Precipitation via thermal treatments is among the most effective approaches to strengthening and is widely applied in the Al industry. Thermal treatments combined with deformation are capable of finely regulating the ...Precipitation via thermal treatments is among the most effective approaches to strengthening and is widely applied in the Al industry. Thermal treatments combined with deformation are capable of finely regulating the process of precipitation and distribution of precipitates. Deformation-induced defects exert significant impacts on the precipitation and already present precipitates, which however is often overlooked. In this study, the interactions between deformation and precipitation/precipitates, and their impacts on mechanical properties were systematically investigated in the solution-treated (ST) Al-0.61Mg-1.17Si-0.5Cu (wt.%), processed by multi-pass equal channel angular pressing (ECAP) and thermal treatments. Novel deformation-mediated cyclic evolution of precipitates is discovered: ST→ (1,2 passes: deformation induced precipitation) Guinier Preston (GP) zones→ (An250/30) Q’ and L phases→ (3-pass: deformation induced fragmentation/resolution) spherical precipitates→ (4-pass: deformation induced further fragmentation/resolution) GP zones. On this basis, we extend the quasi-binary phase diagram of Al-Mg_(2)Si along deformation as the third dimension and construct an innovative defect phase diagram for the Al-Mg-Si-based system. To testify to the effect of deformation-mediated cyclic evolution of precipitation/precipitates on the optimum mechanical properties, peak-aging treatments were performed in samples of ST and 3-pass states. Based on the microscopic characterizations, a distinctive mechanism of peak-aging strengthening is proposed. Notably in the 3-pass ECAPed and peak-aged sample the dominant strengthening phases become the L precipitates that thrived from the segmented and spherical L phases, rather than β’’ precipitates in the solely peak-aged ST sample. Our work provides a feasible example for exploring the combined processing technique of multi-step deformation and thermal treatments, to optimize the mechanical properties.展开更多
Highlights●CRISPR/Cas9 RNP complex-based strategy demonstrates robustness and accuracy in generating gene-edited sheep.●Sheep horn development remains unaffected by partial RXFP2 knockout.●Partial RXFP2 knockout re...Highlights●CRISPR/Cas9 RNP complex-based strategy demonstrates robustness and accuracy in generating gene-edited sheep.●Sheep horn development remains unaffected by partial RXFP2 knockout.●Partial RXFP2 knockout results in unilateral cryptorchidism in sheep.展开更多
Stomata are tiny pores on the plant leaf surface that regulate the exchange of water and gases between the plant and the external environment.They are crucial for photosynthesis,water use efficiency(WUE),and the plant...Stomata are tiny pores on the plant leaf surface that regulate the exchange of water and gases between the plant and the external environment.They are crucial for photosynthesis,water use efficiency(WUE),and the plant’s ability to adapt to environmental changes.Stomatal movement is vital for understanding how plants adapt to environmental stress and optimize resource utilization.Changes in environmental conditions,especially the quality and intensity of light throughout the day,affect stomatal dynamics and diurnal behavior,which in turn impact photosynthetic efficiency and water-use efficiency.In this review,we summarize the biophysical principles and mechanisms of stomatal movement regulated by ion transport at the plasma membrane,vacuolar membrane and metabolic activity through persulfidation or S-nitrosylation modifications.Specifically,we focus on recent progress in the regulation of stomatal movement by different light qualities,and summarize the photochemical and biochemical events underlying photoreceptors as well as the knowledge of novel regulatory functions and signaling in the multilayer control of stomatal movement and environmental adaptation.Furthermore,as rising global temperatures and increased water needs of farming methods are expected to escalate future crop losses,we explore the potential of smart LED lighting and gene editing technology in enhancing photosynthetic efficiency and water-use efficiency,leading to increased crop biomass and higher crop yields.展开更多
Crucial for mediating inflammation and the perception of pain,the ion channel known as transient receptor potential ankyrin 1(TRPA1)holds significant importance.It contributes to the increased production of cytokines ...Crucial for mediating inflammation and the perception of pain,the ion channel known as transient receptor potential ankyrin 1(TRPA1)holds significant importance.It contributes to the increased production of cytokines in the inflammatory cells of cartilage affected by osteoarthritis and represents a promising target for the treatment of this condition.By leveraging the unique advantages of liposomes,a composite microsphere drug delivery system with stable structural properties and high adaptability can be developed,providing a new strategy for osteoarthritis(OA)drug therapy.The liposomes as drug reservoirs for TRPA1 inhibitors were loaded into hyaluronic acid methacrylate(HAMA)hydrogels to make hydrogel microspheres via microfluidic technology.An in vitro inflammatory chondrocyte model was established with interleukin-1β(IL-1β)to demonstrate HAMA@Lipo@HC’s capabilities.A destabilization of the medial meniscus(DMM)mouse model was also created to evaluate the efficacy of intra-articular injections for treating OA.HAMA@Lipo@HC has a uniform particle-size distribution and is injectable.The drug encapsulation rate was 64.29%±2.58%,with a sustained release period of 28 days.Inhibition of TRPA1 via HC-030031 effectively alleviated IL-1β-induced chondrocyte inflammation and matrix degradation.In DMM model OA mice,microspheres showed good long-term sustained drug release properties,improved joint inflammation microenvironment,reduced articular cartilage damage and decreased mechanical nociceptive threshold.This research pioneers the creation of a drug delivery system tailored for delivery into the joint cavity,focusing on TRPA1 as a therapeutic target for osteoarthritis.Additionally,it offers a cutting-edge drug delivery platform aimed at addressing diseases linked to inflammation.展开更多
