Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory...Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory bulb(OB),an early target in neurodegenerative diseases,acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct roles.This study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate(FAC).Olfactory function was assessed through olfactory discrimination tests,while iron levels in OB tissues,cerebrospinal fluid(CSF),and serum were quantified using inductively coupled plasma mass spectrometry(ICP-MS),immunohistochemical staining,and iron assays.Transcriptomic changes and immune responses were assessed using RNA sequencing and immune cell infiltration analysis.Results showed that intranasal FAC administration impaired olfactory function,accompanied by iron deposition in the olfactory mucosa and OB,as well as damage to olfactory sensory neurons.Notably,these effects occurred without elevations in CSF or serum iron levels.OB iron accumulation activated multiple immune cells,including microglia and astrocytes,but did not trigger ferroptosis.Spatial transcriptomic sequencing of healthy adult mouse OBs revealed significant cellular heterogeneity,with an abundance of neuroglia and neurons.Among neurons,GABAergic neurons were the most prevalent,followed by glutamatergic and dopaminergic neurons,while cholinergic and serotonergic neurons were sparsely distributed.Under iron-stressed conditions,oligodendrocytes,dopaminergic neurons,and glutamatergic neurons exhibited significant damage,while GABAergic neurons remained unaffected.These findings highlight the selective vulnerability of neuronal and glial populations to iron-induced stress,offering novel insights into the loss of specific cell types in the OB during iron dysregulation.展开更多
Despite their high-energy conversion efficiency that has earned them the label of next-generation energy utilization devices,protonic ceramic fuel cells(PCFCs)have not yet fully fulfilled their potential in terms of l...Despite their high-energy conversion efficiency that has earned them the label of next-generation energy utilization devices,protonic ceramic fuel cells(PCFCs)have not yet fully fulfilled their potential in terms of low-cost integration and environmentally friendly application,which remain significant concerns that heavily influence their progress towards commercial viability.A pragmatic way of cell recycling is extremely helpful for addressing these concerns.Herein,we unveil a novel concept of reusable PCFCs,and propose a comprehensive recycling scheme for discarded PCFCs.In this research,a recycled cell with a recycled single perovskite cathode exhibited a peak power density(PPD)of 1.10 W cm^(-2)at 700℃,comparable to a pristine cell of 1.05 W cm^(-2).Metal ion rearrangement and phase evolution during the recycling processes were investigated,which were demonstrated to be in high relevance to the performance of recycled cells.This research constitutes a pioneering exploration of the mechanisms underlying recycling efforts and offers valuable insights into the material recycling of solid-state functional devices used for energy conversion and storage.展开更多
Primary sclerosing cholangitis(PSC)is an autoimmune disease characterized by chronic cholestasis,a persistent inflammation of the bile ducts that leads to sclerotic occlusion and cholestasis.Gut microbes,consisting of...Primary sclerosing cholangitis(PSC)is an autoimmune disease characterized by chronic cholestasis,a persistent inflammation of the bile ducts that leads to sclerotic occlusion and cholestasis.Gut microbes,consisting of microorganisms colonized in the human gut,play an important role in nutrient intake,metabolic homeostasis,immune regulation,and immune regulation;however,their presence might aid PSC development.Studies have found that gut-liver axis interactions also play an important role in the pathogenesis of PSC.Patients with PSC have considerably reduced intestinal flora diversity and increased abundance of potentially pathogenic bacteria.Dysbiosis of the intestinal flora leads to increased intestinal permeability,homing of intestinal lymphocytes,entry of bacteria and their associated metabolites,such as bile acids,into the liver,stimulation of hepatic immune activation,and promotion of PSC.Currently,PSC effective treatment is lacking.However,a number of studies have recently investigated the targeted modulation of gut microbes for the treatment of various liver diseases(alcoholic liver disease,metabolic fatty liver,cirrhosis,and autoimmune liver disease).In addition,antibiotics,fecal microbiota transplantation,and probiotics have been reported as successful PSC therapies as well as for the treatment of gut dysbiosis,suggesting their effectiveness for PSC treatment.Therefore,this review briefly summarizes the role of intestinal flora in PSC with the aim of providing new insights into PSC treatment.展开更多
