Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical applicati...Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical application of multi-omics parameters is still restricted by the expensive and less accessible assays,although they accurately reflect immune status.A comprehensive evaluation framework based on“easy-to-obtain”multi-model clinical parameters is urgently required,incorporating clinical features to establish baseline patient profiles and disease staging;routine blood tests assessing systemic metabolic and functional status;immune cell subsets quantifying subcluster dynamics;imaging features delineating tumor morphology,spatial configuration,and perilesional anatomical relationships;immunohistochemical markers positioning qualitative and quantitative detection of tumor antigens from the cellular and molecular level.This integrated phenomic approach aims to improve prognostic stratification and clinical decision-making in hepatocellular carcinoma management conveniently and practically.展开更多
Photo-responsive supramolecular assembly especially supramolecular hydrogels with tunable luminescence show a promising application potential in writable information recording and display materials.Herein,we report ph...Photo-responsive supramolecular assembly especially supramolecular hydrogels with tunable luminescence show a promising application potential in writable information recording and display materials.Herein,we report photo-responsive reversible multicolor supramolecular hydrogel with near-infrared emission,which is constructed by cucurbit[7]uril(CB[7]),cyanostilbene derivative(DAC)and Laponite XLG(LP)via supramolecular cascade assembly.Compared with the free vip molecule DAC,the confinement of macrocycle CB[7]achieve effective near-infrared fluorescence in the aqueous phase from scratch,and the subsequent cascade assembly with LP further restrict the molecular rotation of the DAC,which not only result in a substantial enhancement of the fluorescence intensity,but is also endowed with light-controlled fluorescence on/off both in the solution and hydrogel states.Further,8-hydroxy-1,3,6-pyrenetrisulfonic acid trisodium salt(HPTS)is introduced in the cascade assembly to fabricated photocontrollable reversible multicolor luminescence supramolecular hydrogel between red and green induced by Förster resonance energy transfer,which is successfully employed in reversible multiple information encryption.展开更多
With the continuous development of artificial intelligence and computer vision technology,numerous deep learning-based lane line detection methods have emerged.DeepLabv3+,as a classic semantic segmentation model,has f...With the continuous development of artificial intelligence and computer vision technology,numerous deep learning-based lane line detection methods have emerged.DeepLabv3+,as a classic semantic segmentation model,has found widespread application in the field of lane line detection.However,the accuracy of lane line segmentation is often compromised by factors such as changes in lighting conditions,occlusions,and wear and tear on the lane lines.Additionally,DeepLabv3+suffers from high memory consumption and challenges in deployment on embedded platforms.To address these issues,this paper proposes a lane line detection method for complex road scenes based on DeepLabv3+and MobileNetV4(MNv4).First,the lightweight MNv4 is adopted as the backbone network,and the standard convolutions in ASPP are replaced with depthwise separable convolutions.Second,a polarization attention mechanism is introduced after the ASPP module to enhance the model’s generalization capability.Finally,the Simple Linear Iterative Clustering(SLIC)superpixel segmentation algorithmis employed to preserve lane line edge information.MNv4-DeepLabv3+was tested on the TuSimple and CULane datasets.On the TuSimple dataset,theMean Intersection over Union(MIoU)and Mean Pixel Accuracy(mPA)improved by 1.01%and 7.49%,respectively.On the CULane dataset,MIoU andmPA increased by 3.33%and 7.74%,respectively.Thenumber of parameters decreased from 54.84 to 3.19 M.Experimental results demonstrate that MNv4-DeepLabv3+significantly optimizes model parameter count and enhances segmentation accuracy.展开更多
Penduline tits(genus Remiz)are small passerines distributed across Europe,Central and East Asia,and North Africa,renowned for their elaborate nests and unusually diverse mating systems.However,the taxonomy and evoluti...Penduline tits(genus Remiz)are small passerines distributed across Europe,Central and East Asia,and North Africa,renowned for their elaborate nests and unusually diverse mating systems.However,the taxonomy and evolutionary relationships within this genus have remained contentious due to overlapping breeding distributions and extensive hybridization.Using broad-range geographic sampling and whole-genome sequencing,here we report the phylogenetic relationships within this genus.Our results from maximum likelihood trees,species trees,population structure,and PCA analyses consistently identify four distinct,well-supported monophyletic clades.Based on these robust results,we support dividing Remiz into four species:the Eurasian Penduline Tit(R.pendulinus),Black-headed Penduline Tit(R.macronyx),White-crowned Penduline Tit(R.coronatus),and Chinese Penduline Tit(R.consobrinus).Among these species,R.consobrinus diverged earlier from other species,followed by R.coronatus,and then,R.pendulinus and R.macronyx.R.pendulinus and R.macronyx showed shallow genetic differentiation with recent divergence(~87,000 years ago)and ongoing gene flow.Our findings demonstrate the effectiveness of phylogenomic approaches in resolving taxonomic ambiguities and provide a robust evolutionary framework for tracing the diversification of life history traits,particularly nest structures and mating systems,across the genus.展开更多
