BACKGROUND There is currently no effective targeted therapy for advanced HER2-negative gastric cancer(GC).While immunotherapy combined with chemotherapy is the first-line treatment for GC,patient survival outcomes rem...BACKGROUND There is currently no effective targeted therapy for advanced HER2-negative gastric cancer(GC).While immunotherapy combined with chemotherapy is the first-line treatment for GC,patient survival outcomes remain highly hetero-geneous,highlighting the urgent need for reliable predictive biomarkers.The fibrinogen-to-albumin ratio(FAR)integrates both inflammation(elevated fibrinogen levels)and nutritional status(reduced albumin levels).Although FAR has been associated with immunotherapy resistance in various solid tumors,its prognostic value in GC patients receiving immunochemotherapy remains unclear.AIM To assess the predictive value of the FAR in the long-term prognosis of advanced HER2-negative GC patients receiving sintilimab-based immunotherapy combined with chemotherapy.METHODS This retrospective study included 260 patients with unresectable or metastatic HER2-negative GC who received sintilimab plus chemotherapy from 2021 to 2024.Pre-treatment FAR values were calculated,and the optimal cutoff value was determined using receiver operating characteristic curve analysis.The association between the FAR and overall survival(OS)and progression-free survival(PFS)was analyzed using Kaplan-Meier survival curves and Cox proportional hazards models.Independent prognostic factors were identified by multivariate Cox regression analysis based on OS,and a nomogram model was constructed incorporating FAR.The concordance index(C-index)and calibration curves were used to assess the predictive performance and calibration of the model.RESULTS Patients with high FAR(≥0.08)had significantly shorter median PFS[7.80 months(6.40-8.30)vs 10.00 months(9.30-11.20),P<0.001]and OS[14.20 months(12.20-16.60)vs 19.50 months(18.80-22.00),P<0.001]compared to the group with low FAR(<0.08).Moreover,the group with high FAR had a significantly lower objective response rate(10.22%vs 19.51%,P=0.034)and disease control rate(34.31%vs 49.59%,P=0.013).The incidence of adverse events did not significantly differ between the two groups(P>0.05).Multivariate analysis confirmed the FAR as an independent prognostic factor for OS(HR=2.33,95%CI:1.59-3.43,P<0.001).The nomogram model,incorporating FAR,Eastern Cooperative Oncology Group performance status,programmed cell death ligand 1 expression,tumor stage,and body mass index,demonstrated strong predictive accuracy,with an internal validation C-index of 0.73(95%CI:0.66-0.79).The calibration curve showed a high consistency between predicted and actual survival rates.CONCLUSION Patients with low FAR had significantly better prognostic outcomes than those with high FAR when receiving immunochemotherapy.Thus,FAR may serve as a valuable prognostic biomarker for predicting survival outcomes in patients with advanced HER2-negative GC.展开更多
Traditionally,the construction of stable interphases relies on solvent structures dominated by aggregated anionic structures(AGG/AGG+).Nonetheless,we find that the construction of stable interphases in hightemperature...Traditionally,the construction of stable interphases relies on solvent structures dominated by aggregated anionic structures(AGG/AGG+).Nonetheless,we find that the construction of stable interphases in hightemperature environments is based on contact ion pairs(CIPs)dominated solvation structure here.In detail,in the long-chain phosphate ester-based electrolyte,the spatial site-blocking effect enables the strong solvation co-solvent ether(diethylene glycol dimethyl ether,G2)to exhibit strong ion-dipole interactions,further multicomponent competitive coordination maintaining the CIP,balancing electrode kinetics,and optimizing the high-temperature interphases.High-temperature in-situ Raman spectroscopy monitors the changes in the stable solvent structure during charge/discharge processes for the first time,and time of flight secondary ion mass spectrometry(TOF-SIMS)reveals the stable solid electrolyte interphase(SEI)with full-depth enrichment of the inorganic component.Benefiting from the high-temperature interfacial chemistry-dependent solvent structure,the advanced electrolyte enables stable cycling of 1.6 Ah 18650 batterie at 100-125℃and discharging with high current pulses(~1.83 A)at 150℃,which has rarely been reported so far.In addition,pin-pricking of 18650 batteries at100%state of charge(SoC)without fire or smoke and the moderate thermal runaway temperature(187℃)tested via the accelerating rate calorimetry(ARC)demonstrate the excellent safety of the optimized electrolyte.展开更多
