The design and development of low-cost,efficient,and stable bifunctional electrocatalysts for the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)are desirable for rechargeable metal-air batteries.In t...The design and development of low-cost,efficient,and stable bifunctional electrocatalysts for the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)are desirable for rechargeable metal-air batteries.In this work,N-doped porous hollow carbon spheres encapsulated with ultrafine Fe/Fe3O4 nanoparticles(FeOx@N-PHCS)were fabricated by impregnation and subsequent pyrolysis,using melamine-formaldehyde resin spheres as self-sacrifice templates and polydopamine as N and C sources.The sufficient adsorption of Fe3+on the polydopamine endowed the formation of Fe-Nx species upon high-temperature carbonization.The prepared FeOx@N-PHCS has advanced features of large specific surface area,porous hollow structure,high content of N dopants,sufficient Fe-Nx species and ultrafine FeOx nanoparticles.These features endow FeOx@N-PHCS with enhanced mass transfer and considerable active sites,leading to high activity and stability in catalyzing ORR and OER in alkaline electrolyte.Furthermore,the rechargeable Zn-air battery with FeOx@N-PHCS as air cathode catalyst exhibits a large peak power density,narrow charge-discharge potential gap and robust cycling stability,demonstrating the potential of the fabricated FeOx@N-PHCS as a promising electrode material for metal-air batteries.This new finding may open an avenue for rational design of bifunctional catalysts by integrating different active components within all-in-one catalyst for different electrochemical reactions.展开更多
The exploration of cost-effective non-noble-metal electrocatalysts is highly imperative to replace the state-of-the-art platinum-based catalysts for oxygen reduction reaction(ORR). Here, we prepared cobalt phosphonate...The exploration of cost-effective non-noble-metal electrocatalysts is highly imperative to replace the state-of-the-art platinum-based catalysts for oxygen reduction reaction(ORR). Here, we prepared cobalt phosphonate-derived N-doped cobalt phosphate/carbon nanotube hybrids(Co Pi C-N/CNTs) by hydrothermal treatment of N-containing cobalt phosphonate and oxidized carbon nanotubes(o-CNT) followed by high-temperature calcination under nitrogen atmosphere. The resultant Co Pi C-N/CNT exhibits a superior electrocatalytic performance for the ORR in alkaline media, which is equal to the commercial Pt/C catalyst in the aspect of half-wave potential, onset potential and diffuse limiting current density. Furthermore, the excellent tolerance to methanol and strong durability outperform those of commercial Pt/C. It is found that cobalt phosphonate-derived N-doped cobalt phosphate and the in-situ formed graphitic carbons play key roles on the activity enhancement. Besides, introducing a suitable amount of CNTs enhances the electronic conductivity and further contributes to the improved ORR performance.展开更多
AIM: To comprehensively evaluate the potential association of COL1A1 polymorphisms with high myopia by a systematic review and Meta-analysis. METHODS: All association studies on COL1A1 and high myopia reported up to J...AIM: To comprehensively evaluate the potential association of COL1A1 polymorphisms with high myopia by a systematic review and Meta-analysis. METHODS: All association studies on COL1A1 and high myopia reported up to June 10, 2014 in PubMed, Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were analyzed for single-nucleotide polymorphisms (SNPs) using fixed- and random - effects models according to between-study heterogeneity. Publication bias analyses were conducted by Eggers test. RESULTS: A total of four studies from reported papers were included in this analysis. The Meta-analyses for COL1A1 rs2075555, composed of 2304 high myopia patients and 2272 controls, failed to detect any significant association with high myopia. A total of 971 cases and 649 controls were tested for COL1A1 rs2269336. The association of COL1A1 rs2269336 with high myopia was observed in recessive model (CC vs CG+GG, P = 0.03) and in heterozygous model (CG vsGG, P = 0.04), but not in other models. CONCLUSION: This Meta-analysis shows that COL fill rs2269336 (CC vs CG +GG) affects individual susceptibility to high myopia, whereas there is no association detected between SNPs rs2075555 and high myopia. Given the limited sample size, further investigations including more ethnic groups are required to validate the association.展开更多
