainable photothermal materials with tunable light absorption spectra play a key role in solar energy harvesting and conversion.One possible solution to this quest is to check nature as a source of matters or inspiration.Inspired by the formation of tea stains,a unique class of dark stain materials generated by the interfacial reaction between tea polyphenols and metal substance,we reported the facile preparation and screening of a series of photothermal nanocoating layers via the metal ion(i.e.C u(ll)>Fe(lll),Ni(ll),Zn(ll))promoted in situ polymerization of typical phenolic moieties of tea polyphenols(i.e.,catechol and pyrogallol).It was found that those resulting metal-polyphenolic nanocoatings showed various promising features,such as high blackness and strong adhesion,excellent and tunable light absorption properties,good hydrophilicity and long-term stability.We further fabricated the photothermal composite devices by/n s/'fty formation of meta卜polyphenolic nanocoatings on pristine silks for solar desalination,which demonstrated promising durable evaporation behaviors with excellent evaporation rates and steam generation efficiencies.We believe that this work could provide more opportunities towards new types of bio-inspired and sustainable photothermal nanomaterials for solar energy harvesting applications such as water desalination.
基金supported by grants from the Ministry of Science and Technology(Nos.2016YFC1305002 and 2017YFC1309603)the National Natural Science Foundation of China(Nos.81530024,91749207,81920108009,81770823,and 81670729)+3 种基金the NHC Drug Discovery Program(No.2017ZX09304022-07)the Department of Science and Technology of Hubei State(No.2017ACA096)the Integrated Innovative Team for Major Human Disease Programs of Tongji Medical College,Huazhong University of Science and Technologythe Innovative Funding for Translational Research from Tongji Hospital.
文摘Type 1 diabetes(T1D)is an autoimmune disease that resulted from the severe destruction of the insulin-producingβcells in the pancreases of individuals with a genetic predisposition.Genome-wide studies have identified HLA and other risk genes associated with T1D susceptibility in humans.However,evidence obtained from the incomplete concordance of diabetes incidence among monozygotic twins suggests that environmental factors also play critical roles in T1D pathogenesis.Epigenetics is a rapidly growing field that serves as a bridge to link T1D risk genes and environmental exposures,thereby modulating the expression of critical genes relevant to T1D development beyond the changes of DNA sequences.Indeed,there is compelling evidence that epigenetic changes induced by environmental insults are implicated in T1D pathogenesis.Herein,we sought to summarize the recent progress in terms of epigenetic mechanisms in T1D initiation and progression,and discuss their potential as biomarkers and therapeutic targets in the T1D setting.
基金This research was funded by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)-project:“Multi-Domain Modeling and Optimization of Integrated Renewable Energy and Urban Electric Vehicle Systems”[grant number 410830482].
文摘To support power grid operators to detect and evaluate potential power grid congestions due to the electrification of urban private cars,accurate models are needed to determine the charging energy and power demand of battery electric vehicles(BEVs)with high spatial and temporal resolution.Typically,e-mobility traffic simulations are used for this purpose.In particular,activity-based mobility models are used because they individually model the activity and travel patterns of each person in the considered geographical area.In addition to inaccuracies in determining the spatial distribution of BEV charging demand,one main limitation of the activity-based models proposed in the literature is that they rely on data describing traffic flow in the considered area.However,these data are not available for most places in the world.Therefore,this paper proposes a novel approach to develop an activity-based model that overcomes the spatial limitations and does not require traffic flow data as an input parameter.Instead,a route assignment procedure assigns a destination to each BEV trip based on the evaluation of all possible destinations.The basis of this evaluation is the travel distance and speed between the origin of the trip and the destination,as well as the car-access attractiveness and the availability of parking spots at the destinations.The applicability of this model is demonstrated for the urban area of Berlin,Germany,and its 448 sub-districts.For each district in Berlin,both the required daily BEV charging energy demand and the power demand are determined.In addition,the load shifting potential is investigated for an exemplary district.The results show that peak power demand can be reduced by up to 31.7%in comparison to uncontrolled charging.
基金the National Natural Science Foundation of China(NSFC21978234)for financial assistance in this project
文摘The development of ultrafine particles provided a new way to solve problems in the fields of energy,environment,and medicine,and had become one of the most promising technologies.Therefore,the application of ultrafine particles required the development of cleaner,greener,and more efficient preparation methods.The new freeze-dissolving technology has been applied in manufacturing of KHCO_(3)ultrafine particles,with an aqueous solution of 0.02-0.1 g KHCO_(3)/g water.Frozen ice particles were formed after dripping the solution into liquid nitrogen.The antisolvent ethanol was used to dissolve the ice spherical template at a temperature below 273.15 K,and the pre-formed KHCO_(3)ultrafine particles inside the ice template remained in the ethanol aqueous solution.The ice particles were put into the freeze dryer to isolate the ultrafine KHCO_(3)particles.Compared with the particles produced with traditional freeze-drying technology,the ultrafine powder/particles produced by the freeze-dissolving technology were smaller with narrower size distribution.The freeze-dissolving technology has demonstrated a much more sustainable and efficient manufacturing process than the traditional freeze-drying process.In addition,the influence of the concentrations of KHCO_(3)and the sizes of ice particles were investigated with the discussions of mechanisms.