With the development of hydrate technology,more and more applications have been appeared in many areas.However,hydrate additive is always one research hotspot,it has attracted more and more attention.The influence of ...With the development of hydrate technology,more and more applications have been appeared in many areas.However,hydrate additive is always one research hotspot,it has attracted more and more attention.The influence of two biosurfactants on CO_(2) hydrate formation process were investigated.Through the investigation of experiment research,rhamnolipid and sophorolipid had the promotion effect on CO_(2) hydrate formation kinetics.Hydrate gas storage reached the maximum value 32.01(volume ratio)and conversion ratio of water to hydrate was 19.42%when sophorolipid concentration was 0.05%(mass).Hydrate gas storage capacity reached the maximum value 31.22(volume ratio)and conversion ratio of water to hydrate was 18.94%when rhamnolipid concentration was 0.05%(mass).Through the comparison of gas storage capacity and hydrate formation rate,sophorolipid had stronger promotion effect on CO_(2) hydrate formation kinetics than rhamnolipid.It increased the depth of gas hydration reaction.CO_(2) hydrate formation gas was carried out under the condition of constant temperature and volume.Hydration number was considered in the hydrate calculation process.Combined with hydrate formation kinetic theory of Chen–Guo model,the hydrated gas volume was compared with remaining volume of reactor.This model could calculate the change of CO_(2) hydrate gas storage capacity over time.The calculated values of gas storage was in good agreement with experimental values.So this study has the better guiding function for relevant hydrate technology application.展开更多
Objective:The contribution of long non-coding RNAs(lncRNAs)associated with protein palmitoylation to the progression of hepatocellular carcinoma(HCC)remains largely unclear.This study sought to establish a prognostic ...Objective:The contribution of long non-coding RNAs(lncRNAs)associated with protein palmitoylation to the progression of hepatocellular carcinoma(HCC)remains largely unclear.This study sought to establish a prognostic signature based on palmitoylation-related lncRNAs and explore their functional implications in HCC.Methods:RNA sequencing and clinical data for HCC and normal tissues were sourced from the Cancer Genome Atlas(TCGA).Pearson correlation analysis was used to identify lncRNAs that were co-expressed with palmitoylation-related genes.Univariate Cox regression was applied to select lncRNAs with prognostic value,followed by the construction of a predictive model using the least absolute shrinkage and selection operator(LASSO)regression.A focused analysis was performed on one key lncRNA,AC009403.1.Expression levels of the final nine lncRNAs included in the model were further validated by reverse transcription quantitative polymerase chain reaction(RT-qPCR).Results:A prognostic model for HCC was developed using nine palmitoylation-associated lncRNAs:AC009403.1,AC010789.1,AC026402.2,AC107021.2,AC135050.6,AL353572.4,MKLN1-AS,PRRT3-AS1,and ZNF582-AS1.This model effectively stratified patients into high-and low-risk groups exhibiting significantly different overall survival(OS)and progression-free survival(PFS),with the low-risk group showing more favorable outcomes.The high-risk group was associated with an immunosuppressive microenvironment,higher tumor mutation burden(TMB),and increased sensitivity to certain chemotherapeutic drugs(e.g.,Sorafenib).Finally,RT-qPCR validation revealed that all nine lncRNAs were significantly upregulated in HCC tissues.Conclusion:The nine-lncRNA signature exhibits robust predictive power for HCC prognosis and provides novel insights into the mechanisms of lncRNA-regulated palmitoylation in HCC development.展开更多
Aqueous alkali metal-ion batteries(AAMIBs)have been recognized as emerging electrochemical energy storage technologies for grid-scale applications owning to their intrinsic safety,cost-effectiveness,and environmental ...Aqueous alkali metal-ion batteries(AAMIBs)have been recognized as emerging electrochemical energy storage technologies for grid-scale applications owning to their intrinsic safety,cost-effectiveness,and environmental sustainability.However,the practical application of AAMIBs is still severely constrained by the tendency of aqueous electrolytes to freeze at low temperatures and decompose at high temperatures,limiting their operational temperature range.Considering the urgent need for energy systems with higher adaptability and resilience at various application scenarios,designing novel electrolytes via structure modulation has increasingly emerged as a feasible and economical strategy for the performance optimization of wide-temperature AAMIBs.In this review,the latest advancement of wide-temperature electrolytes for AAMIBs is systematically and comprehensively summarized.Specifically,the key challenges,failure mechanisms,correlations between hydrogen bond behaviors and physicochemical properties,and thermodynamic and kinetic interpretations in aqueous electrolytes are discussed firstly.Additionally,we offer forward-looking insights and innovative design principles for developing aqueous electrolytes capable of operating across a broad temperature range.This review is expected to provide some guidance and reference for the rational design and regulation of widetemperature electrolytes for AAMIBs and promote their future development.展开更多
