A trace analytical method based on solid-phase extraction gas chromatography-tandem mass spectrometry(SPE–GC–MS/MS)was developed for the rapid detection of 256 semi-volatile organic compounds(SVOCs),including 25 pol...A trace analytical method based on solid-phase extraction gas chromatography-tandem mass spectrometry(SPE–GC–MS/MS)was developed for the rapid detection of 256 semi-volatile organic compounds(SVOCs),including 25 polycyclic aromatic hydrocarbons(PAHs),70 polychlorinated biphenyls(PCBs),123 pesticides,20 phthalate esters(PAEs),4 organophosphate esters(OPEs),9 synthetic musks(SMs),and 5 UV filters(UVs)in water.No-tably,this method provided a decent linearity of calibration standards(R^(2)>0.999),excellent method limits of quantification(MLOQs)(0.12–11.41 ng/L),satisfactory matrix spiking recovery rates(60.4%–126%),and high precision(intra-day relative standard deviations(RSDs):1.0%–10.0%,inter-day RSDs:3.0%–15.0%,and inter-week RSDs:3.4%–15.7%),making it suitable for trace-level studies.Statistical analysis revealed that SVOCs with higher volatility exhibited enhanced recovery rates.Validation of the methodology involved analyzing SVOCs in real spring water and river water samples.Twenty-seven SVOCs were detected in spring water and 58 in river water,with an average concentration of 631.73 and 16,095 ng/L,respectively.Among the detected SVOCs,PAEs constituted the predominant proportion.This study underscored the presence of SVOCs contamination specifi-cally within the spring water,although SVOCs concentrations in river water were significantly greater than those found in spring water.In summary,this sensitive method based on SPE–GC–MS/MS was successfully developed and validated for the rapid analysis of a diverse array of 256 SVOCs at trace levels in water,including not only the traditional highly valued PAHs,PCBs,pesticides,and PAEs,but also the emerging OPEs,UVs,and SMs.展开更多
Lithium-ion batteries(LIBs)play a critical role in reducing carbon emissions in the automotive industry.However,they face challenges related to safety and performance failures.Smart technologies offer a promising solu...Lithium-ion batteries(LIBs)play a critical role in reducing carbon emissions in the automotive industry.However,they face challenges related to safety and performance failures.Smart technologies offer a promising solution to address these issues.Bioinspired microcapsules are a common approach to enhancing the performance and safety of smart LIBs.However,despite their potential,this area has not been thoroughly explored.This review provides an overview of the preparation methods for microcapsules,including physical,chemical,and physicochemical techniques.These microcapsules are categorized based on their mechanisms into electrode self-healing burst microcapsules,interphase-forming sustained-release microcapsules,live-lithium sustained-release microcapsules,and flame-retardant burst microcapsules.A comprehensive analysis of their bioinspired design concepts,mechanisms,and performance is presented,along with the design criteria for microcapsules suitable for LIBs.Finally,the review explores the potential applications of microcapsule technologies in LIBs and their future trends,such as enhancing existing technologies for novel applications like solid-state batteries and developing new types of microcapsules.This review aims to provide a foundation for the implementation of microcapsule technologies in LIBs and to highlight the latest advancements in smart batteries.展开更多
We present a study of magnetic transport and radiation properties during compression of a magnetized laboratory plasma.A theta pinch is used to produce a magnetized plasma column undergoing radial implosion,with plasm...We present a study of magnetic transport and radiation properties during compression of a magnetized laboratory plasma.A theta pinch is used to produce a magnetized plasma column undergoing radial implosion,with plasma parameters comprehensively measured through diverse diagnostic techniques.High-resolution observations show the implosion progressing through three stages:compression,expansion,and recompression.An anomalous demagnetization phenomenon is observed during the first compression stage,wherein the magnetic field at the plasma center is depleted as the density increases.We reveal the demagnetization mechanism and formulate a straightforward criterion for determining its occurrence,through analysis based on extended-magnetohydrodynamics theory and a generalized Ohm’s law.Additionally,we quantitatively evaluate the radiation losses and magnetic field variations during the two compression stages,providing experimental evidence that magnetic transport can influence the radiation properties by altering the plasma hydrodynamics.Furthermore,extrapolated results using our findings reveal direct relevance to magnetized inertial confinement fusion,space,and astrophysical plasma scenarios.展开更多
Background Postoperative delirium is one of the most common complications in the older surgical population,but its pathogenesis and biomarkers are largely undetermined.Retinal layer thickness has been demonstrated to ...Background Postoperative delirium is one of the most common complications in the older surgical population,but its pathogenesis and biomarkers are largely undetermined.Retinal layer thickness has been demonstrated to be associated with cognitive function in mild cognitive impairment and patients with Alzheimer’s disease.However,relatively little is known about possible retinal layer thickness among patients with postoperative delirium.Aims We aimed to investigate the relationship between retinal layer thickness and postoperative delirium in this cross-sectional study.Methods The participants(≥65 years old)having elective surgery under general anaesthesia were screened via medical records from Shanghai 10th People’s Hospital.Preoperative macular thickness and peripapillary retinal nerve fibre layer(RNFL)thickness were measured using optical coherence tomography(OCT).The Confusion Assessment Method(CAM)algorithm and CAM-Severity(CAM-S)were used to assess the incidence and severity of postoperative