Waterborne polyurethane(WPU)is attracting widespread attention in the friction field,but pure WPU cannot meet the wear resistance requirements due to poor thermal and self-lubricating properties.Herein,a novel cellulo...Waterborne polyurethane(WPU)is attracting widespread attention in the friction field,but pure WPU cannot meet the wear resistance requirements due to poor thermal and self-lubricating properties.Herein,a novel cellulose/BNNSs-AgNPs aerogel(CBAg)composed of zero-dimensional silver nanoparticles(AgNPs),onedimensional cellulose and two-dimensional boron nitride nanosheets(BNNSs)was successfully fabricated.Specifically,AgNPs were loaded onto the surface of BNNSs,which could serve as bridges to connect adjacent BNNSs.Cellulose was used to construct a 3D skeleton structure for stabilizing better dispersion of inorganic fillers.Finally,the thermal and tribological properties of CBAg-WPU were improved compared to pure WPU,with a 69%increase in thermal conductivity and an 89%reduction in wear rate.This was attributed to the load-bearing capacity of cellulose and outstanding thermal and lubricant capability of BNNSs-AgNPs.In addition,BNNSs and AgNPs inside the aerogel were transferred to the sliding interface and participated in the formation of high-quality friction transfer film,further endowing CBAg-WPU composites prominent tribological performance.Therefore,the novel design of 3D hybrid aerogels provided a promising avenue to improve the tribological performance of WPU composites.展开更多
Ischemic heart disease(IHD)is associated with high morbidity and mortality rates.Reperfusion therapy is the best treatment option for this condition.However,reperfusion can aggravate myocardial damage through a phenom...Ischemic heart disease(IHD)is associated with high morbidity and mortality rates.Reperfusion therapy is the best treatment option for this condition.However,reperfusion can aggravate myocardial damage through a phenomenon known as myocardial ischemia/reperfusion(I/R)injury,which has recently gained the attention of researchers.Several studies have shown that Chinese herbal medicines and their natural monomeric components exert therapeutic effects against I/R injury.This review outlines the current knowledge on the pathological mechanisms through which mitochondria participate in I/R injury,focusing on the issues related to energy metabolism,mitochondrial quality control disorders,oxidative stress,and calcium.The mechanisms by which mitochondria mediate cell death have also been discussed.To develop a resource for the prevention and management of clinical myocardial I/R damage,we compiled the most recent research on the effects of Chinese herbal remedies and their monomer components.展开更多
Integrated-energy systems(IESs)are key to advancing renewable-energy utilization and addressing environmental challenges.Key components of IESs include low-carbon,economic dispatch and demand response,for maximizing r...Integrated-energy systems(IESs)are key to advancing renewable-energy utilization and addressing environmental challenges.Key components of IESs include low-carbon,economic dispatch and demand response,for maximizing renewable-energy consumption and supporting sustainable-energy systems.User participation is central to demand response;however,many users are not inclined to engage actively;therefore,the full potential of demand response remains unrealized.User satisfaction must be prioritized in demand-response assessments.This study proposed a two-stage,capacity-optimization configuration method for user-level energy systems con-sidering thermal inertia and user satisfaction.This method addresses load coordination and complementary issues within the IES and seeks to minimize the annual,total cost for determining equipment capacity configurations while introducing models for system thermal inertia and user satisfaction.Indoor heating is adjusted,for optimizing device output and load profiles,with a focus on typical,daily,economic,and environmental objectives.The studyfindings indicate that the system thermal inertia optimizes energy-system scheduling considering user satisfaction.This optimization mitigates environmental concerns and enhances clean-energy integration.展开更多
On-chip devices for generating pre-designed vectorial optical fields(VOFs)under surface wave(SW)excitations are highly desired in integrated photonics.However,conventional devices are usually of large footprints,low e...On-chip devices for generating pre-designed vectorial optical fields(VOFs)under surface wave(SW)excitations are highly desired in integrated photonics.However,conventional devices are usually of large footprints,low efficiencies,and limited wave-control capabilities.Here,we present a generic approach to design ultra-compact on-chip devices that can efficiently generate pre-designed VOFs under SW excitations,and experimentally verify the concept in terahertz(THz)regime.We first describe how to design SW-excitation metasurfaces for generating circularly polarized complex beams,and experimentally demonstrate two meta-devices to realize directional emission and focusing of THz waves with oppo-site circular polarizations,respectively.We then establish a systematic approach to construct an integrated device via merging two carefully designed metasurfaces,which,under SW excitations,can separately produce pre-designed far-field patterns with different circular polarizations and generate target VOF based on their interference.As a proof of con-cept,we demonstrate experimentally a meta-device that can generate a radially polarized Bessel beam under SW excita-tion at~0.4 THz.Experimental results agree well with full-wave simulations,collectively verifying the performance of our device.Our study paves the road to realizing highly integrated on-chip functional THz devices,which may find many ap-plications in biological sensing,communications,displays,image multiplexing,and beyond.展开更多
