Helicobacter pylori(H.pylori)infection remains a pivotal driver of chronic gastritis,peptic ulcer,gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer,yet its eradication is increasingly frustrated by...Helicobacter pylori(H.pylori)infection remains a pivotal driver of chronic gastritis,peptic ulcer,gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer,yet its eradication is increasingly frustrated by climbing antibiotic resistance and intolerable side-effects of standard triple or quadruple therapies.In recent years,fecal microbiota transplantation(FMT),a strategy that reconstructs the gut ecosystem by introducing a healthy donor microbiome,has emerged as a novel adjunct or alternative.By competitively excluding H.pylori,reinforcing mucosal barrier integrity,modulating host immunity and secreting bacteriocins,FMT can raise eradication rates,relieve dyspeptic symptoms and lower recurrence.This review synthesizes up-to-date pre-clinical,pilot and controlled clinical data,dissects underlying mechanisms,compares delivery routes,donor screening protocols and safety profiles,and discusses regulatory,ethical and standardization hurdles that must be overcome before large-scale clinical application.展开更多
This study proposes a green electrochemical strategy for addressing the high-energy-barrier oxygen evolution reaction(OER)in traditional overall water splitting.Leveraging the thermodynamic advantages of N–H bond act...This study proposes a green electrochemical strategy for addressing the high-energy-barrier oxygen evolution reaction(OER)in traditional overall water splitting.Leveraging the thermodynamic advantages of N–H bond activation/cleavage and N–N coupling processes,the 3,5-diamino-1,2,4-triazole(DAT)oxidative coupling reaction(DATOR)has been introduced to replace the high-energy-barrier oxygen evolution reaction(OER).This substitution enables low-energy-consumption hydrogen production while simultaneously yielding high-value azo energetic materials.Furthermore,to enhance electron and atom economy,the anodic DATOR process allows the hydrogen radicals(H^(*))generated from amine dehydrogenation to chemically combine via the Tafel process,producing hydrogen gas.By constructing coupling system with Pts,n@NiS_(2)@CC cathode and Cu O/CF anode,the operating voltage of the system was significantly reduced(0.96 V@10 m A cm^(-2)),which was 680 mV more energy efficient than conventional water electrolysis(1.64 V).In situ spectroscopy and theoretical calculations indicate that the anode DATOR generates DAAT through the N–H bond cleavage and N–N coupling path mediated by hydroxyl radicals(OH*),while releasing hydrogen gas.The coupling system has been operating stably for more than 300 h at an industrial-grade current density.This research provides new ideas for dual-electrode hydrogen production and green electrosynthesis of functional materials,with significant energy and economic benefits.展开更多
The random distribution of one-dimensional nanofillers in composite polymer electrolytes(CPEs) typically results in tortuous ion transport pathways,severely limiting ionic conductivity and Li^(+) flux uniformity.Herei...The random distribution of one-dimensional nanofillers in composite polymer electrolytes(CPEs) typically results in tortuous ion transport pathways,severely limiting ionic conductivity and Li^(+) flux uniformity.Herein,an innovative electric field-assisted strategy is proposed to construct vertically aligned ion channels in CPEs using lithiated halloysite nano tubes(HNTs-SO_(3)Li)embedded within a polyurethane acrylate/polyethylene glycol diacrylate(PUA/PEGDA) matrix.Under an alternating electric field,the nanotubes orient perpendicularly,forming continuous,low-tortuosity pathways that significantly enhance roomtemperature ionic conductivity.The aligned structure not only shortens Li+transport distances but also homogenizes ion flux at the electrode interface,effectively suppressing lithium dendrite growth.Electrochemical characterization reveals exceptional stability.Three-dimensional structural reconstruction and ion transport simulations further demonstrate that the ordered channels promote uniform Li+distribution and faster ion kinetics compared to disordered systems.This study provides a scalable and efficient approach to designing high-performance CPEs for next-generation solid-state batteries,addressing critical challenges in ionic conductivity,interfacial stability,and dendrite suppression.展开更多