Background Dysregulation of lipid metabolism and its consequences on growth performance in young ruminants have attracted attention,especially in the context of alternative feeding strategies.This study aims to elucid...Background Dysregulation of lipid metabolism and its consequences on growth performance in young ruminants have attracted attention,especially in the context of alternative feeding strategies.This study aims to elucidate the effects of milk replacer(MR)feeding on growth,lipid metabolism,colonic epithelial gene expression,colonic microbiota composition and systemic metabolism in goat kids compared to breast milk(BM)feeding,addressing a critical knowledge gap in early life nutrition.Methods Ten female goat kids were divided into 2 groups:those fed breast milk(BM group)and those fed a milk replacer(MR group).Over a period of 28 d,body weight was monitored and blood and tissue samples were collected for biochemical,transcriptomic and metabolomic analyses.Profiling of the colonial microbiota was performed using 16S rRNA gene sequencing.Intestinal microbiota transplantation(IMT)experiments in gnotobiotic mice were per-formed to validate causality.Results MR-fed pups exhibited reduced daily body-weight gain due to impaired lipid metabolism as evidenced by lower serum and liver total cholesterol(TC)and non-esterified fatty acid(NEFA)concentrations.Transcriptomic analysis of the colonic epithelium revealed upregulated genes involved in negative regulation of lipid metabolism,concomitant with microbiota shifts characterized by a decrease in Firmicutes and an increase in Actinobacteria.Specifically,genera such as Bifidobacterium and Prevotella were enriched in the MR group,while Clostridium and Fae-calibacterium were depleted.Metabolomics analyses confirmed alterations in bile acid and fatty acid metabolic path-ways.IMT experiments in mice recapitulated the metabolic phenotype observed in MR-fed goats,confirming the role of the microbiota in modulating host lipid metabolism.Conclusions Milk replacer feeding in goat kids disrupts lipid metabolism and gut microbiota dynamics,result-ing in reduced growth rates and metabolic alterations.These findings highlight the importance of early nutritional intervention on metabolic programming and suggest that modulation of the gut microbiota may be a target for improving growth and metabolic health in ruminants.This study contributes to the understanding of nutritional management strategies in livestock and their impact on animal health and productivity.展开更多
Given the rapid development of advanced information systems,microgrids(MGs)suffer from more potential attacks that affect their operational performance.Conventional distributed secondary control with a small,fixed sam...Given the rapid development of advanced information systems,microgrids(MGs)suffer from more potential attacks that affect their operational performance.Conventional distributed secondary control with a small,fixed sampling time period inevitably causes the wasteful use of communication resources.This paper proposes a self-triggered secondary control scheme under perturbations from false data injection(FDI)attacks.We designed a linear clock for each DG to trigger its controller at aperiodic and intermittent instants.Sub-sequently,a hash-based defense mechanism(HDM)is designed for detecting and eliminating malicious data infiltrated in the MGs.With the aid of HDM,a self-triggered control scheme achieves the secondary control objectives even in the presence of FDI attacks.Rigorous theoretical analyses and simulation results indicate that the introduced secondary control scheme significantly reduces communication costs and enhances the resilience of MGs under FDI attacks.展开更多
With the rapid development of large-scale regional interconnected power grids,the risk of cascading failures under extreme condi-tions,such as natural disasters and military strikes,has increased significantly.To enha...With the rapid development of large-scale regional interconnected power grids,the risk of cascading failures under extreme condi-tions,such as natural disasters and military strikes,has increased significantly.To enhance the response capability of power systems to extreme events,this study focuses on a method for generator coherency detection.To overcome the shortcomings of the traditional slow coherency method,this paper introduces a novel coherent group identification algorithm based on the theory of nonlinear dynam-ical systems.By analyzing the changing trend of the Euclidean norm of the state variable derivatives in the reduced system,the algorithm can accurately identify the magnitude of the disturbances.Based on the slow coherency methods,the algorithm can correctly recognize coherent generator groups by analyzing system characteristics under varying disturbance magnitudes.This improvement enhances the applicability and accuracy of the coherency detection algorithm under extreme conditions,providing support for emergency control and protection in the power system.Simulations and comparison analyses on IEEE 39-bus system are conducted to validate the accuracy and superiority of the proposed coherent generator group identification method under extreme conditions.展开更多
Continuous cropping leads to high incidence of soilborne diseases such as bacterial wilt caused by Ralstonia solanacearum,which poses a risk to agricultural production.Anaerobic soil disinfestation(ASD)and plant growt...Continuous cropping leads to high incidence of soilborne diseases such as bacterial wilt caused by Ralstonia solanacearum,which poses a risk to agricultural production.Anaerobic soil disinfestation(ASD)and plant growthpromoting rhizobacteria(PGPR)are considered environmentally friendly methods to control bacterial wilt.However,the underlying mechanism of the improvement of soil health and the inhibition of bacterial wilt after ASD treatment and PGPR inoculation needs further exploration.This study evaluated the effect of ASD treatment on soil improvement at pre-planting of tomato,and the effect of ASD treatment combined with the application of Bacillus velezensis Y6(BV)on soil quality,R.solanacearum abundance,and bacterial communities at 90 days before harvesting of tomato.The results showed that ASD treatment reduced R.solanacearum abundance in soil by17.6%at pre-planting and 18.7%at 90 days before harvesting,but BV inoculation did not influence R.solanacearum abundance.ASD and ASD+BV treatments effectively reduced the occurrence of bacterial wilt,improved soil nutrient status and increased soil microbial activity at 90 days before harvesting.Principal co-ordinate analysis showed that the soil bacterial community was significantly influenced by ASD treatment both at pre-planting and at 90 days before harvesting.Further investigation found that ASD contributed to the enrichment of beneficial flora(Bacillus and Streptomyces).Moreover,pH was an important environmental factor affecting the abundance of R.solanacearum in soil.Co-occurrence network analysis showed that ASD treatment significantly increased network connection of bacterial communities and the proportion of beneficial microorganisms(Proteobacteria and Firmicutes),leading to complex soil bacterial co-occurrence networks both at pre-planting and at 90 days before harvesting.Collectively,these results indicate that ASD treatment,but not microbial inoculation can enhance tomato plant resistance to bacterial wilt by improving soil quality and modulating the soil bacterial community.展开更多
