The tight sandstone reservoirs in the first sub-member of Chang 7 member(Chang 71)of Triassic Yanchang Formation in the Jiyuan area,Ordos Basin,show significant variations in microscopic pore-throat structure(PTS)and ...The tight sandstone reservoirs in the first sub-member of Chang 7 member(Chang 71)of Triassic Yanchang Formation in the Jiyuan area,Ordos Basin,show significant variations in microscopic pore-throat structure(PTS)and fluid mobility due to the influences of the northeast and northwest dual provenance systems.This study performed multiple experimental analyses on nine samples from the area to determine the petrological and petrophysical properties,as well as the PTS characteristics of reservoirs in different provenance-controlled regions.On this basis,the pore-throat size distribution(PSD)obtained from high-pressure mercury injection(HPMI)was utilized to convert the NMR movable fluid T2spectrum,allowing for quantitative characterization of the full PSD and the occurrence characteristics of movable fluids.A systematic analysis was conducted on the primary controlling factors affecting fluid mobility in the reservoir.The results indicated that the lithology in the eastern and western regions is lithic arkose.The eastern sandstones,being farther from the provenance,exhibit higher contents of feldspar and lithic fragments,along with the development of more dissolution pores.The reservoir possesses good petrophysical properties,low displacement pressure,and high pore-throat connectivity and homogeneity,indicating strong fluid mobility.In contrast,the western sandstones,being nearer to the provenance,exhibit poor grain sorting,high contents of lithic fragments,strong compaction and cementation effects,resulting in poor petrophysical properties,and strong pore-throat heterogeneity,revealing weak fluid mobility.The range of full PSD in the eastern reservoir is wider than that in the western reservoir,with relatively well-developed macropores.The macropores are the primary space for occurrence of movable fluids,and controls the fluid mobility of the reservoir.The effective porosity of movable fluids(EPMF)quantitatively represents the pore space occupied by movable fluids within the reservoir and correlates well with porosity,permeability,and PTS parameters,making it a valuable parameter for evaluating fluid mobility.Under the multi-provenance system,the eastern and western reservoirs underwent different sedimentation and diagenesis processes,resulting in differential distribution of reservoir mineral components and pore types,which in turn affects the PTS heterogeneity and reservoir quality.The composition and content of reservoir minerals are intrinsic factors influencing fluid mobility,while the microscopic PTS is the primary factor controlling it.Low clay mineral content,welldeveloped macropores,and weak pore-throat heterogeneity all contribute to the storage and seepage of reservoir fluids.展开更多
Inflammation plays a key role in driving the secondary brain injury that follows ischemic stroke.Melatonin is an endogenous neuroendocrine hormone that regulates mitochondrial homeostasis.However,the role and mechanis...Inflammation plays a key role in driving the secondary brain injury that follows ischemic stroke.Melatonin is an endogenous neuroendocrine hormone that regulates mitochondrial homeostasis.However,the role and mechanisms by which melatonin regulates microglial pyroptosis and the inflammatory cascade through double-stranded DNA(dsDNA)-sensing cyclic GMP-AMP synthase(cGAS)signaling warrant further study.Using middle cerebral artery occlusion mice,we investigated the effects of melatonin on cGAS-mediated pyroptosis and neuroinflammation.Middle cerebral artery occlusion model mice exhibited significantly increased DNA damage and cytoplasmic dsDNA release,as reflected byγH2AX staining,as well as heightened activation of the cytosolic dsDNA-sensing cGAS-STING pathway,both of which were notably suppressed by melatonin treatment.Melatonin also mitigated NOD-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasome activation and nuclear factor(NF)-κB/gasdermin D-mediated pyroptosis in microglia following ischemic stroke,while exhibiting the capacity to attenuate the immune response to ischemia in mice.This led to reduced infiltration of peripheral neutrophils and monocytes/macrophages in the ischemic brain.Specifically,melatonin administration resulted in reductions in the numbers of ionized calcium-binding adapter molecule 1-positive cells and production of interleukin-6 and tumor necrosis factor-αby microglia.Regarding neurological outcomes,melatonin significantly reduced cerebral infarct volume and ameliorated neurological deficits in mice.Notably,the neuroprotective effect of melatonin was correlated with the inhibition of cGAS activity.We also developed and tested melatonin co-loaded macrophage membrane-biomimetic reactive oxygen species-responsive nanoparticles(Mф-MLT@FNGs),which exhibited therapeutic properties in middle cerebral artery occlusion mice.Our findings suggest that melatonin acts on microglial pyroptosis to inhibit neuroinflammation and reshape the immune microenvironment through regulation of the cGAS-STING-NF-κB signaling pathway.By doing so,melatonin rescues damaged brain tissue and protects neurological function,highlighting its potential as a neuroprotective treatment for ischemic stroke.展开更多
