Objective:As the prevalence of chronic diseases among the elderly increases year by year,chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world.Methods:This ...Objective:As the prevalence of chronic diseases among the elderly increases year by year,chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world.Methods:This article conducted a retrospective analysis of 1856 elderly people over 65 years old,with a follow-up time of 6 years.The aim is to compare the decline in estimated glomerular filtration rate(EGFR)between hypertensive and non-hypertensive populations under non-intervention conditions,and to explore the impact of blood pressure on EGFR in the elderly.Results:The incidence of hypertension among the elderly in this region is significantly higher than the national level.The EGFR value of hypertensive patients is significantly lower than that of non-hypertensive people.There is a difference in the percentage decline in EGFR between hypertensive and non-hypertensive populations under non-intervention conditions,with hypertensive patients experiencing a higher rate of EGFR decline.When blood pressure is lower than 120/80 mmHg,the EGFR decline ratio is lower compared to when blood pressure is higher than 120/80 mmHg.Conclusion:Lowering blood pressure can effectively slow down the decline of EGFR,and the prevalence of hypertension should be reduced.展开更多
Rat nerve growth factor and total flavonoids from hawthorn leaf contribute to the recovery of neurological function after spinal cord injury,including traumatic,non-traumatic spinal cord injuries.However,it remains ch...Rat nerve growth factor and total flavonoids from hawthorn leaf contribute to the recovery of neurological function after spinal cord injury,including traumatic,non-traumatic spinal cord injuries.However,it remains challenging to efficiently deliver nerve growth factor and total flavonoids from hawthorn leaf to spinal cord injury sites,ensure their sustained release,and minimize further damage.In the present study,we chose a biocompatible and biodegradable gelatin as the substrate,which was crosslinked with the natural biological crosslinker genipin to form a gelatin-genipin hydrogel carrier for the slow release of nerve growth factor and total flavonoids from hawthorn leaf in spinal cord injury sites.The prepared gelatin-genipin hydrogel had good injectable properties and photothermal effects.Furthermore,when the hydrogel with 2%genipin,200 ng/mL nerve growth factor,and 320μg/mL total flavonoids from hawthorn leaf was combined with near infrared irradiation,there was a slow release of total flavonoids from hawthorn leaf and nerve growth factor,reduced oxidative stress,an improved inflammatory microenvironment,and accelerated angiogenesis and axonal regeneration via inhibition of the nuclear factor kappa-B signaling pathway,thereby promoting recovery from spinal cord injury.Collectively,our results indicate that this new hydrogel may improve the prognosis of spinal cord injury,and may represent a new strategy for treating spinal cord injury.展开更多
基金“Clinical Research on Chronic Disease Screening and Therapeutic Guidance for Elderly People Over 60 Years Old”Kunming Science and Technology Plan Project(Project No.:2017-1-S-15382)。
文摘Objective:As the prevalence of chronic diseases among the elderly increases year by year,chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world.Methods:This article conducted a retrospective analysis of 1856 elderly people over 65 years old,with a follow-up time of 6 years.The aim is to compare the decline in estimated glomerular filtration rate(EGFR)between hypertensive and non-hypertensive populations under non-intervention conditions,and to explore the impact of blood pressure on EGFR in the elderly.Results:The incidence of hypertension among the elderly in this region is significantly higher than the national level.The EGFR value of hypertensive patients is significantly lower than that of non-hypertensive people.There is a difference in the percentage decline in EGFR between hypertensive and non-hypertensive populations under non-intervention conditions,with hypertensive patients experiencing a higher rate of EGFR decline.When blood pressure is lower than 120/80 mmHg,the EGFR decline ratio is lower compared to when blood pressure is higher than 120/80 mmHg.Conclusion:Lowering blood pressure can effectively slow down the decline of EGFR,and the prevalence of hypertension should be reduced.
基金Guangxi Science and Technology Base and Talent Special Project,No.GuiKeAD24010037(to SZ)Guangxi Health Commission Self-Funded Research Project,No.Z-A20241029(to YL).
文摘Rat nerve growth factor and total flavonoids from hawthorn leaf contribute to the recovery of neurological function after spinal cord injury,including traumatic,non-traumatic spinal cord injuries.However,it remains challenging to efficiently deliver nerve growth factor and total flavonoids from hawthorn leaf to spinal cord injury sites,ensure their sustained release,and minimize further damage.In the present study,we chose a biocompatible and biodegradable gelatin as the substrate,which was crosslinked with the natural biological crosslinker genipin to form a gelatin-genipin hydrogel carrier for the slow release of nerve growth factor and total flavonoids from hawthorn leaf in spinal cord injury sites.The prepared gelatin-genipin hydrogel had good injectable properties and photothermal effects.Furthermore,when the hydrogel with 2%genipin,200 ng/mL nerve growth factor,and 320μg/mL total flavonoids from hawthorn leaf was combined with near infrared irradiation,there was a slow release of total flavonoids from hawthorn leaf and nerve growth factor,reduced oxidative stress,an improved inflammatory microenvironment,and accelerated angiogenesis and axonal regeneration via inhibition of the nuclear factor kappa-B signaling pathway,thereby promoting recovery from spinal cord injury.Collectively,our results indicate that this new hydrogel may improve the prognosis of spinal cord injury,and may represent a new strategy for treating spinal cord injury.
