Hydraulic fracture growth is significantly influenced by the minimum horizontal principal stress gradient and the fracturing fluid pressure gradient.However,these gradients are often neglected in scaled physical model...Hydraulic fracture growth is significantly influenced by the minimum horizontal principal stress gradient and the fracturing fluid pressure gradient.However,these gradients are often neglected in scaled physical modeling experiments due to difficulties in reproducing them.This study uses centrifugal hypergravity to simulate both gradients and investigate their effects on fracture propagation.Artificial mortar specimens(ϕ200 mm×400 mm)are fractured under 1g(normal gravity),50g,and 100g.Results show that compared to 1g,fractures under 50g and 100g exhibit increasingly uneven propagation,with higher g-values leading to greater asymmetry.To interpret this,a theoretical analysis based on fracture mechanics is conducted.When the fluid pressure gradient exceeds the stress gradient,a positive net gradient is generated,increasing net pressure at the lower fracture tip.This raises the stress intensity factor at the lower tip,promoting downward growth.As g increases,the disparity becomes more significant,resulting in greater fracture deviation.In conclusion,this study,for the first time,has verified and explained that the net gradient can change the propagation of hydraulic fractures,providing important guidance for wellbore placement under stress gradients.展开更多
Monolayer vanadium ditelluride(VTe_(2))exhibits a 2√3×2√3 charge-density-wave(CDW)order intertwined with a Mott-insulating state.However,the physical mechanisms driving the emergence of the CDW order and the Mo...Monolayer vanadium ditelluride(VTe_(2))exhibits a 2√3×2√3 charge-density-wave(CDW)order intertwined with a Mott-insulating state.However,the physical mechanisms driving the emergence of the CDW order and the Mott-insulating state are still not well understood.In this study,we systematically investigate the electronic band structure,phonon dispersion,and electron-phonon coupling(EPC)of monolayer VTe_(2)under applied biaxial strain.Our results reveal that the 2√3×2√3 CDW phase is metastable in free-standing monolayer VTe_(2)but becomes stabilized under compressive strain below ε=-2%.The formation of the CDW order originates predominantly from strong EPC,rather than from Fermi-surface nesting.The narrowing of the bandwidth due to the CDW order,combined with correlation effects associated with the V3d orbitals,collectively drive the system into a Mott-insulating state.Furthermore,we find that tensile strain suppresses the CDW order and induces a superconducting state above a critical strain threshold(ε=2%).These findings enhance our understanding of correlation physics in monolayer VTe_(2)and provide a pathway for strain-engineered manipulation of quantum phases in two-dimensional transition-metal dichalcogenides.展开更多
A couple of layered Li-rich cathode materials Li1.2Mn0.54Ni0.13Co0.13O2 without any carbon modification are successfully synthesized by solvothermal and hydrothermal methods followed by a calcination process. The samp...A couple of layered Li-rich cathode materials Li1.2Mn0.54Ni0.13Co0.13O2 without any carbon modification are successfully synthesized by solvothermal and hydrothermal methods followed by a calcination process. The sample synthesized by the solvothermal method(S-NCM) possesses more homogenous microstructure, lower cation mixing degree and more oxygen vacancies on the surface, compared to the sample prepared by the hydrothermal method(H-NCM). The S-NCM sample exhibits much better cycling performance, higher discharge capacity and more excellent rate performance than H-NCM. At 0.2 C rate,the S-NCM sample delivers a much higher initial discharge capacity of 292.3 mAh g^-1 and the capacity maintains 235 m Ah g^-1 after 150 cycles(80.4% retention), whereas the corresponding capacity values are only 269.2 and 108.5 m Ah g^-1(40.3% retention) for the H-NCM sample. The S-NCM sample also shows the higher rate performance with discharge capacity of 118.3 mAh g^-1 even at a high rate of 10 C, superior to that(46.5 m Ah g^-1) of the H-NCM sample. The superior electrochemical performance of the S-NCM sample can be ascribed to its well-ordered structure, much larger specific surface area and much more oxygen vacancies located on the surface.展开更多
Transition metal nitrides(TMNs)and their composites with carbon materials hold tremendous potential for supercapacitor(SC)electrodes because of their excellent electronic conductivity and electrochemical activity.Howe...Transition metal nitrides(TMNs)and their composites with carbon materials hold tremendous potential for supercapacitor(SC)electrodes because of their excellent electronic conductivity and electrochemical activity.However,realizing cycling stable TMN/carbon-based supercapacitors with economically viable and environmentally-friendly approaches remains a significant challenge.Significantly,polyacrylamide(PAM)hydrogel,as a water-soluble linear polymer electrolyte,is expected to be a remarkable candidate precursor for preparing N-doped porous carbon(NPC)due to the high contents of carbon and nitrogen elements.In this study,vanadium nitride(VN)embedded in PAM hydrogel-derived NPC was fabricated successfully via an ammonia-free process.The VN/NPC delivers a high specific capacitance of 198.3 F g^(−1)at a current density of 1 A g^(−1),with a remarkable cycling stability of 107%after 16,000 cycles.The electrochemical performances of VN/NPC compared to bare VN nanoparticles are strongly improved due to the composite structure.Additionally,the VN/NPC-based solid-state symmetric device delivers an excellent energy density of 21.97µWh cm^(−2)at a power density of 0.5 mW cm^(−2),and an outstanding cycling durability of 90.9%after 18,000 cycles.This work paves the way to design metal nitride/porous carbon materials,which also opens up unique horizons for the recovery of hydrogel electrolyte.展开更多
Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human body.As the primary compliant conductors used in these devices,metallic nanostructure/elastomer composite...Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human body.As the primary compliant conductors used in these devices,metallic nanostructure/elastomer composites often struggle to form conformal contact with the textured skin.Hybrid electrodes have been consequently developed based on conductive nanocomposite and soft hydrogels to establish seamless skin-device interfaces.However,chemical modifications are typically needed for reliable bonding,which can alter their original properties.To overcome this limitation,this study presents a facile fabrication approach for mechanically interlocked nanocomposite/hydrogel hybrid electrodes.In this physical process,soft microfoams are thermally laminated on silver nanowire nanocomposites as a porous interface,which forms an interpenetrating network with the hydrogel.The microfoam-enabled bonding strategy is generally compatible with various polymers.The resulting interlocked hybrids have a 28-fold improved interfacial toughness compared to directly stacked hybrids.These electrodes achieve firm attachment to the skin and low contact impedance using tissue-adhesive hydrogels.They have been successfully integrated into an epidermal sleeve to distinguish hand gestures by sensing mus-cle contractions.Interlocked nanocomposite/hydrogel hybrids reported here offer a promising platform to combine the benefits of both materials for epidermal devices and systems.展开更多