The ground motion attenuation models for PGA,PGV and response spectrum at rock sites and soils sites are derived separately from the digital strong motion records of moderate earthquakes in the Sichuan-Yunnan region a...The ground motion attenuation models for PGA,PGV and response spectrum at rock sites and soils sites are derived separately from the digital strong motion records of moderate earthquakes in the Sichuan-Yunnan region after 2007. By comparison with Yu Yanxiangs attenuation model for rock sites in western China,reliability of the model is verified for moderate earthquake. According to the distribution of strong motion data against magnitude and epicentral distance,the applicability and reliability of the results in this paper are discussed.展开更多
为了解国内外保水剂领域研究进展及应用动态,基于中国知网和Web of Science核心数据库,分别以主题词“保水剂”和检索式“TS=super absorbent polymer OR water retaining agent”检索了2003—2022年保水剂领域相关文献,采用文献计量法...为了解国内外保水剂领域研究进展及应用动态,基于中国知网和Web of Science核心数据库,分别以主题词“保水剂”和检索式“TS=super absorbent polymer OR water retaining agent”检索了2003—2022年保水剂领域相关文献,采用文献计量法和内容分析法从多角度进行分析。结果表明:1)保水剂领域英文文献发文量逐年增加,中文文献略有降低,中英文文献类型均以研究型论文为主。2)中国在该领域的研究程度活跃,美国的研究成果则处于国际领先地位;在基金支持方面,中国的基金项目资助力度超过其他国家,尤其是国家自然科学基金在国内外资助项目中位居前列。3)国内外保水剂研究主要涉及农业科学、材料、化工和环境等学科,研究单位主要集中在农林类高校。4)国内研究内容聚焦在保水剂的应用层面,探讨了保水剂在抗旱造林、园林绿化、土壤改良、建筑材料、道路及工矿区水土保持、保水保肥效率提升以及植物育苗生长等方面单施及复合配施的效果和机制;而国际研究更侧重保水剂的材料合成与改性制备,致力于开发可生物降解的保水剂材料,并应用在生物医药、食品保鲜等新兴领域。当前,随着环保意识的提高和技术水平的不断进步,新型保水剂材料研发制备及其在生物医药、食品保鲜领域的应用已成为研究热点和未来发展趋势。展开更多
文摘The tight sandstone reservoirs in the first sub-member of Chang 7 member(Chang 71)of Triassic Yanchang Formation in the Jiyuan area,Ordos Basin,show significant variations in microscopic pore-throat structure(PTS)and fluid mobility due to the influences of the northeast and northwest dual provenance systems.This study performed multiple experimental analyses on nine samples from the area to determine the petrological and petrophysical properties,as well as the PTS characteristics of reservoirs in different provenance-controlled regions.On this basis,the pore-throat size distribution(PSD)obtained from high-pressure mercury injection(HPMI)was utilized to convert the NMR movable fluid T2spectrum,allowing for quantitative characterization of the full PSD and the occurrence characteristics of movable fluids.A systematic analysis was conducted on the primary controlling factors affecting fluid mobility in the reservoir.The results indicated that the lithology in the eastern and western regions is lithic arkose.The eastern sandstones,being farther from the provenance,exhibit higher contents of feldspar and lithic fragments,along with the development of more dissolution pores.The reservoir possesses good petrophysical properties,low displacement pressure,and high pore-throat connectivity and homogeneity,indicating strong fluid mobility.In contrast,the western sandstones,being nearer to the provenance,exhibit poor grain sorting,high contents of lithic fragments,strong compaction and cementation effects,resulting in poor petrophysical properties,and strong pore-throat heterogeneity,revealing weak fluid mobility.The range of full PSD in the eastern reservoir is wider than that in the western reservoir,with relatively well-developed macropores.The macropores are the primary space for occurrence of movable fluids,and controls the fluid mobility of the reservoir.The effective porosity of movable fluids(EPMF)quantitatively represents the pore space occupied by movable fluids within the reservoir and correlates well with porosity,permeability,and PTS parameters,making it a valuable parameter for evaluating fluid mobility.Under the multi-provenance system,the eastern and western reservoirs underwent different sedimentation and diagenesis processes,resulting in differential distribution of reservoir mineral components and pore types,which in turn affects the PTS heterogeneity and reservoir quality.The composition and content of reservoir minerals are intrinsic factors influencing fluid mobility,while the microscopic PTS is the primary factor controlling it.Low clay mineral content,welldeveloped macropores,and weak pore-throat heterogeneity all contribute to the storage and seepage of reservoir fluids.