Objective:To explore the mechanism of the Peiyuan Jieyu formula in treating depression by assessing its impact on a lipopolysaccharide-induced(LPS-induced)depression mouse model.Methods:We created a mouse model of dep...Objective:To explore the mechanism of the Peiyuan Jieyu formula in treating depression by assessing its impact on a lipopolysaccharide-induced(LPS-induced)depression mouse model.Methods:We created a mouse model of depression by exposing mice that had previously received chronic stress to intraperitoneal LPS injections.The mice were divided into the following groups:control,model,fluoxetine,Tiansi Yin,Sini powder,and low-,medium-,and high-dose Peiyuan Jieyu formula groups.Forced swim and tail suspension tests were used to assess the efficacy of the depression(despair)model,and weight gain rates were also measured.Furthermore,serum levels of various depression and inflammation-associated molecules,including tumor necrosis factor-a(TNF-a),interferon-γ(IFN-γ),tryptophan,5-hydroxytryptamine,kynurenine(KYN),and kynurenic acid(KA)were assessed.Furthermore,the expression levels of ionic calcium-binding adaptor molecule-1(IBA-1)and indoleamine 2,3-dioxygenase(IDO)mRNA in hippocampal microglia were measured.Results:The model group displayed greater despair-associated immobility,which was shortened in response to various doses of Peiyuan Jieyu formula.Furthermore,formula administration significantly reduced serum TNF-a levels and hippocampal IDO mRNA expression.The high formula dose also reduced IFN-γand IBA-1 levels,the latter was also decreased in response to the medium formula dose.However,the low formula dose reduced serum KYN level and KYN/tryptophan(TRP)and KYN/KA ratios.Conclusion:The Peiyuan Jieyu formula holds immense potential in treating depression in a mouse model,potentially inhibiting inflammation and improving TRP-KYN metabolic disorders.展开更多
Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent years.Herein,taking advantage of the“lignin f...Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent years.Herein,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps process.The key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene glycol.The utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling up.In the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.展开更多
In the context of power generation companies, vast amounts of specialized data and expert knowledge have been accumulated. However, challenges such as data silos and fragmented knowledge hinder the effective utilizati...In the context of power generation companies, vast amounts of specialized data and expert knowledge have been accumulated. However, challenges such as data silos and fragmented knowledge hinder the effective utilization of this information. This study proposes a novel framework for intelligent Question-and-Answer (Q&A) systems based on Retrieval-Augmented Generation (RAG) to address these issues. The system efficiently acquires domain-specific knowledge by leveraging external databases, including Relational Databases (RDBs) and graph databases, without additional fine-tuning for Large Language Models (LLMs). Crucially, the framework integrates a Dynamic Knowledge Base Updating Mechanism (DKBUM) and a Weighted Context-Aware Similarity (WCAS) method to enhance retrieval accuracy and mitigate inherent limitations of LLMs, such as hallucinations and lack of specialization. Additionally, the proposed DKBUM dynamically adjusts knowledge weights within the database, ensuring that the most recent and relevant information is utilized, while WCAS refines the alignment between queries and knowledge items by enhanced context understanding. Experimental validation demonstrates that the system can generate timely, accurate, and context-sensitive responses, making it a robust solution for managing complex business logic in specialized industries.展开更多