Understanding interlayer charge transfer is crucial for elucidating interface interactions in heterostructures.As the layer number can significantly influence the interface coupling and band alignment,the charge trans...Understanding interlayer charge transfer is crucial for elucidating interface interactions in heterostructures.As the layer number can significantly influence the interface coupling and band alignment,the charge transfer behaviors can be largely regulated.Here,we constructed two-dimensional(2D)heterostructures consisting of monolayer WS_(2)and few-layer InSe to investigate the impact of InSe thickness on exciton dynamics.We performed photoluminescence(PL)spectroscopy and lifetime measurements on pristine few-layer InSe and the heterostructures with different InSe thicknesses.For pristine InSe layers,we found a non-monotonic layer dependence on PL lifetime,which can be attributed to the interplay between the indirect-to-direct bandgap transition and surface recombination effects.For heterostructures,we demonstrated that the type I band alignment of the heterostructure facilitates electron and hole transfer from monolayer WS_(2)to InSe.As the InSe layer number increases,the reduction in conduction band minimum(CBM)enhances the driving force for charge transfer,thereby improving the transfer efficiency.Furthermore,we fabricated and characterized a WS_(2)/InSe optoelectronic device.By analyzing bias voltage dependent PL spectra,we further demonstrated that the trions in WS_(2)within the heterostructure are positively charged(X^(+)),and their emission intensity can be efficiently modulated by applying different biases.This study not only reveals the layer-dependent characteristics of band alignment and interlayer charge transfer in heterostructures but also provides valuable insights for the applications of 2D semiconductors in optoelectronic devices.展开更多
To lower the operation temperature and increase the durability of solid oxide fuel cells(SOFCs), increasing attentions have been paid on developing cathode materials with good oxygen reduction reaction(ORR)activity at...To lower the operation temperature and increase the durability of solid oxide fuel cells(SOFCs), increasing attentions have been paid on developing cathode materials with good oxygen reduction reaction(ORR)activity at intermediate-temperature(IT, 500-750 ℃) range. However, most cathode materials exhibit poor catalytic activity, or they thermally mismatch with SOFC electrolytes and undergo severe degeneration. Infiltrating catalysts on existing backbone materials has been proved to be an efficient method to construct highly active and durable cathodes. In this mini-review, the advantages of infiltration-based cathode compared with new material-based cathodes are summarized. The merits and drawbacks of different backbones are illustrated. Different types of catalysts for infiltration are depicted in detail. Suggestions on the material/structure optimization of the infiltrated cathodes of IT-SOFC are provided.展开更多
The thermal structure of the lower mantle plays a key role in understanding the dynamic processes of the Earth's evolution and mantle convection.Because intrinsic attenuation in the lower mantle is highly sensitiv...The thermal structure of the lower mantle plays a key role in understanding the dynamic processes of the Earth's evolution and mantle convection.Because intrinsic attenuation in the lower mantle is highly sensitive to temperature,determining of the attenuation of the lower mantle could help us determine its thermal state.We attempted to constrain the attenuation of the lower mantle by measuring the amplitude ratios of p to ScP on the vertical component and s to ScS on the tangential component at short epicentral distances for seismic wave data from deep earthquakes in Northeast China.We calculated the theoretical amplitude ratios of p to ScP and s to ScS by using ray theory and the axial-symmetric spectral element method AxiSEM,as well as by considering the effects of radiation patterns,geometrical spreading,and ScP reflection coefficients.By comparing the observed amplitude ratios with the synthetic results,we constrained the quality factors as Qα≈3,000 and Qβ≈1,300 in the lower mantle beneath Northeast China,which are much larger than those in the preliminary reference Earth model(PREM)model of Qα~800 and Qβ~312.We propose that the lower mantle beneath Northeast China is relatively colder than the average mantle,resulting in weaker intrinsic attenuation and higher velocity.We estimated the temperature of the lower mantle beneath Northeast China as approximately 300–700 K colder than the global average value.展开更多
Recently,natural van der Waals heterostructures of(MnBi2 Te4)m(Bi2 Te3)n have been theoretically predicted and experimentally shown to host tunable magnetic properties and topologically nontrivial surface states.We sy...Recently,natural van der Waals heterostructures of(MnBi2 Te4)m(Bi2 Te3)n have been theoretically predicted and experimentally shown to host tunable magnetic properties and topologically nontrivial surface states.We systematically investigate both the structural and electronic responses of MnBi2 Te4 and MnBi4 Te7 to external pressure.In addition to the suppression of antiferromagnetic order,MnBi2 Te4 is found to undergo a metalsemiconductor-metal transition upon compression.The resistivity of MnBi4 Te7 changes dramatically under high pressure and a non-monotonic evolution of p(T)is observed.The nontrivial topology is proved to persist before the structural phase transition observed in the high-pressure regime.We find that the bulk and surface states respond differently to pressure,which is consistent with the non-monotonic change of the resistivity.Interestingly,a pressure-induced amorphous state is observed in MnBi2 Te4,while two high-pressure phase transitions are revealed in MnBi4 Te7.Our combined theoretical and experimental research establishes MnBi2 Te4 and MnBi4 Te7 as highly tunable magnetic topological insulators,in which phase transitions and new ground states emerge upon compression.展开更多
Iron-based superconductor family FeX(X=S,Se,Te)has been one of the research foci in physics and material science due to their record-breaking superconducting temperature(FeSe film)and rich physical phenomena.Recently,...Iron-based superconductor family FeX(X=S,Se,Te)has been one of the research foci in physics and material science due to their record-breaking superconducting temperature(FeSe film)and rich physical phenomena.Recently,FeS,the least studied Fe X compound(due to the difficulty in synthesizing high quality macroscopic crystals)attracted much attention because of its puzzling superconducting pairing symmetry.In this work,combining scanning tunneling microscopy and angle resolved photoemission spectroscopy(ARPES)with sub-micron spatial resolution,we investigate the intrinsic electronic structures of superconducting FeS from individual single crystalline domains.Unlike FeTe or FeSe,FeS remains identical tetragonal structure from room temperature down to 5 K,and the band structures observed can be well reproduced by our ab-initio calculations.Remarkably,mixed with the 1×1 tetragonal metallic phase,we also observe the coexistence of √5×√5 reconstructed insulating phase in the crystal,which not only helps explain the unusual properties of FeS,but also demonstrates the importance of using spatially resolved experimental tools in the study of this compound.展开更多