The conversion of perhydropolysilazane(PHPS)to silica at low temperature is beneficial for its application on thermally vulnerable substrates.In this work,it is demonstrated that(3-aminopropyl)triethoxysilane(APTES)ha...The conversion of perhydropolysilazane(PHPS)to silica at low temperature is beneficial for its application on thermally vulnerable substrates.In this work,it is demonstrated that(3-aminopropyl)triethoxysilane(APTES)has high catalytic efficiency for the low temperature conversion of PHPS and the catalytic mechanism of APTES was suggested.The influence of temperatu re and humidity on the catalytic conversion process was investigated,and it was found that PHPS can be rapidly converted to silica in 10 min at 80℃with relative humidity of 90%.The achieved silica is mainly composed of SiNO_(3)/SiO_(3)OH and SiO_(4)structure with O/Si of 1.74 and N content of 1%.As an approach to prepare inorganic coating,the low-temperature conversion method achieves a silica coating with low volume shrinkage of 0.86%,low roughness of R_(a)=0.293 nm,high nanoindentation hardness of 3.62 GPa and modulus of 30.06 GPa,which exhibits high potentials as protective coating for va rious materials even those vulnerable to high temperature.展开更多
Photothermal therapy(PTT)is a minimally invasive treatment that kills cancer cells by converting photon energy into heat.The past few decades have witnessed the booming development of photothermal materials,mainly foc...Photothermal therapy(PTT)is a minimally invasive treatment that kills cancer cells by converting photon energy into heat.The past few decades have witnessed the booming development of photothermal materials,mainly focusing on precious metal nanomaterials and carbon nanomaterials,such as nanogold and silver and nanocarbon materials for near-infrared(NIR)light-triggered PTF.As precious metals are expensive and potentially harmful to humans,exploration and development of a new type of photothermal materials has become a research hotspot in this field.Herein,we report narrow bandgap conjugated polymer nanoparticles(PDPP NPs)based on pyrrolo[3,4-c]pyrrole-1,4-dione(DPP)with intense NIR absorption at 900 nm,as well as a photothermal energy conversion efficiency of 75%.This polymer nanoparticle is essentially non-toxic,as the cell viability of mouse remained more than 90%,even when the concentration of PDPP NPs was at 0.5 mg·mL^-1.展开更多
Bottom water coning is the main reason to reduce the recovery of horizontal bottom water reservoir. By water coning, we mean the oil-water interface changes from a horizontal state to a mound-shaped cone and breaks th...Bottom water coning is the main reason to reduce the recovery of horizontal bottom water reservoir. By water coning, we mean the oil-water interface changes from a horizontal state to a mound-shaped cone and breaks through to the wellbore. Autonomous inflow control device(AICD) is an important instrument maintain normal production after bottom water coning, however, the resistance increasing ability of the swirl type AICD is insufficient at present, which seriously affects the water control effect. Aiming this problem, this paper designs a multi-stage resistance-increasing and composite type AICD. The separation mechanism of oil-water two phases in this structure, the resistance form of oil-water single phase and the resistance-increasing principle of water phase are analyzed. Establishing the dual-phase multi-stage separation and resistance-increasing model, and verified by measuring the throttling pressure drop and oil-water volume fraction of the AICD, it is found that the composite type AICD has the effect of ICD and AICD at the same time, which can balance the production rate of each well section at the initial stage of production, delay the occurrence of bottom water coning. In the middle and later stages of production, water-blocking can be effectively increased to achieve water control and stable production.After structural sensitivity analysis, the influence law of various structural parameters on the water control performance of composite AICD was obtained. The simulation calculation results show that,compared with the existing swirl type AICD, composite AICD has higher sensitivity to moisture content,the water phase throttling pressure drop is increased by 4.5 times on average. The composite AICD is suitable for the entire stage of horizontal well production.展开更多