Objective:To understand the current situation of career planning awareness and readiness of freshman medical students with a background in digital medicine,and to provide references for optimizing the medical educatio...Objective:To understand the current situation of career planning awareness and readiness of freshman medical students with a background in digital medicine,and to provide references for optimizing the medical education system and career guidance.Methods:A cross-sectional study was conducted on freshman medical students at a university in Yunnan Province using questionnaire survey.Results:A total of 272 questionnaires were distributed and 264 valid questionnaires were returned,yielding an effective response rate of 97.10%.The average score of digital medical awareness of freshman medical students was(70.50±8.81),and 63.63%of the students had a high awareness(score≧70);The average score of career planning awareness and readiness of freshman medical students was(91.76±14.87),and 60.63%of students had high awareness and readiness(score≧90).Pearson correlation analysis showed that the total score of digital medical awareness was positively correlated with the total score of career planning awareness and readiness(r=0.13,P<0.05).Conclusion:Freshman medical students’career planning awareness and readiness are generally good,but their practical application of digital medical-related skills still needs improvement.It is suggested that schools strengthen the integration of interdisciplinary curriculum,introduce digital vocational training modules,and formulate differentiated guidance strategies for different majors to enhance students’professional competitiveness in the digital medical era.展开更多
The isotope effect on zonal flows(ZFs)and turbulence remains a key issue that is not completely solved in fusion plasmas.This paper presents the first experimental results of the ab initio prediction of causal relatio...The isotope effect on zonal flows(ZFs)and turbulence remains a key issue that is not completely solved in fusion plasmas.This paper presents the first experimental results of the ab initio prediction of causal relation between geodesic acoustic mode(GAM)and ambient turbulence at different isotope masses in the edge of HL-2A tokamak,where transfer entropy method based on information-theoretical approach is utilized as a quantified indicator of causality.Analysis shows that GAM is more pronounced in deuterium plasmas than in hydrogen,leading to a lower heat transport as well as more peaked profiles in the former situation.The causal impact of GAM on conductive heat flux component is stronger than on the convective component,which is resulted from a larger causal influence of zonal flow on temperature fluctuation.While a stronger GAM in deuterium plasmas has larger influence on all flux components,the relative change in temperature fluctuation and coefficient is more obvious when the ion mass varies.These findings not only offer an in-depth understanding of the real causality between zonal flow and turbulence in the present isotope experiments,but also provide useful ways for the physical understandings of transport and zonal flow dynamics in future deuterium-tritium fusion plasmas.展开更多
Gibberellin(GA)is one of the major plant hormones that promote parthenocarpy,a highly valuable agronomic trait.Here,we demonstrated that exogenous GA3application triggered the formation of parthenocarpic fruits with s...Gibberellin(GA)is one of the major plant hormones that promote parthenocarpy,a highly valuable agronomic trait.Here,we demonstrated that exogenous GA3application triggered the formation of parthenocarpic fruits with smaller size but unchanged shape in tomato(Solanum lycopersicum).These fruits exhibited a thicker pericarp,undeveloped ovules,and few jelly tissues,leading to smaller locules with empty cavities.Histological investigation showed that GA treatment produced more cell layers with larger cells in the pericarp,suggesting its promotion in both cell division and expansion.Transcriptomic analyses between GA-3and mock-treated unpollinated ovaries/fruits identified a large number of differentially expressed genes related to hormones,cell division,cell expansion,and transcription factors,implying that they coordinately regulated parthenocarpy conferred by GA.In particular,the downregulation of five reported repressors of tomato parthenocarpy,including two auxin signaling components,AUXIN RESPONSE FACTOR5(SlARF5)and Sl ARF7,and three MADS-box genes,TOMATO APETALA3(TAP3),TOMATO PISTILLATA(TPI),and AGAMOUS-LIKE6(SlAGL6),after GA treatment might play a key role in this process.Furthermore,we found that the knockdown of a GA signaling factor SlMYB33,which was depressed by GA treatment,induced parthenocarpic fruit set in tomato,an effect that might have been achieved by enhancing GA biosynthesis and decreasing the expression of some repressors of tomato parthenocarpy.Thus,our results provide a basis for understanding the regulatory mechanism of GA in tomato parthenocarpy.展开更多