BACKGROUND Helicobacter pylori(H.pylori)has been found to be associated with extragastrointestinal diseases,possibly including adverse food reactions(such as food allergy or intolerance).However,there are few studies ...BACKGROUND Helicobacter pylori(H.pylori)has been found to be associated with extragastrointestinal diseases,possibly including adverse food reactions(such as food allergy or intolerance).However,there are few studies on H.pylori and food allergy or intolerance,and the results are inconsistent.Food-specific immunoglobulin(Ig)G has been revealed to be associated with food allergy or intolerance and can be used as a marker to explore the correlation between H.pylori infection and food allergy or intolerance.AIM To explore the relationship between H.pylori infection and food-specific IgG METHODS We retrospectively analyzed the physical examination data of 21822 subjects from February 2014 to December 2018 in this study.H.pylori infection was detected using the 13C urea breath test.Food-specific IgG of eggs,milk and wheat in serum was assessed.Subjects were grouped according to H.pylori positivity,and the positive rates of three kinds of food-specific IgG were compared between the two groups.Multivariable logistic regression analysis was performed to elucidate the association between H.pylori infection and food-specific IgG.RESULTS The total infection rate of H.pylori was 39.3%,and the total food-specific IgGpositive rates of eggs,milk and wheat were 25.2%,9.0%and 4.9%,respectively.The infection rate of H.pylori was higher in males than in females,while the positive rates of food-specific IgG were lower in males than in females.The positive rates of food-specific IgG decreased with age in both males and females.In the H.pylori-positive groups,the positive rates of food-specific IgG of eggs,milk and wheat were all lower than those in the H.pylori-negative groups.Multivariate logistic regression analysis revealed that H.pylori infection was negatively correlated with the food-specific IgG-positive rates of eggs,milk and wheat(odds ratio value of eggs 0.844-0.873,milk 0.741-0.751 and wheat 0.755-0.788,in different models).CONCLUSION H.pylori infection was found to be negatively associated with the food-specific IgG of eggs,milk and wheat in Southwest China.展开更多
The Chayu area is located at the southeastern margin of the Qinghai-Tibet Plateau.This region was considered to be in the southeastward extension of the Lhasa Block,bounded by Nujiang suture zone in the north and Yarl...The Chayu area is located at the southeastern margin of the Qinghai-Tibet Plateau.This region was considered to be in the southeastward extension of the Lhasa Block,bounded by Nujiang suture zone in the north and Yarlung Zangbo suture zone in the south.The Demala Group complex,a set of high-grade metamorphic gneisses widely distributed in the Chayu area,is known as the Precambrian metamorphic basement of the Lhasa Block in the area.According to field-based investigations and microstructure analysis,the Demala Group complex is considered to mainly consist of banded biotite plagiogneisses,biotite quartzofeldspathic gneiss,granitic gneiss,amphibolite,mica schist,and quartz schist,with many leucogranite veins.The zircon U-Pb ages of two granitic gneiss samples are 205±1 Ma and 218±1 Ma,respectively,representing the ages of their protoliths.The zircons from two biotite plagiogneisses samples show core-rim structures.The U-Pb ages of the cores are mainly 644–446 Ma,1213–865 Ma,and 1780–1400 Ma,reflecting the age characteristics of clastic zircons during sedimentation of the original rocks.The U-Pb ages of the rims are from 203±2 Ma to 190±1 Ma,which represent the age of metamorphism.The zircon U-Pb ages of one sample taken from the leucogranite veins that cut through granitic gneiss foliation range from 24 Ma to 22 Ma,interpreted as the age of the anatexis in the Demala Group complex.Biotite and muscovite separates were selected from the granitic gneiss,banded gneiss,and leucogranite veins for 40Ar/39Ar dating.The plateau ages of three muscovite samples are 16.56±0.21 Ma,16.90±0.21 Ma,and 23.40±0.31 Ma,and the plateau ages of four biotite samples are 16.70±0.24 Ma,16.14±0.19 Ma,15.88±0.20 Ma,and 14.39±0.20 Ma.The mica Ar-Ar ages can reveal the exhumation and cooling history of the Demala Group complex.Combined with the previous research results of the Demala Group complex,the authors refer that the Demala Group complex should be a set of metamorphic complex.The