Glucagon exhibits insulinotropic ability by activating cAMP through glucagon or glucagon-like peptide-1（GLP-1） receptors.To investigate the mechanism of endogenous and exogenous glucagon on insulin release,we studie...Glucagon exhibits insulinotropic ability by activating cAMP through glucagon or glucagon-like peptide-1（GLP-1） receptors.To investigate the mechanism of endogenous and exogenous glucagon on insulin release,we studied the receptor selectivity on pancreatic islet beta-cells by switching the glucose concentration from 20 mmol/L to 0 mmol/L To measure the exact temporal relationship between glucagon and insulin release,we developed a quick,small volume,multi-channel polydimethylsiloxane（PDMS） microchip.At 0 mmol/L glucose,we observed an insulinotropic effect in both INS-1 cells and islets.Meanwhile,we observed a 63 ± 6.27 s delay of endogenous glucagon-induced insulin release.After treatment with glucagon and GLP-1 receptor antagonists,we found that endogenous glucagon utilized the glucagon receptor,whereas exogenous glucagon primarily utilized the GLP-1 receptor to promote insulin secretion.The microchip can also be used to describe the ＂glucagonocentric＂ vision of diabetes pathophysiology.Taken together,the insulinotropic mechanism of different receptors should be taken into account in clinical treatments.展开更多
A series of polymer photodetectors with device configuration of ITO/PEDOT:PSS/P_(3)HT:PC_(61)BM/C_(60)/AI were prepared by using P3HT as the donor material and PC61BM as the acceptor material.By regulating the content...A series of polymer photodetectors with device configuration of ITO/PEDOT:PSS/P_(3)HT:PC_(61)BM/C_(60)/AI were prepared by using P3HT as the donor material and PC61BM as the acceptor material.By regulating the content of 1,8-diiodooctane(DIO)(V/V:1%,3%,5%)as a processing additive,the morphology of the active layer can be greatly improved With Ceo as the hole blocking layer,the dark current density of the device can be reduced by about an order of magnitude.When employing 3%DIO(V/V)in the active layer processing,the photodetetcors present the best performance,and the detectivity of the device is 1.52×10^(12)Jones at 540 nm under a bias of-0.1 V.Moreover,it also has a wider linear dynamic range of 60 dB as well as faster response speed(T1/T2=0.53/0.71μs)than those of devices with other content of DIO additives.展开更多
We devote ourselves to finding exact solutions(including perturbed soliton solutions)to a class of semi-linear Schrödinger equations incorporating Kudryashov's self-phase modulation subject to stochastic pert...We devote ourselves to finding exact solutions(including perturbed soliton solutions)to a class of semi-linear Schrödinger equations incorporating Kudryashov's self-phase modulation subject to stochastic perturbations described by multiplicative white noise based on Stratonvich's calculus.By borrowing ideas of the sub-equation method and utilizing a series of changes of variables,we transform the problem of identifying exact solutions into the task of analyzing the dynamical behaviors of an auxiliary planar Hamiltonian dynamical system.We determine the equilibrium points of the introduced auxiliary Hamiltonian system and analyze their Lyapunov stability.Additionally,we conduct a brief bifurcation analysis and a preliminary chaos analysis of the auxiliary Hamiltonian system,assessing their impact on the Lyapunov stability.Based on the insights gained from investigating the dynamics of the introduced auxiliary Hamiltonian system,we discover‘all'of the exact solutions to the stochastic semi-linear Schrödinger equations under consideration.We obtain explicit formulas for exact solutions by examining the phase portrait of the introduced auxiliary Hamiltonian system.The obtained exact solutions include singular and periodic solutions,as well as perturbed bright and dark solitons.For each type of obtained exact solution,we pick one representative to plot its graph,so as to visually display our theoretical results.Compared with other methods for finding exact solutions to deterministic or stochastic partial differential equations,the dynamical system approach has the merit of yielding all possible exact solutions.The stochastic semi-linear Schrödinger equation under consideration can be used to portray the propagation of pulses in an optical fiber,so our study therefore lays the foundation for discovering new solitons optimized for optical communication and contributes to the improvement of optical technologies.展开更多
