A new Annonaceous acetogenin, named uvarigranin(I),was isolated from the ethanol extract of the roots of Uvaria grandiflora Roxb, together with the known isodesacetyluvaricin (II) Their plane structures and relative c...A new Annonaceous acetogenin, named uvarigranin(I),was isolated from the ethanol extract of the roots of Uvaria grandiflora Roxb, together with the known isodesacetyluvaricin (II) Their plane structures and relative configurations were established on the basis of NMR and MS spectroscopic methods. Compound I belongs to a mono(-1)-trahydrofuran (THF) type acetogenin with an unusual acetoxy group at the adjacent carbon on the THF ring.展开更多
7-Epi-howiinol A, an antitumor lactone, has been synthesized in nine steps starting from alpha-D-glucoheptonic gamma-lactone with an overall yield of 8.5%.
A novel bioactive Annonaceous acetogenin, donhexocin (1), has been isolated from the roots of Goniothalamus donnaiensis (Annonaceae). 1 is a new acetogenin lacking THF rings but bearing six hydroxyls including two vic...A novel bioactive Annonaceous acetogenin, donhexocin (1), has been isolated from the roots of Goniothalamus donnaiensis (Annonaceae). 1 is a new acetogenin lacking THF rings but bearing six hydroxyls including two vic-diol systems in the aliphatic chain. Its structure and stereochemistry has been elucidated by spectoscopic analysis and derivatization.展开更多
Four new steroidal alkaloids, named sarcovagine A-D, were isolated from the roots of Sarcococca vagans. Their structures were determined as 20 alpha-dimethylamino-2 beta,4 beta-dihydroxy-3 beta-tigloylamino-5 alpha-pr...Four new steroidal alkaloids, named sarcovagine A-D, were isolated from the roots of Sarcococca vagans. Their structures were determined as 20 alpha-dimethylamino-2 beta,4 beta-dihydroxy-3 beta-tigloylamino-5 alpha-pregnane (sarcovagine A, 1), 20 alpha-dimethylamino-2 alpha-hydroxy-4 beta-acetoxy-3 beta-tigloylamino-5 alpha-pregnane (sarcovagine B, 2), 20 alpha-dimethylamino-4 beta-acetoxy-3 beta-tigloylamino-5 alpha-pregnane (sarcovagine C, 3), 20 alpha-dimethylamino-3-tigloylamino-5 alpha-pregn-2(3)-en-4-one (sarcovagine D, 4), respectively.展开更多
A new monotetrahydrofuran Annonaceous acetogenin, gardnerin (1) was isolated from the roots of Goniothalamus gardneri Hook. f. et. Thoms. This compound possesses five hydroxyl groups, with two hydroxyl groups at C-8 a...A new monotetrahydrofuran Annonaceous acetogenin, gardnerin (1) was isolated from the roots of Goniothalamus gardneri Hook. f. et. Thoms. This compound possesses five hydroxyl groups, with two hydroxyl groups at C-8 and C-10 positions. The absolute stereochemistry at 8-OH and 10-OH positions Nas determined by converting 1 to its ketolactone isomer, 2,4-cis/trans gardnerin. Bioactivities of this new compound against human tumor cell lines are reported. Five known acetogenin compounds gigantetrocin A and B, annonacin, goniothalamicin, isoannonacin were also found.展开更多
The absolute stereochemistries of Annonaceous acetogenins, tonkinin A and B, have been established by the use of the convenient conversion to their formaldehyde acetal derivatives and the subsequent application of the...The absolute stereochemistries of Annonaceous acetogenins, tonkinin A and B, have been established by the use of the convenient conversion to their formaldehyde acetal derivatives and the subsequent application of the Mosher ester methodology.展开更多
Howiinol A, an active antitumor constituent from the root and stem bark of Goniothamus howii Meer. (Annoaceae) has been synthesized in nine steps from alpha - D - glucoheptonic gamma - lactone with an overall yield of...Howiinol A, an active antitumor constituent from the root and stem bark of Goniothamus howii Meer. (Annoaceae) has been synthesized in nine steps from alpha - D - glucoheptonic gamma - lactone with an overall yield of 12.4%. The absolute configuration of natural howiinol A is further confirmed.展开更多
----(-)S-Ligustiphenol is a new sesquiterpene compound with antiinflammatory and immunosuppressive activities. The total synthesis of its racemate was carried out by a six-step reaction sequence including bromination ...----(-)S-Ligustiphenol is a new sesquiterpene compound with antiinflammatory and immunosuppressive activities. The total synthesis of its racemate was carried out by a six-step reaction sequence including bromination of aldehyde, iodination of m-cresol, protection of phenolic hydroxyl, Grignard reaction,aldol condensation, etc. The target compound was characterized by comparing its H-1 NMR,MS and IR spectra with natural (-) ligustiphenol.展开更多