In recent years,proteolysis-targeting chimeras(PROTACs)have gained widespread attention as an emerging therapeutic approach.PROTACs are bifunctional molecules composed of a target protein-binding ligand,an E3 ubiquiti...In recent years,proteolysis-targeting chimeras(PROTACs)have gained widespread attention as an emerging therapeutic approach.PROTACs are bifunctional molecules composed of a target protein-binding ligand,an E3 ubiquitin ligase ligand,and a linker connecting these ligands.By harnessing the cell’s intrinsic ubiquitin-proteasome system(UPS),they promote the ubiquitination of specific target proteins,leading to their degradation and therapeutic effects.PROTACs show exceptional promise in targeting conventional“undruggable”targets compared to traditional small-molecule inhibitors.This review provides an overview of PROTACs,including their molecular mechanism of action,therapeutic benefits,development history,key design aspects,current research and development challenges,and future trends in nextgeneration PROTAC technology.展开更多
Coal and shale are both unconventional gas reservoirs. Comparison of pore characteristics in shale and coal would help understand organic pore structure in shale and investigate co-exploration of shale gas and coalbed...Coal and shale are both unconventional gas reservoirs. Comparison of pore characteristics in shale and coal would help understand organic pore structure in shale and investigate co-exploration of shale gas and coalbed methane in coal bearing strata. In this study, five shale samples and three coal samples of Taiyuan Formation were collected from Qinshui Basin, China. High pressure mercury injection, scanning electronic microscopy, and fractal theory have been used to compare pore characteristics in shale and coal. The results show that pore volumes in coal are much larger than that in shale, especially pores 3-100 nm. In coal, there are many semi-closed pores in micro pores （〈10 nm） and transition pores （10-100 nm）. On the contrary, micro pores and transition pores are mainly with open pores in shale. The fractal curves show that pores larger than 65 nm in coal and shale reservoir both have obvious self-similarity and the fractal dimension values in shale and coal are similar. But the fractal characteristics of pores smaller than 65 nm in shale reservoir are quite different from that in coal.展开更多
Although manganese Prussian blue analogues(Mn-PBAs)offer advantages as cost-effective,high-energy-density cathode materials for sodium-ion batteries,their practical application is severely constrained by substantial c...Although manganese Prussian blue analogues(Mn-PBAs)offer advantages as cost-effective,high-energy-density cathode materials for sodium-ion batteries,their practical application is severely constrained by substantial capacity degradation during long-term cycling.This performance deterioration is closely associated with the structural instability of the material during the cycling process,which is mainly attributed to the gradual dissolution of the active material into the electrolyte and severe lattice distortion during Na+intercalation/deintercalation.Fortunately,the aforementioned challenges can be effectively addressed by fabricating an in situ engineered nickel cage(ISE-NC)on Mn-PBAs(denoted as Mn-PBAs-NC).Experimental characterization combined with theoretical calculations reveals that this spontaneously formed nickel cage not only suppresses the diffusion of Mn-PBAs into the electrolyte but also acts as a structural stabilizer,significantly alleviating lattice distortion during cycling.This dual stabilization mechanism ensures remarkable cycling stability,with Mn-PBAs-NC delivering a retained capacity of 96.4 mA h g^(−1)(80%capacity retention)over 2,300 cycles at 2 C,elevating the cycle life of Mn-PBAs to unprecedented levels.展开更多
We have carefully read Dr.Yu and his colleagues'~1review on the mechanism of hamstring muscle strain injury in sprinting.There is no doubt that they have done a lot work in this field.Their views are based on 3 pi...We have carefully read Dr.Yu and his colleagues'~1review on the mechanism of hamstring muscle strain injury in sprinting.There is no doubt that they have done a lot work in this field.Their views are based on 3 pieces of evidence.First,observations from in situ animal models suggest that muscle strain injuries are highly associated with eccentric contractions.Second,the magnitude of muscle strain,rather than the force。展开更多
Canopy interception is a significant proportion of incident rainfall and evapotranspiration of forest ecosystems. Hence, identifying its magnitude is vital for studies of eco-hydrological processes and hydrological im...Canopy interception is a significant proportion of incident rainfall and evapotranspiration of forest ecosystems. Hence, identifying its magnitude is vital for studies of eco-hydrological processes and hydrological impact evaluation. In this study, throughfall, stemflow and interception were measured in a pure Larix principis-rupprechtii Mayr.