Objective Emerging evidence suggests that exposure to ultrafine particulate matter(UPM,aerodynamic diameter<0.1μm)is associated with adverse cardiovascular events.Previous studies have found that Shenlian(SL)extra...Objective Emerging evidence suggests that exposure to ultrafine particulate matter(UPM,aerodynamic diameter<0.1μm)is associated with adverse cardiovascular events.Previous studies have found that Shenlian(SL)extract possesses anti-inflammatory and antiapoptotic properties and has a promising protective effect at all stages of the atherosclerotic disease process.In this study,we aimed to investigated whether SL improves UPM-aggravated myocardial ischemic injury by inhibiting inflammation and cell apoptosis.Methods We established a mouse model of MI+UPM.Echocardiographic measurement,measurement of myocardialinfarct size,biochemical analysis,enzyme-linked immunosorbent assay(ELISA),histopathological analysis,Transferase dUTP Nick End Labeling(TUNEL),Western blotting(WB),Polymerase Chain Reaction(PCR)and so on were used to explore the anti-inflammatory and antiapoptotic effects of SL in vivo and in vitro.Results SL treatment can attenuate UPM-induced cardiac dysfunction by improving left ventricular ejection fraction,fractional shortening,and decreasing cardiac infarction area.SL significantly reduced the levels of myocardial enzymes and attenuated UPM-induced morphological alterations.Moreover,SL significantly reduced expression levels of the inflammatory cytokines IL-6,TNF-α,and MCP-1.UPM further increased the infiltration of macrophages in myocardial tissue,whereas SL intervention reversed this phenomenon.UPM also triggered myocardial apoptosis,which was markedly attenuated by SL treatment.The results of in vitro experiments revealed that SL prevented cell damage caused by exposure to UPM combined with hypoxia by reducing the expression of the inflammatory factor NF-κB and inhibiting apoptosis in H9c2 cells.Conclusion Overall,both in vivo and in vitro experiments demonstrated that SL attenuated UPMaggravated myocardial ischemic injury by inhibiting inflammation and cell apoptosis.The mechanisms were related to the downregulation of macrophages infiltrating heart tissues.展开更多
The authors regret to report some missing information in the synthetic reagents and associated changes of the paper.On page 511,the author information reads:“5.0 mmol of citric acid(C_(6)H_(8)O_(7)),5.0 mmol of ferri...The authors regret to report some missing information in the synthetic reagents and associated changes of the paper.On page 511,the author information reads:“5.0 mmol of citric acid(C_(6)H_(8)O_(7)),5.0 mmol of ferric chloride hexahydrate(FeCl_(3)·6H_(2)O),and 10.0 mmol of o-phenylenediamine(C_(6)H_(8)N_(2))were combined with 40 mL of deionized water and magnetically stirred until fully dissolved.”展开更多
Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growin...Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growing observation demands.The observation Scheduling Problem in the MEOS constellation(MEOSSP)is a challenging issue due to the large number of satellites and tasks,as well as complex observation constraints.To address the large-scale and complicated MEOSSP,we develop a Two-Stage Scheduling Algorithm based on the Pointer Network with Attention mechanism(TSSA-PNA).In TSSA-PNA,the MEOS observation scheduling is decomposed into a task allocation stage and a single-MEOS scheduling stage.In the task allocation stage,an adaptive task allocation algorithm with four problem-specific allocation operators is proposed to reallocate the unscheduled tasks to new MEOSs.Regarding the single-MEOS scheduling stage,we design a pointer network based on the encoder-decoder architecture to learn the optimal singleMEOS scheduling solution and introduce the attention mechanism into the encoder to improve the learning efficiency.The Pointer Network with Attention mechanism(PNA)can generate the single-MEOS scheduling solution quickly in an end-to-end manner.These two decomposed stages are performed iteratively to search for the solution with high profit.A greedy local search algorithm is developed to improve the profits further.The performance of the PNA and TSSA-PNA on singleMEOS and multi-MEOS scheduling problems are evaluated in the experiments.The experimental results demonstrate that PNA can obtain the approximate solution for the single-MEOS scheduling problem in a short time.Besides,the TSSA-PNA can achieve higher observation profits than the existing scheduling algorithms within the acceptable computational time for the large-scale MEOS scheduling problem.展开更多