delirium on the first,second and third days after surgery.Results Among 169 participants(mean(standard deviation(SD)71.15(4.36)years),40(24%)developed postoperative delirium.Notably,individuals who developed postoperative delirium exhibited thicker preoperative macular thickness in the right eye compared with those who did not(mean(SD)283.35(27.97)µm vs 273.84(20.14)µm,p=0.013).Furthermore,the thicker preoperative macular thickness of the right eye was associated with a higher incidence of postoperative delirium(adjusted odds ratio 1.593,95%confidence interval(CI)1.093 to 2.322,p=0.015)and greater severity(adjusted mean difference(β)=0.256,95%CI 0.037 to 0.476,p=0.022)after adjustment for age,sex and Mini-Mental State Examination(MMSE)scores.However,such a difference or association did not appear in the left macular or bilateral peripapillary RNFL thicknesses.Conclusions Current findings demonstrated that preoperative macular thickness might serve as a potential non-invasive marker for the vulnerability of developing postoperative delirium in older surgical patients.Further large-scale validation studies should be performed to confirm these results.展开更多
The environmental impacts of acid mine drainage(AMD)from open-pit mining are profoundly detrimental,yet knowledge about its effects on paddy soil microbial communities,especially at greater depths,remains limited.In t...The environmental impacts of acid mine drainage(AMD)from open-pit mining are profoundly detrimental,yet knowledge about its effects on paddy soil microbial communities,especially at greater depths,remains limited.In this investigation,we compared soils affected by AMD versus unaffected soil depth profiles in terms of bacterial diversity and community assembly.The profiles in AMD-polluted soils exhibited tight geochemical gradients,characterized by increased acidity,SO_(4)^(2-),NO_(3)^(-),and heavy metal content compared to unpolluted soils.Notably,AMD significantly diminished soil bacterial biodiversity.A depthwise analysis showed distinct microbial stratification,with certain bacteria like Candidatus_Solibacter and Candidatus_Koribacter predominated in polluted soils,while others like Haliangium and Nitrospira were more prevalent in control soils.Interestingly,despite variable soil conditions,predictedmetabolic pathways,particularly those involving carbon,nitrogen,and sulfur,showed relative stability.AMD pollution induced the upregulation of methylcoenzyme M reductase and sulfate reductase genes.Bacterial communities were more responsive to pH and nutrient content rather than heavy metals,with pH and SO_(4)^(2-)being the primary drivers of microbial diversity and distribution.Additionally,pHwas identified as the most significant influence on the predicted methane,sulfur,and nitrogen metabolism.Furthermore,deterministic processes played a more significant role in community assembly of polluted soils,while heterogeneous selection gained importance with increasing depth in control soils.Additionally,microbial co-occurrences,particularly positive interactions,were more prevalent in the polluted soils with reduced network modularity and keystone taxa.These findings offer insights into sustaining microbial diversity in extreme environments.展开更多
Small interfering RNA(siRNA),a promising revolutionary therapy,faces delivery obstacles due to its poor targeting,strong charge negativity and macromolecular nature.Clinical-approved siRNAs can now only be delivered t...Small interfering RNA(siRNA),a promising revolutionary therapy,faces delivery obstacles due to its poor targeting,strong charge negativity and macromolecular nature.Clinical-approved siRNAs can now only be delivered to the liver mediated by the chemically conjugated N-acetylgalactosamine(GalNAc)ligand,the conjugate can be effectively uptaken into cells through interaction with asialoglycoprotein receptor(ASGPR)highly expressed on liver hepatocytes.To further explore an efficient non-hepatic targeted delivery strategy,in this study,we designed a delivery system that chemically conjugated p53 siRNA to renal tubular cell-targeting peptides for targeting the kidney,which was suitable for industrial transformation.Results showed that peptide-siRNA conjugate could specifically enter renal tubular epithelial cells and silence target genes.In cisplatin-induced acute kidney injury(AKI)mice,peptide-siRNA conjugate blocked the p53-mediated apoptotic pathway and alleviated renal damage.The innovative proposed system to conjugate kidney-targeting peptides with siRNA achieved the efficient kidney-targeted delivery of si RNA and provided a prospective choice for treating AKI.展开更多
The brain parenchymal Langerhans cell histiocytosis （LCH） without systemic disease or lytic skull lesions is extremely rare. We report a 23-year-old male presenting with new onset 1 hour seizure with loss of conscio...The brain parenchymal Langerhans cell histiocytosis （LCH） without systemic disease or lytic skull lesions is extremely rare. We report a 23-year-old male presenting with new onset 1 hour seizure with loss of consciousness 20 days prior to admission, and recurrent seizure 2 weeks later. Brain magnetic resonance imaging （MRI） showed an irregularly mass with enhancement involving the right frontal lobe. Microscopically, the lesion was characterized by sheets of Langerhans cells in addition to reactive inflammatory elements. Immunohistochemically, Langerhans cells were positive for Langerin, CDla and S-100 protein. The patient received no chemotherapy or radiotherapy after surgery. After 24 months of follow-up, no recurrence or other systemic lesions were observed. Although there is no standard treatment for solitary cerebral LCH, the prognosis generally appears to be good.展开更多