（larch） plantation in the Liupan Mountains of northwestern China during the growing season（May–October） of 2015, and simulated using a revised Gash model. During the study period, the total precipitation was 499.0 mm; corresponding total throughfall, stemflow and canopy interception were 410.3, 2.0 and 86.7 mm,accounting for 82.2, 0.4 and 17.4% of the total precipitation, respectively. With increasing rainfall, the canopy interception ratio of individual rainfall events decreased initially and then tended to stabilize. Within the study period, the simulated total canopy interception, throughfall and stemflow were 2.2 mm lower, 2.5 mm higher and 0.3 mm lower than their measured values, with a relative error of 2.5, 0.6 and 15.0%, respectively. As quantified by the model, canopy interception loss（79%） mainly consisted of interception caused by canopy adsorption, while the proportions of additional interception and trunk interception were small. The revised Gash model was highly sensitive to the parameter of canopy storage capacity,followed by the parameters of canopy density and mean rainfall intensity, but less sensitive to the parameters of mean evaporation rate, trunk storage capacity, and stemflow ratio. The revised Gash model satisfactorily simulated the total canopy interception of the larch plantation within the growing season but was less accurate for some individual rainfall events, indicating that some flaws exist in the model structure. Further measures to improve the model’s ability in simulating the interception of individual rainfall events were suggested.展开更多
A β cyclodextrin derivative bearing seven cationic arms and its singly charged analogue, i.e., per-6- deoxy-f-（1-methylimidazol-3-ium-3-yl）-β-cyclodextrin （3） and mono-fi-deoxy-6-（1-methylimidazol- 3-ium-3-yl）...A β cyclodextrin derivative bearing seven cationic arms and its singly charged analogue, i.e., per-6- deoxy-f-（1-methylimidazol-3-ium-3-yl）-β-cyclodextrin （3） and mono-fi-deoxy-6-（1-methylimidazol- 3-ium-3-yl）-β-cyclodextrin （4） were synthesized and fully characterized. Their induced aggregation behaviours towards two anionic surfactant, that is, sodium dodecyl sulfonate （SDS） and dioctyl sodium sulfosuccinate （Aerosol OT, AOT）, were investigated by UV-vis, NMR, Zeta-potential, dynamic light scattering （DLS）, and transmission electron microscopy. The results revealed that host 3 can induce the molecular aggregation of anionic surfactant at concentration far lower than its original CAC, leading to the larger diameter, the narrower size distribution and the higher thermal stability of the induced aggregate towards the anionic surfactant possessing more hydrophobic tails.展开更多
Based on an analysis of the circulation in May associated with the interannual variation of the onset of Yunnan’s rainy season, this study examined the rela-tionship between Arctic Oscillation (AO) and the onset timi...Based on an analysis of the circulation in May associated with the interannual variation of the onset of Yunnan’s rainy season, this study examined the rela-tionship between Arctic Oscillation (AO) and the onset timing of the rainy sea-son by using the NCEP/NCAR reanalysis and observational precipitation data for 1961-2010. The results indicated that, on an interannual time scale, intense Asian summer monsoon and an active EU-pattern wave train circulation in its positive phase, associated with a cold cyclonic cell covering the western part of the East Asian subtropical westerly jet (EASWJ), jointly contributed to the onset of the rainy season in May. Otherwise, the onset might be suppressed. The cold cyclonic cell over East Asia likely led to the southward shift and enhancement of EASWJ as well as its secondary circulation around the jet entrance, which could provide a favorable dynamic and thermal condition for rainfalls in Yunnan as was revealed in previous studies on 10 - 30-day time scale. Further examination showed that the preceding wintertime AO played a significant role in the timing of the onset of the rainy season before the mid-1980s’ by mostly modulating the wave-train-like circulation over East Asia in May. During that time period, when the AO index of the previous winter was positive (negative), Yunnan’s rainy season tended to begin earlier (later) than normal. Correspond-ingly, the precipitation in May was also closely linked to wintertime AO.展开更多
Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural stab...Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural stability.However,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in SIBs.Thus,it is of significance to boost the sodium storage performance of NVP cathode material.Up to now,many methods have been developed to optimize the electrochemical performance of NVP cathode material.In this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology design.The foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so on.Furthermore,the challenges and prospects of high-performance NVP cathode material are also put forward.It is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.展开更多
文摘Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical application of multi-omics parameters is still restricted by the expensive and less accessible assays,although they accurately reflect immune status.A comprehensive evaluation framework based on“easy-to-obtain”multi-model clinical parameters is urgently required,incorporating clinical features to establish baseline patient profiles and disease staging;routine blood tests assessing systemic metabolic and functional status;immune cell subsets quantifying subcluster dynamics;imaging features delineating tumor morphology,spatial configuration,and perilesional anatomical relationships;immunohistochemical markers positioning qualitative and quantitative detection of tumor antigens from the cellular and molecular level.This integrated phenomic approach aims to improve prognostic stratification and clinical decision-making in hepatocellular carcinoma management conveniently and practically.