Lithium-selenium(Li-Se)batteries have attracted increasing attention as one of the next-generation battery systems due to much higher electronic conductivity and comparable volumetric capacity of Se compared to the po...Lithium-selenium(Li-Se)batteries have attracted increasing attention as one of the next-generation battery systems due to much higher electronic conductivity and comparable volumetric capacity of Se compared to the popular sulfur cathode.However,its practical application still faces great challenges,especially the rapid capacity decay triggered by the loss of active Se species.A comprehensive review to uncover the in-depth failure mechanism and provide targeted solutions to promote the stable operation of Li-Se batteries is urgently needed.This review systematically summarizes the strategies in the new perspective,focusing on the optimization of Se utilization in Li-Se batteries by keeping a high Se maintenance in the cathode and accelerating the electrochemical kinetics of lithium polyselenides(LiPSe)conversion.On the basis of stru ctural design and Li_(2)Se active material introduction to accommodate volume expansion,blocking s huttle transport of LiPSe by physical/chemical adsorption,bonding Se with polymers or cathode electrolyte interphase(CEI)construction,and catalytic design to accelerate the conversion of LiPSe,different strategies for improving the utilization of Se have been evaluated and discussed.To address the inevitable loss of Se,prospects on inactive Se reactivation and Li protection are detailedly proposed and analyzed referring to the chemistry and corrosion science.Additionally,the perspectives on the future design and comprehensive parameter evaluations for the optimization of Li-Se batteries are recommended.This review comprehensively explains the causes and solutions of capacity fading and provides potential efforts for lifespan expansion of batteries,shedding light on the future development of Li-Se batteries.展开更多
Transition-metal perovskite oxides,ABO_(3±δ),are promising alternatives to precious metal catalysts for water splitting due to their tunable structures and defect engineering potential.However,polycrystalline pe...Transition-metal perovskite oxides,ABO_(3±δ),are promising alternatives to precious metal catalysts for water splitting due to their tunable structures and defect engineering potential.However,polycrystalline perovskites often show variations in composition and surface structure,complicating the identification of their underlying structure-activity relationship.In this work,we propose a surface ion-exchange strategy that finely tunes anionic and cationic defects on the surface of single-crystal BaNiO_(3),while maintaining its bulk structure and introducing surface Ni-Fe pairs.Through in situ characterization,we reveal that surface defects and Ni-Fe pairs enhance OH^(-)adsorption at both oxygen vacancies and Ni/Fe sites,facilitating a synergistic adsorbate evolution mechanism and lattice oxygen mechanism.Notably,the unique surface structure enables the faster deprotonation of intermediates and oxygen evolution reaction(OER).Thanks to the optimized surface configuration and OER mechanism,the catalyst shows excellent water oxidation performance in both rotating disk electrode and membrane electrode assembly tests.展开更多
Silicon(Si)has gained popularity as a potential anodic material for Li-ion batteries(LIBs)due to its large theoretical capacity.However,low conductivity,large volume expansion,and side reactions during alloying and de...Silicon(Si)has gained popularity as a potential anodic material for Li-ion batteries(LIBs)due to its large theoretical capacity.However,low conductivity,large volume expansion,and side reactions during alloying and de-alloying lead to poor cyclic and bad high-rate performance,which has severely hindered its practical large-scale application.Herein,a novel stamen-structured Si-based anode material with a protective SiO_(x)layer and dual carbon layers(Si@SiO_(x)/C@C)is designed for high-performance LIBs.The protective SiO_(x)layer reduces side reactions and dual carbon layers enhance charge transport to improve reaction kinetics,while the unique structure provides buffering space for volume expansion.Such Si@SiO_(x)/C@C anode demonstrates impressive Li storage properties for a half-battery,including a discharge capacity of 2935 mA h g^(-1)at a current density 0.1 A g^(-1),cyclic performance(814 mA h g^(-1)at 2 A g^(-1)over 500 cycles and 988 mA h g^(-1)over 200 cycles at 1 A g^(-1))and a rate performance(609 mA h g^(-1)at 5 A g^(-1)).It also maintains a high reversible capacity of 131 mA h g^(-1)at 0.25 C after100 cycles for a full battery.This work provides insights into the novel design of multiple protective layers on Si-based anode materials for fast-charging and highly stable LIBs.展开更多
基金the 2026 Health Commission Fund of Guizhou Province,China.the freestatistics suite for its technical support.
