A simple and highly sensitive method for the determination of triamcinolone acetonide in pharmaceutical formulations is presented.The approach is based on the fluorescence of production of triamcinolone acetonide oxid...A simple and highly sensitive method for the determination of triamcinolone acetonide in pharmaceutical formulations is presented.The approach is based on the fluorescence of production of triamcinolone acetonide oxidized by concentrated sulfuric acid.The effect of H2SO4,β-cyclodextrin(β-CD),solvent and cetyltrimethylammonium bromide(CTMAB)were discussed.And two analytical systems were established.One is CTMAB system,the linear range is 0–4.6×10^(-6)mol/L,and the detection limit is 3.59×10^(-8)mol/L.The other isβ-CD and ethanol system,the linear range is 0–2.3×10^(-6)mol/L and the detection limit is 1.91×10^(-8)mol/L.The selectivity of analysis,the analytical figures of optimization,and the accuracy of the method are demonstrated with the determination of triamcinolone acetonide in pharmaceutical preparations.展开更多
基金Supported by the National Natural Science Foun-dation of China(20275028)
文摘A simple and highly sensitive method for the determination of triamcinolone acetonide in pharmaceutical formulations is presented.The approach is based on the fluorescence of production of triamcinolone acetonide oxidized by concentrated sulfuric acid.The effect of H2SO4,β-cyclodextrin(β-CD),solvent and cetyltrimethylammonium bromide(CTMAB)were discussed.And two analytical systems were established.One is CTMAB system,the linear range is 0–4.6×10^(-6)mol/L,and the detection limit is 3.59×10^(-8)mol/L.The other isβ-CD and ethanol system,the linear range is 0–2.3×10^(-6)mol/L and the detection limit is 1.91×10^(-8)mol/L.The selectivity of analysis,the analytical figures of optimization,and the accuracy of the method are demonstrated with the determination of triamcinolone acetonide in pharmaceutical preparations.