To the Editor： Allogeneic hematopoietic siena cell transplantation （aLIo-HSCT） is a curative therapy for patients with acute myelogenous letikemia （A M L） due to the intensive conditioning chemoradiotherapy and t...To the Editor： Allogeneic hematopoietic siena cell transplantation （aLIo-HSCT） is a curative therapy for patients with acute myelogenous letikemia （A M L） due to the intensive conditioning chemoradiotherapy and the effect of graft-versus-leukemia （GVL）. An isolated extramedullary （EM） relapse of acute leukemia （AL） is a rare occurrence observed more commonly after allo-HSCT rather than following convemional chemotherapy alone.展开更多
Scheduling with group technology has been a vivid research area in the past decades.However,group technology with general dual-effect variable processing times needs to be further explored although this kind of group...Scheduling with group technology has been a vivid research area in the past decades.However,group technology with general dual-effect variable processing times needs to be further explored although this kind of group technology plays an important role in some actual manufacturing scenarios.Accordingly,this paper considers group scheduling problems with a kind of general group variable processing times model,where the actual processing time of each job in group is variable due to the dual effect of both the job position and the group position.The objectives of two types of considered problems are to minimize the makespan and the total completion time,respectively.Based on the decomposition analysis,the mathematical logic analysis and the computational complexity proof,it is obtained that the makespan minimization problem and the total completion time minimization problem are both polynomially solvable under the condition that the group number is constant.For three special cases of considered problems,polynomial solving algorithms with lower computational complexity are proposed.展开更多
基金supported by the National Natural Science Foundation of China (32471188,32170984,82301787)。
文摘Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory bulb(OB),an early target in neurodegenerative diseases,acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct roles.This study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate(FAC).Olfactory function was assessed through olfactory discrimination tests,while iron levels in OB tissues,cerebrospinal fluid(CSF),and serum were quantified using inductively coupled plasma mass spectrometry(ICP-MS),immunohistochemical staining,and iron assays.Transcriptomic changes and immune responses were assessed using RNA sequencing and immune cell infiltration analysis.Results showed that intranasal FAC administration impaired olfactory function,accompanied by iron deposition in the olfactory mucosa and OB,as well as damage to olfactory sensory neurons.Notably,these effects occurred without elevations in CSF or serum iron levels.OB iron accumulation activated multiple immune cells,including microglia and astrocytes,but did not trigger ferroptosis.Spatial transcriptomic sequencing of healthy adult mouse OBs revealed significant cellular heterogeneity,with an abundance of neuroglia and neurons.Among neurons,GABAergic neurons were the most prevalent,followed by glutamatergic and dopaminergic neurons,while cholinergic and serotonergic neurons were sparsely distributed.Under iron-stressed conditions,oligodendrocytes,dopaminergic neurons,and glutamatergic neurons exhibited significant damage,while GABAergic neurons remained unaffected.These findings highlight the selective vulnerability of neuronal and glial populations to iron-induced stress,offering novel insights into the loss of specific cell types in the OB during iron dysregulation.
