Coatings of marine equipment inevitably suffer from physical or chemical damage in service,together with biofouling from microbial attachment,leading to a shorter service life of them.Herein,a multi-functional corrosi...Coatings of marine equipment inevitably suffer from physical or chemical damage in service,together with biofouling from microbial attachment,leading to a shorter service life of them.Herein,a multi-functional corrosion-resistant coating with efficient photothermal self-healing and anti-biofouling per-formance was designed by using CuO/g-C_(3)N_(4)(CuO/CN)S-scheme heterojunction filler in combination with polydimethylsiloxane(PDMS)as the coating matrix for achieving the effective protection of Q235 steel.The results of the electrochemical impedance spectroscopy(EIS)experiments indicate that the CuO/CN/PDMS composite coatings possessed excellent corrosion resistance,in which the impedance ra-dius of optimal CuO/CN-1/PDMS composite coating could still remain 3.49×10^(9)Ωcm^(2)after 60 d of immersion in seawater under sunlight irradiation.Meanwhile,the as-prepared CuO/CN/PDMS compos-ite coating not only can be rapidly heated up under the Xenon lamp illumination to achieve complete self-repair of scratches within 45 min,but also exhibited excellent antimicrobial effects in the antifouling experiments.This study opens a new avenue for the development of g-C_(3)N_(4)-based multifunctional coat-ings and provides guidance for the development of the next generation of intelligent protective coatings.展开更多
蕨类植物是地球上起源最为古老的维管植物,在陆生植物演化中具有重要意义。本文通过Web of Science核心数据库(Core Collection)对目前所有关于"fern"、"lycophyte"、"pteridophyte"、"pteridophyta...蕨类植物是地球上起源最为古老的维管植物,在陆生植物演化中具有重要意义。本文通过Web of Science核心数据库(Core Collection)对目前所有关于"fern"、"lycophyte"、"pteridophyte"、"pteridophyta"等的科研论文进行了分析。结果表明:(1) 2000年后,蕨类植物论文数量增加迅速,特别是2006年以来增加显著,现在年均已突破600篇;(2)2010年以来的以蕨类植物为研究材料和对象的学科和研究领域变得越来越多元化,多学科结合和交叉的研究方向成为新趋势;(3)中国正在成为蕨类植物研究的热点国家并且成果显著;(4)中国蕨类植物研究在快速发展的同时也出现了各研究机构之间的发展不同步。期望本论文能给蕨类植物的相关研究提供新的方向,为中国蕨类植物工作者提供借鉴。展开更多
BACKGROUND There is currently no effective targeted therapy for advanced HER2-negative gastric cancer(GC).While immunotherapy combined with chemotherapy is the first-line treatment for GC,patient survival outcomes rem...BACKGROUND There is currently no effective targeted therapy for advanced HER2-negative gastric cancer(GC).While immunotherapy combined with chemotherapy is the first-line treatment for GC,patient survival outcomes remain highly hetero-geneous,highlighting the urgent need for reliable predictive biomarkers.The fibrinogen-to-albumin ratio(FAR)integrates both inflammation(elevated fibrinogen levels)and nutritional status(reduced albumin levels).Although FAR has been associated with immunotherapy resistance in various solid tumors,its prognostic value in GC patients receiving immunochemotherapy remains unclear.AIM To assess the predictive value of the FAR in the long-term prognosis of advanced HER2-negative GC patients receiving sintilimab-based immunotherapy combined with chemotherapy.METHODS This retrospective study included 260 patients with unresectable or metastatic HER2-negative GC who received sintilimab plus chemotherapy from 2021 to 2024.Pre-treatment FAR values were calculated,and the optimal cutoff value was determined using receiver operating characteristic curve analysis.The association between the FAR and overall survival(OS)and progression-free survival(PFS)was analyzed using Kaplan-Meier survival curves and Cox proportional hazards models.Independent prognostic factors were identified by multivariate Cox regression analysis based on OS,and a nomogram model was constructed incorporating FAR.The concordance index(C-index)and calibration curves were used to assess the predictive performance and calibration of the model.RESULTS Patients with high FAR(≥0.08)had significantly shorter median PFS[7.80 months(6.40-8.30)vs 10.00 months(9.30-11.20),P<0.001]and OS[14.20 months(12.20-16.60)vs 19.50 months(18.80-22.00),P<0.001]compared to the group with low FAR(<0.08).Moreover,the group with high FAR had a significantly lower objective response rate(10.22%vs 19.51%,P=0.034)and disease control rate(34.31%vs 49.59%,P=0.013).The incidence of adverse events did not