Objective： Human carbonic anhydrases II （CAII） gene plays an important role in different cancer. However, its relevance to gastric cancer （GC） remains unclear. In the present study, we aimed to investigate the ex...Objective： Human carbonic anhydrases II （CAII） gene plays an important role in different cancer. However, its relevance to gastric cancer （GC） remains unclear. In the present study, we aimed to investigate the expression of CAII in GC and explore its correlation with some clinicopathologic characteristics of GC. Methods： The expression of CAII in 20 specimens of normal gastric mucosa, 38 specimens of intraepithelial neoplasia and 112 specimens of gastric carcinoma were detected by immunohistochemical techniques. Survival in GC with CAII expression was studied. Results： The positive rate of CAII protein in normal gastric mucosa was significantly higher than that in intraepithelial neoplasia and gastric carcinoma （100% vs. 63.16% and 28.57%, P0.001）. The positive rate of CAII protein was significantly higher in gastric carcinoma at early stages than that at advanced stages （70.0% vs. 19.57%, P0.001）. The positive rate of CAII protein was significantly lower in gastric carcinoma with lymph node metastases than that without lymph node metastases （10.81% vs. 37.33%, P0.05）. Furthermore, the positive rate of CAII protein was significantly lower in poorly-differentiated gastric carcinoma than in moderately- or well-differentiated gastric carcinoma （15.94% vs. 31.03% or 60.00%, P0.05）. Moreover, CAII expression was not related with sex, age and tumor size. The patients with CAII-positive tumors showed a better survival rate than those with CAII-negative tumors （P=0.024, log-rank test）. Conclusion： CAII expression was related with stages and lymph node metastases in gastric carcinoma. The reduction of CAII expression in GC might promote tumor cell motility and contribute to tumor growth and metastasis.展开更多
BACKGROUND Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease ofunknown etiology that usually presents as unexplained jaundice. It ischaracterized by adult onset, lack of autoantibodies, infl...BACKGROUND Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease ofunknown etiology that usually presents as unexplained jaundice. It ischaracterized by adult onset, lack of autoantibodies, inflammatory bowel diseaseand loss of interlobular bile ducts.CASE SUMMARY This case presents a 27-year-old woman with elevation of transaminases andalkaline phosphatase without clinical symptoms. Five years ago, the patient hadabnormal transaminases but no cholestasis. Three months before admission,physical examination revealed an increase in transaminases. Oralhepatoprotective drugs did not show any significant improvement, and she wasadmitted to hospital for further diagnosis and treatment. Liver biopsy confirmedIAD. After about 2 wk of ursodeoxycholic acid treatment, serological andhistological examination showed a significant response.CONCLUSION IAD is a manifestation of cholestasis, but also may be an abnormal increase intransaminase in the early stage.展开更多
Circularly polarized luminescence(CPL)-active nanoclusters hold great promise for advanced photonic applications,yet the improvement of the;glum;has always been the core challenge in this field for a long time.Herein,...Circularly polarized luminescence(CPL)-active nanoclusters hold great promise for advanced photonic applications,yet the improvement of the;glum;has always been the core challenge in this field for a long time.Herein,we report the enantiomeric pairs of homometallic cationic(R/S)-[Ag_(2)1(S_(2)PO_(2)C_(17)H_(14))12]+(R/S-Ag_(2)1)and heterometallic neutral(R/S)-[PtAg_(2)0(S_(2)PO_(2)C_(17)H_(14))_(12)](R/S-PtAg_(2)0)clusters stabilized by a bis-thiophosphinate spiro ligand and featuring eight free electrons.R/S-Ag_(2)1 exhibits a single emission with a;glum;value of 4.7×10^(-4),whereas R/S-PtAg_(2)0 with only one atom changed exhibits visible-near-infrared(NIR)dual emission CPL behavior,with a visible-light emission;glum;value of 6.4×10^(-4)and an NIR emission;glum;value of 1.3×10^(-2)—among the highest reported for metal clusters.Research has revealed that the luminescence of R/S-PtAg_(2)0 originates from two independent triplet excited states:a core-based charge transfer(CT)state and a ligand-to-core CT state,which are bridged by a direct CT process mediated by ligand vibrations.The high;glum;value of R/S-PtAg_(2)0 in the NIR region stems from the strong correlation between its electronic cloud and the peripheral chiral ligands.Furthermore,vip-induced modulation of ligand rigidity enables tunable emission modes—visible-only,NIR-only,or dual-visible-NIR.This work presents a novel strategy for constructing DECPL-active metal clusters,offering fundamental insights into the design principles governing CPL efficiency and paving the way for multifunctional photonic systems,such as optical encryption.展开更多