Cimicifugamide, a new natural compound isolated from the roots of Cimicifuga dahurica, was totally synthesized by a reaction sequence of seven steps in an overall yield of 31 %. D-Galactose was used as starting materi...Cimicifugamide, a new natural compound isolated from the roots of Cimicifuga dahurica, was totally synthesized by a reaction sequence of seven steps in an overall yield of 31 %. D-Galactose was used as starting material, trifluoroacetoxy was used as leaving group at C-1. The target product was characterized by IR, MS, H-1-NMR C-13-NMR and elemental analysis.展开更多
Two new polyoxygenated cyclohexenes,named uvarigranol E (I) andF(VII),were isolated from the rhizome of Uvaria grandiflora. On the basis ofspectral analysis and chemical derivatizations, including preparation of Moshe...Two new polyoxygenated cyclohexenes,named uvarigranol E (I) andF(VII),were isolated from the rhizome of Uvaria grandiflora. On the basis ofspectral analysis and chemical derivatizations, including preparation of Mosheresters,the structures of I and VII were established as IR-acetoxymethyl-l,2Sdihydroxy-3 R,6S-dibenzoyloxy-cyclohex-4-ene and IR-hydroxymethyl-l,2Sdihydroxy-3R,6S-dibenzoyloxy cyclohex-4-ene.展开更多
文摘A new Annonaceous acetogenin, named uvarigranin(I),was isolated from the ethanol extract of the roots of Uvaria grandiflora Roxb, together with the known isodesacetyluvaricin (II) Their plane structures and relative configurations were established on the basis of NMR and MS spectroscopic methods. Compound I belongs to a mono(-1)-trahydrofuran (THF) type acetogenin with an unusual acetoxy group at the adjacent carbon on the THF ring.
文摘7-Epi-howiinol A, an antitumor lactone, has been synthesized in nine steps starting from alpha-D-glucoheptonic gamma-lactone with an overall yield of 8.5%.
文摘A novel bioactive Annonaceous acetogenin, donhexocin (1), has been isolated from the roots of Goniothalamus donnaiensis (Annonaceae). 1 is a new acetogenin lacking THF rings but bearing six hydroxyls including two vic-diol systems in the aliphatic chain. Its structure and stereochemistry has been elucidated by spectoscopic analysis and derivatization.
文摘A new monotetrahydrofuran Annonaceous acetogenin, gardnerin (1) was isolated from the roots of Goniothalamus gardneri Hook. f. et. Thoms. This compound possesses five hydroxyl groups, with two hydroxyl groups at C-8 and C-10 positions. The absolute stereochemistry at 8-OH and 10-OH positions Nas determined by converting 1 to its ketolactone isomer, 2,4-cis/trans gardnerin. Bioactivities of this new compound against human tumor cell lines are reported. Five known acetogenin compounds gigantetrocin A and B, annonacin, goniothalamicin, isoannonacin were also found.
文摘The absolute stereochemistries of Annonaceous acetogenins, tonkinin A and B, have been established by the use of the convenient conversion to their formaldehyde acetal derivatives and the subsequent application of the Mosher ester methodology.
文摘Howiinol A, an active antitumor constituent from the root and stem bark of Goniothamus howii Meer. (Annoaceae) has been synthesized in nine steps from alpha - D - glucoheptonic gamma - lactone with an overall yield of 12.4%. The absolute configuration of natural howiinol A is further confirmed.
文摘----(-)S-Ligustiphenol is a new sesquiterpene compound with antiinflammatory and immunosuppressive activities. The total synthesis of its racemate was carried out by a six-step reaction sequence including bromination of aldehyde, iodination of m-cresol, protection of phenolic hydroxyl, Grignard reaction,aldol condensation, etc. The target compound was characterized by comparing its H-1 NMR,MS and IR spectra with natural (-) ligustiphenol.
文摘Cimicifugamide, a new natural compound isolated from the roots of Cimicifuga dahurica, was totally synthesized by a reaction sequence of seven steps in an overall yield of 31 %. D-Galactose was used as starting material, trifluoroacetoxy was used as leaving group at C-1. The target product was characterized by IR, MS, H-1-NMR C-13-NMR and elemental analysis.
文摘Two new polyoxygenated cyclohexenes,named uvarigranol E (I) andF(VII),were isolated from the rhizome of Uvaria grandiflora. On the basis ofspectral analysis and chemical derivatizations, including preparation of Mosheresters,the structures of I and VII were established as IR-acetoxymethyl-l,2Sdihydroxy-3 R,6S-dibenzoyloxy-cyclohex-4-ene and IR-hydroxymethyl-l,2Sdihydroxy-3R,6S-dibenzoyloxy cyclohex-4-ene.