Phase engineering of molybdenum disulfide(MoS_(2))can achieve phase transformation from the semiconducting phase(2H-MoS_(2))with poor conductivity to the metallic phase(1T-MoS_(2))with superior electrochemical propert...Phase engineering of molybdenum disulfide(MoS_(2))can achieve phase transformation from the semiconducting phase(2H-MoS_(2))with poor conductivity to the metallic phase(1T-MoS_(2))with superior electrochemical properties.Therefore,it is desirable to prepare high concentration 1T-MoS_(2)by simple and facile methods.In this work,MoS_(2)with high concentration of 1T phase is successfully prepared by one-pot hydrothermal synthesis through the synergistic effect of HNO_(3)and CH_(3)CH_(2)OH,which is stable for more than half of a year.The as-synthesized MoS_(2)shows high capacitance of 392Fg^(-1)at 1A g^(-1)as used for supercapacitors electrodes,and displays excellent capacitance retention(83%after 10,000 cycles).Asymmetric supercapacitors(ASCs)devices assembled by the as-synthesized MoS_(2)and MnO_(2)on carbon cloths,exhibit high energy and power densities(0.194 m Wh cm^(-2)and 13.466 mW cm^(-2)).These results shed a light to realize 1T phase MoS_(2)through the synergistic effect in hydrothermal processing.展开更多
Ca3Co409 thin films have been first prepared on polycrystalline AI203 substrates using chemical solution deposition method by multiple annealing processing. It is observed that the derived thin films are c-axis orient...Ca3Co409 thin films have been first prepared on polycrystalline AI203 substrates using chemical solution deposition method by multiple annealing processing. It is observed that the derived thin films are c-axis oriented although the substrates are polycrystalline AI203 substrates, suggesting the self-assembled c-axis orientation. The annealing temperature effects on the properties are investigated and discussed. The best performances are attributed to the 850 ℃-annealed sample, whose resistivity, Seebeck coefficient and power factor at 300 K are 7.4 mΩ cm, 117 μV/K and 0.18 mW/m K-2 respectively, which is even better than those of the thin films deposited on single crystal substrates. The results will provide an effective route to optimize the properties of Ca3Co409 thin films using chemical solution deposition by multiple annealing processing even the substrates are polycrystalline.展开更多
Realization of Kondo lattice in superconducting van der Waals materials not only provides a unique opportunity for tuning the Kondo lattice behavior by electrical gating or intercalation,but also is helpful for furthe...Realization of Kondo lattice in superconducting van der Waals materials not only provides a unique opportunity for tuning the Kondo lattice behavior by electrical gating or intercalation,but also is helpful for further understanding the heavy fermion superconductivity.Here we report a low-temperature and vector-magneticfield scanning tunneling microscopy and spectroscopy study on a superconducting compound(4Hb-TaS_(2))with alternate stacking of 1T-TaS_(2)and 1H-TaS_(2)layers.We observe the quasi-two-dimensional superconductivity in the 1H-TaS_(2)layer with anisotropic response to the in-plane and out-of-plane magnetic fields.In the 1T-TaS_(2)layer,we detect the Kondo resonance peak that results from the Kondo screening of the unpaired electrons in the Star-of-David clusters.We also find that the intensity of the Kondo resonance peak is sensitive to its relative position with the Fermi level,and it can be significantly enhanced when it is further shifted towards the Fermi level by evaporating Pb atoms onto the 1T-TaS_(2)surface.Our results not only are important for fully understanding the electronic properties of 4Hb-TaS_(2),but also pave the way for creating tunable Kondo lattice in the superconducting van der Waals materials.展开更多
Searching for effective hydrogen evolution reaction(HER)electrocatalysts is crucial for water splitting.Transition metal nitrides(TMNs)are very attractive potential candidates since of high electrical conductivity,rob...Searching for effective hydrogen evolution reaction(HER)electrocatalysts is crucial for water splitting.Transition metal nitrides(TMNs)are very attractive potential candidates since of high electrical conductivity,robust stability,element rich and high activity.Antiperovskite metal nitrides provide chemical flexibility since two different types of transition metal elements are contained,allowing partial substitution both for A-and M-sites.Herein,we report a novel antiperovskite metal nitride Ag_(x)Ni_(1-x)NNi_(3)(0≤x≤0.80)thin film used as highly effective HER electrocatalysts.Pure phase antiperovskite nitride can be successfully obtained for Ag_(x)Ni_(1-x)NNi_(3)with x less than 0.80.The Ag_(0.76)Ni_(0.24)NNi_(3) towards HER shows an overpotential of 122 mV at 10 mA cm^(-2)in alkaline media.Furthermore,considering the role of Ag for adsorbing hydroxyl groups,chemical engineering has been carried out for designing metal/antiperovskite nitride Ag/Ag_(x)Ni_(1-x)NNi_(3)composite electrocatalysts.The 0.18 Ag/Ag_(0.80)Ni_(0.20)NNi_(3)electrocatalyst shows a mere 13 and 81 mV of overpotential to reach 1 and 10 mA cm^(-2),respectively,showing high durability in alkaline media.These results will provide a novel type of HER catalysts based on antiperovskite metal nitrides and a strategic design for metal/antiperovskite metal nitride composite electrocatalysts for HER in alkaline media.展开更多
Spinel compounds are of great interest in both fundamental and application-oriented perspectives due to the geometric magnetic frustration inherent to their lattice and the resulting complex magnetic states.Here,we ap...Spinel compounds are of great interest in both fundamental and application-oriented perspectives due to the geometric magnetic frustration inherent to their lattice and the resulting complex magnetic states.Here,we applied x-ray diffraction,magnetization,heat capacity and powder inelastic neutron scattering measurements,along with theoretical calculations,to study the exotic properties of chromite-spinel oxides CoCr_(2)O_(4) and MnCr_(2)O_(4).The temperature dependence of the phonon spectra provides an insight into the correlation between oxygen motion and the magnetic order,as well as the magnetoelectric effect in the ground state of MnCr_(2)O_(4).Moreover,spin-wave excitations in CoCr_(2)O_(4) and MnCr_(2)O_(4) are compared with Heisenberg model calculations.This approach enables the precise determination of exchange energies and offers a comprehensive understanding of the spin dynamics and relevant exchange interactions in complicated spiral spin ordering.展开更多