significantly differ between the two groups(P>0.05).Multivariate analysis confirmed the FAR as an independent prognostic factor for OS(HR=2.33,95%CI:1.59-3.43,P<0.001).The nomogram model,incorporating FAR,Eastern Cooperative Oncology Group performance status,programmed cell death ligand 1 expression,tumor stage,and body mass index,demonstrated strong predictive accuracy,with an internal validation C-index of 0.73(95%CI:0.66-0.79).The calibration curve showed a high consistency between predicted and actual survival rates.CONCLUSION Patients with low FAR had significantly better prognostic outcomes than those with high FAR when receiving immunochemotherapy.Thus,FAR may serve as a valuable prognostic biomarker for predicting survival outcomes in patients with advanced HER2-negative GC.展开更多
Traditionally,the construction of stable interphases relies on solvent structures dominated by aggregated anionic structures(AGG/AGG+).Nonetheless,we find that the construction of stable interphases in hightemperature...Traditionally,the construction of stable interphases relies on solvent structures dominated by aggregated anionic structures(AGG/AGG+).Nonetheless,we find that the construction of stable interphases in hightemperature environments is based on contact ion pairs(CIPs)dominated solvation structure here.In detail,in the long-chain phosphate ester-based electrolyte,the spatial site-blocking effect enables the strong solvation co-solvent ether(diethylene glycol dimethyl ether,G2)to exhibit strong ion-dipole interactions,further multicomponent competitive coordination maintaining the CIP,balancing electrode kinetics,and optimizing the high-temperature interphases.High-temperature in-situ Raman spectroscopy monitors the changes in the stable solvent structure during charge/discharge processes for the first time,and time of flight secondary ion mass spectrometry(TOF-SIMS)reveals the stable solid electrolyte interphase(SEI)with full-depth enrichment of the inorganic component.Benefiting from the high-temperature interfacial chemistry-dependent solvent structure,the advanced electrolyte enables stable cycling of 1.6 Ah 18650 batterie at 100-125℃and discharging with high current pulses(~1.83 A)at 150℃,which has rarely been reported so far.In addition,pin-pricking of 18650 batteries at100%state of charge(SoC)without fire or smoke and the moderate thermal runaway temperature(187℃)tested via the accelerating rate calorimetry(ARC)demonstrate the excellent safety of the optimized electrolyte.展开更多
AIM:To evaluate the effect of different monochromatic lights on the refractive status and the secretion levels of neurotransmitters in the progressive myopic model of guinea pigs.METHODS:Guinea pigs(n=90)underwent dif...AIM:To evaluate the effect of different monochromatic lights on the refractive status and the secretion levels of neurotransmitters in the progressive myopic model of guinea pigs.METHODS:Guinea pigs(n=90)underwent different monochromatic lights irradiation for two weeks were randomly divided into 6 groups:white light(control),ultraviolet(UV),blue,green,red,and simulative sunlight(simSUN).The refractive status and axial length(AL)were measured.Transmission electron microscopy,Masson’s trichrome staining and hematoxylin-eosin staining were performed to observe the structural changes of retina and sclera.High-performance liquid chromatography(HPLC),western blotting and immunofluorescence were used to measure neurotransmitters and their receptors.RESULTS:Myopia models were established successfully.When compared the degrees of change in myopic eyes of control group,the UV group showed a minor decrease in AL and refraction,along with a significant increase in scleral thickness.In contrast,the red and green groups revealed a net increase in AL and refraction,coupled with a net decrease in scleral thickness(all,P<0.01).The dopamine concentration increased in the UV group,while concentrations of serotonin and melatonin significantly decreased(all,P<0.01).The groups that were exposed to UV,blue and simSUN,the expression of dopamine receptor D2(DRD2)increased,and the expression of hydroxytryptamine receptor 2A(HTR2A)and melatonin receptor type 2(MT2)decreased significantly when compared to the control group(all P<0.01).CONCLUSION:Exposure to short-wavelength light could slow the development of myopia by promoting the production of dopamine and suppressing the serotonin and melatonin concentration.The neurotransmitter receptors MT2,DRD2,and HTR2A in the sclera appear to play different roles by different color lights in myopic guinea pigs.展开更多