In the past few years,deep learning has developed rapidly,and many researchers try to combine their subjects with deep learning.The algorithm based on Recurrent Neural Network(RNN)has been successfully applied in the ...In the past few years,deep learning has developed rapidly,and many researchers try to combine their subjects with deep learning.The algorithm based on Recurrent Neural Network(RNN)has been successfully applied in the fields of weather forecasting,stock forecasting,action recognition,etc.because of its excellent performance in processing Spatio-temporal sequence data.Among them,algorithms based on LSTM and GRU have developed most rapidly because of their good design.This paper reviews the RNN-based Spatio-temporal sequence prediction algorithm,introduces the development history of RNN and the common application directions of the Spatio-temporal sequence prediction,and includes precipitation nowcasting algorithms and traffic flow forecasting algorithms.At the same time,it also compares the advantages and disadvantages,and innovations of each algorithm.The purpose of this article is to give readers a clear understanding of solutions to such problems.Finally,it prospects the future development of RNN in the Spatio-temporal sequence prediction algorithm.展开更多
Objective： To explore angiopoietins （Ang-1, Ang-2）/Tie-2 expression and angiogenesis in stomach carcinomas. Methods： RT-PCR and immunohistochemistry were used to detect angiopoietins/Tie- 2 mRNA and protein expres...Objective： To explore angiopoietins （Ang-1, Ang-2）/Tie-2 expression and angiogenesis in stomach carcinomas. Methods： RT-PCR and immunohistochemistry were used to detect angiopoietins/Tie- 2 mRNA and protein expression in stomach carcinomas and their adjacent normal mucosa. Microvessel density （MVD） was counted according to CD34 immunohistochemical staining. Results： There was positive expression of Angiopoietins/Tie-2 mRNA and protein in stomach carcinomas and their paired adjacent normal mucosa. It was found that correlation between Ang-1 protein, Tie-2 mRNA expression and MVD was negative （F=-0.440, F=-0.267; P〈0.05）, while the correlation between Ang-2 mRNA and its protein, Ang-2/Ang-1 protein ratio and MVD was positive （F=0.319, F=-729, F=739; P〈0.05）. Moreover, MVD in groups with Ang-2 mRNAT/N ratio over 1.2 （the ratio of Ang-2 mRNA in stomach carcinoma to its adjacent normal mucosa） was higher than those with the ratio under 1.2. Conclusion： It was suggested that Ang-1 and Ang-2 antagonizes in the angiogenesis and the anglogenesis in tumor ultimately depended on Ang-2/Ang-1 ratio, once the expression of Ang-2 is higher than Ang-1 in some degree, the angiogenesis in tumors was promoted, otherwise oppositely. In other words, Ang-2 plays dominant role in the action of angiogenesis in tumors.展开更多
Scheduled for launch in 2030,the enhanced X-ray Timing and Polarization(eXTP)telescope is a Chinese space-based mission aimed at studying extreme conditions and phenomena in astrophysics.eXTP will feature three main p...Scheduled for launch in 2030,the enhanced X-ray Timing and Polarization(eXTP)telescope is a Chinese space-based mission aimed at studying extreme conditions and phenomena in astrophysics.eXTP will feature three main payloads:Spectroscopy Focusing Array(SFA),Polarimetry Focusing Array(PFA),and a Wide-field Camera(W2C).This white paper outlines observatory science,incorporating key scientific advances and instrumental changes since the publication of the previous white paper.We will discuss perspectives of eXTP on the research domains of flare stars,supernova remnants,pulsar wind nebulae,cataclysmic variables,X-ray binaries,ultraluminous X-ray sources,active galactic nucleus(AGN),and pulsar-based positioning and timekeeping.展开更多
Palladium-catalyzed asymmetric allylic C-H functionalization is an efficient method for the construction of enantiomerically enriched allylic derivatives.This includes asymmetric allylic amination reactions for the ef...Palladium-catalyzed asymmetric allylic C-H functionalization is an efficient method for the construction of enantiomerically enriched allylic derivatives.This includes asymmetric allylic amination reactions for the efficient construction of chiral amines.However,the asymmetric allylic C-H amination of alkenes by Lewis basic amines is a longstanding challenge.Herein,we present a highly efficient method for the palladium-catalyzed asymmetric intramolecular allylic C-H amination reaction.This method provides a means for synthesizing a range of biologically important enantioenriched isoindolines with high yields and excellent enantioselectivities(up to 98%yield and 98%ee).展开更多
As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray as...As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.展开更多
Finding the electromagnetic （EM） counterpart of binary compact star merger, especially the binary neutron star （BNS） merger, is critically important for gravitational wave （GW） astronomy, cosmology and fundament...Finding the electromagnetic （EM） counterpart of binary compact star merger, especially the binary neutron star （BNS） merger, is critically important for gravitational wave （GW） astronomy, cosmology and fundamental physics. On Aug. 17, 2017, Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart, GRB 170817A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope （HE） onboard Insight-HXMT （Hard X-ray Modulation Telescope） is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart （SSS17a/AT2017gfo） with very large collection area （M000 cm2） and microsecond time resolution in 0.2-5 MeV. In addition, Insight-HXMT quickly implemented a Target of Opportunity （TOO） observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy （0.2-5 MeV） radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817A. Meanwhile, Insight-HXMT/HE provides one of the most stringent constraints （-10-7 to 104 erg/cm2/s） for both GRB170817A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event.展开更多