The dimensionality of quantum materials strongly affects their physical properties.Although many emergent phenomena,such as charge-density wave and Luttinger liquid behavior,are well understood in one-dimensional(1D)s...The dimensionality of quantum materials strongly affects their physical properties.Although many emergent phenomena,such as charge-density wave and Luttinger liquid behavior,are well understood in one-dimensional(1D)systems,the generalization to explore them in higher dimensional systems is still a challenging task.In this study,we aim to bridge this gap by systematically investigating the crystal and electronic structures of molybdenum-oxide family compounds,where the contexture of 1D chains facilitates rich emergent properties.While the quasi-1D chains in these materials share general similarities,such as the motifs made up of MoO_(6)octahedrons,they exhibit vast complexity and remarkable tunability.We disassemble the 1D chains in molybdenum oxides with different dimensions and construct effective models to excellently fit their low-energy electronic structures obtained by ab initio calculations.Furthermore,we discuss the implications of such chains on other physical properties of the materials and the practical significance of the effective models.Our work establishes the molybdenum oxides as simple and tunable model systems for studying and manipulating the dimensionality in quantum systems.展开更多
Ternary transition metal chalcogenides provide a rich platform to search and study intriguing electronic properties. Using angle-resolved photoemission spectroscopy and ab initio calculation, we investigate the electr...Ternary transition metal chalcogenides provide a rich platform to search and study intriguing electronic properties. Using angle-resolved photoemission spectroscopy and ab initio calculation, we investigate the electronic structure of Cu_(2)TlX_(2)(X = Se, Te), ternary transition metal chalcogenides with quasi-two-dimensional crystal structure. The band dispersions near the Fermi level are mainly contributed by the Te/Se p orbitals. According to our ab-initio calculation, the electronic structure changes from a semiconductor with indirect band gap in Cu_(2)TlSe_(2) to a semimetal in Cu_(2)TlTe_(2), suggesting a band-gap tunability with the composition of Se and Te. By comparing ARPES experimental data with the calculated results, we identify strong modulation of the band structure by spin–orbit coupling in the compounds. Our results provide a ternary platform to study and engineer the electronic properties of transition metal chalcogenides related to large spin–orbit coupling.展开更多
Sheep is an important livestock species raised globally to produce meat,milk,wool,and other by-products.During the Neolithic Revolution,sheep were domesticated in the Fertile Crescent of Southwest Asia around 10,000 y...Sheep is an important livestock species raised globally to produce meat,milk,wool,and other by-products.During the Neolithic Revolution,sheep were domesticated in the Fertile Crescent of Southwest Asia around 10,000 years ago(Chessa et al.,2009).展开更多
目的研究妊娠中期贫血对新生儿体格发育指标的影响。方法选取2019年1月—2019年10月在本院分娩的单胎无其它并发症及合并症的产妇382例作为研究对象,入院待产时回顾性收集妊娠中期血常规结果,分娩后立即测量新生儿出生体重和身长,并计...目的研究妊娠中期贫血对新生儿体格发育指标的影响。方法选取2019年1月—2019年10月在本院分娩的单胎无其它并发症及合并症的产妇382例作为研究对象,入院待产时回顾性收集妊娠中期血常规结果,分娩后立即测量新生儿出生体重和身长,并计算体质指数。所有数据采用SPSS软件进行统计学分析。结果贫血组孕妇所分娩新生儿的体重(2730.47±183.94 g vs 3366.78±306.98 g)、身长(48.49±1.39 cm vs 50.64±1.37 cm)以及出生孕周(38.56±1.35周vs 39.38±0.98周)均小于对照组(均P<0.05),而两组的体质指数(BMI)无统计学差异(20.99±4.64 kg/m^(2) vs 20.98±4.52 kg/m^(2),P>0.05)。贫血孕妇早产及低体重儿的发生率均高于正常孕妇(均为10.59%vs 0%,P<0.05)。妊娠中期血红蛋白水平与出生体重及身长均存在正相关(r值分别为0.331和0.377,均P<0.05)。结论妊娠中期贫血是早产和低出生体重儿的危险因素,新生儿出生体重和身长与母体血红蛋白浓度存在正相关。展开更多
Traditional active power sharing in microgrids,achieved by the distributed average consensus,requires each controller to continuously trigger and communicate with each other,which is a wasteful use of the limited comp...Traditional active power sharing in microgrids,achieved by the distributed average consensus,requires each controller to continuously trigger and communicate with each other,which is a wasteful use of the limited computation and communication resources of the secondary controller.To enhance the efficiency of secondary control,we developed a novel distributed self-triggered active power-sharing control strategy by introducing the signum function and a flexible linear clock.Unlike continuous communication–based controllers,the proposed self-triggered distributed controller prompts distributed generators to perform control actions and share information with their neighbors only at specific time instants monitored by the linear clock.Therefore,this approach results in a significant reduction in both the computation and communication requirements.Moreover,this design naturally avoids Zeno behavior.Furthermore,a modified triggering condition was established to achieve further reductions in computation and communication.The simulation results confirmed that the proposed control scheme achieves distributed active power sharing with very few controller triggers,thereby substantially enhancing the efficacy of secondary control in MGs.展开更多
In this work,mechanical alloying of the alternating stacked pure Al and Zn thin foils was accomplished via high-pressure torsion(HPT).In the alloyed Al-Zn system,an exotic phase transformation from hexagonal close-pac...In this work,mechanical alloying of the alternating stacked pure Al and Zn thin foils was accomplished via high-pressure torsion(HPT).In the alloyed Al-Zn system,an exotic phase transformation from hexagonal close-packed(HCP)to face-centered cubic(FCC)was identified.The atomic-scale evolution process and underlying mechanism of phase transformation down to atomic scale are provided by molecular dynamics simulation and high-resolution transmission electron microscopy.The HCP→FCC phase transformation was attributed to the sliding of Shockley partial dislocations generated at the Al-Zn grain boundaries,which resulted in an[2110][011]and(0001)/(111)orientation relationship between the two phases.This work provides a new approach for the in-depth study of the solid phase transformation of Al-Zn alloys and also shed lights on understanding the mechanical properties of the HPT processed Al-Zn alloys.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.U22A20187,52171007,52371111,and 52371177).