In the dual context of VUCA era and digital transformation,enterprise resilience,as the core ability of organizations to resist shocks,adapt to changes,and achieve sustainable development,has increasingly highlighted ...In the dual context of VUCA era and digital transformation,enterprise resilience,as the core ability of organizations to resist shocks,adapt to changes,and achieve sustainable development,has increasingly highlighted its theoretical connotation and practical value.This article systematically explores the interdisciplinary theoretical origins,multidimensional dynamic measurement methods,and complex influencing factors of enterprise resilience.Research has shown that:(1)the concept of resilience originates from ecology,engineering,and physics,and extends to the field of complex adaptive systems,forming a micro capability integration framework of“pre crisis prevention crisis response crisis recovery”,as well as macro strategic attributes that support high-quality development of the national economy;(2)Resilience measurement needs to integrate subjective and objective dynamic indicators:at the subjective level,Likert scale is used to evaluate organizational capability traits,and at the objective level,financial performance fluctuations,market performance,and crisis learning behavior are combined;(3)Resilience is driven by the synergy of multiple levels of factors:internal dependence on organizational capability foundation,digital empowerment,external resource linkage,policy environment,and sustainable governance.Its interaction mechanism accelerates capability updates through digital iteration,policy activates resource networks,and ultimately constructs an organizational resilience system of“survival adaptation evolution”.This article provides a unified analytical framework for the study of enterprise resilience,and provides theoretical guidance and practical paths for organizations in the digital age to cultivate risk resistance capabilities and achieve resilience evolution.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22006057 and 21906072)the China Postdoctoral Science Foundation(No.2023M743178)+2 种基金the Jiangsu Province Industry-University-Research Cooperation Project(No.BY20231482)the Open Fund of the Key Laboratory of Solar Cell electrode Materials in China Petroleum,Chemical Industry(No.2024A093)the Key Laboratory of Functional Inorganic Mate-rial Chemistry(Heilongjiang University),Ministry of Education and Postgraduate Research&Practice Innovation Program of Jiangsu Province(China)(No.SJCX24_2481).
文摘Coatings of marine equipment inevitably suffer from physical or chemical damage in service,together with biofouling from microbial attachment,leading to a shorter service life of them.Herein,a multi-functional corrosion-resistant coating with efficient photothermal self-healing and anti-biofouling per-formance was designed by using CuO/g-C_(3)N_(4)(CuO/CN)S-scheme heterojunction filler in combination with polydimethylsiloxane(PDMS)as the coating matrix for achieving the effective protection of Q235 steel.The results of the electrochemical impedance spectroscopy(EIS)experiments indicate that the CuO/CN/PDMS composite coatings possessed excellent corrosion resistance,in which the impedance ra-dius of optimal CuO/CN-1/PDMS composite coating could still remain 3.49×10^(9)Ωcm^(2)after 60 d of immersion in seawater under sunlight irradiation.Meanwhile,the as-prepared CuO/CN/PDMS compos-ite coating not only can be rapidly heated up under the Xenon lamp illumination to achieve complete self-repair of scratches within 45 min,but also exhibited excellent antimicrobial effects in the antifouling experiments.This study opens a new avenue for the development of g-C_(3)N_(4)-based multifunctional coat-ings and provides guidance for the development of the next generation of intelligent protective coatings.