Due to their potential use in creating advanced electronic textiles for wearable technology,functional fibers have garnered enormous interests.The presence of stretchable smart fibers has significantly expanded the ap...Due to their potential use in creating advanced electronic textiles for wearable technology,functional fibers have garnered enormous interests.The presence of stretchable smart fibers has significantly expanded the application scenarios of intelligent fibers.However,preparing fibers that possess both excellent electrical performance and high stretchability remains a formidable challenge.The fabrication of stretchable multifunctional fiber-based sensors employing a scalable method is reported here.Using a thermal drawing process,the collaborative interplay between the hollow confined channels of superelastic poly(styrene-b-(ethylene-co-butylene)-b-styrene)(SEBS)thermally drawn fibers and the high fluidity of liquid metal(LM)ensures the exceptional electrical performance of the fibers.Simultaneously,the presence of a helical structure further enhances both the sensing and mechanical properties.The helical two LM channel fiber-based sensors are capable of displaying more than 1000%strain,high stability over 1000 cycles,a quick pressure response and release time of 30.45 and 45.35 ms,and outstanding electrical conductivity of 8.075×10^(5)S/m.In addition,the electrical conductivity of this fiber increases with strain level,reaching 3×10^(6)S/m when the strain is 500%.Furthermore,due to their superior tension and compression sensing capabilities,flexible helical sensors offer considerable potential for use in wearable electronics applications such as human motion detection,Morse code compilation,multichannel sensing,and more.展开更多
Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for ophthalmologists.Because nanophthalmos patients who have undergone filt...Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for ophthalmologists.Because nanophthalmos patients who have undergone filtration surgery or other intraocular procedures are more susceptible to severe complications,including choroidal effusion,malignant glaucoma,and explosive choroidal hemorrhage,all of which can lead to vision loss[1].This dilemma is particularly pronounced in patients with shorter axial lengths.Micropulse transscleral laser therapy(M-TLT),also known as micropulse transscleral cyclophotocoagulation(MP-TSCPC),is a nonincisional laser therapy surgery for glaucoma[2].In 2015,Golan and Kurtz[3]were the first to report four patients with secondary angle-closure glaucoma in nanophthalmos with axial lengths ranging between 17 and 19 mm(mean 18 mm)who were successfully treated with M-TLT,and choroidal detachment was observed in all patients(recovery spontaneously in two patients and recovery after systemic steroid treatment in the other two),of which two had a slight decrease in visual acuity.展开更多
The tight tuff reservoir is an unusual type of unconventional reservoir with strong heterogeneity.However,there is a lack of research on the microscopic pore structure that causes the heterogeneity of tuff reservoirs....The tight tuff reservoir is an unusual type of unconventional reservoir with strong heterogeneity.However,there is a lack of research on the microscopic pore structure that causes the heterogeneity of tuff reservoirs.Using the Chang 7 Formation in Ordos Basin,China as a case study,carbon-dioxide gas adsorption,nitrogen gas adsorption and high-pressure mercury injection are integrated to investigate the multi-scale pore structure characteristics of tuff reservoirs.Meanwhile,the fractal dimension is introduced to characterize the complexity of pore structure in tuff reservoirs.By this multi-experimental method,the quantitative characterizations of the full-range pore size distribution of four tuff types were obtained and compared in the size ranges of micropores,mesopores and macropores.Fractal dimension curves derived from full-range pores are divided into six segments as D1,D2,D3,D4,D5 and D6 corresponding to fractal characteristics of micropores,smaller mesopores,larger mesopores,smaller macropores,medium macropores and larger macropores,respectively.The macropore volume,average macropore radius and fractal dimension D5 significantly control petrophysical properties.The larger macropore volume,average macropore radius and D5 correspond to favorable pore structure and good reservoir quality,which provides new indexes for the tuff reservoir evaluation.This study enriches the understanding of the heterogeneity of pore structures and contributes to unconventional oil and gas exploration and development.展开更多
Cancer cell spheroids(CCS) are a valuable three-dimensional cell model in cancer studies because they could replicate numerous characteristics of solid tumors. Increasing researches have used matrix-assisted laser des...Cancer cell spheroids(CCS) are a valuable three-dimensional cell model in cancer studies because they could replicate numerous characteristics of solid tumors. Increasing researches have used matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI) to investigate the spatial distribution of endogenous compounds(e.g., lipids) in CCS. However, only limited lipid species can be detected owing to a low ion yield by using MALDI. Besides, it is still challenging to fully characterize the structural diversity of lipids due to the existence of isomeric/isobaric species. Here, we carried out the initial application of MALDI coupled with laser-postionization(MALDI-2) and trapped ion mobility spectrometry(TIMS) imaging in HCT116 colon CCS to address these challenges. We demonstrated that MALDI-2 is capable of detecting more number and classes of lipids in HCT116 colon CCS with higher signal intensities than MALDI. TIMS could successfully separate numerous isobaric/isomeric species of lipids in CCS. Interestingly, we found that some isomeric/isobaric species have totally different spatial distributions in colon CCS. Further MS/MS imaging analysis was employed to determine the compositions of fatty acid chains for isomeric species by examining disparities in signal intensities and spatial distributions of product ions. This work stresses the robust ability of TIMS and MALDI-2 imaging in analyzing endogenous lipids in CCS, which could potentially become powerful tools for future cancer studies.展开更多