文摘Precipitation via thermal treatments is among the most effective approaches to strengthening and is widely applied in the Al industry. Thermal treatments combined with deformation are capable of finely regulating the process of precipitation and distribution of precipitates. Deformation-induced defects exert significant impacts on the precipitation and already present precipitates, which however is often overlooked. In this study, the interactions between deformation and precipitation/precipitates, and their impacts on mechanical properties were systematically investigated in the solution-treated (ST) Al-0.61Mg-1.17Si-0.5Cu (wt.%), processed by multi-pass equal channel angular pressing (ECAP) and thermal treatments. Novel deformation-mediated cyclic evolution of precipitates is discovered: ST→ (1,2 passes: deformation induced precipitation) Guinier Preston (GP) zones→ (An250/30) Q’ and L phases→ (3-pass: deformation induced fragmentation/resolution) spherical precipitates→ (4-pass: deformation induced further fragmentation/resolution) GP zones. On this basis, we extend the quasi-binary phase diagram of Al-Mg_(2)Si along deformation as the third dimension and construct an innovative defect phase diagram for the Al-Mg-Si-based system. To testify to the effect of deformation-mediated cyclic evolution of precipitation/precipitates on the optimum mechanical properties, peak-aging treatments were performed in samples of ST and 3-pass states. Based on the microscopic characterizations, a distinctive mechanism of peak-aging strengthening is proposed. Notably in the 3-pass ECAPed and peak-aged sample the dominant strengthening phases become the L precipitates that thrived from the segmented and spherical L phases, rather than β’’ precipitates in the solely peak-aged ST sample. Our work provides a feasible example for exploring the combined processing technique of multi-step deformation and thermal treatments, to optimize the mechanical properties.
基金supported by the National Key Research and Development Program of China(2022YFD1300200)the National Natural Science Foundation of China(32161143010,32202646,and 32272848)+2 种基金the China Agriculture Research System(CARS-39)the Key Special Project of Ningxia Science and Technology Department,China(2021BEF02024)the local grants,China(NXTS2021-001,2022GD-TSLD-46,NK2022010207,and NXTS2022-001)。
文摘Highlights●CRISPR/Cas9 RNP complex-based strategy demonstrates robustness and accuracy in generating gene-edited sheep.●Sheep horn development remains unaffected by partial RXFP2 knockout.●Partial RXFP2 knockout results in unilateral cryptorchidism in sheep.
基金funded by the National Natural Science Foundation of China(Grant Nos.32272698,32441072,32122081)National Key Research and Development Program of China(Grant No.2023YFF1002000)+4 种基金Liaoning Province Youth Science Foundation A-Class Project(formerly Liaoning Natural Science Foundation Outstanding Youth Project,Grant No.2025-JQ-05)Liaoning Province’s Future Industry Frontier Technology Project(Grant Nos.2025JH2/101330184 and 2025JH2/101330185)National Postdoctoral Program for Innovative Talents(Grant No.BX20250016)Open Project Program of State Key Laboratory of Crop Stress Biology for Arid Areas of China(Grant No.SKLCSRHPKF2025017)HAAFS Science and Technology Innovation Special Project(Grant No.2023KJCXZX-JZS-10).
文摘Stomata are tiny pores on the plant leaf surface that regulate the exchange of water and gases between the plant and the external environment.They are crucial for photosynthesis,water use efficiency(WUE),and the plant’s ability to adapt to environmental changes.Stomatal movement is vital for understanding how plants adapt to environmental stress and optimize resource utilization.Changes in environmental conditions,especially the quality and intensity of light throughout the day,affect stomatal dynamics and diurnal behavior,which in turn impact photosynthetic efficiency and water-use efficiency.In this review,we summarize the biophysical principles and mechanisms of stomatal movement regulated by ion transport at the plasma membrane,vacuolar membrane and metabolic activity through persulfidation or S-nitrosylation modifications.Specifically,we focus on recent progress in the regulation of stomatal movement by different light qualities,and summarize the photochemical and biochemical events underlying photoreceptors as well as the knowledge of novel regulatory functions and signaling in the multilayer control of stomatal movement and environmental adaptation.Furthermore,as rising global temperatures and increased water needs of farming methods are expected to escalate future crop losses,we explore the potential of smart LED lighting and gene editing technology in enhancing photosynthetic efficiency and water-use efficiency,leading to increased crop biomass and higher crop yields.
基金supported by the National Key Research and Development Program of China(No.82230071)National Natural Science Foundation of China(Nos.82202674,82202334)Wenzhou Science and Technology Project(Nos.Y20220178,Y20220016).
文摘Crucial for mediating inflammation and the perception of pain,the ion channel known as transient receptor potential ankyrin 1(TRPA1)holds significant importance.It contributes to the increased production of cytokines in the inflammatory cells of cartilage affected by osteoarthritis and represents a promising target for the treatment of this condition.By leveraging the unique advantages of liposomes,a composite microsphere drug delivery system with stable structural properties and high adaptability can be developed,providing a new strategy for osteoarthritis(OA)drug therapy.The liposomes as drug reservoirs for TRPA1 inhibitors were loaded into hyaluronic acid methacrylate(HAMA)hydrogels to make hydrogel microspheres via microfluidic technology.An in vitro inflammatory chondrocyte model was established with interleukin-1β(IL-1β)to demonstrate HAMA@Lipo@HC’s capabilities.A destabilization of the medial meniscus(DMM)mouse model was also created to evaluate the efficacy of intra-articular injections for treating OA.HAMA@Lipo@HC has a uniform particle-size distribution and is injectable.The drug encapsulation rate was 64.29%±2.58%,with a sustained release period of 28 days.Inhibition of TRPA1 via HC-030031 effectively alleviated IL-1β-induced chondrocyte inflammation and matrix degradation.In DMM model OA mice,microspheres showed good long-term sustained drug release properties,improved joint inflammation microenvironment,reduced articular cartilage damage and decreased mechanical nociceptive threshold.This research pioneers the creation of a drug delivery system tailored for delivery into the joint cavity,focusing on TRPA1 as a therapeutic target for osteoarthritis.Additionally,it offers a cutting-edge drug delivery platform aimed at addressing diseases linked to inflammation.