AIM:To evaluate the effect of different monochromatic lights on the refractive status and the secretion levels of neurotransmitters in the progressive myopic model of guinea pigs.METHODS:Guinea pigs(n=90)underwent dif...AIM:To evaluate the effect of different monochromatic lights on the refractive status and the secretion levels of neurotransmitters in the progressive myopic model of guinea pigs.METHODS:Guinea pigs(n=90)underwent different monochromatic lights irradiation for two weeks were randomly divided into 6 groups:white light(control),ultraviolet(UV),blue,green,red,and simulative sunlight(simSUN).The refractive status and axial length(AL)were measured.Transmission electron microscopy,Masson’s trichrome staining and hematoxylin-eosin staining were performed to observe the structural changes of retina and sclera.High-performance liquid chromatography(HPLC),western blotting and immunofluorescence were used to measure neurotransmitters and their receptors.RESULTS:Myopia models were established successfully.When compared the degrees of change in myopic eyes of control group,the UV group showed a minor decrease in AL and refraction,along with a significant increase in scleral thickness.In contrast,the red and green groups revealed a net increase in AL and refraction,coupled with a net decrease in scleral thickness(all,P<0.01).The dopamine concentration increased in the UV group,while concentrations of serotonin and melatonin significantly decreased(all,P<0.01).The groups that were exposed to UV,blue and simSUN,the expression of dopamine receptor D2(DRD2)increased,and the expression of hydroxytryptamine receptor 2A(HTR2A)and melatonin receptor type 2(MT2)decreased significantly when compared to the control group(all P<0.01).CONCLUSION:Exposure to short-wavelength light could slow the development of myopia by promoting the production of dopamine and suppressing the serotonin and melatonin concentration.The neurotransmitter receptors MT2,DRD2,and HTR2A in the sclera appear to play different roles by different color lights in myopic guinea pigs.展开更多
In the dual context of VUCA era and digital transformation,enterprise resilience,as the core ability of organizations to resist shocks,adapt to changes,and achieve sustainable development,has increasingly highlighted ...In the dual context of VUCA era and digital transformation,enterprise resilience,as the core ability of organizations to resist shocks,adapt to changes,and achieve sustainable development,has increasingly highlighted its theoretical connotation and practical value.This article systematically explores the interdisciplinary theoretical origins,multidimensional dynamic measurement methods,and complex influencing factors of enterprise resilience.Research has shown that:(1)the concept of resilience originates from ecology,engineering,and physics,and extends to the field of complex adaptive systems,forming a micro capability integration framework of“pre crisis prevention crisis response crisis recovery”,as well as macro strategic attributes that support high-quality development of the national economy;(2)Resilience measurement needs to integrate subjective and objective dynamic indicators:at the subjective level,Likert scale is used to evaluate organizational capability traits,and at the objective level,financial performance fluctuations,market performance,and crisis learning behavior are combined;(3)Resilience is driven by the synergy of multiple levels of factors:internal dependence on organizational capability foundation,digital empowerment,external resource linkage,policy environment,and sustainable governance.Its interaction mechanism accelerates capability updates through digital iteration,policy activates resource networks,and ultimately constructs an organizational resilience system of“survival adaptation evolution”.This article provides a unified analytical framework for the study of enterprise resilience,and provides theoretical guidance and practical paths for organizations in the digital age to cultivate risk resistance capabilities and achieve resilience evolution.展开更多
Dear Editor,Light fields give relatively complete description of scenes from perspective of angles and positions of rays. At present time, most of the computer vision algorithms take 2D images as input which are simpl...Dear Editor,Light fields give relatively complete description of scenes from perspective of angles and positions of rays. At present time, most of the computer vision algorithms take 2D images as input which are simplified expression of light fields with depth information discarded. In theory, computer vision tasks may achieve better performance as long as complete light fields are acquired.展开更多
Perovskite oxides with diverse composition and structure have exhibited grand advances in boosting the oxygen reduction and evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electroch...Perovskite oxides with diverse composition and structure have exhibited grand advances in boosting the oxygen reduction and evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electrochemical cell(R-PCEC)toward the sustainable hydrogen production and utilization.However,enhancement of their activity and stability remains challenging.Herein,we develop the Ta-regulated BaCo_(0.7)Fe_(0.3)O_(3-δ)perovskite oxygen electrode(Ba(Co_(0.7)Fe_(0.3))_(1-x)Ta_xO_(3-δ))with abundant oxygen defects and achieve the simultaneous enhancement in the electrocatalytic activity and stability toward ORR and OER.As-fabricated R-PCEC with(Ba(Co_(0.7)Fe_(0.3))_(0.9)Ta_(0.1)O_(3-δ))(BCFT10)oxygen electrode performs high power density of 1.47 W·cm^(-2)at 650℃in fuel cell mode,and the current density is up to-2.11 A·cm^(-2)at 1.4 V at 650℃in electrolysis mode,as well as the good stability in both the fuel cell and electrolysis modes.Importantly,the cell also demonstrates a stable cycling operation between fuel cell and electrolysis mode,suggesting a great potential of BCFT10 as oxygen electrode material for R-PCECs.展开更多