基金financially supported by the Research Startup Project for High-Level Talent Attraction in Inner Mongolia Agricultural University(No.NDYB2023-40)the Natural Science Research Fund for Colleges and Universities in Anhui Province(No.2022AH050309)+3 种基金The Scientific Research Foundation of Education Department of Anhui Province of China(No.KJ2021ZD0043)the University Synergy Innovation Program of Anhui Province of China(No.GXXT-2022-010)the High-Level Talent Project of Talent Development Fund of Inner Mongoliathe Start-Up Funding from Inner Mongolia University of Technology(No.YLXKZX-NGD-039)
文摘Despite their high-energy conversion efficiency that has earned them the label of next-generation energy utilization devices,protonic ceramic fuel cells(PCFCs)have not yet fully fulfilled their potential in terms of low-cost integration and environmentally friendly application,which remain significant concerns that heavily influence their progress towards commercial viability.A pragmatic way of cell recycling is extremely helpful for addressing these concerns.Herein,we unveil a novel concept of reusable PCFCs,and propose a comprehensive recycling scheme for discarded PCFCs.In this research,a recycled cell with a recycled single perovskite cathode exhibited a peak power density(PPD)of 1.10 W cm^(-2)at 700℃,comparable to a pristine cell of 1.05 W cm^(-2).Metal ion rearrangement and phase evolution during the recycling processes were investigated,which were demonstrated to be in high relevance to the performance of recycled cells.This research constitutes a pioneering exploration of the mechanisms underlying recycling efforts and offers valuable insights into the material recycling of solid-state functional devices used for energy conversion and storage.
基金Supported by the National Natural Science Foundation of China,No.31960236the Talent Innovation and Entrepreneurship Project of Lanzhou City,No.2019-RC-34the Lanzhou Cheng guan District Science and Technology Planning Project,No.2020SHFZ0029.
文摘Primary sclerosing cholangitis(PSC)is an autoimmune disease characterized by chronic cholestasis,a persistent inflammation of the bile ducts that leads to sclerotic occlusion and cholestasis.Gut microbes,consisting of microorganisms colonized in the human gut,play an important role in nutrient intake,metabolic homeostasis,immune regulation,and immune regulation;however,their presence might aid PSC development.Studies have found that gut-liver axis interactions also play an important role in the pathogenesis of PSC.Patients with PSC have considerably reduced intestinal flora diversity and increased abundance of potentially pathogenic bacteria.Dysbiosis of the intestinal flora leads to increased intestinal permeability,homing of intestinal lymphocytes,entry of bacteria and their associated metabolites,such as bile acids,into the liver,stimulation of hepatic immune activation,and promotion of PSC.Currently,PSC effective treatment is lacking.However,a number of studies have recently investigated the targeted modulation of gut microbes for the treatment of various liver diseases(alcoholic liver disease,metabolic fatty liver,cirrhosis,and autoimmune liver disease).In addition,antibiotics,fecal microbiota transplantation,and probiotics have been reported as successful PSC therapies as well as for the treatment of gut dysbiosis,suggesting their effectiveness for PSC treatment.Therefore,this review briefly summarizes the role of intestinal flora in PSC with the aim of providing new insights into PSC treatment.
基金financially supported by the National Natural Science Foundation of China(No.21872152)Guangdong Natural Science Foundation(No.2019A1515111028)Xiejialin Foundation in the Institute of High Energy Physics(No.E15466U210)。
文摘The conversion of perhydropolysilazane(PHPS)to silica at low temperature is beneficial for its application on thermally vulnerable substrates.In this work,it is demonstrated that(3-aminopropyl)triethoxysilane(APTES)has high catalytic efficiency for the low temperature conversion of PHPS and the catalytic mechanism of APTES was suggested.The influence of temperatu re and humidity on the catalytic conversion process was investigated,and it was found that PHPS can be rapidly converted to silica in 10 min at 80℃with relative humidity of 90%.The achieved silica is mainly composed of SiNO_(3)/SiO_(3)OH and SiO_(4)structure with O/Si of 1.74 and N content of 1%.As an approach to prepare inorganic coating,the low-temperature conversion method achieves a silica coating with low volume shrinkage of 0.86%,low roughness of R_(a)=0.293 nm,high nanoindentation hardness of 3.62 GPa and modulus of 30.06 GPa,which exhibits high potentials as protective coating for va rious materials even those vulnerable to high temperature.