基金financially supported by National Natural Science Foundation of China (32160801)China Agriculture Research System (CARS-39-12)+1 种基金Young Talent Fund of Association for Science and Technology in Shaanxi, China (2023-6-2-1)“Double-chain” project on livestock breeding (2022GDTSLD-46)
文摘Background Dysregulation of lipid metabolism and its consequences on growth performance in young ruminants have attracted attention,especially in the context of alternative feeding strategies.This study aims to elucidate the effects of milk replacer(MR)feeding on growth,lipid metabolism,colonic epithelial gene expression,colonic microbiota composition and systemic metabolism in goat kids compared to breast milk(BM)feeding,addressing a critical knowledge gap in early life nutrition.Methods Ten female goat kids were divided into 2 groups:those fed breast milk(BM group)and those fed a milk replacer(MR group).Over a period of 28 d,body weight was monitored and blood and tissue samples were collected for biochemical,transcriptomic and metabolomic analyses.Profiling of the colonial microbiota was performed using 16S rRNA gene sequencing.Intestinal microbiota transplantation(IMT)experiments in gnotobiotic mice were per-formed to validate causality.Results MR-fed pups exhibited reduced daily body-weight gain due to impaired lipid metabolism as evidenced by lower serum and liver total cholesterol(TC)and non-esterified fatty acid(NEFA)concentrations.Transcriptomic analysis of the colonic epithelium revealed upregulated genes involved in negative regulation of lipid metabolism,concomitant with microbiota shifts characterized by a decrease in Firmicutes and an increase in Actinobacteria.Specifically,genera such as Bifidobacterium and Prevotella were enriched in the MR group,while Clostridium and Fae-calibacterium were depleted.Metabolomics analyses confirmed alterations in bile acid and fatty acid metabolic path-ways.IMT experiments in mice recapitulated the metabolic phenotype observed in MR-fed goats,confirming the role of the microbiota in modulating host lipid metabolism.Conclusions Milk replacer feeding in goat kids disrupts lipid metabolism and gut microbiota dynamics,result-ing in reduced growth rates and metabolic alterations.These findings highlight the importance of early nutritional intervention on metabolic programming and suggest that modulation of the gut microbiota may be a target for improving growth and metabolic health in ruminants.This study contributes to the understanding of nutritional management strategies in livestock and their impact on animal health and productivity.
基金supported by Hainan Provincial Natural Science Foundation of China(No.524RC532)Research Startup Funding from Hainan Institute of Zhejiang University(No.0210-6602-A12202)Project of Sanya Yazhou Bay Science and Technology City(No.SKJC-2022-PTDX-009/010/011).
文摘Given the rapid development of advanced information systems,microgrids(MGs)suffer from more potential attacks that affect their operational performance.Conventional distributed secondary control with a small,fixed sampling time period inevitably causes the wasteful use of communication resources.This paper proposes a self-triggered secondary control scheme under perturbations from false data injection(FDI)attacks.We designed a linear clock for each DG to trigger its controller at aperiodic and intermittent instants.Sub-sequently,a hash-based defense mechanism(HDM)is designed for detecting and eliminating malicious data infiltrated in the MGs.With the aid of HDM,a self-triggered control scheme achieves the secondary control objectives even in the presence of FDI attacks.Rigorous theoretical analyses and simulation results indicate that the introduced secondary control scheme significantly reduces communication costs and enhances the resilience of MGs under FDI attacks.
基金supported by National Natural Science Foundation of China(Grant No:52477133)Science and Technology Project of China Southern Power Grid(Grant No.GDKJXM20231178(036100KC23110012)+1 种基金GDKJXM20240389(030000KC24040053))Sanya Yazhou Bay Science and Technology City(Grant No:SKJC-JYRC-2024-66).
文摘With the rapid development of large-scale regional interconnected power grids,the risk of cascading failures under extreme condi-tions,such as natural disasters and military strikes,has increased significantly.To enhance the response capability of power systems to extreme events,this study focuses on a method for generator coherency detection.To overcome the shortcomings of the traditional slow coherency method,this paper introduces a novel coherent group identification algorithm based on the theory of nonlinear dynam-ical systems.By analyzing the changing trend of the Euclidean norm of the state variable derivatives in the reduced system,the algorithm can accurately identify the magnitude of the disturbances.Based on the slow coherency methods,the algorithm can correctly recognize coherent generator groups by analyzing system characteristics under varying disturbance magnitudes.This improvement enhances the applicability and accuracy of the coherency detection algorithm under extreme conditions,providing support for emergency control and protection in the power system.Simulations and comparison analyses on IEEE 39-bus system are conducted to validate the accuracy and superiority of the proposed coherent generator group identification method under extreme conditions.
基金the National Natural Science Foundation of China(31870420)the Science and Technology Program of Guangdong Province,China(2121A0505030057)。
文摘Continuous cropping leads to high incidence of soilborne diseases such as bacterial wilt caused by Ralstonia solanacearum,which poses a risk to agricultural production.Anaerobic soil disinfestation(ASD)and plant growthpromoting rhizobacteria(PGPR)are considered environmentally friendly methods to control bacterial wilt.However,the underlying mechanism of the improvement of soil health and the inhibition of bacterial wilt after ASD treatment and PGPR inoculation needs further exploration.This study evaluated the effect of ASD treatment on soil improvement at pre-planting of tomato,and the effect of ASD treatment combined with the application of Bacillus velezensis Y6(BV)on soil quality,R.solanacearum abundance,and bacterial communities at 90 days before harvesting of tomato.The results showed that ASD treatment reduced R.solanacearum abundance in soil by17.6%at pre-planting and 18.7%at 90 days before harvesting,but BV inoculation did not influence R.solanacearum abundance.ASD and ASD+BV treatments effectively reduced the occurrence of bacterial wilt,improved soil nutrient status and increased soil microbial activity at 90 days before harvesting.Principal co-ordinate analysis showed that the soil bacterial community was significantly influenced by ASD treatment both at pre-planting and at 90 days before harvesting.Further investigation found that ASD contributed to the enrichment of beneficial flora(Bacillus and Streptomyces).Moreover,pH was an important environmental factor affecting the abundance of R.solanacearum in soil.Co-occurrence network analysis showed that ASD treatment significantly increased network connection of bacterial communities and the proportion of beneficial microorganisms(Proteobacteria and Firmicutes),leading to complex soil bacterial co-occurrence networks both at pre-planting and at 90 days before harvesting.Collectively,these results indicate that ASD treatment,but not microbial inoculation can enhance tomato plant resistance to bacterial wilt by improving soil quality and modulating the soil bacterial community.