基金supported by the National Natural Science Foundation of China (No.81172576)by a grant from Technology Division of Chenzhou, China (No. 2008gl15)
文摘Objective： Human carbonic anhydrases II （CAII） gene plays an important role in different cancer. However, its relevance to gastric cancer （GC） remains unclear. In the present study, we aimed to investigate the expression of CAII in GC and explore its correlation with some clinicopathologic characteristics of GC. Methods： The expression of CAII in 20 specimens of normal gastric mucosa, 38 specimens of intraepithelial neoplasia and 112 specimens of gastric carcinoma were detected by immunohistochemical techniques. Survival in GC with CAII expression was studied. Results： The positive rate of CAII protein in normal gastric mucosa was significantly higher than that in intraepithelial neoplasia and gastric carcinoma （100% vs. 63.16% and 28.57%, P0.001）. The positive rate of CAII protein was significantly higher in gastric carcinoma at early stages than that at advanced stages （70.0% vs. 19.57%, P0.001）. The positive rate of CAII protein was significantly lower in gastric carcinoma with lymph node metastases than that without lymph node metastases （10.81% vs. 37.33%, P0.05）. Furthermore, the positive rate of CAII protein was significantly lower in poorly-differentiated gastric carcinoma than in moderately- or well-differentiated gastric carcinoma （15.94% vs. 31.03% or 60.00%, P0.05）. Moreover, CAII expression was not related with sex, age and tumor size. The patients with CAII-positive tumors showed a better survival rate than those with CAII-negative tumors （P=0.024, log-rank test）. Conclusion： CAII expression was related with stages and lymph node metastases in gastric carcinoma. The reduction of CAII expression in GC might promote tumor cell motility and contribute to tumor growth and metastasis.
文摘BACKGROUND Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease ofunknown etiology that usually presents as unexplained jaundice. It ischaracterized by adult onset, lack of autoantibodies, inflammatory bowel diseaseand loss of interlobular bile ducts.CASE SUMMARY This case presents a 27-year-old woman with elevation of transaminases andalkaline phosphatase without clinical symptoms. Five years ago, the patient hadabnormal transaminases but no cholestasis. Three months before admission,physical examination revealed an increase in transaminases. Oralhepatoprotective drugs did not show any significant improvement, and she wasadmitted to hospital for further diagnosis and treatment. Liver biopsy confirmedIAD. After about 2 wk of ursodeoxycholic acid treatment, serological andhistological examination showed a significant response.CONCLUSION IAD is a manifestation of cholestasis, but also may be an abnormal increase intransaminase in the early stage.
基金supported by the Excellent Youth Foundation of Henan Scientific Committee(Grant 232300421022,Xi-Yan Dong)the National Natural Science Foundation of China(Grant 92461304,Shuang-Quan Zang,Grant 92356304,Shuang-Quan Zang,Grant U21A20277,Xi-Yan Dong,Grant 22575078,Xi-Yan Dong)+1 种基金Program for Innovative Research Team(in Science and Technology)in University of Henan Province(Grant IRTSTHN,25IRTSTHN001,Xi-Yan Dong)Zhengzhou University.
文摘Circularly polarized luminescence(CPL)-active nanoclusters hold great promise for advanced photonic applications,yet the improvement of the;glum;has always been the core challenge in this field for a long time.Herein,we report the enantiomeric pairs of homometallic cationic(R/S)-[Ag_(2)1(S_(2)PO_(2)C_(17)H_(14))12]+(R/S-Ag_(2)1)and heterometallic neutral(R/S)-[PtAg_(2)0(S_(2)PO_(2)C_(17)H_(14))_(12)](R/S-PtAg_(2)0)clusters stabilized by a bis-thiophosphinate spiro ligand and featuring eight free electrons.R/S-Ag_(2)1 exhibits a single emission with a;glum;value of 4.7×10^(-4),whereas R/S-PtAg_(2)0 with only one atom changed exhibits visible-near-infrared(NIR)dual emission CPL behavior,with a visible-light emission;glum;value of 6.4×10^(-4)and an NIR emission;glum;value of 1.3×10^(-2)—among the highest reported for metal clusters.Research has revealed that the luminescence of R/S-PtAg_(2)0 originates from two independent triplet excited states:a core-based charge transfer(CT)state and a ligand-to-core CT state,which are bridged by a direct CT process mediated by ligand vibrations.The high;glum;value of R/S-PtAg_(2)0 in the NIR region stems from the strong correlation between its electronic cloud and the peripheral chiral ligands.Furthermore,vip-induced modulation of ligand rigidity enables tunable emission modes—visible-only,NIR-only,or dual-visible-NIR.This work presents a novel strategy for constructing DECPL-active metal clusters,offering fundamental insights into the design principles governing CPL efficiency and paving the way for multifunctional photonic systems,such as optical encryption.