文摘Helicobacter pylori(H.pylori)infection remains a pivotal driver of chronic gastritis,peptic ulcer,gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer,yet its eradication is increasingly frustrated by climbing antibiotic resistance and intolerable side-effects of standard triple or quadruple therapies.In recent years,fecal microbiota transplantation(FMT),a strategy that reconstructs the gut ecosystem by introducing a healthy donor microbiome,has emerged as a novel adjunct or alternative.By competitively excluding H.pylori,reinforcing mucosal barrier integrity,modulating host immunity and secreting bacteriocins,FMT can raise eradication rates,relieve dyspeptic symptoms and lower recurrence.This review synthesizes up-to-date pre-clinical,pilot and controlled clinical data,dissects underlying mechanisms,compares delivery routes,donor screening protocols and safety profiles,and discusses regulatory,ethical and standardization hurdles that must be overcome before large-scale clinical application.
基金support from the National Natural Science Foundation of China(22473089,22573079)Shaanxi Key Research and Development Project(2024GX-YBXM-452)+3 种基金the Postdoctoral Research Project of Shaanxi(2023BSHYDZZ137)the Young Elite Scientists Sponsorship Program by Xi’an Association for Science and Technology(959202313084)the Scientific Research Program Funded by Education Department of Shaanxi Provincial Government(24JS050)the Zhijian Laboratory Program(2024-ZJSYS-KF02-03)。
文摘This study proposes a green electrochemical strategy for addressing the high-energy-barrier oxygen evolution reaction(OER)in traditional overall water splitting.Leveraging the thermodynamic advantages of N–H bond activation/cleavage and N–N coupling processes,the 3,5-diamino-1,2,4-triazole(DAT)oxidative coupling reaction(DATOR)has been introduced to replace the high-energy-barrier oxygen evolution reaction(OER).This substitution enables low-energy-consumption hydrogen production while simultaneously yielding high-value azo energetic materials.Furthermore,to enhance electron and atom economy,the anodic DATOR process allows the hydrogen radicals(H^(*))generated from amine dehydrogenation to chemically combine via the Tafel process,producing hydrogen gas.By constructing coupling system with Pts,n@NiS_(2)@CC cathode and Cu O/CF anode,the operating voltage of the system was significantly reduced(0.96 V@10 m A cm^(-2)),which was 680 mV more energy efficient than conventional water electrolysis(1.64 V).In situ spectroscopy and theoretical calculations indicate that the anode DATOR generates DAAT through the N–H bond cleavage and N–N coupling path mediated by hydroxyl radicals(OH*),while releasing hydrogen gas.The coupling system has been operating stably for more than 300 h at an industrial-grade current density.This research provides new ideas for dual-electrode hydrogen production and green electrosynthesis of functional materials,with significant energy and economic benefits.
基金the Program of National Key Research and Development of China (No.2022YFB3603702, No. 2023YFC3905301)Hubei Provincial Natural Science Foundation of China (No. 2025AFA025)the Research Fund of Jianghan University (No. 2023KJZX01)。
文摘The random distribution of one-dimensional nanofillers in composite polymer electrolytes(CPEs) typically results in tortuous ion transport pathways,severely limiting ionic conductivity and Li^(+) flux uniformity.Herein,an innovative electric field-assisted strategy is proposed to construct vertically aligned ion channels in CPEs using lithiated halloysite nano tubes(HNTs-SO_(3)Li)embedded within a polyurethane acrylate/polyethylene glycol diacrylate(PUA/PEGDA) matrix.Under an alternating electric field,the nanotubes orient perpendicularly,forming continuous,low-tortuosity pathways that significantly enhance roomtemperature ionic conductivity.The aligned structure not only shortens Li+transport distances but also homogenizes ion flux at the electrode interface,effectively suppressing lithium dendrite growth.Electrochemical characterization reveals exceptional stability.Three-dimensional structural reconstruction and ion transport simulations further demonstrate that the ordered channels promote uniform Li+distribution and faster ion kinetics compared to disordered systems.This study provides a scalable and efficient approach to designing high-performance CPEs for next-generation solid-state batteries,addressing critical challenges in ionic conductivity,interfacial stability,and dendrite suppression.
