On the basis of the mild transformation of alkenyl triflates into alkynes promoted by LiCl, a one-pot protocol using alkenyl triflate precursors was developed for copper-mediated azide–alkyne cycloaddition. This prot...On the basis of the mild transformation of alkenyl triflates into alkynes promoted by LiCl, a one-pot protocol using alkenyl triflate precursors was developed for copper-mediated azide–alkyne cycloaddition. This protocol may provide an opportunity of sequentially click reactions for the construction of bifunctional probes in chemical biology studies.展开更多
An efficient kinetic resolution(KR)protocol for 1,2-diamines has been developed through asymmetric electrophilic aminations of anilines enabled by chiral phosphoric acid catalysis.A wide array of substituted 1,2-diami...An efficient kinetic resolution(KR)protocol for 1,2-diamines has been developed through asymmetric electrophilic aminations of anilines enabled by chiral phosphoric acid catalysis.A wide array of substituted 1,2-diamines were compatible with this method,generating both the recovered staring materials and the amination products with high enantioselectivities(with s-factor up to 218).Notably,this method is amenable to the kinetic resolution of 1,2-diamines bearingα-tertiary amine moieties,which represents the first KR of this type of 1,2-diamines.Facile removal of the introduced hydrazine group and oxidative cleavage of the N-aryl group to release the free primary amine demonstrate the value of this method.展开更多
Scheme 1 in the article should be corrected as follows:On page 3, left column, the sentence of “The absolute configurations of the products were assigned by analogy to recovered (S)-1e,” should be revised to “The a...Scheme 1 in the article should be corrected as follows:On page 3, left column, the sentence of “The absolute configurations of the products were assigned by analogy to recovered (S)-1e,” should be revised to “The absolute configurations of the products were assigned by analogy to recovered (S)-1f”.展开更多
基金Financial support was provided by the National Natural Science Foundation of China (Nos. 21525209, 21621002, 21772225, and 21761142003)the Chinese Academy of Sciences (Strategic Priority Research Program (No. XDB20000000)+3 种基金Key Research Program of Frontier Sciences (No. QYZDB-SSW-SLH040))Shanghai Science and Technology Commission (Nos. 15JC1400400 and 17XD1404600)the National Program for Support of TopNotch Young Professionals of Chinathe K. C. Wong Education Foundation
文摘On the basis of the mild transformation of alkenyl triflates into alkynes promoted by LiCl, a one-pot protocol using alkenyl triflate precursors was developed for copper-mediated azide–alkyne cycloaddition. This protocol may provide an opportunity of sequentially click reactions for the construction of bifunctional probes in chemical biology studies.
基金NSFC(Grant No.22171186) and ShanghaiTech University start-up funding for financial supportthe support from Analytical Instrumentation Center(contract no.SPST-AIC10112914),SPST。
文摘An efficient kinetic resolution(KR)protocol for 1,2-diamines has been developed through asymmetric electrophilic aminations of anilines enabled by chiral phosphoric acid catalysis.A wide array of substituted 1,2-diamines were compatible with this method,generating both the recovered staring materials and the amination products with high enantioselectivities(with s-factor up to 218).Notably,this method is amenable to the kinetic resolution of 1,2-diamines bearingα-tertiary amine moieties,which represents the first KR of this type of 1,2-diamines.Facile removal of the introduced hydrazine group and oxidative cleavage of the N-aryl group to release the free primary amine demonstrate the value of this method.
文摘Scheme 1 in the article should be corrected as follows:On page 3, left column, the sentence of “The absolute configurations of the products were assigned by analogy to recovered (S)-1e,” should be revised to “The absolute configurations of the products were assigned by analogy to recovered (S)-1f”.
