Hydrogels have drawn considerable attention in the past two decades due to their excellent biocompatibility and multi-stimuli responsiveness. They have a wide range of applications in the fields related to tissue engi...Hydrogels have drawn considerable attention in the past two decades due to their excellent biocompatibility and multi-stimuli responsiveness. They have a wide range of applications in the fields related to tissue engineering, sensors and biomedicine. Their applications are strongly influenced by the surface properties of hydrogels and the interfacial interactions between hydrogels and other substrates. In particular, the surface wettability and adhesion of hydrogels decide their applications as drug carriers and wound dressing materials. Nevertheless, there is a lack of systematic discussion on the surface functionalization strategies of hydrogels. Therefore, this review aims at summarizing the strategies of functionalizing the surfaces of hydrogels and bonding hydrogels with other solid substrates. It also explores the challenges and future perspectives of interfacial engineering of hydrogels.展开更多
In this study, Li_3AlF_6 was employed to simulate the molten salt LiF–BeF_2 to explore its pyrohydrolysis behavior and that of its components, i.e., LiF and AlF_3,respectively. The influence of the accelerators α-Al...In this study, Li_3AlF_6 was employed to simulate the molten salt LiF–BeF_2 to explore its pyrohydrolysis behavior and that of its components, i.e., LiF and AlF_3,respectively. The influence of the accelerators α-Al_2O_3 and AlF_3 on the pyrohydrolysis of LiF and Li_3AlF_6 was investigated. Finally, the solid pyrohydrolytic products were characterized by means of X-ray diffraction, and the corresponding reaction mechanisms were proposed. These experimental results indicated that AlF_3 was completely hydrolyzed to the corresponding oxide α-Al_2O_3 at 650 ℃ in 1 h, whereas the complete hydrolysis of LiF and Li_3AlF_6 required the assistance of either α-Al_2O_3 or AlF_3 under the same conditions. The influence of the accelerator α-Al_2O_3 and AlF_3 on the pyrohydrolytic behavior of Li_3AlF_6 provides references for future research studies on the pyrohydrolysis of LiF–BeF_2 and multi-component molten salts.展开更多
Dear Editor,Extracellular vesicles,especially exosomes,have emerged as promising diagnostic sources for cancers due to their easy and quick accessibility.1,2 Additionally,it has been demonstrated that circulating miRN...Dear Editor,Extracellular vesicles,especially exosomes,have emerged as promising diagnostic sources for cancers due to their easy and quick accessibility.1,2 Additionally,it has been demonstrated that circulating miRNAs serve as promising biomarkers for the diagnosis of multiple diseases.3,4 Cholangiocarcinoma(CCA)and gallbladder carcinoma(GBC)are two malignant biliary tract cancers.It has been estimated that patients with unresectable GBC have a 5-year survival of only less than 5%,while CCA patients suffer from an overall 5-year survival of~10%.5 Hence,circulating diagnostic biomarkers would benefit the diagnosis and treatment of GBC and CCA patients.We sequenced exosomal small RNA from five CCA patients and four GBC patients before and after surgery and enrolled 40 healthy individuals,45 more CCA patients and 24 more GBC patients to validate the sequencing results to identify diagnostic biomarkers for GBC and CCA.展开更多
基金financially supported by the National Natural Science Foundation of China(No.21574004)Xiamen Southern Oceanographic Center(No.14GQT61HJ31)+3 种基金the 111 project(No.B14009)the Fundamental Research Funds for the Central Universitiesthe National ‘Young Thousand Talents Program’the Academic Excellence Foundation of BUAA for PHD Students
文摘Hydrogels have drawn considerable attention in the past two decades due to their excellent biocompatibility and multi-stimuli responsiveness. They have a wide range of applications in the fields related to tissue engineering, sensors and biomedicine. Their applications are strongly influenced by the surface properties of hydrogels and the interfacial interactions between hydrogels and other substrates. In particular, the surface wettability and adhesion of hydrogels decide their applications as drug carriers and wound dressing materials. Nevertheless, there is a lack of systematic discussion on the surface functionalization strategies of hydrogels. Therefore, this review aims at summarizing the strategies of functionalizing the surfaces of hydrogels and bonding hydrogels with other solid substrates. It also explores the challenges and future perspectives of interfacial engineering of hydrogels.
基金supported by the‘‘Strategic Priority Research Program’’of the Chinese Academy of Sciences(No.XDA02030000)
文摘In this study, Li_3AlF_6 was employed to simulate the molten salt LiF–BeF_2 to explore its pyrohydrolysis behavior and that of its components, i.e., LiF and AlF_3,respectively. The influence of the accelerators α-Al_2O_3 and AlF_3 on the pyrohydrolysis of LiF and Li_3AlF_6 was investigated. Finally, the solid pyrohydrolytic products were characterized by means of X-ray diffraction, and the corresponding reaction mechanisms were proposed. These experimental results indicated that AlF_3 was completely hydrolyzed to the corresponding oxide α-Al_2O_3 at 650 ℃ in 1 h, whereas the complete hydrolysis of LiF and Li_3AlF_6 required the assistance of either α-Al_2O_3 or AlF_3 under the same conditions. The influence of the accelerator α-Al_2O_3 and AlF_3 on the pyrohydrolytic behavior of Li_3AlF_6 provides references for future research studies on the pyrohydrolysis of LiF–BeF_2 and multi-component molten salts.
基金supported by the National Natural Science Foundation of China(81772798)National Natural Science Fund Youth Project(81700007)+3 种基金Research and Innovation Fund of the Ministry of Education(2018A03026)Beijing Natural Science Foundation(2019A10)“Qingmiao”Project of Beijing Municipal Hospital Administration(2018QM4)Beijing Top Talent Project(2018000021223ZK11).
文摘Dear Editor,Extracellular vesicles,especially exosomes,have emerged as promising diagnostic sources for cancers due to their easy and quick accessibility.1,2 Additionally,it has been demonstrated that circulating miRNAs serve as promising biomarkers for the diagnosis of multiple diseases.3,4 Cholangiocarcinoma(CCA)and gallbladder carcinoma(GBC)are two malignant biliary tract cancers.It has been estimated that patients with unresectable GBC have a 5-year survival of only less than 5%,while CCA patients suffer from an overall 5-year survival of~10%.5 Hence,circulating diagnostic biomarkers would benefit the diagnosis and treatment of GBC and CCA patients.We sequenced exosomal small RNA from five CCA patients and four GBC patients before and after surgery and enrolled 40 healthy individuals,45 more CCA patients and 24 more GBC patients to validate the sequencing results to identify diagnostic biomarkers for GBC and CCA.