Modern suspension bridges exhibit a trend of lighter structures,more diversified structural forms,and longer spans,the latter already exceeding two kilometers.Bridge performance under dead and live loads depends on th...Modern suspension bridges exhibit a trend of lighter structures,more diversified structural forms,and longer spans,the latter already exceeding two kilometers.Bridge performance under dead and live loads depends on their structural and main cable systems,while cablesupported bridges especially rely on the design analysis and construction control of the main cable.This literary survey systematically analyzes the research progress and state-ofthe-art status quo in the structural systems and design theories of suspension bridges,focusing on the structural systems,main cable shape analyses,live load effect analyses,and emerging lucrative research directions.More than 100 reliable references have been surveyed.(1)Multi-span or multi-main cable schemes appeal to increasing attention,which may become a better choice in terms of structural systems in scenarios with extremely long spans and heavy loads.The cable layouts,such as spatial main cables and hybrid cable-stayed suspension systems have also become feasible approaches for enhancing structural stiffness.(2)The shape-finding analysis during the construction phase is more complex and has more essential factors than that of the completed bridge state.Refined theories combining analytical methods and finite element methods are more suitable for the shape-finding analysis of complex cable systems than any single theory of the two,especially for novel cable systems.(3)The live load effect analysis methods based on traditional deflection theory or modified/improved deflection theories still have wide applications,but the refined theory of treating hangers as discrete members is also constantly developing,which is expected to provide new ideas for more complex structural analysis under the different types of live loads and their distribution forms.展开更多
A variety of engineered nanoparticles,including lipid nanoparticles,polymer nanoparticles,gold nanoparticles,and biomimetic nanoparticles,have been studied as delivery vehicles for biomedical applications.When assessi...A variety of engineered nanoparticles,including lipid nanoparticles,polymer nanoparticles,gold nanoparticles,and biomimetic nanoparticles,have been studied as delivery vehicles for biomedical applications.When assessing the efficacy of a nanoparticle-based delivery system,in vitro testing with a model delivery system is crucial because it allows for real-time,in situ quantitative transport analysis,which is often difficult with in vivo animal models.The advent of tissue engineering has offered methods to create experimental models that can closely mimic the 3D microenvironment in the human body.This review paper overviews the types of nanoparticle vehicles,their application areas,and the design strategies to improve delivery efficiency,followed by the uses of engineered microtissues and methods of analysis.In particular,this review highlights studies on multicellular spheroids and other 3D tissue engineering approaches for cancer drug development.The use of bio-engineered tissues can potentially provide low-cost,high-throughput,and quantitative experimental platforms for the development of nanoparticle-based delivery systems.展开更多
Studying the wetting behaviors of multicellular spheroids is crucial in the fields of embryo implantation, cancer propagation, and tissue repair. Existing strategies for controlling the wetting of multicellular sphero...Studying the wetting behaviors of multicellular spheroids is crucial in the fields of embryo implantation, cancer propagation, and tissue repair. Existing strategies for controlling the wetting of multicellular spheroids mainly focus on surface chemistry and substrate rigidity. Although topography is another important feature in the biological micro-environment, its effect on multicellular spheroid wetting has seldom been explored. In this study, the influence of topography on the surface wetting of multicellular spheroids was investigated using subcellular- patterned opal films with controllable colloidal particle diameters （from 200 to 1,500 nm）. The wetting of hepatoma carcinoma cellular （Hep G2） spheroids was impaired on opal films compared with that on flat substrates, and the wetting rate decreased as colloidal particle diameter increased. The decrement reached 48.5% when the colloidal particle diameter was 1,500 nm. The subcellular-patterned topography in opal films drastically reduced the cellular mobility in precursor films, especially the frontier cells in the leading edge. The frontier cells failed to form mature focal adhesions and stress fibers on micro-patterned opal films. This was due to gaps between colloidal particles leaving adhesion vacancies, causing weak cell-substrate adhesion and consequent retarded migration of Hep G2 spheroids. Our study manifests the inhibiting effects of subcellular-patterned topography on the wetting behaviors of multicellular spheroids, providing new insight into tissue wetting-associated treatments and biomaterial design.展开更多
It is well acknowledged to all that an active equalization strategy can overcome the inconsistency of lithium-ion cell's voltage and state of charge(SOC)in series-connected lithium-ion battery(LIB)pack in the elec...It is well acknowledged to all that an active equalization strategy can overcome the inconsistency of lithium-ion cell's voltage and state of charge(SOC)in series-connected lithium-ion battery(LIB)pack in the electric vehicle application.In this regard,a novel dual threshold trigger mechanism based active equalization strategy(DTTMbased AES)is proposed to overcome the inherent inconsistency of cells and to improve the equalization efficiency for a series-connected LIB pack.First,a modified dual-layer inductor equalization circuit is constructed to make it possible for the energy transfer path optimization.Next,based on the designed dual threshold trigger mechanism provoked by battery voltage and SOC,an active equalization strategy is proposed,each single cell's SOC in the battery packs is estimated using the extended Kalman particle filter algorithm.Besides,on the basis of the modified equalization circuit,the improved particle swarm optimization is adopted to optimize the energy transfer path with aiming to reduce the equalization time.Lastly,the simulation and experimental results are provided to validate the proposed DTTM-based AES.展开更多
基金supported by the National Natural Science Foundation of China(No.51939009)Shenzhen Science and Technology Program(Nos.JCYJ20241202125905008 and GXWD20201231165807007-20200810165349001).
