BACKGROUND Genetic screening for breast cancer gene 1(BRCA)1/2 mutations can inform breast/ovarian/pancreatic cancer patients of suitable therapeutic interventions.Four to seven percent of pancreatic cancer patients h...BACKGROUND Genetic screening for breast cancer gene 1(BRCA)1/2 mutations can inform breast/ovarian/pancreatic cancer patients of suitable therapeutic interventions.Four to seven percent of pancreatic cancer patients have germline BRCA mutations.BRCA genes aid in DNA repair,especially homologous recombination,which impacts genomic stability and cancer cell growth.BRCA1 regulates the cell cycle,ubiquitination,and chromatin remodeling,whereas BRCA2 stimulates the immune response.They predict the efficacy of platinum chemotherapy or polymerase(PARP)inhibitors such as olaparib.AIM To determine the trends and future directions in the use of olaparib for pancreatic cancer treatment.METHODS To evaluate the trends in how olaparib works in pancreatic cancer,we performed a bibliometric analysis.One hundred and ninety-six related publications were accessed from the Web of Science Core Collection and were published between 2009 and 2022.The analytic parameters included publications,related citations,productive countries and institutes,influential authors,and keyword development.RESULTS This study visualizes and discusses the current research,including the present global trends and future directions in olaparib and pancreatic cancer.Overall,this study sheds light on optimizing the use of olaparib in pancreatic cancer treatment,Feng X et al.The use of olaparib in pancreatic cancer WJGO https://www.wjgnet.com 4490 November 15,2024 Volume 16 Issue 11 offering valuable guidance for researchers in this field.CONCLUSION Our findings identified trends in olaparib and pancreatic cancer,with China and the USA leading and with global cooperation tightening.O'Reilly EM's team and Memorial Sloan-Kettering had the highest output.The Journal of Clinical Oncology was the most cited journal.More PARP inhibitors are emerging,and combination therapy is suggested for future therapeutic trends.展开更多
Interstitial oxygen(O)contamination remains a substantial challenge for metal injection molding(MIM)of titanium alloys.Herein,this critical problem is successfully addressed by regulating the thermal debinding tempera...Interstitial oxygen(O)contamination remains a substantial challenge for metal injection molding(MIM)of titanium alloys.Herein,this critical problem is successfully addressed by regulating the thermal debinding temperature and incorporating the oxygen scavenger LaB_(6).Results indicate that the surface oxide layer(with a thickness of(13.4±0.5)nm)of Ti_(6)Al4V powder begins to dissolve into the Ti matrix within the temperature range of 663–775℃.O contamination in MIM Ti alloys can be effectively mitigated by lowering the thermal debinding temperature and adding LaB6powder.As a result of reduced dissolved O content,the slips of mixedanddislocations are effectively accelerated,leading to improved ductility.Moreover,grain refinement,along with the in situ formation of Ti B whiskers and second-phase La_(2)O_(3)particles,enhances the strength of the material.The fabricated MIM Ti6Al4V sample exhibits excellent mechanical properties,achieving an ultimate tensile strength of(967±5)MPa,a yield strength of(866±8)MPa,and an elongation of 21.4%±0.7%.These tensile properties represent some of the best results reported in the literature for MIM Ti_(6)Al4V alloys.This study offers valuable insights into the development of high-performance MIM Ti alloys and other metal materials.展开更多
BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal malignancies with high mortality and short survival time.Computed tomography(CT)plays an important role in the diagnosis,staging and treatment...BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal malignancies with high mortality and short survival time.Computed tomography(CT)plays an important role in the diagnosis,staging and treatment of pancreatic tumour.Pancreatic cancer generally shows a low enhancement pattern compared with normal pancreatic tissue.AIM To analyse whether preoperative enhanced CT could be used to predict postoperative overall survival in patients with