基金This work was financially supported by the National Natural Science Foundation of China(No.21474105)and the Project of the Natural Science and En-gineering Research Council of Canada.
文摘Photothermal therapy(PTT)is a minimally invasive treatment that kills cancer cells by converting photon energy into heat.The past few decades have witnessed the booming development of photothermal materials,mainly focusing on precious metal nanomaterials and carbon nanomaterials,such as nanogold and silver and nanocarbon materials for near-infrared(NIR)light-triggered PTF.As precious metals are expensive and potentially harmful to humans,exploration and development of a new type of photothermal materials has become a research hotspot in this field.Herein,we report narrow bandgap conjugated polymer nanoparticles(PDPP NPs)based on pyrrolo[3,4-c]pyrrole-1,4-dione(DPP)with intense NIR absorption at 900 nm,as well as a photothermal energy conversion efficiency of 75%.This polymer nanoparticle is essentially non-toxic,as the cell viability of mouse remained more than 90%,even when the concentration of PDPP NPs was at 0.5 mg·mL^-1.
基金supported by National Natural Science Foundation(52204050)Sichuan Science and Technology Program(2021ZHCG0013,22ZDYF3009)。
文摘Bottom water coning is the main reason to reduce the recovery of horizontal bottom water reservoir. By water coning, we mean the oil-water interface changes from a horizontal state to a mound-shaped cone and breaks through to the wellbore. Autonomous inflow control device(AICD) is an important instrument maintain normal production after bottom water coning, however, the resistance increasing ability of the swirl type AICD is insufficient at present, which seriously affects the water control effect. Aiming this problem, this paper designs a multi-stage resistance-increasing and composite type AICD. The separation mechanism of oil-water two phases in this structure, the resistance form of oil-water single phase and the resistance-increasing principle of water phase are analyzed. Establishing the dual-phase multi-stage separation and resistance-increasing model, and verified by measuring the throttling pressure drop and oil-water volume fraction of the AICD, it is found that the composite type AICD has the effect of ICD and AICD at the same time, which can balance the production rate of each well section at the initial stage of production, delay the occurrence of bottom water coning. In the middle and later stages of production, water-blocking can be effectively increased to achieve water control and stable production.After structural sensitivity analysis, the influence law of various structural parameters on the water control performance of composite AICD was obtained. The simulation calculation results show that,compared with the existing swirl type AICD, composite AICD has higher sensitivity to moisture content,the water phase throttling pressure drop is increased by 4.5 times on average. The composite AICD is suitable for the entire stage of horizontal well production.
基金supported by the National Natural Science Foundation of China (Nos. 41076064, 31371444)
文摘Glucagon exhibits insulinotropic ability by activating cAMP through glucagon or glucagon-like peptide-1（GLP-1） receptors.To investigate the mechanism of endogenous and exogenous glucagon on insulin release,we studied the receptor selectivity on pancreatic islet beta-cells by switching the glucose concentration from 20 mmol/L to 0 mmol/L To measure the exact temporal relationship between glucagon and insulin release,we developed a quick,small volume,multi-channel polydimethylsiloxane（PDMS） microchip.At 0 mmol/L glucose,we observed an insulinotropic effect in both INS-1 cells and islets.Meanwhile,we observed a 63 ± 6.27 s delay of endogenous glucagon-induced insulin release.After treatment with glucagon and GLP-1 receptor antagonists,we found that endogenous glucagon utilized the glucagon receptor,whereas exogenous glucagon primarily utilized the GLP-1 receptor to promote insulin secretion.The microchip can also be used to describe the ＂glucagonocentric＂ vision of diabetes pathophysiology.Taken together,the insulinotropic mechanism of different receptors should be taken into account in clinical treatments.