文摘A trace analytical method based on solid-phase extraction gas chromatography-tandem mass spectrometry(SPE–GC–MS/MS)was developed for the rapid detection of 256 semi-volatile organic compounds(SVOCs),including 25 polycyclic aromatic hydrocarbons(PAHs),70 polychlorinated biphenyls(PCBs),123 pesticides,20 phthalate esters(PAEs),4 organophosphate esters(OPEs),9 synthetic musks(SMs),and 5 UV filters(UVs)in water.No-tably,this method provided a decent linearity of calibration standards(R^(2)>0.999),excellent method limits of quantification(MLOQs)(0.12–11.41 ng/L),satisfactory matrix spiking recovery rates(60.4%–126%),and high precision(intra-day relative standard deviations(RSDs):1.0%–10.0%,inter-day RSDs:3.0%–15.0%,and inter-week RSDs:3.4%–15.7%),making it suitable for trace-level studies.Statistical analysis revealed that SVOCs with higher volatility exhibited enhanced recovery rates.Validation of the methodology involved analyzing SVOCs in real spring water and river water samples.Twenty-seven SVOCs were detected in spring water and 58 in river water,with an average concentration of 631.73 and 16,095 ng/L,respectively.Among the detected SVOCs,PAEs constituted the predominant proportion.This study underscored the presence of SVOCs contamination specifi-cally within the spring water,although SVOCs concentrations in river water were significantly greater than those found in spring water.In summary,this sensitive method based on SPE–GC–MS/MS was successfully developed and validated for the rapid analysis of a diverse array of 256 SVOCs at trace levels in water,including not only the traditional highly valued PAHs,PCBs,pesticides,and PAEs,but also the emerging OPEs,UVs,and SMs.
基金supported by the Jilin Provincial Science and Technology Development Plan Project(No.20220508003RC)the National Natural Science Foundation of China(52202440,52003012)。
文摘Lithium-ion batteries(LIBs)play a critical role in reducing carbon emissions in the automotive industry.However,they face challenges related to safety and performance failures.Smart technologies offer a promising solution to address these issues.Bioinspired microcapsules are a common approach to enhancing the performance and safety of smart LIBs.However,despite their potential,this area has not been thoroughly explored.This review provides an overview of the preparation methods for microcapsules,including physical,chemical,and physicochemical techniques.These microcapsules are categorized based on their mechanisms into electrode self-healing burst microcapsules,interphase-forming sustained-release microcapsules,live-lithium sustained-release microcapsules,and flame-retardant burst microcapsules.A comprehensive analysis of their bioinspired design concepts,mechanisms,and performance is presented,along with the design criteria for microcapsules suitable for LIBs.Finally,the review explores the potential applications of microcapsule technologies in LIBs and their future trends,such as enhancing existing technologies for novel applications like solid-state batteries and developing new types of microcapsules.This review aims to provide a foundation for the implementation of microcapsule technologies in LIBs and to highlight the latest advancements in smart batteries.
基金the State Key Development Program for Basic Research of China(Grant No.2022YFA1602503)the National Natural Science Foundation of China(Grant Nos.12120101005 and 12205247)
文摘We present a study of magnetic transport and radiation properties during compression of a magnetized laboratory plasma.A theta pinch is used to produce a magnetized plasma column undergoing radial implosion,with plasma parameters comprehensively measured through diverse diagnostic techniques.High-resolution observations show the implosion progressing through three stages:compression,expansion,and recompression.An anomalous demagnetization phenomenon is observed during the first compression stage,wherein the magnetic field at the plasma center is depleted as the density increases.We reveal the demagnetization mechanism and formulate a straightforward criterion for determining its occurrence,through analysis based on extended-magnetohydrodynamics theory and a generalized Ohm’s law.Additionally,we quantitatively evaluate the radiation losses and magnetic field variations during the two compression stages,providing experimental evidence that magnetic transport can influence the radiation properties by altering the plasma hydrodynamics.Furthermore,extrapolated results using our findings reveal direct relevance to magnetized inertial confinement fusion,space,and astrophysical plasma scenarios.
基金supported by grants from National Natural Science Foundation of China(81720108012,82001118)Ministry of Science and Technology of China(2021ZD0202003)+1 种基金Shanghai‘Rising Stars of Medical Talents’Youth Development Program(SHWSRS(2023)-62)Henry K.Beecher Professorship from Harvard University。
文摘Background Postoperative delirium is one of the most common complications in the older surgical population,but its pathogenesis and biomarkers are largely undetermined.Retinal layer thickness has been demonstrated to be associated with cognitive function in mild cognitive impairment and patients with Alzheimer’s disease.However,relatively little is known about possible retinal layer thickness among patients with postoperative delirium.Aims We aimed to investigate the relationship between retinal layer thickness and postoperative delirium in this cross-sectional study.Methods The participants(≥65 years old)having elective surgery under general anaesthesia were screened via medical records from Shanghai 10th People’s Hospital.Preoperative macular thickness and peripapillary retinal nerve fibre layer(RNFL)thickness were measured using optical coherence tomography(OCT).The Confusion Assessment Method(CAM)algorithm and CAM-Severity(CAM-S)were used to assess the incidence and severity of postoperative delirium on the first,second and third days after surgery.Results Among 169 participants(mean(standard deviation(SD)71.15(4.36)years),40(24%)developed postoperative delirium.Notably,individuals who developed postoperative delirium exhibited thicker preoperative macular thickness in the right eye compared with those who did not(mean(SD)283.35(27.97)µm vs 273.84(20.14)µm,p=0.013).Furthermore,the thicker preoperative macular thickness of the right eye was associated with a higher incidence of postoperative delirium(adjusted odds ratio 1.593,95%confidence interval(CI)1.093 to 2.322,p=0.015)and greater severity(adjusted mean difference(β)=0.256,95%CI 0.037 to 0.476,p=0.022)after adjustment for age,sex and Mini-Mental State Examination(MMSE)scores.However,such a difference or association did not appear in the left macular or bilateral peripapillary RNFL thicknesses.Conclusions Current findings demonstrated that preoperative macular thickness might serve as a potential non-invasive marker for the vulnerability of developing postoperative delirium in older surgical patients.Further large-scale validation studies should be performed to confirm these results.