PDAC.METHODS Sixty-seven patients with PDAC undergoing pancreatic resection were enrolled retrospectively.All patients underwent preoperative unenhanced and enhanced CT examination,the CT values of which were measured.The ratio of the preoperative CT value increase from the nonenhancement phase to the portal venous phase between pancreatic tumour and normal pancreatic tissue was calculated.The cut-off value of ratios was obtained by the receiver operating characteristic(ROC)curve of the tumour relative enhancement ratio(TRER),according to which patients were divided into low-and high-enhancement groups.Univariate and multivariate analyses were performed using Cox regression based on TRER grouping.Finally,the correlation between TRER and clinicopathological characteristics was analysed.RESULTS The area under the curve of the ROC curve was 0.768(P<0.05),and the cut-off value of the ROC curve was calculated as 0.7.TRER≤0.7 was defined as the low-enhancement group,and TRER>0.7 was defined as the high-enhancement group.According to the TRER grouping,the Kaplan-Meier survival curve analysis results showed that the median survival(10.0 mo)with TRER≤0.7 was significantly shorter than that(22.0 mo)with TRER>0.7(P<0.05).In the univariate and multivariate analyses,the prognosis of patients with TRER≤0.7 was significantly worse than that of patients with TRER>0.7(P<0.05).Our results demonstrated that patients in the low TRER group were more likely to have higher American Joint Committee on Cancer stage,tumour stage and lymph node stage(all P<0.05),and TRER was significantly negatively correlated with tumour size(P<0.05).CONCLUSION TRER≤0.7 in patients with PDAC may represent a tumour with higher clinical stage and result in a shorter overall survival.展开更多
依据“基于人工智能技术的工商管理发展”学术研讨会,本文结合相关研究前沿问题和国家重大需求,系统总结了当前工商管理关于人工智能研究的现状、机遇与挑战。总体来看,当前研究主要将人工智能技术作为研究工具、方法或情景,将人工智能...依据“基于人工智能技术的工商管理发展”学术研讨会,本文结合相关研究前沿问题和国家重大需求,系统总结了当前工商管理关于人工智能研究的现状、机遇与挑战。总体来看,当前研究主要将人工智能技术作为研究工具、方法或情景,将人工智能作为研究对象构建新创理论的实证研究相对不足,面临理论发展滞后、研究方法不足、研究路径单一、跨学科整合不足以及对相关伦理问题重视度不够等五大挑战。在此基础上,利用Web of Science全面检索并梳理了2022年1月至2024年3月间与人工智能主题直接相关的工商管理期刊论文225篇,归纳了当前工商管理学科各个细分方向研究的主要进展,凝练了面向人工智能的组织结构与设计、组织能力演化、组织行为与人力资源管理变革、人机协同、数字营销、金融财会风险监管、信息系统、管理哲学与文化等八大方面的关键科学问题,指出了我国工商管理学科在人工智能时代的发展目标与研究方向。展开更多
基金the Zhejiang Provincial Medical and Health Science and Technology Program,No.2024KY1109.
文摘BACKGROUND Genetic screening for breast cancer gene 1(BRCA)1/2 mutations can inform breast/ovarian/pancreatic cancer patients of suitable therapeutic interventions.Four to seven percent of pancreatic cancer patients have germline BRCA mutations.BRCA genes aid in DNA repair,especially homologous recombination,which impacts genomic stability and cancer cell growth.BRCA1 regulates the cell cycle,ubiquitination,and chromatin remodeling,whereas BRCA2 stimulates the immune response.They predict the efficacy of platinum chemotherapy or polymerase(PARP)inhibitors such as olaparib.AIM To determine the trends and future directions in the use of olaparib for pancreatic cancer treatment.METHODS To evaluate the trends in how olaparib works in pancreatic cancer,we performed a bibliometric analysis.One hundred and ninety-six related publications were accessed from the Web of Science Core Collection and were published between 2009 and 2022.The analytic parameters included publications,related citations,productive countries and institutes,influential authors,and keyword development.RESULTS This study visualizes and discusses the current research,including the present global trends and future directions in olaparib and pancreatic cancer.Overall,this study sheds light on optimizing the use of olaparib in pancreatic cancer treatment,Feng X et al.The use of olaparib in pancreatic cancer WJGO https://www.wjgnet.com 4490 November 15,2024 Volume 16 Issue 11 offering valuable guidance for researchers in this field.CONCLUSION Our findings identified trends in olaparib and pancreatic cancer,with China and the USA leading and with global cooperation tightening.O'Reilly EM's team and Memorial Sloan-Kettering had the highest output.The Journal of Clinical Oncology was the most cited journal.More PARP inhibitors are emerging,and combination therapy is suggested for future therapeutic trends.