complex includes not only Precambrian basement metamorphic rock series,but also Paleozoic sedimentary rock and Mesozoic granitic rock.Based on the deformation characteristics,the authors concluded that two stages of the metamorphism and deformation can be revealed in the Demala Group complex since the Mesozoic,namely Late Triassic-Early Jurassic(203–190 Ma)and Oligocene–Miocene(24–14 Ma).The early stage of metamorphism(ranging from 203–190 Ma)was related to the Late Triassic tectono-magmatism in the area.The anatexis and uplifting-exhumation of the later stage(24–14 Ma)were related to the shearing of the Jiali strike-slip fault zone.The Miocene structures are response to the large-scale southeastward escape of crustal materials and block rotation in Southeast Tibet after India-Eurasia collision.展开更多
BACKGROUND Paprosky type ⅢB acetabular bone defects are very difficult to reconstruct.For severe defects,we developed our own cup-on-cup technique.We defined the tantalum metal (TM) revision shell with the peripheral...BACKGROUND Paprosky type ⅢB acetabular bone defects are very difficult to reconstruct.For severe defects,we developed our own cup-on-cup technique.We defined the tantalum metal (TM) revision shell with the peripheral titanium ring removed as a TM-cup augment and the cementless hemispherical acetabulum component combined with a TM-cup augment as the cup-on-cup technique.AIM To report the short-term results of patients with typeⅢB acetabular bone defects reconstructed using the cup-on-cup technique.METHODS We retrospectively reviewed six patients (six hips) with a mean age of 59 years who underwent acetabular reconstruction using our cup-on-cup technique between January 2015 and January 2017.All acetabular bone defects were classified as typeⅢB without pelvic discontinuity using the system of Paprosky All patients were followed both clinically and radiographically for a mean duration of 42 mo.RESULTS The mean Harris hip score improved from 32.4 pre-operatively to 80.7 at the last follow-up.The mean vertical position of the hip rotation centre changed from60.9 mm pre-operatively to 31.7 mm post-operatively,and the mean horizontal position changed from 33.6 mm pre-operatively to 38.9 mm post-operatively.Greater trochanteric migration after extended trochanteric osteotomy occurred in one of six hips at 3 mo.There was no evidence of component migration at the last follow-up.CONCLUSION The short-term results suggest that our cup-on-cup technique could beconsidered an effective management option for Paprosky type ⅢB acetabular bone defects without pelvic discontinuity.展开更多
Folate-containing dextran ligand （FA-Dextran-DTPA） was synthesized by the incorporation of diethylenetriamine- pentaacetic acid （DTPA） and folate （FA） as a tumor-targeting group into dextran as a polymer carrier...Folate-containing dextran ligand （FA-Dextran-DTPA） was synthesized by the incorporation of diethylenetriamine- pentaacetic acid （DTPA） and folate （FA） as a tumor-targeting group into dextran as a polymer carrier. This ligand was further reacted with gadolinium chloride to make a dextran gadolinium complex FA-Dextran-DTPA-Gd. The ligand and its gadolinium complex were characterized by 1H-NMR, FTIR, UV-Vis, average particle sizes and zeta potential, as well. In vitro properties including relaxivity, cytotoxicity assay, cellular uptake assay, and magnetic resonance imaging （MRI） were also evaluated. Compared with Gd-DTPA, FA-Dextran-DTPA-Gd possessed obviously higher relaxation effectiveness and lower cytotoxicity to HeLa cells. FA-Dextran-DTPA-Gd had a high affinity to the H460 and MDA-MB-231 tumor cells and can be taken up selectively by these tumor cells. Moreover, FA-Dextran-DTPA-Gd showed enhanced signal intensities （SI） of MRI and enhanced the contrast of MR images of tumor cells. These results indicated that FA-Dextran-DTPA-Gd showed the potential as a tumor-targeting contrast agent in MRI.展开更多