Recently,near-ambient superconductivity was claimed in nitrogen-doped lutetium hydride(LuH_(3-δ)N_(ε)).Unfortunately,all follow-up research still cannot find superconductivity signs in successfully synthesized lutet...Recently,near-ambient superconductivity was claimed in nitrogen-doped lutetium hydride(LuH_(3-δ)N_(ε)).Unfortunately,all follow-up research still cannot find superconductivity signs in successfully synthesized lutetium dihydride(LuH_(2)) and N-doped LuH_(2±x)N_(y).However,a similar intriguing observation was the pressure-induced color changes(from blue to pink and subsequent red).The physical understanding of its origin and the correlation between the color,crystal structure,and chemical composition of Lu–H–N is still lacking.In this work,we systematically investigated the optical properties of LuH_(2) and LuH_(3),and the effects of hydrogen vacancies and nitrogen doping using the first-principles calculations by considering both interband and intraband contributions.Our results demonstrate that the evolution of reflectivity peaks near blue and red light,which is driven by changes in the band gap and Fermi velocity of free electrons,resulting in the blue-to-red color change under pressure.In contrast,LuH_(3) exhibits gray and no color change up to 50 GPa.Furthermore,we investigated the effects of hydrogen vacancies and nitrogen doping on its optical properties.Hydrogen vacancies can significantly decrease the pressure of blue-to-red color change in LuH_(2) but do not have a noticeable effect on the color of LuH_(3).The N-doped LuH_(2) with the substitution of a hydrogen atom at the tetrahedral position maintains the color change when the N-doping concentration is low.As the doping level increases,this trend becomes less obvious,while other N-doped structures do not show a blue-to-red color change.Our results can clarify the origin of the experimental observed blue-to-red color change in lutetium hydride and also provide a further understanding of the potential N-doped lutetium dihydride.展开更多
Quasi-static experiments and analytical investigations of ultra-high-strength bars(UHSB)reinforced walls with two shear span ratios of 1.5 and 2.2,were conducted.The hysteretic responses of test walls in terms of dama...Quasi-static experiments and analytical investigations of ultra-high-strength bars(UHSB)reinforced walls with two shear span ratios of 1.5 and 2.2,were conducted.The hysteretic responses of test walls in terms of damage evolution,load-displacement curves,curvature profiles,reinforcement strain,and residual drift ratio were explored.Experimental results indicated that all test walls exhibited drift-hardening behavior.Specimens achieved a maximum residual drift ratio of 0.27%before 2%drift ratio,satisfying the limit value of 0.5%.The calculation of hysteresis curves calculation of the test walls was conducted considering the weak bond behavior of UHSB and verified by the experimental results.展开更多
Despite significant advances in targeted therapies and immunotherapies,non-small cell lung cancer(NSCLC)continues to present a global health challenge,with a modest five-year survival rate of 28%,largely due to the em...Despite significant advances in targeted therapies and immunotherapies,non-small cell lung cancer(NSCLC)continues to present a global health challenge,with a modest five-year survival rate of 28%,largely due to the emergence of treatment-resistant and metastatic tumors.In response,we synthesized a novel bioactive compound,ethyl 6-chlorocoumarin-3-carboxylyl L-theanine(TClC),which significantly inhibited NSCLC growth,epithelial mesenchymal transition(EMT),migration,and invasion in vitro and tumor growth and metastasis in vivo without inducing toxicity.TClC disrupts autocrine loops that promote tumor progression,particularly in stem-like CD133-positive NSCLC(CD133+LC)cells,which are pivotal in tumor metastasis.Through targeted molecular assays,we identified direct binding targets of TClC,including Akt,NF-κB,β-catenin,EZH2,and PD-L1.This interaction not only suppresses the expression of oncogenic factors and cancer stem cell markers but also downregulates the expression of a multidrug resistance transporter,underscoring the compound’s poly-pharmacological potential.These results position TClC as a promising candidate for NSCLC treatment,signaling a new era in the development of cancer therapies that directly target multiple critical cancer pathways.展开更多
Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 i...Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy.展开更多
This experiment was conducted to investigate the effects of dietary arginine levels on growth performance, body composition, serum biochemical indices and resistance ability against ammonia-nitrogen stress in juvenile...This experiment was conducted to investigate the effects of dietary arginine levels on growth performance, body composition, serum biochemical indices and resistance ability against ammonia-nitrogen stress in juvenile yellow catfish(Pelteobagrus fulvidraco). Five isonitrogenous and isolipidic diets(42%protein and 9% lipid) were formulated to contain graded levels of arginine(2.44%, 2.64%, 2.81%, 3.01% and3.23% of diet), by supplementing L-Arginine HCI. Seven hundred juvenile yellow catfish with an initial average body weight of 1.13 ± 0.02 g were randomly divided into 5 groups with 4 replicates of 35 fish each and each group was fed one of the diets. After 56 d feeding, fish were exposed to 100 mg/L of ammonia-nitrogen for 72 h. The results showed that weight gain(WG) and specific growth rate(SGR) in2.64% and 2.81% groups were significantly higher than those in 3.23% group(P < 0.05). The feed conversation ratio(FCR) in 2,64%, 2,81% and 3.01% groups was significantly decreased when compared with3,23% group. The protein efficiency ratio(PER) in 2.64% group was significantly higher than that in 2.44%and 3.23% groups(P < 0.05). The condition factor(CF) of fish was significantly higher in 2.81% group than that in 2,44% group(P < 0.05). Dietary arginine levels had no significant effect on hepatosomatic index(HSI), viscerosomatic index(VSI), and whole-body dry matter, crude protein, crude lipid, ash contents, as well as serum total protein(TP), triglyceride(TG), glucose(GLU), urea nitrogen(UN) contents and aspartate aminotransferase(AST), alanine aminotransferase(ALT) activities(P> 0.05). After the fish were challenged to ammonia-nitrogen for 72 h, their cumulative mortality rate in 2.81% group was significantly lower than that in 2.44% group(P < 0.05). The results suggested that dietary arginine level at 2.81%could optimize anti-ammonia-nitrogen stress ability of juvenile yellow catfish and a level of 3.23%arginine seemed to depress the growth performance of fish and decreased their tolerance to the ammonia-nitrogen stress under current study. A quadratic regression analysis based on WG indicated that the optimal dietary arginine requirement of juvenile yellow catfish was estimated to be 2.74% of the diet(6.45% of dietary protein) under current culture conditions.展开更多