基金National Natural Science Foundation of China (NSFC) (No.22131008)the Haihe Laboratory of Sustainable Chemical Transformations for financial support。
文摘Photo-responsive supramolecular assembly especially supramolecular hydrogels with tunable luminescence show a promising application potential in writable information recording and display materials.Herein,we report photo-responsive reversible multicolor supramolecular hydrogel with near-infrared emission,which is constructed by cucurbit[7]uril(CB[7]),cyanostilbene derivative(DAC)and Laponite XLG(LP)via supramolecular cascade assembly.Compared with the free vip molecule DAC,the confinement of macrocycle CB[7]achieve effective near-infrared fluorescence in the aqueous phase from scratch,and the subsequent cascade assembly with LP further restrict the molecular rotation of the DAC,which not only result in a substantial enhancement of the fluorescence intensity,but is also endowed with light-controlled fluorescence on/off both in the solution and hydrogel states.Further,8-hydroxy-1,3,6-pyrenetrisulfonic acid trisodium salt(HPTS)is introduced in the cascade assembly to fabricated photocontrollable reversible multicolor luminescence supramolecular hydrogel between red and green induced by Förster resonance energy transfer,which is successfully employed in reversible multiple information encryption.
文摘With the continuous development of artificial intelligence and computer vision technology,numerous deep learning-based lane line detection methods have emerged.DeepLabv3+,as a classic semantic segmentation model,has found widespread application in the field of lane line detection.However,the accuracy of lane line segmentation is often compromised by factors such as changes in lighting conditions,occlusions,and wear and tear on the lane lines.Additionally,DeepLabv3+suffers from high memory consumption and challenges in deployment on embedded platforms.To address these issues,this paper proposes a lane line detection method for complex road scenes based on DeepLabv3+and MobileNetV4(MNv4).First,the lightweight MNv4 is adopted as the backbone network,and the standard convolutions in ASPP are replaced with depthwise separable convolutions.Second,a polarization attention mechanism is introduced after the ASPP module to enhance the model’s generalization capability.Finally,the Simple Linear Iterative Clustering(SLIC)superpixel segmentation algorithmis employed to preserve lane line edge information.MNv4-DeepLabv3+was tested on the TuSimple and CULane datasets.On the TuSimple dataset,theMean Intersection over Union(MIoU)and Mean Pixel Accuracy(mPA)improved by 1.01%and 7.49%,respectively.On the CULane dataset,MIoU andmPA increased by 3.33%and 7.74%,respectively.Thenumber of parameters decreased from 54.84 to 3.19 M.Experimental results demonstrate that MNv4-DeepLabv3+significantly optimizes model parameter count and enhances segmentation accuracy.
基金supported by the National Natural Science Foundation of China(32161143024,32500368,31970405)the Third Xinjiang Scientific Expedition Program(2022xjkk0200)+2 种基金INSF-NSFC Joint Research Project(No.4002006)HUN-REN-Debrecen University Reproductive Strategies Research Group grant(Ref 1102207)supported by the Postdoctoral Fellowship Program of CPSF under Grant Number GZC20240121。
文摘Penduline tits(genus Remiz)are small passerines distributed across Europe,Central and East Asia,and North Africa,renowned for their elaborate nests and unusually diverse mating systems.However,the taxonomy and evolutionary relationships within this genus have remained contentious due to overlapping breeding distributions and extensive hybridization.Using broad-range geographic sampling and whole-genome sequencing,here we report the phylogenetic relationships within this genus.Our results from maximum likelihood trees,species trees,population structure,and PCA analyses consistently identify four distinct,well-supported monophyletic clades.Based on these robust results,we support dividing Remiz into four species:the Eurasian Penduline Tit(R.pendulinus),Black-headed Penduline Tit(R.macronyx),White-crowned Penduline Tit(R.coronatus),and Chinese Penduline Tit(R.consobrinus).Among these species,R.consobrinus diverged earlier from other species,followed by R.coronatus,and then,R.pendulinus and R.macronyx.R.pendulinus and R.macronyx showed shallow genetic differentiation with recent divergence(~87,000 years ago)and ongoing gene flow.Our findings demonstrate the effectiveness of phylogenomic approaches in resolving taxonomic ambiguities and provide a robust evolutionary framework for tracing the diversification of life history traits,particularly nest structures and mating systems,across the genus.