基金supported by the National Natural Science Foundation of China(81373584)。
文摘Objective:To explore the mechanism of the Peiyuan Jieyu formula in treating depression by assessing its impact on a lipopolysaccharide-induced(LPS-induced)depression mouse model.Methods:We created a mouse model of depression by exposing mice that had previously received chronic stress to intraperitoneal LPS injections.The mice were divided into the following groups:control,model,fluoxetine,Tiansi Yin,Sini powder,and low-,medium-,and high-dose Peiyuan Jieyu formula groups.Forced swim and tail suspension tests were used to assess the efficacy of the depression(despair)model,and weight gain rates were also measured.Furthermore,serum levels of various depression and inflammation-associated molecules,including tumor necrosis factor-a(TNF-a),interferon-γ(IFN-γ),tryptophan,5-hydroxytryptamine,kynurenine(KYN),and kynurenic acid(KA)were assessed.Furthermore,the expression levels of ionic calcium-binding adaptor molecule-1(IBA-1)and indoleamine 2,3-dioxygenase(IDO)mRNA in hippocampal microglia were measured.Results:The model group displayed greater despair-associated immobility,which was shortened in response to various doses of Peiyuan Jieyu formula.Furthermore,formula administration significantly reduced serum TNF-a levels and hippocampal IDO mRNA expression.The high formula dose also reduced IFN-γand IBA-1 levels,the latter was also decreased in response to the medium formula dose.However,the low formula dose reduced serum KYN level and KYN/tryptophan(TRP)and KYN/KA ratios.Conclusion:The Peiyuan Jieyu formula holds immense potential in treating depression in a mouse model,potentially inhibiting inflammation and improving TRP-KYN metabolic disorders.
基金supported by the Fundamental Research Funds for the Central Universities(QNTD202302)National Natural Science Foundation of China(22378024)the Foreign expert program(G2022109001L).
文摘Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent years.Herein,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps process.The key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene glycol.The utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling up.In the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.
文摘In the context of power generation companies, vast amounts of specialized data and expert knowledge have been accumulated. However, challenges such as data silos and fragmented knowledge hinder the effective utilization of this information. This study proposes a novel framework for intelligent Question-and-Answer (Q&A) systems based on Retrieval-Augmented Generation (RAG) to address these issues. The system efficiently acquires domain-specific knowledge by leveraging external databases, including Relational Databases (RDBs) and graph databases, without additional fine-tuning for Large Language Models (LLMs). Crucially, the framework integrates a Dynamic Knowledge Base Updating Mechanism (DKBUM) and a Weighted Context-Aware Similarity (WCAS) method to enhance retrieval accuracy and mitigate inherent limitations of LLMs, such as hallucinations and lack of specialization. Additionally, the proposed DKBUM dynamically adjusts knowledge weights within the database, ensuring that the most recent and relevant information is utilized, while WCAS refines the alignment between queries and knowledge items by enhanced context understanding. Experimental validation demonstrates that the system can generate timely, accurate, and context-sensitive responses, making it a robust solution for managing complex business logic in specialized industries.
基金supported by CACMS Innovation Fund(No CI2021A04611,CI2021A05106)Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2021B015)+1 种基金Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2023E001TS01)Fundamental research funds for the central public welfare research institutes(L2022035).