Flexible ferroelectric memories,endowing with high data storage density,provide a chance for the nextgeneration wearable electronics.Here,flexible inorganic Mn-doped BiFeO_(3) thin films were directly integrated on fl...Flexible ferroelectric memories,endowing with high data storage density,provide a chance for the nextgeneration wearable electronics.Here,flexible inorganic Mn-doped BiFeO_(3) thin films were directly integrated on fluorophlogopite mica(F-Mica)substrates by an easy and low-cost all solution chemical solution deposition(AS-CSD)route.The integration of LaNiO_(3) buffer layer can improve the film surface density and uniformity.The flexible characteristic can be achieved by reducing the thickness of F-Mica substrates for the ferroelectric thin films.In contrast to BiFe_(0.93)Mn_(0.07)O_(3)/LaNiO_(3)/Si thin film deposited on rigid substrates(Si),the BiFe_(0.93)Mn_(0.07)O_(3)/LaNiO_(3)/F-mica fabricated on F-Mica show better ferroelectric performances due to the improved crystal growth and less defects.More importantly,the obtained BiFe_(0.93)Mn_(0.07)O_(3)/LaNiO_(3)/F-mica ferroelectric thin films still show large remnant polarization of Pr ~64 μC/cm^(2)(deterioration of ~7.2%),good antifatigue properties up to 1.2×10^(8) cycles and outstanding retention behaviors for 1.6×10^(4) s after continuous bending.This work will provide a feasible route to fabricate flexible inorganic ferroelectric thin films through low-cost solution method and show attractive comprehensive performances in next-generation wearable smart devices.展开更多
Polarization-sensitive photodetection and imaging have great application value in fields such as polarization division multiplexing optical communication,remote sensing,near-field imaging and military monitoring.Pursu...Polarization-sensitive photodetection and imaging have great application value in fields such as polarization division multiplexing optical communication,remote sensing,near-field imaging and military monitoring.Pursuing a high polarization ratio has always been the research hotspot in polarization-sensitive photodetectors.In this paper,we report a compression strain enhanced polarization ratio inβ-gallium oxide(β-Ga_(2)O_(3))single crystal flake.A rigorous crystallographic analysis confirmed its high crystalline quality and orientation.Angle-resolved polarization Raman spectroscopy(ARPRS)was adopted to study the anisotropy of its optical properties.Extensive ARPRS measurements and theoretical calculation consistently demonstrate the strong optical anisotropy in the high-qualityβ-Ga_(2)O_(3)flake.A polarization ratio of 0.96 was obtained in the flatβ-Ga_(2)O_(3)flake.Furthermore,mechanical strain of±0.7%was introduced intoβ-Ga_(2)O_(3).An increased polarization ratio of 0.98 was achieved in the case of 0.7%compression strain,which is,to the best of our knowledge,the highest value for UVC polarization-sensitive photodetectors.That corresponds to an improved polarization rejection ratio of 100.This work proposed a new path towards improving polarization sensitivity by applying strain engineering in the active material.展开更多
Cr_2Ge_2Te_6is an intrinsic ferromagnetic semiconductor with van der Waals type layered structure,thus represents a promising material for novel electronic and spintronic devices.Here we combine scanning tunneling mic...Cr_2Ge_2Te_6is an intrinsic ferromagnetic semiconductor with van der Waals type layered structure,thus represents a promising material for novel electronic and spintronic devices.Here we combine scanning tunneling microscopy and first-principles calculations to investigate the electronic structure of Cr_2Ge_2Te_6.Tunneling spectroscopy reveals a surprising large energy level shift and change of energy gap size across the ferromagnetic to paramagnetic phase transition,as well as a peculiar double-peak electronic state on the Cr-site defect.These features can be quantitatively explained by density functional theory calculations,which uncover a close relationship between the electronic structure and magnetic order.These findings shed important new lights on the microscopic electronic structure and origin of magnetic order in Cr_2Ge_2Te_6.展开更多
Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal g...Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor(EGFR)-mutated advanced non-small cell lung cancer(NSCLC).Metastatic disease in the central nervous system(CNS)remains a challenge in the management of NSCLC.This study aimed to compare the efficacy of aumolertinib versus gefitinib among patients with baseline CNS metastases in the ANEAS study.Methods:Eligible patients were enrolled and randomly assigned in a 1:1 ratio to orally receive either aumolertinib or gefitinib in a double-blinded fashion.Patients with asymptomatic,stable CNS metastases were included.Follow-up imaging of the same modality as the initial CNS imaging was performed every 6 weeks for 15 months,then every 12weeks.CNS responsewas assessed by a neuroradiological blinded,independent central review(neuroradiological-BICR).The primary endpoint for this subgroup analysis was CNS progression-free survival(PFS).Results:Of the 429 patients enrolled and randomized in the ANEAS study,106 patients were found to have CNS metastases(CNS Full Analysis Set,cFAS)at baseline by neuroradiological-BICR,and 60 of them had CNS target lesions(CNS Evaluable for Response,cEFR).Treatment with aumolertinib significantly prolonged median CNS PFS compared with gefitinib in both cFAS(29.0 vs.8.3 months;hazard ratio[HR]=0.31;95%confidence interval[CI],0.17-0.56;P<0.001)and cEFR(29.0 vs.8.3 months;HR=0.26;95%CI,0.11-0.57;P<0.001).The confirmed CNS overall response rate in cEFRwas 85.7%and 75.0%in patients treated with aumolertinib and gefitinib,respectively.Competing risk analysis showed that the estimated probability of CNS progression without prior non-CNS progression or death was consistently lower with aumolertinib than with gefitinib in patients with and without CNSmetastases at baseline.No new safety findings were observed.Conclusions:These results indicate a potential advantage of aumolertinib over gefitinib in terms of CNS PFS and the risk of CNS progression in patients with EGFR-mutated advanced NSCLC with baseline CNS metastases.展开更多
基金supports of Basic Science Center Program for Multiphase Evolution in Hyper-gravity of the National Natural Science Foundation of China(No.51988101)National Natural Science Foundation of China(Nos.52109138 and 52122403)Young Elite Scientists Sponsorship Program by CAST(No.2023QNRC001).
文摘Hydraulic fracture growth is significantly influenced by the minimum horizontal principal stress gradient and the fracturing fluid pressure gradient.However,these gradients are often neglected in scaled physical modeling experiments due to difficulties in reproducing them.This study uses centrifugal hypergravity to simulate both gradients and investigate their effects on fracture propagation.Artificial mortar specimens(ϕ200 mm×400 mm)are fractured under 1g(normal gravity),50g,and 100g.Results show that compared to 1g,fractures under 50g and 100g exhibit increasingly uneven propagation,with higher g-values leading to greater asymmetry.To interpret this,a theoretical analysis based on fracture mechanics is conducted.When the fluid pressure gradient exceeds the stress gradient,a positive net gradient is generated,increasing net pressure at the lower fracture tip.This raises the stress intensity factor at the lower tip,promoting downward growth.As g increases,the disparity becomes more significant,resulting in greater fracture deviation.In conclusion,this study,for the first time,has verified and explained that the net gradient can change the propagation of hydraulic fractures,providing important guidance for wellbore placement under stress gradients.