文摘A series of polymer photodetectors with device configuration of ITO/PEDOT:PSS/P_(3)HT:PC_(61)BM/C_(60)/AI were prepared by using P3HT as the donor material and PC61BM as the acceptor material.By regulating the content of 1,8-diiodooctane(DIO)(V/V:1%,3%,5%)as a processing additive,the morphology of the active layer can be greatly improved With Ceo as the hole blocking layer,the dark current density of the device can be reduced by about an order of magnitude.When employing 3%DIO(V/V)in the active layer processing,the photodetetcors present the best performance,and the detectivity of the device is 1.52×10^(12)Jones at 540 nm under a bias of-0.1 V.Moreover,it also has a wider linear dynamic range of 60 dB as well as faster response speed(T1/T2=0.53/0.71μs)than those of devices with other content of DIO additives.
基金partially supported by Qing Lan Project of Jiangsu,Suqian Sci.&Tech.Program(Grant Nos.Z2023131 and M202206)the Startup Foundation for Newly Recruited Employees,the Xichu Talents Foundation of Suqian University(Grant No.2022XRC033)the National Natural Science Foundation of China(Grant No.11701050)。
文摘We devote ourselves to finding exact solutions(including perturbed soliton solutions)to a class of semi-linear Schrödinger equations incorporating Kudryashov's self-phase modulation subject to stochastic perturbations described by multiplicative white noise based on Stratonvich's calculus.By borrowing ideas of the sub-equation method and utilizing a series of changes of variables,we transform the problem of identifying exact solutions into the task of analyzing the dynamical behaviors of an auxiliary planar Hamiltonian dynamical system.We determine the equilibrium points of the introduced auxiliary Hamiltonian system and analyze their Lyapunov stability.Additionally,we conduct a brief bifurcation analysis and a preliminary chaos analysis of the auxiliary Hamiltonian system,assessing their impact on the Lyapunov stability.Based on the insights gained from investigating the dynamics of the introduced auxiliary Hamiltonian system,we discover‘all'of the exact solutions to the stochastic semi-linear Schrödinger equations under consideration.We obtain explicit formulas for exact solutions by examining the phase portrait of the introduced auxiliary Hamiltonian system.The obtained exact solutions include singular and periodic solutions,as well as perturbed bright and dark solitons.For each type of obtained exact solution,we pick one representative to plot its graph,so as to visually display our theoretical results.Compared with other methods for finding exact solutions to deterministic or stochastic partial differential equations,the dynamical system approach has the merit of yielding all possible exact solutions.The stochastic semi-linear Schrödinger equation under consideration can be used to portray the propagation of pulses in an optical fiber,so our study therefore lays the foundation for discovering new solitons optimized for optical communication and contributes to the improvement of optical technologies.
文摘To the Editor： Allogeneic hematopoietic siena cell transplantation （aLIo-HSCT） is a curative therapy for patients with acute myelogenous letikemia （A M L） due to the intensive conditioning chemoradiotherapy and the effect of graft-versus-leukemia （GVL）. An isolated extramedullary （EM） relapse of acute leukemia （AL） is a rare occurrence observed more commonly after allo-HSCT rather than following convemional chemotherapy alone.
基金the National Natural Science Foundation of China(No.71573121)China Postdoctoral Science Foundation Funded Project(No.2016M590453)the Fundamental Research Funds for the Central Universities(Nos.NS2016080 and NR2016005).
文摘Scheduling with group technology has been a vivid research area in the past decades.However,group technology with general dual-effect variable processing times needs to be further explored although this kind of group technology plays an important role in some actual manufacturing scenarios.Accordingly,this paper considers group scheduling problems with a kind of general group variable processing times model,where the actual processing time of each job in group is variable due to the dual effect of both the job position and the group position.The objectives of two types of considered problems are to minimize the makespan and the total completion time,respectively.Based on the decomposition analysis,the mathematical logic analysis and the computational complexity proof,it is obtained that the makespan minimization problem and the total completion time minimization problem are both polynomially solvable under the condition that the group number is constant.For three special cases of considered problems,polynomial solving algorithms with lower computational complexity are proposed.