基金supported by the Educational Commission of Anhui Province of China(No.KJ2021A0168)the Research Fund of Anhui Agricultural University(No.rc422112).
文摘The environmental impacts of acid mine drainage(AMD)from open-pit mining are profoundly detrimental,yet knowledge about its effects on paddy soil microbial communities,especially at greater depths,remains limited.In this investigation,we compared soils affected by AMD versus unaffected soil depth profiles in terms of bacterial diversity and community assembly.The profiles in AMD-polluted soils exhibited tight geochemical gradients,characterized by increased acidity,SO_(4)^(2-),NO_(3)^(-),and heavy metal content compared to unpolluted soils.Notably,AMD significantly diminished soil bacterial biodiversity.A depthwise analysis showed distinct microbial stratification,with certain bacteria like Candidatus_Solibacter and Candidatus_Koribacter predominated in polluted soils,while others like Haliangium and Nitrospira were more prevalent in control soils.Interestingly,despite variable soil conditions,predictedmetabolic pathways,particularly those involving carbon,nitrogen,and sulfur,showed relative stability.AMD pollution induced the upregulation of methylcoenzyme M reductase and sulfate reductase genes.Bacterial communities were more responsive to pH and nutrient content rather than heavy metals,with pH and SO_(4)^(2-)being the primary drivers of microbial diversity and distribution.Additionally,pHwas identified as the most significant influence on the predicted methane,sulfur,and nitrogen metabolism.Furthermore,deterministic processes played a more significant role in community assembly of polluted soils,while heterogeneous selection gained importance with increasing depth in control soils.Additionally,microbial co-occurrences,particularly positive interactions,were more prevalent in the polluted soils with reduced network modularity and keystone taxa.These findings offer insights into sustaining microbial diversity in extreme environments.
基金supported by the National Key Technologies Research and Development Plan(No.2021YFE0106900)the National Natural Science Foundation of China(No.82173769)+1 种基金the Basic Research Cooperation Project of Beijing,Tianjin,Hebei from the Natural Science Foundation of Tianjin(No.20JCZXJC00070)the Applied Basic Research Multi-investment Foundation of Tianjin(No.21JCYBJC01540)。
文摘Small interfering RNA(siRNA),a promising revolutionary therapy,faces delivery obstacles due to its poor targeting,strong charge negativity and macromolecular nature.Clinical-approved siRNAs can now only be delivered to the liver mediated by the chemically conjugated N-acetylgalactosamine(GalNAc)ligand,the conjugate can be effectively uptaken into cells through interaction with asialoglycoprotein receptor(ASGPR)highly expressed on liver hepatocytes.To further explore an efficient non-hepatic targeted delivery strategy,in this study,we designed a delivery system that chemically conjugated p53 siRNA to renal tubular cell-targeting peptides for targeting the kidney,which was suitable for industrial transformation.Results showed that peptide-siRNA conjugate could specifically enter renal tubular epithelial cells and silence target genes.In cisplatin-induced acute kidney injury(AKI)mice,peptide-siRNA conjugate blocked the p53-mediated apoptotic pathway and alleviated renal damage.The innovative proposed system to conjugate kidney-targeting peptides with siRNA achieved the efficient kidney-targeted delivery of si RNA and provided a prospective choice for treating AKI.
文摘The brain parenchymal Langerhans cell histiocytosis （LCH） without systemic disease or lytic skull lesions is extremely rare. We report a 23-year-old male presenting with new onset 1 hour seizure with loss of consciousness 20 days prior to admission, and recurrent seizure 2 weeks later. Brain magnetic resonance imaging （MRI） showed an irregularly mass with enhancement involving the right frontal lobe. Microscopically, the lesion was characterized by sheets of Langerhans cells in addition to reactive inflammatory elements. Immunohistochemically, Langerhans cells were positive for Langerin, CDla and S-100 protein. The patient received no chemotherapy or radiotherapy after surgery. After 24 months of follow-up, no recurrence or other systemic lesions were observed. Although there is no standard treatment for solitary cerebral LCH, the prognosis generally appears to be good.
基金This work was supported by the National Natural Science Foundation of China(Grant No.42075007)the Open Project of Provincial Key Laboratory for Computer Information Processing Technology under Grant KJS1935Soochow University,and the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘In the past few years,deep learning has developed rapidly,and many researchers try to combine their subjects with deep learning.The algorithm based on Recurrent Neural Network(RNN)has been successfully applied in the fields of weather forecasting,stock forecasting,action recognition,etc.because of its excellent performance in processing Spatio-temporal sequence data.Among them,algorithms based on LSTM and GRU have developed most rapidly because of their good design.This paper reviews the RNN-based Spatio-temporal sequence prediction algorithm,introduces the development history of RNN and the common application directions of the Spatio-temporal sequence prediction,and includes precipitation nowcasting algorithms and traffic flow forecasting algorithms.At the same time,it also compares the advantages and disadvantages,and innovations of each algorithm.The purpose of this article is to give readers a clear understanding of solutions to such problems.Finally,it prospects the future development of RNN in the Spatio-temporal sequence prediction algorithm.
基金Supported by a grant from the Natural Sciences Foundation of Fujian (No. C0110013).