Exploring feasible synthesis approaches to highly efficient and robust bifunctional electrocatalysts toward both oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)is triggering researcher’s even-increas...Exploring feasible synthesis approaches to highly efficient and robust bifunctional electrocatalysts toward both oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)is triggering researcher’s even-increasing interest in rechargeable Zn-air batteries.Herein,sulfur-doped bimetal FeCo phosphide nanoparticles dispersed on N,P,S-tri-doped graphene(donated as S-FeCo3P/NPSG)are rationally prepared through a controllable one-step carbothermal-phosphorization strategy.The modified charge distribution and electron-donor properties of S-FeCo3P/NPSG caused by S decoration render a significantly beneficial effect on the electrocatalytic activities.Consequently,the S-FeCo3P/NPSG electrode exhibits extraordinary bifunctional activities toward oxygen electrochemistry of the OER overpotential of 290 m V at 10 m A cm^(-2) and the ORR half-wave potential of 0.83 V,approaching to that of noblemetal IrO_(2)(289 m V)and Pt/C(0.84 V),respectively,but with more stronger operation stability in alkaline media.When S-FeCo3P/NPSG serves as the air cathode for liquid-state Zn-air battery,the large peak power density and energy density,as well as superb discharge-charge durability(cycling life>600 h)of this device are obtained.Furthermore,all-solid-state Zn-air battery with S-FeCo3P/NPSG as air electrode also displays excellent mechanical flexibility,high power density and stable cycling stability.The self-reconstruction behavior of the S-FeCo3P/NPSG cathode catalysts is also investigated during the electrocatalytic Zn-air battery operation.This work would provide some novel inspiration from aspects of bonding and charge distribution for the rational construction of active and cost-efficient bifucntional oxygen electrocatalysts for energy storage and conversion devices.展开更多
AIM:To systematically understand the genetic association between methylenetetrahydrofolate reductase(MTHFR)C677 T polymorphism and primary open angle glaucoma(POAG).METHODS:A comprehensive literature search in Google ...AIM:To systematically understand the genetic association between methylenetetrahydrofolate reductase(MTHFR)C677 T polymorphism and primary open angle glaucoma(POAG).METHODS:A comprehensive literature search in Google Scholar,Pub Med,Science Citation Index,Foreign Medical Literature Retrieval Service,Chinese National Knowledge Infrastructure and Wanfang Databases was performed to collect all eligible studies up to August 2019.Study selection,data abstraction and study quality evaluation were performed by two independent investigators.Odds ratios(ORs)with 95%confidence intervals(CIs)were calculated to assess the association.RESULTS:Eighteen case-control studies including 2156 cases and 2201 controls were identified.There was no significant difference in the terms of MTHFR C677 T polymorphism and POAG in the Caucasian population(for T vs C OR=1.11,95%CI:0.88 to 1.39;for TT vs CC OR=1.01,95%CI:0.76 to 1.36;for TT+TC vs CC OR=1.15,95%CI:0.84 to 1.58 and for TT vs TC+CC OR=1.02,95%CI:0.78 to 1.33).However,a significant effect was revealed in the Asian population(for T vs C OR=1.34,95%CI:1.12 to 1.59;for TT+TC vs CC OR=1.41,95%CI:1.14 to 1.76).CONCLUSION:Based on 18 eligible studies,we provide a correlation between MTHFR C677 T polymorphism and POAG among the Asians subgroup indicating that the T allele or TT+TC genotype may play a critical role in POAG development in Asians.展开更多
Reluctance linear actuator, which has a unique property of small volume, low current and can produce great force, is a very promising actuator for the fine stage of the next-generation lithographic scanner. But the st...Reluctance linear actuator, which has a unique property of small volume, low current and can produce great force, is a very promising actuator for the fine stage of the next-generation lithographic scanner. But the strong nonlinearities including the hysteresis, between the current and output force limits the reluctance linear actuator applications in nanometer positioning. In this paper, a new nonlinear control method is proposed for the stage having paired reluctance linear actuator with hysteresis using the direct adaptive neural network, which is used as a learning machine of nonlinearity. The feature of this method lies in that the nonlinear compensator in conventional methods, which computed the current reference from that of the input and output force is not used. This naturally overcomes the robustness issue with respect to parameter uncertainty. Simulation results show that the proposed method is effective in overcoming the nonlinearity between the input current and output force and promising in precision stage control.展开更多
基金supported by the National Natural Science Foundation of China(21421001,21573115,21875118)Tianjin Science and Technology Commission(18JCTPJC55900)+1 种基金the Natural Science Foundation of Tianjin(17JCYBJC17100,19JCZDJC37700)the 111 Project(B12015).