基金financially supported by the National Natural Science Foundation of China(Nos.52274359 and 52304379)Beijing Natural Science Foundation,China(No.L212021)+4 种基金China National Postdoctoral Program for Innovative Talents(No.BX20220034)China Postdoctoral Science Foundation(No.2022M720403)Fundamental Research Funds for the Central Universities,China(Nos.FRFTP-19005C1Z and 00007718)AECC University Research Cooperation Project,China(No.HFZL2021CXY021)State Key Lab of Advanced Metals and Materials,University of Science and Technology Beijing,China(Nos.2021Z-03 and 2022Z-14)。
文摘Interstitial oxygen(O)contamination remains a substantial challenge for metal injection molding(MIM)of titanium alloys.Herein,this critical problem is successfully addressed by regulating the thermal debinding temperature and incorporating the oxygen scavenger LaB_(6).Results indicate that the surface oxide layer(with a thickness of(13.4±0.5)nm)of Ti_(6)Al4V powder begins to dissolve into the Ti matrix within the temperature range of 663–775℃.O contamination in MIM Ti alloys can be effectively mitigated by lowering the thermal debinding temperature and adding LaB6powder.As a result of reduced dissolved O content,the slips of mixedanddislocations are effectively accelerated,leading to improved ductility.Moreover,grain refinement,along with the in situ formation of Ti B whiskers and second-phase La_(2)O_(3)particles,enhances the strength of the material.The fabricated MIM Ti6Al4V sample exhibits excellent mechanical properties,achieving an ultimate tensile strength of(967±5)MPa,a yield strength of(866±8)MPa,and an elongation of 21.4%±0.7%.These tensile properties represent some of the best results reported in the literature for MIM Ti_(6)Al4V alloys.This study offers valuable insights into the development of high-performance MIM Ti alloys and other metal materials.
基金Supported by the Medical Centre of Minimally Invasive Technology of Fujian Province,No.2017[171],and No.2017[4]Joint Funds for the Innovation of Science and Technology,Fujian Province,No.2017Y9059the United Fujian Provincial Health and Education Project for Tackling the Key Research,No.2019-WJ-07.
文摘BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal malignancies with high mortality and short survival time.Computed tomography(CT)plays an important role in the diagnosis,staging and treatment of pancreatic tumour.Pancreatic cancer generally shows a low enhancement pattern compared with normal pancreatic tissue.AIM To analyse whether preoperative enhanced CT could be used to predict postoperative overall survival in patients with PDAC.METHODS Sixty-seven patients with PDAC undergoing pancreatic resection were enrolled retrospectively.All patients underwent preoperative unenhanced and enhanced CT examination,the CT values of which were measured.The ratio of the preoperative CT value increase from the nonenhancement phase to the portal venous phase between pancreatic tumour and normal pancreatic tissue was calculated.The cut-off value of ratios was obtained by the receiver operating characteristic(ROC)curve of the tumour relative enhancement ratio(TRER),according to which patients were divided into low-and high-enhancement groups.Univariate and multivariate analyses were performed using Cox regression based on TRER grouping.Finally,the correlation between TRER and clinicopathological characteristics was analysed.RESULTS The area under the curve of the ROC curve was 0.768(P<0.05),and the cut-off value of the ROC curve was calculated as 0.7.TRER≤0.7 was defined as the low-enhancement group,and TRER>0.7 was defined as the high-enhancement group.According to the TRER grouping,the Kaplan-Meier survival curve analysis results showed that the median survival(10.0 mo)with TRER≤0.7 was significantly shorter than that(22.0 mo)with TRER>0.7(P<0.05).In the univariate and multivariate analyses,the prognosis of patients with TRER≤0.7 was significantly worse than that of patients with TRER>0.7(P<0.05).Our results demonstrated that patients in the low TRER group were more likely to have higher American Joint Committee on Cancer stage,tumour stage and lymph node stage(all P<0.05),and TRER was significantly negatively correlated with tumour size(P<0.05).CONCLUSION TRER≤0.7 in patients with PDAC may represent a tumour with higher clinical stage and result in a shorter overall survival.
文摘依据“基于人工智能技术的工商管理发展”学术研讨会,本文结合相关研究前沿问题和国家重大需求,系统总结了当前工商管理关于人工智能研究的现状、机遇与挑战。总体来看,当前研究主要将人工智能技术作为研究工具、方法或情景,将人工智能作为研究对象构建新创理论的实证研究相对不足,面临理论发展滞后、研究方法不足、研究路径单一、跨学科整合不足以及对相关伦理问题重视度不够等五大挑战。在此基础上,利用Web of Science全面检索并梳理了2022年1月至2024年3月间与人工智能主题直接相关的工商管理期刊论文225篇,归纳了当前工商管理学科各个细分方向研究的主要进展,凝练了面向人工智能的组织结构与设计、组织能力演化、组织行为与人力资源管理变革、人机协同、数字营销、金融财会风险监管、信息系统、管理哲学与文化等八大方面的关键科学问题,指出了我国工商管理学科在人工智能时代的发展目标与研究方向。