文摘BACKGROUND There is currently no effective targeted therapy for advanced HER2-negative gastric cancer(GC).While immunotherapy combined with chemotherapy is the first-line treatment for GC,patient survival outcomes remain highly hetero-geneous,highlighting the urgent need for reliable predictive biomarkers.The fibrinogen-to-albumin ratio(FAR)integrates both inflammation(elevated fibrinogen levels)and nutritional status(reduced albumin levels).Although FAR has been associated with immunotherapy resistance in various solid tumors,its prognostic value in GC patients receiving immunochemotherapy remains unclear.AIM To assess the predictive value of the FAR in the long-term prognosis of advanced HER2-negative GC patients receiving sintilimab-based immunotherapy combined with chemotherapy.METHODS This retrospective study included 260 patients with unresectable or metastatic HER2-negative GC who received sintilimab plus chemotherapy from 2021 to 2024.Pre-treatment FAR values were calculated,and the optimal cutoff value was determined using receiver operating characteristic curve analysis.The association between the FAR and overall survival(OS)and progression-free survival(PFS)was analyzed using Kaplan-Meier survival curves and Cox proportional hazards models.Independent prognostic factors were identified by multivariate Cox regression analysis based on OS,and a nomogram model was constructed incorporating FAR.The concordance index(C-index)and calibration curves were used to assess the predictive performance and calibration of the model.RESULTS Patients with high FAR(≥0.08)had significantly shorter median PFS[7.80 months(6.40-8.30)vs 10.00 months(9.30-11.20),P<0.001]and OS[14.20 months(12.20-16.60)vs 19.50 months(18.80-22.00),P<0.001]compared to the group with low FAR(<0.08).Moreover,the group with high FAR had a significantly lower objective response rate(10.22%vs 19.51%,P=0.034)and disease control rate(34.31%vs 49.59%,P=0.013).The incidence of adverse events did not significantly differ between the two groups(P>0.05).Multivariate analysis confirmed the FAR as an independent prognostic factor for OS(HR=2.33,95%CI:1.59-3.43,P<0.001).The nomogram model,incorporating FAR,Eastern Cooperative Oncology Group performance status,programmed cell death ligand 1 expression,tumor stage,and body mass index,demonstrated strong predictive accuracy,with an internal validation C-index of 0.73(95%CI:0.66-0.79).The calibration curve showed a high consistency between predicted and actual survival rates.CONCLUSION Patients with low FAR had significantly better prognostic outcomes than those with high FAR when receiving immunochemotherapy.Thus,FAR may serve as a valuable prognostic biomarker for predicting survival outcomes in patients with advanced HER2-negative GC.
基金supported by the National Natural Science Foundation of China(grant no.52072322,52202235)the Department of Science and Technology of Sichuan Province(CN)(grant no.23GJHZ0147)the Research and Innovation Fund for Graduate Students of Southwest Petroleum University(No.:2022KYCX111)。
文摘Traditionally,the construction of stable interphases relies on solvent structures dominated by aggregated anionic structures(AGG/AGG+).Nonetheless,we find that the construction of stable interphases in hightemperature environments is based on contact ion pairs(CIPs)dominated solvation structure here.In detail,in the long-chain phosphate ester-based electrolyte,the spatial site-blocking effect enables the strong solvation co-solvent ether(diethylene glycol dimethyl ether,G2)to exhibit strong ion-dipole interactions,further multicomponent competitive coordination maintaining the CIP,balancing electrode kinetics,and optimizing the high-temperature interphases.High-temperature in-situ Raman spectroscopy monitors the changes in the stable solvent structure during charge/discharge processes for the first time,and time of flight secondary ion mass spectrometry(TOF-SIMS)reveals the stable solid electrolyte interphase(SEI)with full-depth enrichment of the inorganic component.Benefiting from the high-temperature interfacial chemistry-dependent solvent structure,the advanced electrolyte enables stable cycling of 1.6 Ah 18650 batterie at 100-125℃and discharging with high current pulses(~1.83 A)at 150℃,which has rarely been reported so far.In addition,pin-pricking of 18650 batteries at100%state of charge(SoC)without fire or smoke and the moderate thermal runaway temperature(187℃)tested via the accelerating rate calorimetry(ARC)demonstrate the excellent safety of the optimized electrolyte.
基金Supported by the Zhejiang Traditional Chinese Medicine Science and Technology Plan(No.2023ZL241)Zhejiang Medical Science and Technology Plan(No.2025KY648).