文摘The design and development of low-cost,efficient,and stable bifunctional electrocatalysts for the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)are desirable for rechargeable metal-air batteries.In this work,N-doped porous hollow carbon spheres encapsulated with ultrafine Fe/Fe3O4 nanoparticles(FeOx@N-PHCS)were fabricated by impregnation and subsequent pyrolysis,using melamine-formaldehyde resin spheres as self-sacrifice templates and polydopamine as N and C sources.The sufficient adsorption of Fe3+on the polydopamine endowed the formation of Fe-Nx species upon high-temperature carbonization.The prepared FeOx@N-PHCS has advanced features of large specific surface area,porous hollow structure,high content of N dopants,sufficient Fe-Nx species and ultrafine FeOx nanoparticles.These features endow FeOx@N-PHCS with enhanced mass transfer and considerable active sites,leading to high activity and stability in catalyzing ORR and OER in alkaline electrolyte.Furthermore,the rechargeable Zn-air battery with FeOx@N-PHCS as air cathode catalyst exhibits a large peak power density,narrow charge-discharge potential gap and robust cycling stability,demonstrating the potential of the fabricated FeOx@N-PHCS as a promising electrode material for metal-air batteries.This new finding may open an avenue for rational design of bifunctional catalysts by integrating different active components within all-in-one catalyst for different electrochemical reactions.
基金supported by the National Natural Science Foundation of China(21421001,21573115)~~
文摘The exploration of cost-effective non-noble-metal electrocatalysts is highly imperative to replace the state-of-the-art platinum-based catalysts for oxygen reduction reaction(ORR). Here, we prepared cobalt phosphonate-derived N-doped cobalt phosphate/carbon nanotube hybrids(Co Pi C-N/CNTs) by hydrothermal treatment of N-containing cobalt phosphonate and oxidized carbon nanotubes(o-CNT) followed by high-temperature calcination under nitrogen atmosphere. The resultant Co Pi C-N/CNT exhibits a superior electrocatalytic performance for the ORR in alkaline media, which is equal to the commercial Pt/C catalyst in the aspect of half-wave potential, onset potential and diffuse limiting current density. Furthermore, the excellent tolerance to methanol and strong durability outperform those of commercial Pt/C. It is found that cobalt phosphonate-derived N-doped cobalt phosphate and the in-situ formed graphitic carbons play key roles on the activity enhancement. Besides, introducing a suitable amount of CNTs enhances the electronic conductivity and further contributes to the improved ORR performance.
基金Supported in part by grants from the Natural Science Foundation of China(No.81371048)the Youth Innovation Medical Science Project of Sichuan Medical Association(Q14048)the West Light Foundation of The Chinese Academy of Sciences(2015)
文摘AIM: To comprehensively evaluate the potential association of COL1A1 polymorphisms with high myopia by a systematic review and Meta-analysis. METHODS: All association studies on COL1A1 and high myopia reported up to June 10, 2014 in PubMed, Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were analyzed for single-nucleotide polymorphisms (SNPs) using fixed- and random - effects models according to between-study heterogeneity. Publication bias analyses were conducted by Eggers test. RESULTS: A total of four studies from reported papers were included in this analysis. The Meta-analyses for COL1A1 rs2075555, composed of 2304 high myopia patients and 2272 controls, failed to detect any significant association with high myopia. A total of 971 cases and 649 controls were tested for COL1A1 rs2269336. The association of COL1A1 rs2269336 with high myopia was observed in recessive model (CC vs CG+GG, P = 0.03) and in heterozygous model (CG vsGG, P = 0.04), but not in other models. CONCLUSION: This Meta-analysis shows that COL fill rs2269336 (CC vs CG +GG) affects individual susceptibility to high myopia, whereas there is no association detected between SNPs rs2075555 and high myopia. Given the limited sample size, further investigations including more ethnic groups are required to validate the association.