基金supported by the Science Foundation of Zhejiang Pharmaceutical University Science Foundation of XIAO2024006General project of Education Department of Zhejiang Province(2024116/Y202456535)Fenghua District Science and Technology Association Natural Science Foundation Project 05,which were greatly acknowledged.
文摘With the development of hydrate technology,more and more applications have been appeared in many areas.However,hydrate additive is always one research hotspot,it has attracted more and more attention.The influence of two biosurfactants on CO_(2) hydrate formation process were investigated.Through the investigation of experiment research,rhamnolipid and sophorolipid had the promotion effect on CO_(2) hydrate formation kinetics.Hydrate gas storage reached the maximum value 32.01(volume ratio)and conversion ratio of water to hydrate was 19.42%when sophorolipid concentration was 0.05%(mass).Hydrate gas storage capacity reached the maximum value 31.22(volume ratio)and conversion ratio of water to hydrate was 18.94%when rhamnolipid concentration was 0.05%(mass).Through the comparison of gas storage capacity and hydrate formation rate,sophorolipid had stronger promotion effect on CO_(2) hydrate formation kinetics than rhamnolipid.It increased the depth of gas hydration reaction.CO_(2) hydrate formation gas was carried out under the condition of constant temperature and volume.Hydration number was considered in the hydrate calculation process.Combined with hydrate formation kinetic theory of Chen–Guo model,the hydrated gas volume was compared with remaining volume of reactor.This model could calculate the change of CO_(2) hydrate gas storage capacity over time.The calculated values of gas storage was in good agreement with experimental values.So this study has the better guiding function for relevant hydrate technology application.
基金supported by the Science and Technology Program in Guangxi Province(2023JJD140004).
文摘Objective:The contribution of long non-coding RNAs(lncRNAs)associated with protein palmitoylation to the progression of hepatocellular carcinoma(HCC)remains largely unclear.This study sought to establish a prognostic signature based on palmitoylation-related lncRNAs and explore their functional implications in HCC.Methods:RNA sequencing and clinical data for HCC and normal tissues were sourced from the Cancer Genome Atlas(TCGA).Pearson correlation analysis was used to identify lncRNAs that were co-expressed with palmitoylation-related genes.Univariate Cox regression was applied to select lncRNAs with prognostic value,followed by the construction of a predictive model using the least absolute shrinkage and selection operator(LASSO)regression.A focused analysis was performed on one key lncRNA,AC009403.1.Expression levels of the final nine lncRNAs included in the model were further validated by reverse transcription quantitative polymerase chain reaction(RT-qPCR).Results:A prognostic model for HCC was developed using nine palmitoylation-associated lncRNAs:AC009403.1,AC010789.1,AC026402.2,AC107021.2,AC135050.6,AL353572.4,MKLN1-AS,PRRT3-AS1,and ZNF582-AS1.This model effectively stratified patients into high-and low-risk groups exhibiting significantly different overall survival(OS)and progression-free survival(PFS),with the low-risk group showing more favorable outcomes.The high-risk group was associated with an immunosuppressive microenvironment,higher tumor mutation burden(TMB),and increased sensitivity to certain chemotherapeutic drugs(e.g.,Sorafenib).Finally,RT-qPCR validation revealed that all nine lncRNAs were significantly upregulated in HCC tissues.Conclusion:The nine-lncRNA signature exhibits robust predictive power for HCC prognosis and provides novel insights into the mechanisms of lncRNA-regulated palmitoylation in HCC development.
基金supported by the National Natural Science Foundation of China(52002297)National Key R&D Program of China(2022VFB2404800)+1 种基金Wuhan Yellow Crane Talents Program,China Postdoctoral Science Foundation(No.2024M752495)the Postdoctoral Fellowship Program of CPSF(No.GZB20230552).
