目的:探究C反应蛋白/白蛋白比率(C-reactive protein to albumin ratio,CAR)在接受动脉化疗栓塞术和射频消融术肝癌患者中的预后评估价值。方法:回顾性分析接受动脉化疗栓塞术和射频消融术治疗的98例肝癌患者的临床预后资料。基线CAR值...目的:探究C反应蛋白/白蛋白比率(C-reactive protein to albumin ratio,CAR)在接受动脉化疗栓塞术和射频消融术肝癌患者中的预后评估价值。方法:回顾性分析接受动脉化疗栓塞术和射频消融术治疗的98例肝癌患者的临床预后资料。基线CAR值定义为治疗前基线水平的C反应蛋白水平/白蛋白水平,并利用受试者工作特征曲线(receiver operating characteristic,ROC)确定CAR的最佳临界值。根据临界值将患者分为CAR低和高2组,分析基线CAR水平与患者临床病理因素及预后的关系。结果:ROC曲线分析表明,CAR的最佳临界值为0.125(特异性:63.64%,灵敏度:72.41%,P=0.027)。临床病理相关性分析显示,高基线CAR水平与肿瘤直径、肿瘤数目、Child-Pugh分级及肝硬化显著正相关(均P<0.05)。Kaplan-Meier生存分析表明,与低基线CAR水平患者相比,高基线CAR水平患者的中位总生存期(overall survival,OS)显著缩短(24个月vs13个月,P=0.002)。单因素分析结果提示,肿瘤直径、Child-Pugh分级、肝硬化、门静脉癌栓和CAR水平与患者的OS相关(均P<0.05);进一步的Cox多因素结果证实,CAR(HR:2.411,95%CI:1.126~5.163,P=0.024)是影响接受动脉化疗栓塞术和射频消融术肝癌患者OS的独立因素。结论:CAR可有效预测接受动脉化疗栓塞术和射频消融术肝癌患者的预后,其检测方法简单且价格低廉,具有成为新的非侵入性生物标志物的潜力。展开更多
In this paper,a new spatial quadrature modulation(NSQM)scheme is proposed to improve the error performance of indoor visible light communication(VLC)systems.NSQM is different from generalized spatial quadrature modula...In this paper,a new spatial quadrature modulation(NSQM)scheme is proposed to improve the error performance of indoor visible light communication(VLC)systems.NSQM is different from generalized spatial quadrature modulation(SQM)in two aspects.First,the transmitted optical signal is directly detected at the receiver,which does not need to estimate the indices of the transmitted antenna.Second,an optimization approach is used with NSQM to minimize the upper error bound of the transmitted signals.In addition,several NSQM schemes are described in detail.Numerical results show that the proposed NSQM scheme achieves superior error performance compared with the SQM scheme.展开更多
文摘目的:探究C反应蛋白/白蛋白比率(C-reactive protein to albumin ratio,CAR)在接受动脉化疗栓塞术和射频消融术肝癌患者中的预后评估价值。方法:回顾性分析接受动脉化疗栓塞术和射频消融术治疗的98例肝癌患者的临床预后资料。基线CAR值定义为治疗前基线水平的C反应蛋白水平/白蛋白水平,并利用受试者工作特征曲线(receiver operating characteristic,ROC)确定CAR的最佳临界值。根据临界值将患者分为CAR低和高2组,分析基线CAR水平与患者临床病理因素及预后的关系。结果:ROC曲线分析表明,CAR的最佳临界值为0.125(特异性:63.64%,灵敏度:72.41%,P=0.027)。临床病理相关性分析显示,高基线CAR水平与肿瘤直径、肿瘤数目、Child-Pugh分级及肝硬化显著正相关(均P<0.05)。Kaplan-Meier生存分析表明,与低基线CAR水平患者相比,高基线CAR水平患者的中位总生存期(overall survival,OS)显著缩短(24个月vs13个月,P=0.002)。单因素分析结果提示,肿瘤直径、Child-Pugh分级、肝硬化、门静脉癌栓和CAR水平与患者的OS相关(均P<0.05);进一步的Cox多因素结果证实,CAR(HR:2.411,95%CI:1.126~5.163,P=0.024)是影响接受动脉化疗栓塞术和射频消融术肝癌患者OS的独立因素。结论:CAR可有效预测接受动脉化疗栓塞术和射频消融术肝癌患者的预后,其检测方法简单且价格低廉,具有成为新的非侵入性生物标志物的潜力。
基金supported by the National Natural Science Foundation of China(61771474)Shandong Provincial Major Scientific and Technological Innovation Project(2019JZZY020505)。
文摘In this paper,a new spatial quadrature modulation(NSQM)scheme is proposed to improve the error performance of indoor visible light communication(VLC)systems.NSQM is different from generalized spatial quadrature modulation(SQM)in two aspects.First,the transmitted optical signal is directly detected at the receiver,which does not need to estimate the indices of the transmitted antenna.Second,an optimization approach is used with NSQM to minimize the upper error bound of the transmitted signals.In addition,several NSQM schemes are described in detail.Numerical results show that the proposed NSQM scheme achieves superior error performance compared with the SQM scheme.