文摘Objective Emerging evidence suggests that exposure to ultrafine particulate matter(UPM,aerodynamic diameter<0.1μm)is associated with adverse cardiovascular events.Previous studies have found that Shenlian(SL)extract possesses anti-inflammatory and antiapoptotic properties and has a promising protective effect at all stages of the atherosclerotic disease process.In this study,we aimed to investigated whether SL improves UPM-aggravated myocardial ischemic injury by inhibiting inflammation and cell apoptosis.Methods We established a mouse model of MI+UPM.Echocardiographic measurement,measurement of myocardialinfarct size,biochemical analysis,enzyme-linked immunosorbent assay(ELISA),histopathological analysis,Transferase dUTP Nick End Labeling(TUNEL),Western blotting(WB),Polymerase Chain Reaction(PCR)and so on were used to explore the anti-inflammatory and antiapoptotic effects of SL in vivo and in vitro.Results SL treatment can attenuate UPM-induced cardiac dysfunction by improving left ventricular ejection fraction,fractional shortening,and decreasing cardiac infarction area.SL significantly reduced the levels of myocardial enzymes and attenuated UPM-induced morphological alterations.Moreover,SL significantly reduced expression levels of the inflammatory cytokines IL-6,TNF-α,and MCP-1.UPM further increased the infiltration of macrophages in myocardial tissue,whereas SL intervention reversed this phenomenon.UPM also triggered myocardial apoptosis,which was markedly attenuated by SL treatment.The results of in vitro experiments revealed that SL prevented cell damage caused by exposure to UPM combined with hypoxia by reducing the expression of the inflammatory factor NF-κB and inhibiting apoptosis in H9c2 cells.Conclusion Overall,both in vivo and in vitro experiments demonstrated that SL attenuated UPMaggravated myocardial ischemic injury by inhibiting inflammation and cell apoptosis.The mechanisms were related to the downregulation of macrophages infiltrating heart tissues.
文摘The authors regret to report some missing information in the synthetic reagents and associated changes of the paper.On page 511,the author information reads:“5.0 mmol of citric acid(C_(6)H_(8)O_(7)),5.0 mmol of ferric chloride hexahydrate(FeCl_(3)·6H_(2)O),and 10.0 mmol of o-phenylenediamine(C_(6)H_(8)N_(2))were combined with 40 mL of deionized water and magnetically stirred until fully dissolved.”
基金supported by the National Natural Science Foundation of China(No.62101587)the National Funded Postdoctoral Researcher Program of China(No.GZC20233578)。
文摘Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growing observation demands.The observation Scheduling Problem in the MEOS constellation(MEOSSP)is a challenging issue due to the large number of satellites and tasks,as well as complex observation constraints.To address the large-scale and complicated MEOSSP,we develop a Two-Stage Scheduling Algorithm based on the Pointer Network with Attention mechanism(TSSA-PNA).In TSSA-PNA,the MEOS observation scheduling is decomposed into a task allocation stage and a single-MEOS scheduling stage.In the task allocation stage,an adaptive task allocation algorithm with four problem-specific allocation operators is proposed to reallocate the unscheduled tasks to new MEOSs.Regarding the single-MEOS scheduling stage,we design a pointer network based on the encoder-decoder architecture to learn the optimal singleMEOS scheduling solution and introduce the attention mechanism into the encoder to improve the learning efficiency.The Pointer Network with Attention mechanism(PNA)can generate the single-MEOS scheduling solution quickly in an end-to-end manner.These two decomposed stages are performed iteratively to search for the solution with high profit.A greedy local search algorithm is developed to improve the profits further.The performance of the PNA and TSSA-PNA on singleMEOS and multi-MEOS scheduling problems are evaluated in the experiments.The experimental results demonstrate that PNA can obtain the approximate solution for the single-MEOS scheduling problem in a short time.Besides,the TSSA-PNA can achieve higher observation profits than the existing scheduling algorithms within the acceptable computational time for the large-scale MEOS scheduling problem.