文摘AIM:To evaluate the effect of different monochromatic lights on the refractive status and the secretion levels of neurotransmitters in the progressive myopic model of guinea pigs.METHODS:Guinea pigs(n=90)underwent different monochromatic lights irradiation for two weeks were randomly divided into 6 groups:white light(control),ultraviolet(UV),blue,green,red,and simulative sunlight(simSUN).The refractive status and axial length(AL)were measured.Transmission electron microscopy,Masson’s trichrome staining and hematoxylin-eosin staining were performed to observe the structural changes of retina and sclera.High-performance liquid chromatography(HPLC),western blotting and immunofluorescence were used to measure neurotransmitters and their receptors.RESULTS:Myopia models were established successfully.When compared the degrees of change in myopic eyes of control group,the UV group showed a minor decrease in AL and refraction,along with a significant increase in scleral thickness.In contrast,the red and green groups revealed a net increase in AL and refraction,coupled with a net decrease in scleral thickness(all,P<0.01).The dopamine concentration increased in the UV group,while concentrations of serotonin and melatonin significantly decreased(all,P<0.01).The groups that were exposed to UV,blue and simSUN,the expression of dopamine receptor D2(DRD2)increased,and the expression of hydroxytryptamine receptor 2A(HTR2A)and melatonin receptor type 2(MT2)decreased significantly when compared to the control group(all P<0.01).CONCLUSION:Exposure to short-wavelength light could slow the development of myopia by promoting the production of dopamine and suppressing the serotonin and melatonin concentration.The neurotransmitter receptors MT2,DRD2,and HTR2A in the sclera appear to play different roles by different color lights in myopic guinea pigs.
基金2025 Nanjing University of Science and Technology Zijin College Campus level Scientific ResearchResearch on the Mechanism,Path,and Policy of Generative AI Cracking the Bottom Logic of Organizational Resilience(Project No.:2025ZXSK0401004)。
文摘In the dual context of VUCA era and digital transformation,enterprise resilience,as the core ability of organizations to resist shocks,adapt to changes,and achieve sustainable development,has increasingly highlighted its theoretical connotation and practical value.This article systematically explores the interdisciplinary theoretical origins,multidimensional dynamic measurement methods,and complex influencing factors of enterprise resilience.Research has shown that:(1)the concept of resilience originates from ecology,engineering,and physics,and extends to the field of complex adaptive systems,forming a micro capability integration framework of“pre crisis prevention crisis response crisis recovery”,as well as macro strategic attributes that support high-quality development of the national economy;(2)Resilience measurement needs to integrate subjective and objective dynamic indicators:at the subjective level,Likert scale is used to evaluate organizational capability traits,and at the objective level,financial performance fluctuations,market performance,and crisis learning behavior are combined;(3)Resilience is driven by the synergy of multiple levels of factors:internal dependence on organizational capability foundation,digital empowerment,external resource linkage,policy environment,and sustainable governance.Its interaction mechanism accelerates capability updates through digital iteration,policy activates resource networks,and ultimately constructs an organizational resilience system of“survival adaptation evolution”.This article provides a unified analytical framework for the study of enterprise resilience,and provides theoretical guidance and practical paths for organizations in the digital age to cultivate risk resistance capabilities and achieve resilience evolution.
文摘Dear Editor,Light fields give relatively complete description of scenes from perspective of angles and positions of rays. At present time, most of the computer vision algorithms take 2D images as input which are simplified expression of light fields with depth information discarded. In theory, computer vision tasks may achieve better performance as long as complete light fields are acquired.
基金financially supported by the National Key R&D Program of China(No.2022YFB4002201)the National Natural Science Foundation of China(Nos.52072362 and 52302119)+3 种基金Jilin Province Science and Technology Development Plan Funding Project(Nos.SKL202302039 and 20220201112GX)Jiangsu Province Innovation Support Program(No.BE2023092-2)Youth Innovation Promotion Association CAS(No.2021223)Open Funds of the State Key Laboratory of Rare Earth Resource Utilization(No.RERU2022008)。
文摘Perovskite oxides with diverse composition and structure have exhibited grand advances in boosting the oxygen reduction and evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electrochemical cell(R-PCEC)toward the sustainable hydrogen production and utilization.However,enhancement of their activity and stability remains challenging.Herein,we develop the Ta-regulated BaCo_(0.7)Fe_(0.3)O_(3-δ)perovskite oxygen electrode(Ba(Co_(0.7)Fe_(0.3))_(1-x)Ta_xO_(3-δ))with abundant oxygen defects and achieve the simultaneous enhancement in the electrocatalytic activity and stability toward ORR and OER.As-fabricated R-PCEC with(Ba(Co_(0.7)Fe_(0.3))_(0.9)Ta_(0.1)O_(3-δ))(BCFT10)oxygen electrode performs high power density of 1.47 W·cm^(-2)at 650℃in fuel cell mode,and the current density is up to-2.11 A·cm^(-2)at 1.4 V at 650℃in electrolysis mode,as well as the good stability in both the fuel cell and electrolysis modes.Importantly,the cell also demonstrates a stable cycling operation between fuel cell and electrolysis mode,suggesting a great potential of BCFT10 as oxygen electrode material for R-PCECs.