基金by Key Research and Development Projects of the Ministry of Science and Technology,China,No.2017YFC0113901.
文摘BACKGROUND Helicobacter pylori(H.pylori)has been found to be associated with extragastrointestinal diseases,possibly including adverse food reactions(such as food allergy or intolerance).However,there are few studies on H.pylori and food allergy or intolerance,and the results are inconsistent.Food-specific immunoglobulin(Ig)G has been revealed to be associated with food allergy or intolerance and can be used as a marker to explore the correlation between H.pylori infection and food allergy or intolerance.AIM To explore the relationship between H.pylori infection and food-specific IgG METHODS We retrospectively analyzed the physical examination data of 21822 subjects from February 2014 to December 2018 in this study.H.pylori infection was detected using the 13C urea breath test.Food-specific IgG of eggs,milk and wheat in serum was assessed.Subjects were grouped according to H.pylori positivity,and the positive rates of three kinds of food-specific IgG were compared between the two groups.Multivariable logistic regression analysis was performed to elucidate the association between H.pylori infection and food-specific IgG.RESULTS The total infection rate of H.pylori was 39.3%,and the total food-specific IgGpositive rates of eggs,milk and wheat were 25.2%,9.0%and 4.9%,respectively.The infection rate of H.pylori was higher in males than in females,while the positive rates of food-specific IgG were lower in males than in females.The positive rates of food-specific IgG decreased with age in both males and females.In the H.pylori-positive groups,the positive rates of food-specific IgG of eggs,milk and wheat were all lower than those in the H.pylori-negative groups.Multivariate logistic regression analysis revealed that H.pylori infection was negatively correlated with the food-specific IgG-positive rates of eggs,milk and wheat(odds ratio value of eggs 0.844-0.873,milk 0.741-0.751 and wheat 0.755-0.788,in different models).CONCLUSION H.pylori infection was found to be negatively associated with the food-specific IgG of eggs,milk and wheat in Southwest China.
基金a project of National Natural Science Foundation of China(41773026)two geological survey projects initiated by the China Geological Survey(DD20190053,DD20160021).
文摘The Chayu area is located at the southeastern margin of the Qinghai-Tibet Plateau.This region was considered to be in the southeastward extension of the Lhasa Block,bounded by Nujiang suture zone in the north and Yarlung Zangbo suture zone in the south.The Demala Group complex,a set of high-grade metamorphic gneisses widely distributed in the Chayu area,is known as the Precambrian metamorphic basement of the Lhasa Block in the area.According to field-based investigations and microstructure analysis,the Demala Group complex is considered to mainly consist of banded biotite plagiogneisses,biotite quartzofeldspathic gneiss,granitic gneiss,amphibolite,mica schist,and quartz schist,with many leucogranite veins.The zircon U-Pb ages of two granitic gneiss samples are 205±1 Ma and 218±1 Ma,respectively,representing the ages of their protoliths.The zircons from two biotite plagiogneisses samples show core-rim structures.The U-Pb ages of the cores are mainly 644–446 Ma,1213–865 Ma,and 1780–1400 Ma,reflecting the age characteristics of clastic zircons during sedimentation of the original rocks.The U-Pb ages of the rims are from 203±2 Ma to 190±1 Ma,which represent the age of metamorphism.The zircon U-Pb ages of one sample taken from the leucogranite veins that cut through granitic gneiss foliation range from 24 Ma to 22 Ma,interpreted as the age of the anatexis in the Demala Group complex.Biotite and muscovite separates were selected from the granitic gneiss,banded gneiss,and leucogranite veins for 40Ar/39Ar dating.The plateau ages of three muscovite samples are 16.56±0.21 Ma,16.90±0.21 Ma,and 23.40±0.31 Ma,and the plateau ages of four biotite samples are 16.70±0.24 Ma,16.14±0.19 Ma,15.88±0.20 Ma,and 14.39±0.20 Ma.The mica Ar-Ar ages can reveal the exhumation and cooling history of the Demala Group complex.Combined with the previous research results of the Demala Group complex,the authors refer that the Demala Group complex should be a set of metamorphic complex.The complex includes not only Precambrian basement metamorphic rock series,but also Paleozoic sedimentary rock and Mesozoic granitic rock.Based on the deformation characteristics,the authors concluded that two stages of the metamorphism and deformation can be revealed in the Demala Group complex since the Mesozoic,namely Late Triassic-Early Jurassic(203–190 Ma)and Oligocene–Miocene(24–14 Ma).The early stage of metamorphism(ranging from 203–190 Ma)was related to the Late Triassic tectono-magmatism in the area.The anatexis and uplifting-exhumation of the later stage(24–14 Ma)were related to the shearing of the Jiali strike-slip fault zone.The Miocene structures are response to the large-scale southeastward escape of crustal materials and block rotation in Southeast Tibet after India-Eurasia collision.