基金supported by the China Scholarship Council(No.201809370046)a scholarship from the Laboratory of Inorganic Materials Chemistry,Universitéde Namur+5 种基金the National Key R&D Program of China(2016YFA0202602)the National Natural Science Foundation of China(No.U1663225,22293020,22293022 and 52103342)the Program of Introducing Talents of Discipline to Universities-Plan 111(Grant No.B20002)from the Ministry of Science and Technologythe Program for Changjiang Scholars and Innovative Research Team in University(IRT_15R52)of the Chinese Ministry of EducationBelgium-China Governmental Key Cooperation Program WBI-MOST(SUB/2021/IND493971/524448)the“Plan of relance”Wallonia Government(2310153-Bat Factory)。
文摘Lithium-selenium(Li-Se)batteries have attracted increasing attention as one of the next-generation battery systems due to much higher electronic conductivity and comparable volumetric capacity of Se compared to the popular sulfur cathode.However,its practical application still faces great challenges,especially the rapid capacity decay triggered by the loss of active Se species.A comprehensive review to uncover the in-depth failure mechanism and provide targeted solutions to promote the stable operation of Li-Se batteries is urgently needed.This review systematically summarizes the strategies in the new perspective,focusing on the optimization of Se utilization in Li-Se batteries by keeping a high Se maintenance in the cathode and accelerating the electrochemical kinetics of lithium polyselenides(LiPSe)conversion.On the basis of stru ctural design and Li_(2)Se active material introduction to accommodate volume expansion,blocking s huttle transport of LiPSe by physical/chemical adsorption,bonding Se with polymers or cathode electrolyte interphase(CEI)construction,and catalytic design to accelerate the conversion of LiPSe,different strategies for improving the utilization of Se have been evaluated and discussed.To address the inevitable loss of Se,prospects on inactive Se reactivation and Li protection are detailedly proposed and analyzed referring to the chemistry and corrosion science.Additionally,the perspectives on the future design and comprehensive parameter evaluations for the optimization of Li-Se batteries are recommended.This review comprehensively explains the causes and solutions of capacity fading and provides potential efforts for lifespan expansion of batteries,shedding light on the future development of Li-Se batteries.
基金supported by the National Natural Science Foundation of China(No.22278203)the Program for Jiangsu SpeciallyAppointed Professors(R2023T05)+1 种基金the Startup Foundation for Introducing Talent of NUIST(2024R078)the Natural Science Foundation of Jiangsu Province(BK20240707)。
文摘Transition-metal perovskite oxides,ABO_(3±δ),are promising alternatives to precious metal catalysts for water splitting due to their tunable structures and defect engineering potential.However,polycrystalline perovskites often show variations in composition and surface structure,complicating the identification of their underlying structure-activity relationship.In this work,we propose a surface ion-exchange strategy that finely tunes anionic and cationic defects on the surface of single-crystal BaNiO_(3),while maintaining its bulk structure and introducing surface Ni-Fe pairs.Through in situ characterization,we reveal that surface defects and Ni-Fe pairs enhance OH^(-)adsorption at both oxygen vacancies and Ni/Fe sites,facilitating a synergistic adsorbate evolution mechanism and lattice oxygen mechanism.Notably,the unique surface structure enables the faster deprotonation of intermediates and oxygen evolution reaction(OER).Thanks to the optimized surface configuration and OER mechanism,the catalyst shows excellent water oxidation performance in both rotating disk electrode and membrane electrode assembly tests.
基金supported by the National Key R&D Program of China(2021YFE0115800)the National Natural Science Foundation of China(22275142,22293022,U22B6011,52103285)+1 种基金the 111 National Project(Grant No.B20002)the Fundamental Research Funds for the Central Universities(2020-YB-005)。
文摘Silicon(Si)has gained popularity as a potential anodic material for Li-ion batteries(LIBs)due to its large theoretical capacity.However,low conductivity,large volume expansion,and side reactions during alloying and de-alloying lead to poor cyclic and bad high-rate performance,which has severely hindered its practical large-scale application.Herein,a novel stamen-structured Si-based anode material with a protective SiO_(x)layer and dual carbon layers(Si@SiO_(x)/C@C)is designed for high-performance LIBs.The protective SiO_(x)layer reduces side reactions and dual carbon layers enhance charge transport to improve reaction kinetics,while the unique structure provides buffering space for volume expansion.Such Si@SiO_(x)/C@C anode demonstrates impressive Li storage properties for a half-battery,including a discharge capacity of 2935 mA h g^(-1)at a current density 0.1 A g^(-1),cyclic performance(814 mA h g^(-1)at 2 A g^(-1)over 500 cycles and 988 mA h g^(-1)over 200 cycles at 1 A g^(-1))and a rate performance(609 mA h g^(-1)at 5 A g^(-1)).It also maintains a high reversible capacity of 131 mA h g^(-1)at 0.25 C after100 cycles for a full battery.This work provides insights into the novel design of multiple protective layers on Si-based anode materials for fast-charging and highly stable LIBs.