文摘蕨类植物是地球上起源最为古老的维管植物,在陆生植物演化中具有重要意义。本文通过Web of Science核心数据库(Core Collection)对目前所有关于"fern"、"lycophyte"、"pteridophyte"、"pteridophyta"等的科研论文进行了分析。结果表明:(1) 2000年后,蕨类植物论文数量增加迅速,特别是2006年以来增加显著,现在年均已突破600篇;(2)2010年以来的以蕨类植物为研究材料和对象的学科和研究领域变得越来越多元化,多学科结合和交叉的研究方向成为新趋势;(3)中国正在成为蕨类植物研究的热点国家并且成果显著;(4)中国蕨类植物研究在快速发展的同时也出现了各研究机构之间的发展不同步。期望本论文能给蕨类植物的相关研究提供新的方向,为中国蕨类植物工作者提供借鉴。
文摘BACKGROUND There is currently no effective targeted therapy for advanced HER2-negative gastric cancer(GC).While immunotherapy combined with chemotherapy is the first-line treatment for GC,patient survival outcomes remain highly hetero-geneous,highlighting the urgent need for reliable predictive biomarkers.The fibrinogen-to-albumin ratio(FAR)integrates both inflammation(elevated fibrinogen levels)and nutritional status(reduced albumin levels).Although FAR has been associated with immunotherapy resistance in various solid tumors,its prognostic value in GC patients receiving immunochemotherapy remains unclear.AIM To assess the predictive value of the FAR in the long-term prognosis of advanced HER2-negative GC patients receiving sintilimab-based immunotherapy combined with chemotherapy.METHODS This retrospective study included 260 patients with unresectable or metastatic HER2-negative GC who received sintilimab plus chemotherapy from 2021 to 2024.Pre-treatment FAR values were calculated,and the optimal cutoff value was determined using receiver operating characteristic curve analysis.The association between the FAR and overall survival(OS)and progression-free survival(PFS)was analyzed using Kaplan-Meier survival curves and Cox proportional hazards models.Independent prognostic factors were identified by multivariate Cox regression analysis based on OS,and a nomogram model was constructed incorporating FAR.The concordance index(C-index)and calibration curves were used to assess the predictive performance and calibration of the model.RESULTS Patients with high FAR(≥0.08)had significantly shorter median PFS[7.80 months(6.40-8.30)vs 10.00 months(9.30-11.20),P<0.001]and OS[14.20 months(12.20-16.60)vs 19.50 months(18.80-22.00),P<0.001]compared to the group with low FAR(<0.08).Moreover,the group with high FAR had a significantly lower objective response rate(10.22%vs 19.51%,P=0.034)and disease control rate(34.31%vs 49.59%,P=0.013).The incidence of adverse events did not significantly differ between the two groups(P>0.05).Multivariate analysis confirmed the FAR as an independent prognostic factor for OS(HR=2.33,95%CI:1.59-3.43,P<0.001).The nomogram model,incorporating FAR,Eastern Cooperative Oncology Group performance status,programmed cell death ligand 1 expression,tumor stage,and body mass index,demonstrated strong predictive accuracy,with an internal validation C-index of 0.73(95%CI:0.66-0.79).The calibration curve showed a high consistency between predicted and actual survival rates.CONCLUSION Patients with low FAR had significantly better prognostic outcomes than those with high FAR when receiving immunochemotherapy.Thus,FAR may serve as a valuable prognostic biomarker for predicting survival outcomes in patients with advanced HER2-negative GC.
基金supported by the National Natural Science Foundation of China(grant no.52072322,52202235)the Department of Science and Technology of Sichuan Province(CN)(grant no.23GJHZ0147)the Research and Innovation Fund for Graduate Students of Southwest Petroleum University(No.:2022KYCX111)。
文摘Traditionally,the construction of stable interphases relies on solvent structures dominated by aggregated anionic structures(AGG/AGG+).Nonetheless,we find that the construction of stable interphases in hightemperature environments is based on contact ion pairs(CIPs)dominated solvation structure here.In detail,in the long-chain phosphate ester-based electrolyte,the spatial site-blocking effect enables the strong solvation co-solvent ether(diethylene glycol dimethyl ether,G2)to exhibit strong ion-dipole interactions,further multicomponent competitive coordination maintaining the CIP,balancing electrode kinetics,and optimizing the high-temperature interphases.High-temperature in-situ Raman spectroscopy monitors the changes in the stable solvent structure during charge/discharge processes for the first time,and time of flight secondary ion mass spectrometry(TOF-SIMS)reveals the stable solid electrolyte interphase(SEI)with full-depth enrichment of the inorganic component.Benefiting from the high-temperature interfacial chemistry-dependent solvent structure,the advanced electrolyte enables stable cycling of 1.6 Ah 18650 batterie at 100-125℃and discharging with high current pulses(~1.83 A)at 150℃,which has rarely been reported so far.In addition,pin-pricking of 18650 batteries at100%state of charge(SoC)without fire or smoke and the moderate thermal runaway temperature(187℃)tested via the accelerating rate calorimetry(ARC)demonstrate the excellent safety of the optimized electrolyte.
