Fiber optic sensing technology,with its low transmission loss,wide bandwidth,and broad dynamic range,offers significant advantages for high-sensitivity measurements.In this study,a multi-band soliton modulation system...Fiber optic sensing technology,with its low transmission loss,wide bandwidth,and broad dynamic range,offers significant advantages for high-sensitivity measurements.In this study,a multi-band soliton modulation system for stress sensing is proposed,utilizing Ti_(3)C_(2)T_(x)to generate ultrashort pulses.By applying stress to microfibers,dichromatic periodic multisoliton mode-locking at 1530 nm and 1555.2 nm is achieved.Vibrational mechanical stress further modulates cross-phase interactions between solitons,inducing higher-order bound solitons with small-amplitude oscillations.These dynamic processes reveal complex nonlinear optical behaviors and enhance sensing capabilities.Additionally,the feasibility of stable mode-locking of Ti_(3)C_(2)T_(x)in a 1µm multimode cavity is analyzed using the multimode nonlinear Schrodinger equation,and multisoliton states are experimentally demonstrated by integrating a 1µm narrow-linewidth ultrafast multimode laser with a stressed microfiber.展开更多
气化温度是影响生物质气化性能的重要参数,而工业气化炉内温度分布不均匀,阻碍了生物质高效气化的发展进程。为了预防或减少温度分布不均所造成的不良影响,提高生物质气化性能,通过实验方法研究了炉内温度梯度(axial temperature gradie...气化温度是影响生物质气化性能的重要参数,而工业气化炉内温度分布不均匀,阻碍了生物质高效气化的发展进程。为了预防或减少温度分布不均所造成的不良影响,提高生物质气化性能,通过实验方法研究了炉内温度梯度(axial temperature gradient,ATG)对生物质气化三相产物的影响。实验设定落下床的上段炉温为1300℃不变,下段炉温范围为900℃~1300℃以模拟工业气化炉火焰区存在的轴向温度梯度,以碳转化率和冷煤气效率为评价指标,对松木屑的气化特性进行了实验分析。结果表明:在ATG为100℃~300℃范围内,合成气中有效气体(CO+H_(2))产率、碳转化率和冷煤气效率随着ATG的增大而逐渐减小。半焦产率均低于0.2%,表明松木屑在上段炉(450 mm)1300℃高温区域内几乎实现了半焦的完全气化。碳烟为生物质高温气流床气化的主要含碳固体产物,其产率为半焦产率的3~6倍,且难以被完全清除。当上下两段的ATG高于300℃时,气相均相重整和气-固非均相反应在下段低温区几乎停滞,产物产率、碳转化率和冷煤气效率几乎保持不变,同时有少量焦油生成,占比约0.01%。展开更多
BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies worldwide.Syndecan-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool ...BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies worldwide.Syndecan-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum samples.Cancer(CRC)is among the most prevalent and life-threatening malignancies worldwide.mSDC2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum samples.AIM To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in China.METHODS A high-risk Chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal mSDC2 testing.Sensitivity and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were determined.High-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the test.RESULTS A total of 1035 high-risk individuals were included in this study according to established criteria.Among them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological examinations.Sensitivities of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other groups.Positive predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high-risk Chinese population.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.12275240,12261131495,and 12475008)the Natural Science Foundation of Zhejiang Province(Grant No.LY24A050002).
文摘Fiber optic sensing technology,with its low transmission loss,wide bandwidth,and broad dynamic range,offers significant advantages for high-sensitivity measurements.In this study,a multi-band soliton modulation system for stress sensing is proposed,utilizing Ti_(3)C_(2)T_(x)to generate ultrashort pulses.By applying stress to microfibers,dichromatic periodic multisoliton mode-locking at 1530 nm and 1555.2 nm is achieved.Vibrational mechanical stress further modulates cross-phase interactions between solitons,inducing higher-order bound solitons with small-amplitude oscillations.These dynamic processes reveal complex nonlinear optical behaviors and enhance sensing capabilities.Additionally,the feasibility of stable mode-locking of Ti_(3)C_(2)T_(x)in a 1µm multimode cavity is analyzed using the multimode nonlinear Schrodinger equation,and multisoliton states are experimentally demonstrated by integrating a 1µm narrow-linewidth ultrafast multimode laser with a stressed microfiber.
文摘气化温度是影响生物质气化性能的重要参数,而工业气化炉内温度分布不均匀,阻碍了生物质高效气化的发展进程。为了预防或减少温度分布不均所造成的不良影响,提高生物质气化性能,通过实验方法研究了炉内温度梯度(axial temperature gradient,ATG)对生物质气化三相产物的影响。实验设定落下床的上段炉温为1300℃不变,下段炉温范围为900℃~1300℃以模拟工业气化炉火焰区存在的轴向温度梯度,以碳转化率和冷煤气效率为评价指标,对松木屑的气化特性进行了实验分析。结果表明:在ATG为100℃~300℃范围内,合成气中有效气体(CO+H_(2))产率、碳转化率和冷煤气效率随着ATG的增大而逐渐减小。半焦产率均低于0.2%,表明松木屑在上段炉(450 mm)1300℃高温区域内几乎实现了半焦的完全气化。碳烟为生物质高温气流床气化的主要含碳固体产物,其产率为半焦产率的3~6倍,且难以被完全清除。当上下两段的ATG高于300℃时,气相均相重整和气-固非均相反应在下段低温区几乎停滞,产物产率、碳转化率和冷煤气效率几乎保持不变,同时有少量焦油生成,占比约0.01%。
基金Supported by the Science and Technology Program of Panyu Central Hospital,No.PY-2023-003the Science and Technology Program of Panyu,No.2020-Z04-054+4 种基金the Science and Technology Project of the Guangzhou Health Commission,No.20211A011114the Science and Technology Program of Guangzhou,No.202002020023the General University Youth Innovative Talent Project of Guangdong Province,No.2022KQNCX281the Guangdong Provincial Key Field Special Project for Ordinary Colleges and Universities,No.2023ZDZX2097the Foshan Engineering Technology Research Center for Prepared Food Processing and Quality Evaluation,No.2022-KJZX113.
文摘BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies worldwide.Syndecan-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum samples.Cancer(CRC)is among the most prevalent and life-threatening malignancies worldwide.mSDC2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum samples.AIM To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in China.METHODS A high-risk Chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal mSDC2 testing.Sensitivity and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were determined.High-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the test.RESULTS A total of 1035 high-risk individuals were included in this study according to established criteria.Among them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological examinations.Sensitivities of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other groups.Positive predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high-risk Chinese population.