基金supported by the National Natural Science Foundation of China(Grant Nos.92263107,U23A20570,52221001,62090035,and 52022029)the Hunan Provincial Natural Science Foundation of China(Grant No.2024RC1034)。
文摘Understanding interlayer charge transfer is crucial for elucidating interface interactions in heterostructures.As the layer number can significantly influence the interface coupling and band alignment,the charge transfer behaviors can be largely regulated.Here,we constructed two-dimensional(2D)heterostructures consisting of monolayer WS_(2)and few-layer InSe to investigate the impact of InSe thickness on exciton dynamics.We performed photoluminescence(PL)spectroscopy and lifetime measurements on pristine few-layer InSe and the heterostructures with different InSe thicknesses.For pristine InSe layers,we found a non-monotonic layer dependence on PL lifetime,which can be attributed to the interplay between the indirect-to-direct bandgap transition and surface recombination effects.For heterostructures,we demonstrated that the type I band alignment of the heterostructure facilitates electron and hole transfer from monolayer WS_(2)to InSe.As the InSe layer number increases,the reduction in conduction band minimum(CBM)enhances the driving force for charge transfer,thereby improving the transfer efficiency.Furthermore,we fabricated and characterized a WS_(2)/InSe optoelectronic device.By analyzing bias voltage dependent PL spectra,we further demonstrated that the trions in WS_(2)within the heterostructure are positively charged(X^(+)),and their emission intensity can be efficiently modulated by applying different biases.This study not only reveals the layer-dependent characteristics of band alignment and interlayer charge transfer in heterostructures but also provides valuable insights for the applications of 2D semiconductors in optoelectronic devices.
基金supported by the Natural Science foundation of China (No.51972043)Foundation of Yangtze Delta Region Institute (Hu Zhou) of UESTC,China (Nos.U03210010 and U03210028)+1 种基金the Sichuan-Hong Kong Collaborative Research Fund (No.2021YFH0184)the Application Fundamental Research Project of Sichuan Province (No.2019YJ0169) the New Scholar Fund of UESTC。
文摘To lower the operation temperature and increase the durability of solid oxide fuel cells(SOFCs), increasing attentions have been paid on developing cathode materials with good oxygen reduction reaction(ORR)activity at intermediate-temperature(IT, 500-750 ℃) range. However, most cathode materials exhibit poor catalytic activity, or they thermally mismatch with SOFC electrolytes and undergo severe degeneration. Infiltrating catalysts on existing backbone materials has been proved to be an efficient method to construct highly active and durable cathodes. In this mini-review, the advantages of infiltration-based cathode compared with new material-based cathodes are summarized. The merits and drawbacks of different backbones are illustrated. Different types of catalysts for infiltration are depicted in detail. Suggestions on the material/structure optimization of the infiltrated cathodes of IT-SOFC are provided.
基金supported by funding from the National Natural Science Foundation of China (grant no. 41904061)China Postdoctoral Science Foundation (grant no. 2018M640742)
文摘The thermal structure of the lower mantle plays a key role in understanding the dynamic processes of the Earth's evolution and mantle convection.Because intrinsic attenuation in the lower mantle is highly sensitive to temperature,determining of the attenuation of the lower mantle could help us determine its thermal state.We attempted to constrain the attenuation of the lower mantle by measuring the amplitude ratios of p to ScP on the vertical component and s to ScS on the tangential component at short epicentral distances for seismic wave data from deep earthquakes in Northeast China.We calculated the theoretical amplitude ratios of p to ScP and s to ScS by using ray theory and the axial-symmetric spectral element method AxiSEM,as well as by considering the effects of radiation patterns,geometrical spreading,and ScP reflection coefficients.By comparing the observed amplitude ratios with the synthetic results,we constrained the quality factors as Qα≈3,000 and Qβ≈1,300 in the lower mantle beneath Northeast China,which are much larger than those in the preliminary reference Earth model(PREM)model of Qα~800 and Qβ~312.We propose that the lower mantle beneath Northeast China is relatively colder than the average mantle,resulting in weaker intrinsic attenuation and higher velocity.We estimated the temperature of the lower mantle beneath Northeast China as approximately 300–700 K colder than the global average value.
基金Supported by the National Key Research and Development Program of China under Grant Nos.2018YFA0704300 and2017YFE0131300the National Natural Science Foundation of China under Grant Nos.U1932217,11974246,11874263 and10225417+1 种基金the Natural Science Foundation of Shanghai under Grant No.19ZR1477300the support from Analytical Instrumentation Center(SPST-AIC10112914),SPST,ShanghaiTech Universitysupported by Collaborative Research Project of Materials and Structures Laboratory,Tokyo Institute of Technology,Japan,Part of this research is supported by COMPRES(NSF Cooperative Agreement EAR-1661511)。
文摘Recently,natural van der Waals heterostructures of(MnBi2 Te4)m(Bi2 Te3)n have been theoretically predicted and experimentally shown to host tunable magnetic properties and topologically nontrivial surface states.We systematically investigate both the structural and electronic responses of MnBi2 Te4 and MnBi4 Te7 to external pressure.In addition to the suppression of antiferromagnetic order,MnBi2 Te4 is found to undergo a metalsemiconductor-metal transition upon compression.The resistivity of MnBi4 Te7 changes dramatically under high pressure and a non-monotonic evolution of p(T)is observed.The nontrivial topology is proved to persist before the structural phase transition observed in the high-pressure regime.We find that the bulk and surface states respond differently to pressure,which is consistent with the non-monotonic change of the resistivity.Interestingly,a pressure-induced amorphous state is observed in MnBi2 Te4,while two high-pressure phase transitions are revealed in MnBi4 Te7.Our combined theoretical and experimental research establishes MnBi2 Te4 and MnBi4 Te7 as highly tunable magnetic topological insulators,in which phase transitions and new ground states emerge upon compression.
基金Project supported by CAS-Shanghai Science Research Center,China(Grant No.CAS-SSRC-YH-2015-01)the National Key R&D Program of China(Grant No.2017YFA0305400)+4 种基金the National Natural Science Foundation of China(Grant Nos.11674229,11227902,and 11604207)the EPSRC Platform Grant(Grant No.EP/M020517/1)Hefei Science Center,Chinese Academy of Sciences(Grant No.2015HSC-UE013)Science and Technology Commission of Shanghai Municipality,China(Grant No.14520722100)the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(Grant No.XDB04040200)。
文摘Iron-based superconductor family FeX(X=S,Se,Te)has been one of the research foci in physics and material science due to their record-breaking superconducting temperature(FeSe film)and rich physical phenomena.Recently,FeS,the least studied Fe X compound(due to the difficulty in synthesizing high quality macroscopic crystals)attracted much attention because of its puzzling superconducting pairing symmetry.In this work,combining scanning tunneling microscopy and angle resolved photoemission spectroscopy(ARPES)with sub-micron spatial resolution,we investigate the intrinsic electronic structures of superconducting FeS from individual single crystalline domains.Unlike FeTe or FeSe,FeS remains identical tetragonal structure from room temperature down to 5 K,and the band structures observed can be well reproduced by our ab-initio calculations.Remarkably,mixed with the 1×1 tetragonal metallic phase,we also observe the coexistence of √5×√5 reconstructed insulating phase in the crystal,which not only helps explain the unusual properties of FeS,but also demonstrates the importance of using spatially resolved experimental tools in the study of this compound.