基金Project supported by the National Key Research and Development Program of China(Grant No.2022YFA1403203)。
文摘Monolayer vanadium ditelluride(VTe_(2))exhibits a 2√3×2√3 charge-density-wave(CDW)order intertwined with a Mott-insulating state.However,the physical mechanisms driving the emergence of the CDW order and the Mott-insulating state are still not well understood.In this study,we systematically investigate the electronic band structure,phonon dispersion,and electron-phonon coupling(EPC)of monolayer VTe_(2)under applied biaxial strain.Our results reveal that the 2√3×2√3 CDW phase is metastable in free-standing monolayer VTe_(2)but becomes stabilized under compressive strain below ε=-2%.The formation of the CDW order originates predominantly from strong EPC,rather than from Fermi-surface nesting.The narrowing of the bandwidth due to the CDW order,combined with correlation effects associated with the V3d orbitals,collectively drive the system into a Mott-insulating state.Furthermore,we find that tensile strain suppresses the CDW order and induces a superconducting state above a critical strain threshold(ε=2%).These findings enhance our understanding of correlation physics in monolayer VTe_(2)and provide a pathway for strain-engineered manipulation of quantum phases in two-dimensional transition-metal dichalcogenides.
基金supported financially by the National Key Research and Development Program(No.2017YFA0402800)the National Natural Science Foundation of China(Nos.U1732160and 11504380)
文摘A couple of layered Li-rich cathode materials Li1.2Mn0.54Ni0.13Co0.13O2 without any carbon modification are successfully synthesized by solvothermal and hydrothermal methods followed by a calcination process. The sample synthesized by the solvothermal method(S-NCM) possesses more homogenous microstructure, lower cation mixing degree and more oxygen vacancies on the surface, compared to the sample prepared by the hydrothermal method(H-NCM). The S-NCM sample exhibits much better cycling performance, higher discharge capacity and more excellent rate performance than H-NCM. At 0.2 C rate,the S-NCM sample delivers a much higher initial discharge capacity of 292.3 mAh g^-1 and the capacity maintains 235 m Ah g^-1 after 150 cycles(80.4% retention), whereas the corresponding capacity values are only 269.2 and 108.5 m Ah g^-1(40.3% retention) for the H-NCM sample. The S-NCM sample also shows the higher rate performance with discharge capacity of 118.3 mAh g^-1 even at a high rate of 10 C, superior to that(46.5 m Ah g^-1) of the H-NCM sample. The superior electrochemical performance of the S-NCM sample can be ascribed to its well-ordered structure, much larger specific surface area and much more oxygen vacancies located on the surface.
基金supported by the National Natural Science Foundation of China(Grant No.52272251)the Users with Excellence Program of Hefei Science Center CAS(No.2021HSCUE009).
文摘Transition metal nitrides(TMNs)and their composites with carbon materials hold tremendous potential for supercapacitor(SC)electrodes because of their excellent electronic conductivity and electrochemical activity.However,realizing cycling stable TMN/carbon-based supercapacitors with economically viable and environmentally-friendly approaches remains a significant challenge.Significantly,polyacrylamide(PAM)hydrogel,as a water-soluble linear polymer electrolyte,is expected to be a remarkable candidate precursor for preparing N-doped porous carbon(NPC)due to the high contents of carbon and nitrogen elements.In this study,vanadium nitride(VN)embedded in PAM hydrogel-derived NPC was fabricated successfully via an ammonia-free process.The VN/NPC delivers a high specific capacitance of 198.3 F g^(−1)at a current density of 1 A g^(−1),with a remarkable cycling stability of 107%after 16,000 cycles.The electrochemical performances of VN/NPC compared to bare VN nanoparticles are strongly improved due to the composite structure.Additionally,the VN/NPC-based solid-state symmetric device delivers an excellent energy density of 21.97µWh cm^(−2)at a power density of 0.5 mW cm^(−2),and an outstanding cycling durability of 90.9%after 18,000 cycles.This work paves the way to design metal nitride/porous carbon materials,which also opens up unique horizons for the recovery of hydrogel electrolyte.
基金We acknowledge the support from the National Key Research and Development Program of China(Grant No.2022YFA1405000)the Natural Science Foundation of Jiangsu Province,Major Project(Grant No.BK20212004)+1 种基金the National Natural Science Foundation of China(Grant No.62374083)the State Key Laboratory of Analytical Chemistry for Life Science(Grant No.5431ZZXM2205).
文摘Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human body.As the primary compliant conductors used in these devices,metallic nanostructure/elastomer composites often struggle to form conformal contact with the textured skin.Hybrid electrodes have been consequently developed based on conductive nanocomposite and soft hydrogels to establish seamless skin-device interfaces.However,chemical modifications are typically needed for reliable bonding,which can alter their original properties.To overcome this limitation,this study presents a facile fabrication approach for mechanically interlocked nanocomposite/hydrogel hybrid electrodes.In this physical process,soft microfoams are thermally laminated on silver nanowire nanocomposites as a porous interface,which forms an interpenetrating network with the hydrogel.The microfoam-enabled bonding strategy is generally compatible with various polymers.The resulting interlocked hybrids have a 28-fold improved interfacial toughness compared to directly stacked hybrids.These electrodes achieve firm attachment to the skin and low contact impedance using tissue-adhesive hydrogels.They have been successfully integrated into an epidermal sleeve to distinguish hand gestures by sensing mus-cle contractions.Interlocked nanocomposite/hydrogel hybrids reported here offer a promising platform to combine the benefits of both materials for epidermal devices and systems.
基金supported by the National Key R&D Program of China(Nos.2016YFA0401801)Natural Science Foundation of Anhui Province(No.1608085QE107)the Users with Excellence Program of Hefei Science Center CAS(No.2021HSC-UE009)。
文摘Phase engineering of molybdenum disulfide(MoS_(2))can achieve phase transformation from the semiconducting phase(2H-MoS_(2))with poor conductivity to the metallic phase(1T-MoS_(2))with superior electrochemical properties.Therefore,it is desirable to prepare high concentration 1T-MoS_(2)by simple and facile methods.In this work,MoS_(2)with high concentration of 1T phase is successfully prepared by one-pot hydrothermal synthesis through the synergistic effect of HNO_(3)and CH_(3)CH_(2)OH,which is stable for more than half of a year.The as-synthesized MoS_(2)shows high capacitance of 392Fg^(-1)at 1A g^(-1)as used for supercapacitors electrodes,and displays excellent capacitance retention(83%after 10,000 cycles).Asymmetric supercapacitors(ASCs)devices assembled by the as-synthesized MoS_(2)and MnO_(2)on carbon cloths,exhibit high energy and power densities(0.194 m Wh cm^(-2)and 13.466 mW cm^(-2)).These results shed a light to realize 1T phase MoS_(2)through the synergistic effect in hydrothermal processing.
基金supported by the National Natural Science Foundation of China (Nos. 50802096, 10904150 and10904151)
文摘Ca3Co409 thin films have been first prepared on polycrystalline AI203 substrates using chemical solution deposition method by multiple annealing processing. It is observed that the derived thin films are c-axis oriented although the substrates are polycrystalline AI203 substrates, suggesting the self-assembled c-axis orientation. The annealing temperature effects on the properties are investigated and discussed. The best performances are attributed to the 850 ℃-annealed sample, whose resistivity, Seebeck coefficient and power factor at 300 K are 7.4 mΩ cm, 117 μV/K and 0.18 mW/m K-2 respectively, which is even better than those of the thin films deposited on single crystal substrates. The results will provide an effective route to optimize the properties of Ca3Co409 thin films using chemical solution deposition by multiple annealing processing even the substrates are polycrystalline.