基金National Key Research and Development Program of China,No.2017YFB1104104.
文摘BACKGROUND Paprosky type ⅢB acetabular bone defects are very difficult to reconstruct.For severe defects,we developed our own cup-on-cup technique.We defined the tantalum metal (TM) revision shell with the peripheral titanium ring removed as a TM-cup augment and the cementless hemispherical acetabulum component combined with a TM-cup augment as the cup-on-cup technique.AIM To report the short-term results of patients with typeⅢB acetabular bone defects reconstructed using the cup-on-cup technique.METHODS We retrospectively reviewed six patients (six hips) with a mean age of 59 years who underwent acetabular reconstruction using our cup-on-cup technique between January 2015 and January 2017.All acetabular bone defects were classified as typeⅢB without pelvic discontinuity using the system of Paprosky All patients were followed both clinically and radiographically for a mean duration of 42 mo.RESULTS The mean Harris hip score improved from 32.4 pre-operatively to 80.7 at the last follow-up.The mean vertical position of the hip rotation centre changed from60.9 mm pre-operatively to 31.7 mm post-operatively,and the mean horizontal position changed from 33.6 mm pre-operatively to 38.9 mm post-operatively.Greater trochanteric migration after extended trochanteric osteotomy occurred in one of six hips at 3 mo.There was no evidence of component migration at the last follow-up.CONCLUSION The short-term results suggest that our cup-on-cup technique could beconsidered an effective management option for Paprosky type ⅢB acetabular bone defects without pelvic discontinuity.
基金financially supported by the National Natural Science Foundation of China(Nos.51173140 and 51373128)Wuhan Scientific and Technological Project(No.2013010501010131)+1 种基金Wuhan Science and Technology Innovation Team of Hi-tech Industrial Project,Hubei Province(No.2015070504020217)Innovation Fund for Post-graduate Education(Nos.CX2014058 and CX2013083),Wuhan Institute of Technology,China
文摘Folate-containing dextran ligand （FA-Dextran-DTPA） was synthesized by the incorporation of diethylenetriamine- pentaacetic acid （DTPA） and folate （FA） as a tumor-targeting group into dextran as a polymer carrier. This ligand was further reacted with gadolinium chloride to make a dextran gadolinium complex FA-Dextran-DTPA-Gd. The ligand and its gadolinium complex were characterized by 1H-NMR, FTIR, UV-Vis, average particle sizes and zeta potential, as well. In vitro properties including relaxivity, cytotoxicity assay, cellular uptake assay, and magnetic resonance imaging （MRI） were also evaluated. Compared with Gd-DTPA, FA-Dextran-DTPA-Gd possessed obviously higher relaxation effectiveness and lower cytotoxicity to HeLa cells. FA-Dextran-DTPA-Gd had a high affinity to the H460 and MDA-MB-231 tumor cells and can be taken up selectively by these tumor cells. Moreover, FA-Dextran-DTPA-Gd showed enhanced signal intensities （SI） of MRI and enhanced the contrast of MR images of tumor cells. These results indicated that FA-Dextran-DTPA-Gd showed the potential as a tumor-targeting contrast agent in MRI.