基金Supported by the Zhejiang Traditional Chinese Medicine Science and Technology Plan(No.2023ZL241)Zhejiang Medical Science and Technology Plan(No.2025KY648).
文摘AIM:To evaluate the effect of different monochromatic lights on the refractive status and the secretion levels of neurotransmitters in the progressive myopic model of guinea pigs.METHODS:Guinea pigs(n=90)underwent different monochromatic lights irradiation for two weeks were randomly divided into 6 groups:white light(control),ultraviolet(UV),blue,green,red,and simulative sunlight(simSUN).The refractive status and axial length(AL)were measured.Transmission electron microscopy,Masson’s trichrome staining and hematoxylin-eosin staining were performed to observe the structural changes of retina and sclera.High-performance liquid chromatography(HPLC),western blotting and immunofluorescence were used to measure neurotransmitters and their receptors.RESULTS:Myopia models were established successfully.When compared the degrees of change in myopic eyes of control group,the UV group showed a minor decrease in AL and refraction,along with a significant increase in scleral thickness.In contrast,the red and green groups revealed a net increase in AL and refraction,coupled with a net decrease in scleral thickness(all,P<0.01).The dopamine concentration increased in the UV group,while concentrations of serotonin and melatonin significantly decreased(all,P<0.01).The groups that were exposed to UV,blue and simSUN,the expression of dopamine receptor D2(DRD2)increased,and the expression of hydroxytryptamine receptor 2A(HTR2A)and melatonin receptor type 2(MT2)decreased significantly when compared to the control group(all P<0.01).CONCLUSION:Exposure to short-wavelength light could slow the development of myopia by promoting the production of dopamine and suppressing the serotonin and melatonin concentration.The neurotransmitter receptors MT2,DRD2,and HTR2A in the sclera appear to play different roles by different color lights in myopic guinea pigs.
基金2025 Nanjing University of Science and Technology Zijin College Campus level Scientific ResearchResearch on the Mechanism,Path,and Policy of Generative AI Cracking the Bottom Logic of Organizational Resilience(Project No.:2025ZXSK0401004)。
文摘In the dual context of VUCA era and digital transformation,enterprise resilience,as the core ability of organizations to resist shocks,adapt to changes,and achieve sustainable development,has increasingly highlighted its theoretical connotation and practical value.This article systematically explores the interdisciplinary theoretical origins,multidimensional dynamic measurement methods,and complex influencing factors of enterprise resilience.Research has shown that:(1)the concept of resilience originates from ecology,engineering,and physics,and extends to the field of complex adaptive systems,forming a micro capability integration framework of“pre crisis prevention crisis response crisis recovery”,as well as macro strategic attributes that support high-quality development of the national economy;(2)Resilience measurement needs to integrate subjective and objective dynamic indicators:at the subjective level,Likert scale is used to evaluate organizational capability traits,and at the objective level,financial performance fluctuations,market performance,and crisis learning behavior are combined;(3)Resilience is driven by the synergy of multiple levels of factors:internal dependence on organizational capability foundation,digital empowerment,external resource linkage,policy environment,and sustainable governance.Its interaction mechanism accelerates capability updates through digital iteration,policy activates resource networks,and ultimately constructs an organizational resilience system of“survival adaptation evolution”.This article provides a unified analytical framework for the study of enterprise resilience,and provides theoretical guidance and practical paths for organizations in the digital age to cultivate risk resistance capabilities and achieve resilience evolution.