基金the financial support from the National Key R&D Program of China(Grant No.2020YFA0309602)the National Natural Science Foundation of China(Grant No.11874042)+7 种基金the support from National Natural Science Foundation of China(Grant No.12004250)the support from the National Natural Science Foundation of China(Grant No.12004251)the National Natural Science Foundation of China(Grant Nos.11674326 and 11774351)the start-up funding from Shanghai Tech Universitythe Shanghai Sailing Program(Grant No.20YF1430700)the Shanghai Sailing Program(Grant No.21YF1429200)the support from the National Key R&D Program(Grant No.2021YFA1600201)the Joint Funds of the National Natural Science Foundation of China and the Chinese Academy of Sciences’Large-Scale Scientific Facility(Grant Nos.U1832141,U1932217 and U2032215)。
文摘Realization of Kondo lattice in superconducting van der Waals materials not only provides a unique opportunity for tuning the Kondo lattice behavior by electrical gating or intercalation,but also is helpful for further understanding the heavy fermion superconductivity.Here we report a low-temperature and vector-magneticfield scanning tunneling microscopy and spectroscopy study on a superconducting compound(4Hb-TaS_(2))with alternate stacking of 1T-TaS_(2)and 1H-TaS_(2)layers.We observe the quasi-two-dimensional superconductivity in the 1H-TaS_(2)layer with anisotropic response to the in-plane and out-of-plane magnetic fields.In the 1T-TaS_(2)layer,we detect the Kondo resonance peak that results from the Kondo screening of the unpaired electrons in the Star-of-David clusters.We also find that the intensity of the Kondo resonance peak is sensitive to its relative position with the Fermi level,and it can be significantly enhanced when it is further shifted towards the Fermi level by evaporating Pb atoms onto the 1T-TaS_(2)surface.Our results not only are important for fully understanding the electronic properties of 4Hb-TaS_(2),but also pave the way for creating tunable Kondo lattice in the superconducting van der Waals materials.
基金financially supported by the National Key R&D Program of China(Nos.2016YFA0401801 and 2014CB931704)the Natural Science Foundation of Anhui Province(No.1608085QE107)+1 种基金the Key Research Program of Frontier Sciences,CAS(No.QYZDB-SSW-SLH015)supported by the Youth Innovation Promotion Association of CAS(No.2014283)。
文摘Searching for effective hydrogen evolution reaction(HER)electrocatalysts is crucial for water splitting.Transition metal nitrides(TMNs)are very attractive potential candidates since of high electrical conductivity,robust stability,element rich and high activity.Antiperovskite metal nitrides provide chemical flexibility since two different types of transition metal elements are contained,allowing partial substitution both for A-and M-sites.Herein,we report a novel antiperovskite metal nitride Ag_(x)Ni_(1-x)NNi_(3)(0≤x≤0.80)thin film used as highly effective HER electrocatalysts.Pure phase antiperovskite nitride can be successfully obtained for Ag_(x)Ni_(1-x)NNi_(3)with x less than 0.80.The Ag_(0.76)Ni_(0.24)NNi_(3) towards HER shows an overpotential of 122 mV at 10 mA cm^(-2)in alkaline media.Furthermore,considering the role of Ag for adsorbing hydroxyl groups,chemical engineering has been carried out for designing metal/antiperovskite nitride Ag/Ag_(x)Ni_(1-x)NNi_(3)composite electrocatalysts.The 0.18 Ag/Ag_(0.80)Ni_(0.20)NNi_(3)electrocatalyst shows a mere 13 and 81 mV of overpotential to reach 1 and 10 mA cm^(-2),respectively,showing high durability in alkaline media.These results will provide a novel type of HER catalysts based on antiperovskite metal nitrides and a strategic design for metal/antiperovskite metal nitride composite electrocatalysts for HER in alkaline media.
基金the financial support from the National Key Research and Development Program of China(Grant No.2022YFA1402702)the National Science Foundation of China(Grant Nos.U2032213 and 12004243)+8 种基金the National Science Foundation of China(Grant No.12274412)the Interdisciplinary Program of Wuhan National High Magnetic Field Center(Grant No.WHMFC 202122)Huazhong University of Science and Technologythe support from the National Natural Science Foundation of China(Grant No.52101236)Guangdong Basic and Applied Basic Research Foundation(Grant No.2021B1515140014)the Guangdong Provincial Key Laboratory of Extreme Conditionsfinancial support from the National Key Research and Development Program of China(Grant Nos.2021YFA1600201 and 2023YFA1607402)the support of NSF-DMR-2003117supported by a beamtime allocation RB1910163 from the Science and Technology Facilities Council。
文摘Spinel compounds are of great interest in both fundamental and application-oriented perspectives due to the geometric magnetic frustration inherent to their lattice and the resulting complex magnetic states.Here,we applied x-ray diffraction,magnetization,heat capacity and powder inelastic neutron scattering measurements,along with theoretical calculations,to study the exotic properties of chromite-spinel oxides CoCr_(2)O_(4) and MnCr_(2)O_(4).The temperature dependence of the phonon spectra provides an insight into the correlation between oxygen motion and the magnetic order,as well as the magnetoelectric effect in the ground state of MnCr_(2)O_(4).Moreover,spin-wave excitations in CoCr_(2)O_(4) and MnCr_(2)O_(4) are compared with Heisenberg model calculations.This approach enables the precise determination of exchange energies and offers a comprehensive understanding of the spin dynamics and relevant exchange interactions in complicated spiral spin ordering.
基金supported by the National Key Research and Development Program of China(Grant Nos.2022YFA1403203 and 2021YFA1600200)the National Natural Science Foundation of China(Grant Nos.U2032215 and 12241405)。
文摘Recently,near-ambient superconductivity was claimed in nitrogen-doped lutetium hydride(LuH_(3-δ)N_(ε)).Unfortunately,all follow-up research still cannot find superconductivity signs in successfully synthesized lutetium dihydride(LuH_(2)) and N-doped LuH_(2±x)N_(y).However,a similar intriguing observation was the pressure-induced color changes(from blue to pink and subsequent red).The physical understanding of its origin and the correlation between the color,crystal structure,and chemical composition of Lu–H–N is still lacking.In this work,we systematically investigated the optical properties of LuH_(2) and LuH_(3),and the effects of hydrogen vacancies and nitrogen doping using the first-principles calculations by considering both interband and intraband contributions.Our results demonstrate that the evolution of reflectivity peaks near blue and red light,which is driven by changes in the band gap and Fermi velocity of free electrons,resulting in the blue-to-red color change under pressure.In contrast,LuH_(3) exhibits gray and no color change up to 50 GPa.Furthermore,we investigated the effects of hydrogen vacancies and nitrogen doping on its optical properties.Hydrogen vacancies can significantly decrease the pressure of blue-to-red color change in LuH_(2) but do not have a noticeable effect on the color of LuH_(3).The N-doped LuH_(2) with the substitution of a hydrogen atom at the tetrahedral position maintains the color change when the N-doping concentration is low.As the doping level increases,this trend becomes less obvious,while other N-doped structures do not show a blue-to-red color change.Our results can clarify the origin of the experimental observed blue-to-red color change in lutetium hydride and also provide a further understanding of the potential N-doped lutetium dihydride.