文摘Aqueous alkali metal-ion batteries(AAMIBs)have been recognized as emerging electrochemical energy storage technologies for grid-scale applications owning to their intrinsic safety,cost-effectiveness,and environmental sustainability.However,the practical application of AAMIBs is still severely constrained by the tendency of aqueous electrolytes to freeze at low temperatures and decompose at high temperatures,limiting their operational temperature range.Considering the urgent need for energy systems with higher adaptability and resilience at various application scenarios,designing novel electrolytes via structure modulation has increasingly emerged as a feasible and economical strategy for the performance optimization of wide-temperature AAMIBs.In this review,the latest advancement of wide-temperature electrolytes for AAMIBs is systematically and comprehensively summarized.Specifically,the key challenges,failure mechanisms,correlations between hydrogen bond behaviors and physicochemical properties,and thermodynamic and kinetic interpretations in aqueous electrolytes are discussed firstly.Additionally,we offer forward-looking insights and innovative design principles for developing aqueous electrolytes capable of operating across a broad temperature range.This review is expected to provide some guidance and reference for the rational design and regulation of widetemperature electrolytes for AAMIBs and promote their future development.
文摘In recent years,proteolysis-targeting chimeras(PROTACs)have gained widespread attention as an emerging therapeutic approach.PROTACs are bifunctional molecules composed of a target protein-binding ligand,an E3 ubiquitin ligase ligand,and a linker connecting these ligands.By harnessing the cell’s intrinsic ubiquitin-proteasome system(UPS),they promote the ubiquitination of specific target proteins,leading to their degradation and therapeutic effects.PROTACs show exceptional promise in targeting conventional“undruggable”targets compared to traditional small-molecule inhibitors.This review provides an overview of PROTACs,including their molecular mechanism of action,therapeutic benefits,development history,key design aspects,current research and development challenges,and future trends in nextgeneration PROTAC technology.
基金The authors thank the National Science Foundation of China （41472135）, the Research and Innovation Project for College Graduates of Jiangsu Province （KYLX15-1396）, the Scientific Research Foundation of the Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process, Ministry of Education （China University of Mining and Technology） （No. 2015-04） for the support of the research.
文摘Coal and shale are both unconventional gas reservoirs. Comparison of pore characteristics in shale and coal would help understand organic pore structure in shale and investigate co-exploration of shale gas and coalbed methane in coal bearing strata. In this study, five shale samples and three coal samples of Taiyuan Formation were collected from Qinshui Basin, China. High pressure mercury injection, scanning electronic microscopy, and fractal theory have been used to compare pore characteristics in shale and coal. The results show that pore volumes in coal are much larger than that in shale, especially pores 3-100 nm. In coal, there are many semi-closed pores in micro pores （〈10 nm） and transition pores （10-100 nm）. On the contrary, micro pores and transition pores are mainly with open pores in shale. The fractal curves show that pores larger than 65 nm in coal and shale reservoir both have obvious self-similarity and the fractal dimension values in shale and coal are similar. But the fractal characteristics of pores smaller than 65 nm in shale reservoir are quite different from that in coal.
基金financially supported by the Ten-thousand Talents Programthe K. C. Wong Pioneer Talent Program+3 种基金China Three Gorges Corporation (WWKY-2021–0027)Inner Mongolia Science and Technology Plan (2021ZD0033)the National Natural Science Foundation of China (52202121)funded by China Petroleum&Chemical Corporation (123091)
文摘Although manganese Prussian blue analogues(Mn-PBAs)offer advantages as cost-effective,high-energy-density cathode materials for sodium-ion batteries,their practical application is severely constrained by substantial capacity degradation during long-term cycling.This performance deterioration is closely associated with the structural instability of the material during the cycling process,which is mainly attributed to the gradual dissolution of the active material into the electrolyte and severe lattice distortion during Na+intercalation/deintercalation.Fortunately,the aforementioned challenges can be effectively addressed by fabricating an in situ engineered nickel cage(ISE-NC)on Mn-PBAs(denoted as Mn-PBAs-NC).Experimental characterization combined with theoretical calculations reveals that this spontaneously formed nickel cage not only suppresses the diffusion of Mn-PBAs into the electrolyte but also acts as a structural stabilizer,significantly alleviating lattice distortion during cycling.This dual stabilization mechanism ensures remarkable cycling stability,with Mn-PBAs-NC delivering a retained capacity of 96.4 mA h g^(−1)(80%capacity retention)over 2,300 cycles at 2 C,elevating the cycle life of Mn-PBAs to unprecedented levels.
