The global burden of cancer,with over 19 million new cases annually,underscores the urgent need for effective therapies.Among the most promising anticancer compounds is camptothecin(CPT),a monoterpene alkaloid predomi...The global burden of cancer,with over 19 million new cases annually,underscores the urgent need for effective therapies.Among the most promising anticancer compounds is camptothecin(CPT),a monoterpene alkaloid predominantly derived from Nothapodytes species.Despite its significantpharmaceutical value,the exploitation of such Threatened Plant Species with Widespread Distribution(TPSWD),particularly driven by the global demand for natural compounds in anticancer therapies,presents a paradox in which their widespread distribution fails to ensure their secure conservation status.Furthermore,the lack of in-depth biogeographic and systematic studies complicates efforts to balance resource utilization with biodiversity preservation.The asymmetric distribution of CPT within plant taxa,along with limited knowledge of its biosynthetic pathways and the enzymes and genes involved,further hampers sustainable production.Here,we review the current knowledge on the production and protection of Nothapodytes,focusing on their plant resources,active ingredients,and natural drug derivatives.We also explore strategies for rescuing and sustainably utilizing Nothapodytes,including biotechnological advancements and integrated conservation practices.Finally,we propose future directions to address conservation challenges,ensuring a sustainable supply of CPT while safeguarding these TPSWD species.展开更多
H3PW12O40/TiO2-SiO2 was synthesized by impregnation method which significantly improved the catalytic activity under simulated natural light. The prop- erties of the samples were characterized by Fourier trans- form i...H3PW12O40/TiO2-SiO2 was synthesized by impregnation method which significantly improved the catalytic activity under simulated natural light. The prop- erties of the samples were characterized by Fourier trans- form infrared spectra （FTIR）, X-ray powder diffraction pattern （XRD）, Scanning electron micrographs （SEM）, and Zeta potential. Degradation of methyl violet was used as a probe reaction to explore the influencing factors on the photodegradation reaction. The results show that the opti- mal conditions are as follows： initial concentration of methyl violet of 10 mg·L^-1, pH of 3.0, catalyst dosage of 2.9 g·L^-1, and light irradiation time of 2.5 h. Under these conditions, the degradation rate of methyl violet is 95.4 %. The reaction on photodegradation for methyl violet can be expressed as the first-order kinetic model, and the possible mechanism for the photocatalysis under simulated natural light is suggested. After used continuously for five times, the catalyst keeps the inherent photocatalytic activity for degradation of dyes. The photodegradation of methyl orange, methyl red, naphthol green B, and methylene blue was also tested, and the degradation rate of dyes can reach 81%-100%.展开更多
基金supported by the National Key R&D Program of China(2024YFF1306700)the Key Project of Basic Research of Yunnan Province,China(202301AS070001)the Regional Innovative Development Joint Fund of NSFC(U23A20149).
文摘The global burden of cancer,with over 19 million new cases annually,underscores the urgent need for effective therapies.Among the most promising anticancer compounds is camptothecin(CPT),a monoterpene alkaloid predominantly derived from Nothapodytes species.Despite its significantpharmaceutical value,the exploitation of such Threatened Plant Species with Widespread Distribution(TPSWD),particularly driven by the global demand for natural compounds in anticancer therapies,presents a paradox in which their widespread distribution fails to ensure their secure conservation status.Furthermore,the lack of in-depth biogeographic and systematic studies complicates efforts to balance resource utilization with biodiversity preservation.The asymmetric distribution of CPT within plant taxa,along with limited knowledge of its biosynthetic pathways and the enzymes and genes involved,further hampers sustainable production.Here,we review the current knowledge on the production and protection of Nothapodytes,focusing on their plant resources,active ingredients,and natural drug derivatives.We also explore strategies for rescuing and sustainably utilizing Nothapodytes,including biotechnological advancements and integrated conservation practices.Finally,we propose future directions to address conservation challenges,ensuring a sustainable supply of CPT while safeguarding these TPSWD species.
基金financially supported by the Hubei Key Laboratory of Pollutant Analysis & Reuse Technology (No.KL2013M08)
文摘H3PW12O40/TiO2-SiO2 was synthesized by impregnation method which significantly improved the catalytic activity under simulated natural light. The prop- erties of the samples were characterized by Fourier trans- form infrared spectra （FTIR）, X-ray powder diffraction pattern （XRD）, Scanning electron micrographs （SEM）, and Zeta potential. Degradation of methyl violet was used as a probe reaction to explore the influencing factors on the photodegradation reaction. The results show that the opti- mal conditions are as follows： initial concentration of methyl violet of 10 mg·L^-1, pH of 3.0, catalyst dosage of 2.9 g·L^-1, and light irradiation time of 2.5 h. Under these conditions, the degradation rate of methyl violet is 95.4 %. The reaction on photodegradation for methyl violet can be expressed as the first-order kinetic model, and the possible mechanism for the photocatalysis under simulated natural light is suggested. After used continuously for five times, the catalyst keeps the inherent photocatalytic activity for degradation of dyes. The photodegradation of methyl orange, methyl red, naphthol green B, and methylene blue was also tested, and the degradation rate of dyes can reach 81%-100%.