基金supported by the Visiting Scholar Foundation of Key Laboratory of New Technology for Construction of Cities in Mountain Area in Chongqing University, China
基金supported by the Joint Program of Natural Science Foundation of Beijing Municipality and Beijing Municipal Education Commission(No.KZ202110005008).
文摘Quasi-static experiments and analytical investigations of ultra-high-strength bars(UHSB)reinforced walls with two shear span ratios of 1.5 and 2.2,were conducted.The hysteretic responses of test walls in terms of damage evolution,load-displacement curves,curvature profiles,reinforcement strain,and residual drift ratio were explored.Experimental results indicated that all test walls exhibited drift-hardening behavior.Specimens achieved a maximum residual drift ratio of 0.27%before 2%drift ratio,satisfying the limit value of 0.5%.The calculation of hysteresis curves calculation of the test walls was conducted considering the weak bond behavior of UHSB and verified by the experimental results.
基金supported by the National Key Research and Development Program of China(2017YFB0702600,2017YFB0702602,2017YFB0702602-2)the Shandong Provincial Natural Science Foundation(ZR2019MH076,ZR2022MH291)+3 种基金the Ministry of Science and Technology of the People’s Republic of China(“863 grant”,2012AA020206)the Department of Science and Technology of Shan-dong Province(20092009GG10002087)the National Natural Science Foundation of China(81603024,30973553)the NIH grant R01 CA186100,Wenzhou Institute University of Chinese Academy of Sciences,and Corbett Estate Fund for the Cancer Research(62285-531021-41800,62285-531021-51800,62285-531021-61800,62285-531021-71800).
文摘Despite significant advances in targeted therapies and immunotherapies,non-small cell lung cancer(NSCLC)continues to present a global health challenge,with a modest five-year survival rate of 28%,largely due to the emergence of treatment-resistant and metastatic tumors.In response,we synthesized a novel bioactive compound,ethyl 6-chlorocoumarin-3-carboxylyl L-theanine(TClC),which significantly inhibited NSCLC growth,epithelial mesenchymal transition(EMT),migration,and invasion in vitro and tumor growth and metastasis in vivo without inducing toxicity.TClC disrupts autocrine loops that promote tumor progression,particularly in stem-like CD133-positive NSCLC(CD133+LC)cells,which are pivotal in tumor metastasis.Through targeted molecular assays,we identified direct binding targets of TClC,including Akt,NF-κB,β-catenin,EZH2,and PD-L1.This interaction not only suppresses the expression of oncogenic factors and cancer stem cell markers but also downregulates the expression of a multidrug resistance transporter,underscoring the compound’s poly-pharmacological potential.These results position TClC as a promising candidate for NSCLC treatment,signaling a new era in the development of cancer therapies that directly target multiple critical cancer pathways.
基金This study was funded by RemeGen Co.,Ltd.This work was also supported by the National Natural Science Foundation of China(No.91959205)the Ministry of Science and Technology of China(No.2017YFC1308900,No.2018ZX09201-015)Beijing Municipal Health Commission(No.2020-1-1022)。
文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy.
基金supported by the National Natural Science Foundation of China (31402307)the construction of public service platform for the evaluation of the value of aquatic feed and feed additives in Guangdong Province(2015A040404033)
文摘This experiment was conducted to investigate the effects of dietary arginine levels on growth performance, body composition, serum biochemical indices and resistance ability against ammonia-nitrogen stress in juvenile yellow catfish(Pelteobagrus fulvidraco). Five isonitrogenous and isolipidic diets(42%protein and 9% lipid) were formulated to contain graded levels of arginine(2.44%, 2.64%, 2.81%, 3.01% and3.23% of diet), by supplementing L-Arginine HCI. Seven hundred juvenile yellow catfish with an initial average body weight of 1.13 ± 0.02 g were randomly divided into 5 groups with 4 replicates of 35 fish each and each group was fed one of the diets. After 56 d feeding, fish were exposed to 100 mg/L of ammonia-nitrogen for 72 h. The results showed that weight gain(WG) and specific growth rate(SGR) in2.64% and 2.81% groups were significantly higher than those in 3.23% group(P < 0.05). The feed conversation ratio(FCR) in 2,64%, 2,81% and 3.01% groups was significantly decreased when compared with3,23% group. The protein efficiency ratio(PER) in 2.64% group was significantly higher than that in 2.44%and 3.23% groups(P < 0.05). The condition factor(CF) of fish was significantly higher in 2.81% group than that in 2,44% group(P < 0.05). Dietary arginine levels had no significant effect on hepatosomatic index(HSI), viscerosomatic index(VSI), and whole-body dry matter, crude protein, crude lipid, ash contents, as well as serum total protein(TP), triglyceride(TG), glucose(GLU), urea nitrogen(UN) contents and aspartate aminotransferase(AST), alanine aminotransferase(ALT) activities(P> 0.05). After the fish were challenged to ammonia-nitrogen for 72 h, their cumulative mortality rate in 2.81% group was significantly lower than that in 2.44% group(P < 0.05). The results suggested that dietary arginine level at 2.81%could optimize anti-ammonia-nitrogen stress ability of juvenile yellow catfish and a level of 3.23%arginine seemed to depress the growth performance of fish and decreased their tolerance to the ammonia-nitrogen stress under current study. A quadratic regression analysis based on WG indicated that the optimal dietary arginine requirement of juvenile yellow catfish was estimated to be 2.74% of the diet(6.45% of dietary protein) under current culture conditions.
基金supported by the National Key Basic Research program(Grant No.2014CB931704)the Joint Funds of the National Natural Science Foundation of China and the Chinese Academy of Sciences Large-Scale Scientific Facility(Grant No.U1432137).