文摘Objective： To explore angiopoietins （Ang-1, Ang-2）/Tie-2 expression and angiogenesis in stomach carcinomas. Methods： RT-PCR and immunohistochemistry were used to detect angiopoietins/Tie- 2 mRNA and protein expression in stomach carcinomas and their adjacent normal mucosa. Microvessel density （MVD） was counted according to CD34 immunohistochemical staining. Results： There was positive expression of Angiopoietins/Tie-2 mRNA and protein in stomach carcinomas and their paired adjacent normal mucosa. It was found that correlation between Ang-1 protein, Tie-2 mRNA expression and MVD was negative （F=-0.440, F=-0.267; P〈0.05）, while the correlation between Ang-2 mRNA and its protein, Ang-2/Ang-1 protein ratio and MVD was positive （F=0.319, F=-729, F=739; P〈0.05）. Moreover, MVD in groups with Ang-2 mRNAT/N ratio over 1.2 （the ratio of Ang-2 mRNA in stomach carcinoma to its adjacent normal mucosa） was higher than those with the ratio under 1.2. Conclusion： It was suggested that Ang-1 and Ang-2 antagonizes in the angiogenesis and the anglogenesis in tumor ultimately depended on Ang-2/Ang-1 ratio, once the expression of Ang-2 is higher than Ang-1 in some degree, the angiogenesis in tumors was promoted, otherwise oppositely. In other words, Ang-2 plays dominant role in the action of angiogenesis in tumors.
基金supported by the China’s Space Origins Exploration Program,the National Natural Science Foundation of China(Grant Nos.12273010,12333007,12433004,12233002,12373041,and 12422306)the International Partnership Program of Chinese Academy of Sciences(Grant No.113111KYSB20190020)+9 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA15020100)the Spanish MICIU(Grant Nos.PID2021-124581OB-I0,PID2024-155316NB-I00,and 2021SGR00426)the Ramon y Cajal Fellowship(Grant Nos.RYC2021-032718-I,and RYC2018-025950-I)the European Union NextGenerationEU/PRTR,the Spanish MINECO(Grant Nos.PID2022-136828NB-C44,and PID2023-148661NB-I00)the E.U.FEDER Funds,the AGAUR/Generalitat de Catalunya(Grant No.SGR-386/2021)the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)-Projektnummer(Grant No.549824807)the Programma di Ricerca Fondamentale INAF 2023,the National SKA Program of China(Grant No.2020SKA0120300)the National Key R&D Program of China(Grant No.2021YFA0718500)the Xinjiang Tianchi Program,the Hong Kong Government under HKU(Grant No.17304524)the Bagui Scholars Program.
文摘Scheduled for launch in 2030,the enhanced X-ray Timing and Polarization(eXTP)telescope is a Chinese space-based mission aimed at studying extreme conditions and phenomena in astrophysics.eXTP will feature three main payloads:Spectroscopy Focusing Array(SFA),Polarimetry Focusing Array(PFA),and a Wide-field Camera(W2C).This white paper outlines observatory science,incorporating key scientific advances and instrumental changes since the publication of the previous white paper.We will discuss perspectives of eXTP on the research domains of flare stars,supernova remnants,pulsar wind nebulae,cataclysmic variables,X-ray binaries,ultraluminous X-ray sources,active galactic nucleus(AGN),and pulsar-based positioning and timekeeping.
基金support was provided by the State Key Laboratory of Pulp and Paper Engineering,China(grant no.2022PY01)the National Natural Science Foundation of China(grant nos.22231002 and 21871095)the KeyArea Research and Development Program of Guangdong Province,China(grant no.2020B010188001)。
文摘Palladium-catalyzed asymmetric allylic C-H functionalization is an efficient method for the construction of enantiomerically enriched allylic derivatives.This includes asymmetric allylic amination reactions for the efficient construction of chiral amines.However,the asymmetric allylic C-H amination of alkenes by Lewis basic amines is a longstanding challenge.Herein,we present a highly efficient method for the palladium-catalyzed asymmetric intramolecular allylic C-H amination reaction.This method provides a means for synthesizing a range of biologically important enantioenriched isoindolines with high yields and excellent enantioselectivities(up to 98%yield and 98%ee).
基金project funded by China National Space Administration(CNSA)and the Chinese Academy of Sciences(CAS)support from the National Key Research and Development Program of China(Grant No.2016YFA0400800)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA04010202,XDA04010300,and XDB23040400)the National Natural Science Foundation of China(Grant Nos.U1838201,and U1838102).
文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.
基金supported by the National Program on Key Research and Development Project(Grant No.2016YFA0400800)from the Ministry of Science and Technology of China(MOST)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB23040400)the Hundred Talent Program of Chinese Academy of Sciences,the National Natural Science Foundation of China(Grant Nos.11233001,11503027,11403026,11473027,and11733009)
文摘Finding the electromagnetic （EM） counterpart of binary compact star merger, especially the binary neutron star （BNS） merger, is critically important for gravitational wave （GW） astronomy, cosmology and fundamental physics. On Aug. 17, 2017, Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart, GRB 170817A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope （HE） onboard Insight-HXMT （Hard X-ray Modulation Telescope） is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart （SSS17a/AT2017gfo） with very large collection area （M000 cm2） and microsecond time resolution in 0.2-5 MeV. In addition, Insight-HXMT quickly implemented a Target of Opportunity （TOO） observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy （0.2-5 MeV） radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817A. Meanwhile, Insight-HXMT/HE provides one of the most stringent constraints （-10-7 to 104 erg/cm2/s） for both GRB170817A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event.