基金supported by the Natural Science Foundation of Heilongjiang Province,No.YQ2021H011(to QL)China Postdoctoral Science Foundation,Nos.2020M670925,2022T150172(to QL)+2 种基金Postdoctoral Foundation of Heilongjiang Province,Nos.LBH‐Z19027,LBH‐TZ2019(to QL)Institute Cultivation Fund,No.PYMS2023-1(to QL)Natural Science Foundation of Jiangsu Province,No.BK20241233(to YL).
文摘Inflammation plays a key role in driving the secondary brain injury that follows ischemic stroke.Melatonin is an endogenous neuroendocrine hormone that regulates mitochondrial homeostasis.However,the role and mechanisms by which melatonin regulates microglial pyroptosis and the inflammatory cascade through double-stranded DNA(dsDNA)-sensing cyclic GMP-AMP synthase(cGAS)signaling warrant further study.Using middle cerebral artery occlusion mice,we investigated the effects of melatonin on cGAS-mediated pyroptosis and neuroinflammation.Middle cerebral artery occlusion model mice exhibited significantly increased DNA damage and cytoplasmic dsDNA release,as reflected byγH2AX staining,as well as heightened activation of the cytosolic dsDNA-sensing cGAS-STING pathway,both of which were notably suppressed by melatonin treatment.Melatonin also mitigated NOD-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasome activation and nuclear factor(NF)-κB/gasdermin D-mediated pyroptosis in microglia following ischemic stroke,while exhibiting the capacity to attenuate the immune response to ischemia in mice.This led to reduced infiltration of peripheral neutrophils and monocytes/macrophages in the ischemic brain.Specifically,melatonin administration resulted in reductions in the numbers of ionized calcium-binding adapter molecule 1-positive cells and production of interleukin-6 and tumor necrosis factor-αby microglia.Regarding neurological outcomes,melatonin significantly reduced cerebral infarct volume and ameliorated neurological deficits in mice.Notably,the neuroprotective effect of melatonin was correlated with the inhibition of cGAS activity.We also developed and tested melatonin co-loaded macrophage membrane-biomimetic reactive oxygen species-responsive nanoparticles(Mф-MLT@FNGs),which exhibited therapeutic properties in middle cerebral artery occlusion mice.Our findings suggest that melatonin acts on microglial pyroptosis to inhibit neuroinflammation and reshape the immune microenvironment through regulation of the cGAS-STING-NF-κB signaling pathway.By doing so,melatonin rescues damaged brain tissue and protects neurological function,highlighting its potential as a neuroprotective treatment for ischemic stroke.
基金sponsored jointly by the special fund for basic research and operating expenses of Institute of Crustal Dynamics,CEA(ZDJ2013-04)"National Nature Science Foundation of China(51278469)
文摘The ground motion attenuation models for PGA,PGV and response spectrum at rock sites and soils sites are derived separately from the digital strong motion records of moderate earthquakes in the Sichuan-Yunnan region after 2007. By comparison with Yu Yanxiangs attenuation model for rock sites in western China,reliability of the model is verified for moderate earthquake. According to the distribution of strong motion data against magnitude and epicentral distance,the applicability and reliability of the results in this paper are discussed.
文摘为了解国内外保水剂领域研究进展及应用动态,基于中国知网和Web of Science核心数据库,分别以主题词“保水剂”和检索式“TS=super absorbent polymer OR water retaining agent”检索了2003—2022年保水剂领域相关文献,采用文献计量法和内容分析法从多角度进行分析。结果表明:1)保水剂领域英文文献发文量逐年增加,中文文献略有降低,中英文文献类型均以研究型论文为主。2)中国在该领域的研究程度活跃,美国的研究成果则处于国际领先地位;在基金支持方面,中国的基金项目资助力度超过其他国家,尤其是国家自然科学基金在国内外资助项目中位居前列。3)国内外保水剂研究主要涉及农业科学、材料、化工和环境等学科,研究单位主要集中在农林类高校。4)国内研究内容聚焦在保水剂的应用层面,探讨了保水剂在抗旱造林、园林绿化、土壤改良、建筑材料、道路及工矿区水土保持、保水保肥效率提升以及植物育苗生长等方面单施及复合配施的效果和机制;而国际研究更侧重保水剂的材料合成与改性制备,致力于开发可生物降解的保水剂材料,并应用在生物医药、食品保鲜等新兴领域。当前,随着环保意识的提高和技术水平的不断进步,新型保水剂材料研发制备及其在生物医药、食品保鲜领域的应用已成为研究热点和未来发展趋势。