文摘The dimensionality of quantum materials strongly affects their physical properties.Although many emergent phenomena,such as charge-density wave and Luttinger liquid behavior,are well understood in one-dimensional(1D)systems,the generalization to explore them in higher dimensional systems is still a challenging task.In this study,we aim to bridge this gap by systematically investigating the crystal and electronic structures of molybdenum-oxide family compounds,where the contexture of 1D chains facilitates rich emergent properties.While the quasi-1D chains in these materials share general similarities,such as the motifs made up of MoO_(6)octahedrons,they exhibit vast complexity and remarkable tunability.We disassemble the 1D chains in molybdenum oxides with different dimensions and construct effective models to excellently fit their low-energy electronic structures obtained by ab initio calculations.Furthermore,we discuss the implications of such chains on other physical properties of the materials and the practical significance of the effective models.Our work establishes the molybdenum oxides as simple and tunable model systems for studying and manipulating the dimensionality in quantum systems.
基金supported by the National Natural Science Foundation of China (Grant No. 11774190)。
文摘Ternary transition metal chalcogenides provide a rich platform to search and study intriguing electronic properties. Using angle-resolved photoemission spectroscopy and ab initio calculation, we investigate the electronic structure of Cu_(2)TlX_(2)(X = Se, Te), ternary transition metal chalcogenides with quasi-two-dimensional crystal structure. The band dispersions near the Fermi level are mainly contributed by the Te/Se p orbitals. According to our ab-initio calculation, the electronic structure changes from a semiconductor with indirect band gap in Cu_(2)TlSe_(2) to a semimetal in Cu_(2)TlTe_(2), suggesting a band-gap tunability with the composition of Se and Te. By comparing ARPES experimental data with the calculated results, we identify strong modulation of the band structure by spin–orbit coupling in the compounds. Our results provide a ternary platform to study and engineer the electronic properties of transition metal chalcogenides related to large spin–orbit coupling.
文摘Sheep is an important livestock species raised globally to produce meat,milk,wool,and other by-products.During the Neolithic Revolution,sheep were domesticated in the Fertile Crescent of Southwest Asia around 10,000 years ago(Chessa et al.,2009).
文摘目的研究妊娠中期贫血对新生儿体格发育指标的影响。方法选取2019年1月—2019年10月在本院分娩的单胎无其它并发症及合并症的产妇382例作为研究对象,入院待产时回顾性收集妊娠中期血常规结果,分娩后立即测量新生儿出生体重和身长,并计算体质指数。所有数据采用SPSS软件进行统计学分析。结果贫血组孕妇所分娩新生儿的体重(2730.47±183.94 g vs 3366.78±306.98 g)、身长(48.49±1.39 cm vs 50.64±1.37 cm)以及出生孕周(38.56±1.35周vs 39.38±0.98周)均小于对照组(均P<0.05),而两组的体质指数(BMI)无统计学差异(20.99±4.64 kg/m^(2) vs 20.98±4.52 kg/m^(2),P>0.05)。贫血孕妇早产及低体重儿的发生率均高于正常孕妇(均为10.59%vs 0%,P<0.05)。妊娠中期血红蛋白水平与出生体重及身长均存在正相关(r值分别为0.331和0.377,均P<0.05)。结论妊娠中期贫血是早产和低出生体重儿的危险因素,新生儿出生体重和身长与母体血红蛋白浓度存在正相关。
基金Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology(Northeast Electric Power University)Open Fund(MPSS2023⁃01)National Natural Science Foundation of China(No.52477133)+2 种基金Hainan Provincial Natural Science Foundation of China(No.524RC532)Research Startup Funding from Hainan Institute of Zhejiang University(No.0210-6602-A12202)Project of Sanya Yazhou Bay Science and Technology City(No.SKJC-2022-PTDX-009/010/011).
文摘Traditional active power sharing in microgrids,achieved by the distributed average consensus,requires each controller to continuously trigger and communicate with each other,which is a wasteful use of the limited computation and communication resources of the secondary controller.To enhance the efficiency of secondary control,we developed a novel distributed self-triggered active power-sharing control strategy by introducing the signum function and a flexible linear clock.Unlike continuous communication–based controllers,the proposed self-triggered distributed controller prompts distributed generators to perform control actions and share information with their neighbors only at specific time instants monitored by the linear clock.Therefore,this approach results in a significant reduction in both the computation and communication requirements.Moreover,this design naturally avoids Zeno behavior.Furthermore,a modified triggering condition was established to achieve further reductions in computation and communication.The simulation results confirmed that the proposed control scheme achieves distributed active power sharing with very few controller triggers,thereby substantially enhancing the efficacy of secondary control in MGs.
基金funded by the National Natural Science Foundation of China(Grant Nos.51905215,U22A20187)the Major Scientific and Technological Innovation Project of Shandong Province of China(Grant No.2019JZZY020111).
文摘In this work,mechanical alloying of the alternating stacked pure Al and Zn thin foils was accomplished via high-pressure torsion(HPT).In the alloyed Al-Zn system,an exotic phase transformation from hexagonal close-packed(HCP)to face-centered cubic(FCC)was identified.The atomic-scale evolution process and underlying mechanism of phase transformation down to atomic scale are provided by molecular dynamics simulation and high-resolution transmission electron microscopy.The HCP→FCC phase transformation was attributed to the sliding of Shockley partial dislocations generated at the Al-Zn grain boundaries,which resulted in an[2110][011]and(0001)/(111)orientation relationship between the two phases.This work provides a new approach for the in-depth study of the solid phase transformation of Al-Zn alloys and also shed lights on understanding the mechanical properties of the HPT processed Al-Zn alloys.