基金supported by the National Natural Science Foundation of China(21875118,22179065,and 22105108)the Natural Science Foundation of Tianjin(19JCZDJC37700)+1 种基金the 111 project(B12015)China Postdoctoral Science Foundation(2020M680860)。
文摘Exploring feasible synthesis approaches to highly efficient and robust bifunctional electrocatalysts toward both oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)is triggering researcher’s even-increasing interest in rechargeable Zn-air batteries.Herein,sulfur-doped bimetal FeCo phosphide nanoparticles dispersed on N,P,S-tri-doped graphene(donated as S-FeCo3P/NPSG)are rationally prepared through a controllable one-step carbothermal-phosphorization strategy.The modified charge distribution and electron-donor properties of S-FeCo3P/NPSG caused by S decoration render a significantly beneficial effect on the electrocatalytic activities.Consequently,the S-FeCo3P/NPSG electrode exhibits extraordinary bifunctional activities toward oxygen electrochemistry of the OER overpotential of 290 m V at 10 m A cm^(-2) and the ORR half-wave potential of 0.83 V,approaching to that of noblemetal IrO_(2)(289 m V)and Pt/C(0.84 V),respectively,but with more stronger operation stability in alkaline media.When S-FeCo3P/NPSG serves as the air cathode for liquid-state Zn-air battery,the large peak power density and energy density,as well as superb discharge-charge durability(cycling life>600 h)of this device are obtained.Furthermore,all-solid-state Zn-air battery with S-FeCo3P/NPSG as air electrode also displays excellent mechanical flexibility,high power density and stable cycling stability.The self-reconstruction behavior of the S-FeCo3P/NPSG cathode catalysts is also investigated during the electrocatalytic Zn-air battery operation.This work would provide some novel inspiration from aspects of bonding and charge distribution for the rational construction of active and cost-efficient bifucntional oxygen electrocatalysts for energy storage and conversion devices.
基金National Key Research and Development Plan(No.2017YFC0113901)the Department of Science and Technology of Sichuan Province,China(No.2017JZ0039)+1 种基金the Science Research Project for Cadres’Health Care of Sichuan Province(No.2017-205)Science and Technology Department of Sichuan Province(No.2019JDJQ0031,No.2020ZYD035)。
文摘AIM:To systematically understand the genetic association between methylenetetrahydrofolate reductase(MTHFR)C677 T polymorphism and primary open angle glaucoma(POAG).METHODS:A comprehensive literature search in Google Scholar,Pub Med,Science Citation Index,Foreign Medical Literature Retrieval Service,Chinese National Knowledge Infrastructure and Wanfang Databases was performed to collect all eligible studies up to August 2019.Study selection,data abstraction and study quality evaluation were performed by two independent investigators.Odds ratios(ORs)with 95%confidence intervals(CIs)were calculated to assess the association.RESULTS:Eighteen case-control studies including 2156 cases and 2201 controls were identified.There was no significant difference in the terms of MTHFR C677 T polymorphism and POAG in the Caucasian population(for T vs C OR=1.11,95%CI:0.88 to 1.39;for TT vs CC OR=1.01,95%CI:0.76 to 1.36;for TT+TC vs CC OR=1.15,95%CI:0.84 to 1.58 and for TT vs TC+CC OR=1.02,95%CI:0.78 to 1.33).However,a significant effect was revealed in the Asian population(for T vs C OR=1.34,95%CI:1.12 to 1.59;for TT+TC vs CC OR=1.41,95%CI:1.14 to 1.76).CONCLUSION:Based on 18 eligible studies,we provide a correlation between MTHFR C677 T polymorphism and POAG among the Asians subgroup indicating that the T allele or TT+TC genotype may play a critical role in POAG development in Asians.
文摘Reluctance linear actuator, which has a unique property of small volume, low current and can produce great force, is a very promising actuator for the fine stage of the next-generation lithographic scanner. But the strong nonlinearities including the hysteresis, between the current and output force limits the reluctance linear actuator applications in nanometer positioning. In this paper, a new nonlinear control method is proposed for the stage having paired reluctance linear actuator with hysteresis using the direct adaptive neural network, which is used as a learning machine of nonlinearity. The feature of this method lies in that the nonlinear compensator in conventional methods, which computed the current reference from that of the input and output force is not used. This naturally overcomes the robustness issue with respect to parameter uncertainty. Simulation results show that the proposed method is effective in overcoming the nonlinearity between the input current and output force and promising in precision stage control.