基金financially supported by the National Key R&D Program of China(No.2022YFB3706703)the National Natural Science Foundation of China(Nos.52078134 and 52378138)the Postgraduate Research&Practice Innovation Program of the Jiangsu Province of China(No.KYCX22_0220).
文摘Modern suspension bridges exhibit a trend of lighter structures,more diversified structural forms,and longer spans,the latter already exceeding two kilometers.Bridge performance under dead and live loads depends on their structural and main cable systems,while cablesupported bridges especially rely on the design analysis and construction control of the main cable.This literary survey systematically analyzes the research progress and state-ofthe-art status quo in the structural systems and design theories of suspension bridges,focusing on the structural systems,main cable shape analyses,live load effect analyses,and emerging lucrative research directions.More than 100 reliable references have been surveyed.(1)Multi-span or multi-main cable schemes appeal to increasing attention,which may become a better choice in terms of structural systems in scenarios with extremely long spans and heavy loads.The cable layouts,such as spatial main cables and hybrid cable-stayed suspension systems have also become feasible approaches for enhancing structural stiffness.(2)The shape-finding analysis during the construction phase is more complex and has more essential factors than that of the completed bridge state.Refined theories combining analytical methods and finite element methods are more suitable for the shape-finding analysis of complex cable systems than any single theory of the two,especially for novel cable systems.(3)The live load effect analysis methods based on traditional deflection theory or modified/improved deflection theories still have wide applications,but the refined theory of treating hangers as discrete members is also constantly developing,which is expected to provide new ideas for more complex structural analysis under the different types of live loads and their distribution forms.
基金NSF(CCSS-1809047,CAREER-1653702)NIH(1R01AR072027-01,1R03AR069383-01)the office of undergraduate research(OUR)at the University of Connecticut for providing funds to support this study.
文摘A variety of engineered nanoparticles,including lipid nanoparticles,polymer nanoparticles,gold nanoparticles,and biomimetic nanoparticles,have been studied as delivery vehicles for biomedical applications.When assessing the efficacy of a nanoparticle-based delivery system,in vitro testing with a model delivery system is crucial because it allows for real-time,in situ quantitative transport analysis,which is often difficult with in vivo animal models.The advent of tissue engineering has offered methods to create experimental models that can closely mimic the 3D microenvironment in the human body.This review paper overviews the types of nanoparticle vehicles,their application areas,and the design strategies to improve delivery efficiency,followed by the uses of engineered microtissues and methods of analysis.In particular,this review highlights studies on multicellular spheroids and other 3D tissue engineering approaches for cancer drug development.The use of bio-engineered tissues can potentially provide low-cost,high-throughput,and quantitative experimental platforms for the development of nanoparticle-based delivery systems.
基金This research is supported by National Natural Science Foundation of China （Nos. 21425314, 21434009, and 21421061）, National Program for Special Support of Eminent Professionals, Beijing Municipal Science ＆ Technology Commission （No. Z161100000116037）, and MOST （No. 2013YQ190467）.
文摘Studying the wetting behaviors of multicellular spheroids is crucial in the fields of embryo implantation, cancer propagation, and tissue repair. Existing strategies for controlling the wetting of multicellular spheroids mainly focus on surface chemistry and substrate rigidity. Although topography is another important feature in the biological micro-environment, its effect on multicellular spheroid wetting has seldom been explored. In this study, the influence of topography on the surface wetting of multicellular spheroids was investigated using subcellular- patterned opal films with controllable colloidal particle diameters （from 200 to 1,500 nm）. The wetting of hepatoma carcinoma cellular （Hep G2） spheroids was impaired on opal films compared with that on flat substrates, and the wetting rate decreased as colloidal particle diameter increased. The decrement reached 48.5% when the colloidal particle diameter was 1,500 nm. The subcellular-patterned topography in opal films drastically reduced the cellular mobility in precursor films, especially the frontier cells in the leading edge. The frontier cells failed to form mature focal adhesions and stress fibers on micro-patterned opal films. This was due to gaps between colloidal particles leaving adhesion vacancies, causing weak cell-substrate adhesion and consequent retarded migration of Hep G2 spheroids. Our study manifests the inhibiting effects of subcellular-patterned topography on the wetting behaviors of multicellular spheroids, providing new insight into tissue wetting-associated treatments and biomaterial design.
基金supported by the Artificial intelligence technology project of Xi'an Science and Technology Bureau(No.21RGZN0014).
文摘It is well acknowledged to all that an active equalization strategy can overcome the inconsistency of lithium-ion cell's voltage and state of charge(SOC)in series-connected lithium-ion battery(LIB)pack in the electric vehicle application.In this regard,a novel dual threshold trigger mechanism based active equalization strategy(DTTMbased AES)is proposed to overcome the inherent inconsistency of cells and to improve the equalization efficiency for a series-connected LIB pack.First,a modified dual-layer inductor equalization circuit is constructed to make it possible for the energy transfer path optimization.Next,based on the designed dual threshold trigger mechanism provoked by battery voltage and SOC,an active equalization strategy is proposed,each single cell's SOC in the battery packs is estimated using the extended Kalman particle filter algorithm.Besides,on the basis of the modified equalization circuit,the improved particle swarm optimization is adopted to optimize the energy transfer path with aiming to reduce the equalization time.Lastly,the simulation and experimental results are provided to validate the proposed DTTM-based AES.