文摘We have carefully read Dr.Yu and his colleagues'~1review on the mechanism of hamstring muscle strain injury in sprinting.There is no doubt that they have done a lot work in this field.Their views are based on 3 pieces of evidence.First,observations from in situ animal models suggest that muscle strain injuries are highly associated with eccentric contractions.Second,the magnitude of muscle strain,rather than the force。
基金supported by the National Key Research and Development Program of China(2016YFC0501603)the National Natural Science Foundation of China(Nos.41671025+2 种基金413904614123085241471029)
文摘Canopy interception is a significant proportion of incident rainfall and evapotranspiration of forest ecosystems. Hence, identifying its magnitude is vital for studies of eco-hydrological processes and hydrological impact evaluation. In this study, throughfall, stemflow and interception were measured in a pure Larix principis-rupprechtii Mayr.（larch） plantation in the Liupan Mountains of northwestern China during the growing season（May–October） of 2015, and simulated using a revised Gash model. During the study period, the total precipitation was 499.0 mm; corresponding total throughfall, stemflow and canopy interception were 410.3, 2.0 and 86.7 mm,accounting for 82.2, 0.4 and 17.4% of the total precipitation, respectively. With increasing rainfall, the canopy interception ratio of individual rainfall events decreased initially and then tended to stabilize. Within the study period, the simulated total canopy interception, throughfall and stemflow were 2.2 mm lower, 2.5 mm higher and 0.3 mm lower than their measured values, with a relative error of 2.5, 0.6 and 15.0%, respectively. As quantified by the model, canopy interception loss（79%） mainly consisted of interception caused by canopy adsorption, while the proportions of additional interception and trunk interception were small. The revised Gash model was highly sensitive to the parameter of canopy storage capacity,followed by the parameters of canopy density and mean rainfall intensity, but less sensitive to the parameters of mean evaporation rate, trunk storage capacity, and stemflow ratio. The revised Gash model satisfactorily simulated the total canopy interception of the larch plantation within the growing season but was less accurate for some individual rainfall events, indicating that some flaws exist in the model structure. Further measures to improve the model’s ability in simulating the interception of individual rainfall events were suggested.
基金973 Programme (No. 2011CB932502)NNSFC (Nos. 91227107, 21432004, and 21272125) for financial support
文摘A β cyclodextrin derivative bearing seven cationic arms and its singly charged analogue, i.e., per-6- deoxy-f-（1-methylimidazol-3-ium-3-yl）-β-cyclodextrin （3） and mono-fi-deoxy-6-（1-methylimidazol- 3-ium-3-yl）-β-cyclodextrin （4） were synthesized and fully characterized. Their induced aggregation behaviours towards two anionic surfactant, that is, sodium dodecyl sulfonate （SDS） and dioctyl sodium sulfosuccinate （Aerosol OT, AOT）, were investigated by UV-vis, NMR, Zeta-potential, dynamic light scattering （DLS）, and transmission electron microscopy. The results revealed that host 3 can induce the molecular aggregation of anionic surfactant at concentration far lower than its original CAC, leading to the larger diameter, the narrower size distribution and the higher thermal stability of the induced aggregate towards the anionic surfactant possessing more hydrophobic tails.
文摘Based on an analysis of the circulation in May associated with the interannual variation of the onset of Yunnan’s rainy season, this study examined the rela-tionship between Arctic Oscillation (AO) and the onset timing of the rainy sea-son by using the NCEP/NCAR reanalysis and observational precipitation data for 1961-2010. The results indicated that, on an interannual time scale, intense Asian summer monsoon and an active EU-pattern wave train circulation in its positive phase, associated with a cold cyclonic cell covering the western part of the East Asian subtropical westerly jet (EASWJ), jointly contributed to the onset of the rainy season in May. Otherwise, the onset might be suppressed. The cold cyclonic cell over East Asia likely led to the southward shift and enhancement of EASWJ as well as its secondary circulation around the jet entrance, which could provide a favorable dynamic and thermal condition for rainfalls in Yunnan as was revealed in previous studies on 10 - 30-day time scale. Further examination showed that the preceding wintertime AO played a significant role in the timing of the onset of the rainy season before the mid-1980s’ by mostly modulating the wave-train-like circulation over East Asia in May. During that time period, when the AO index of the previous winter was positive (negative), Yunnan’s rainy season tended to begin earlier (later) than normal. Correspond-ingly, the precipitation in May was also closely linked to wintertime AO.
基金partly supported by the National Natural Science Foundation of China(Grant No.52272225).
文摘Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural stability.However,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in SIBs.Thus,it is of significance to boost the sodium storage performance of NVP cathode material.Up to now,many methods have been developed to optimize the electrochemical performance of NVP cathode material.In this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology design.The foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so on.Furthermore,the challenges and prospects of high-performance NVP cathode material are also put forward.It is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.