文摘Flexible ferroelectric memories,endowing with high data storage density,provide a chance for the nextgeneration wearable electronics.Here,flexible inorganic Mn-doped BiFeO_(3) thin films were directly integrated on fluorophlogopite mica(F-Mica)substrates by an easy and low-cost all solution chemical solution deposition(AS-CSD)route.The integration of LaNiO_(3) buffer layer can improve the film surface density and uniformity.The flexible characteristic can be achieved by reducing the thickness of F-Mica substrates for the ferroelectric thin films.In contrast to BiFe_(0.93)Mn_(0.07)O_(3)/LaNiO_(3)/Si thin film deposited on rigid substrates(Si),the BiFe_(0.93)Mn_(0.07)O_(3)/LaNiO_(3)/F-mica fabricated on F-Mica show better ferroelectric performances due to the improved crystal growth and less defects.More importantly,the obtained BiFe_(0.93)Mn_(0.07)O_(3)/LaNiO_(3)/F-mica ferroelectric thin films still show large remnant polarization of Pr ~64 μC/cm^(2)(deterioration of ~7.2%),good antifatigue properties up to 1.2×10^(8) cycles and outstanding retention behaviors for 1.6×10^(4) s after continuous bending.This work will provide a feasible route to fabricate flexible inorganic ferroelectric thin films through low-cost solution method and show attractive comprehensive performances in next-generation wearable smart devices.
基金supported by the National Natural Science Foundation of China(Grant Nos.61505109,12174275,62174113,and 11974108)Youth Innovative Talents Attracting and Cultivating Plan of Colleges and Universities in Shandong Province(No.21)+2 种基金Youth Innovation Team of Colleges and Universities in Shandong Province(Grant No.2022KJ223)Guangdong Basic and Applied Basic Research Foundation(Grant No.2022A1515110607)Shandong Provincial Natural Science Foundation(Grant Nos.ZR2021QF020,ZR2022QF055,and ZR2021QE080)。
文摘Polarization-sensitive photodetection and imaging have great application value in fields such as polarization division multiplexing optical communication,remote sensing,near-field imaging and military monitoring.Pursuing a high polarization ratio has always been the research hotspot in polarization-sensitive photodetectors.In this paper,we report a compression strain enhanced polarization ratio inβ-gallium oxide(β-Ga_(2)O_(3))single crystal flake.A rigorous crystallographic analysis confirmed its high crystalline quality and orientation.Angle-resolved polarization Raman spectroscopy(ARPRS)was adopted to study the anisotropy of its optical properties.Extensive ARPRS measurements and theoretical calculation consistently demonstrate the strong optical anisotropy in the high-qualityβ-Ga_(2)O_(3)flake.A polarization ratio of 0.96 was obtained in the flatβ-Ga_(2)O_(3)flake.Furthermore,mechanical strain of±0.7%was introduced intoβ-Ga_(2)O_(3).An increased polarization ratio of 0.98 was achieved in the case of 0.7%compression strain,which is,to the best of our knowledge,the highest value for UVC polarization-sensitive photodetectors.That corresponds to an improved polarization rejection ratio of 100.This work proposed a new path towards improving polarization sensitivity by applying strain engineering in the active material.
基金supported by the Basic Science Center Project of NSFC(51788104)the MOST of China(2015CB921000)+6 种基金the support from Tsinghua University Initiative Scientific Research Program and NSFC(11774196)S.H.Z.is supported by the National Postdoctoral Program for Innovative Talents of China(BX201600091)the China Postdoctoral Science Foundation(2017M610858)the support of the National Key Research and Development Program(2016YFA0300404)NSFC Grant(11674326)the Joint Funds of NSFC and the Chinese Academy of Sciences’Large-Scale Scientific Facility(U1432139)supported in part by the Beijing Advanced Innovation Center for Future Chip(ICFC)
文摘Cr_2Ge_2Te_6is an intrinsic ferromagnetic semiconductor with van der Waals type layered structure,thus represents a promising material for novel electronic and spintronic devices.Here we combine scanning tunneling microscopy and first-principles calculations to investigate the electronic structure of Cr_2Ge_2Te_6.Tunneling spectroscopy reveals a surprising large energy level shift and change of energy gap size across the ferromagnetic to paramagnetic phase transition,as well as a peculiar double-peak electronic state on the Cr-site defect.These features can be quantitatively explained by density functional theory calculations,which uncover a close relationship between the electronic structure and magnetic order.These findings shed important new lights on the microscopic electronic structure and origin of magnetic order in Cr_2Ge_2Te_6.
基金Hansoh Pharmaceutical Group Co.LtdNational Natural Science Foundation of China,Grant/Award Numbers:82030045,82241227+3 种基金National Multi-disciplinary Treatment Project for Major Diseases,Grant/Award Number:2020NMDTPCollaborative Innovation Center for Clinical and Translational Science by Ministry of Education&Shanghai,Grant/Award Numbers:CCTS-202204,CCTS-202304Shanghai Chest Hospital Basic Research Project,Grant/Award Number:2023YNKT-1Pujiang Program,Grant/Award Number:22PJ1420700。
文摘Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor(EGFR)-mutated advanced non-small cell lung cancer(NSCLC).Metastatic disease in the central nervous system(CNS)remains a challenge in the management of NSCLC.This study aimed to compare the efficacy of aumolertinib versus gefitinib among patients with baseline CNS metastases in the ANEAS study.Methods:Eligible patients were enrolled and randomly assigned in a 1:1 ratio to orally receive either aumolertinib or gefitinib in a double-blinded fashion.Patients with asymptomatic,stable CNS metastases were included.Follow-up imaging of the same modality as the initial CNS imaging was performed every 6 weeks for 15 months,then every 12weeks.CNS responsewas assessed by a neuroradiological blinded,independent central review(neuroradiological-BICR).The primary endpoint for this subgroup analysis was CNS progression-free survival(PFS).Results:Of the 429 patients enrolled and randomized in the ANEAS study,106 patients were found to have CNS metastases(CNS Full Analysis Set,cFAS)at baseline by neuroradiological-BICR,and 60 of them had CNS target lesions(CNS Evaluable for Response,cEFR).Treatment with aumolertinib significantly prolonged median CNS PFS compared with gefitinib in both cFAS(29.0 vs.8.3 months;hazard ratio[HR]=0.31;95%confidence interval[CI],0.17-0.56;P<0.001)and cEFR(29.0 vs.8.3 months;HR=0.26;95%CI,0.11-0.57;P<0.001).The confirmed CNS overall response rate in cEFRwas 85.7%and 75.0%in patients treated with aumolertinib and gefitinib,respectively.Competing risk analysis showed that the estimated probability of CNS progression without prior non-CNS progression or death was consistently lower with aumolertinib than with gefitinib in patients with and without CNSmetastases at baseline.No new safety findings were observed.Conclusions:These results indicate a potential advantage of aumolertinib over gefitinib in terms of CNS PFS and the risk of CNS progression in patients with EGFR-mutated advanced NSCLC with baseline CNS metastases.