Global inland surface water bodies such as lakes and reservoirs,important components of the hydrosphere and ecosphere,are increasingly affected by climate change.Generating bathymetric volume-areaheight (BVAH) curves ...Global inland surface water bodies such as lakes and reservoirs,important components of the hydrosphere and ecosphere,are increasingly affected by climate change.Generating bathymetric volume-areaheight (BVAH) curves for global inland surface water bodies can enhance our understanding of their topography and climate impacts.However,accurately quantifying the topographic patterns of these water bodies remains challenging due to the difficulties in collecting comprehensive bathymetric data.Therefore,we collected and processed over 2000 bathymetric maps of global water bodies from over 50 different data sources and then developed the BVAH model.Finally,the BVAH hydrological curves of 16671 global inland surface water bodies (larger than 10 km~2) were generated.The results include but are not limited to (1) For most targeted water bodies,area (A) and volume (V) exhibit significant power function relationships with surface heights (H),with optimal power values quantified as 1.42 for A and 2.42 for V.(2) The BVAH model outperforms GLOBathy in estimating area and volume changes,achieving higher correlation coefficients (CC) of approximately 0.962 for the area and 0.991 for volume,and demonstrating lower percentages of root mean squared errors (PRMSE) around 10.9% for the area and 4.8% for volume.(3) In the case study of the Xizang Plateau and various large global reservoirs,the BVAH curve database can capture dynamic volume changes.As a unified simulation of the bathymetric topographical patterns,our bathymetric dataset and corresponding BVAH curve database have great potential to contribute to effective water resource management and ecological conservation efforts worldwide.展开更多
Self-repairing coatings hold promise for prolonging the lifespan of steel structures and reducing carbon dioxide emissions from metal corrosion.Reversible chemistry-based intrinsic self-repairing has emerged as a cutt...Self-repairing coatings hold promise for prolonging the lifespan of steel structures and reducing carbon dioxide emissions from metal corrosion.Reversible chemistry-based intrinsic self-repairing has emerged as a cutting-edge strategy for addressing material damage.However,achieving effective repair at damaged coating interfaces remains challenging due to adhesion limitations between the coating and substrate.In this study,we propose an innovative approach to efficiently repair coating damage using photothermal-induced confined solid-liquid transition.We developed a unique structured coating by incorporating ther-moplastic epoxy resin(EP)into a polyethersulfone(PES)network skeleton through controlled reaction-induced phase separation.Additionally,we synthesized visible-light transmittable copper sulfide(CuS)nanocrystals as photothermal fillers to impart PES/EP-CuS coating with colorability.Upon near-infrared(NIR)laser irradiation,the EP phase undergoes confined solid-liquid transition at the crack site,enabling it to flow through the PES skeleton and seal the crack.This process promotes contact between damaged interfaces and closes the crack through interfacial tension.The PES/EP-CuS coating exhibited exceptional anti-corrosion restoration during service,showcasing its robust self-repairing capability.展开更多
Triclocarban(TCC)is a common antimicrobial agent that has been widely used in medical care.Given the close association between TCC treatment and metabolic disorders,we assessed whether long-term treatment to TCC at a ...Triclocarban(TCC)is a common antimicrobial agent that has been widely used in medical care.Given the close association between TCC treatment and metabolic disorders,we assessed whether long-term treatment to TCC at a human-relevant concentration could induce nephrotoxicity by disrupting the metabolic levels in a mouse model.Matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI)was applied to investigate the alterations in the spatial distributions and abundances of TCC,endogenous and exogenous metabolites in the kidney after TCC treatment.The results showed that TCC treatment induced the changes in the organ weight,organ coefficient and histopathology of the mouse kidney.MSI data revealed that TCC accumulated in all regions of the kidney,while its five metabolites mainly distributed in the cortex regions.The abundances of 79 biomolecules associated with pathways of leukotriene E4 metabolism,biosynthesis and degradation of glycerophospholipids and glycerolipids,ceramide-to-sphingomyelin signaling were significantly altered in the kidney after TCC treatment.These biomolecules showed distinctive distributions in the kidney and displayed a favorable spatial correlation with the pathological damage.This work offers new insights into the related mechanisms of TCC-induced nephrotocicity and exhibits the potential of MALDI-MSI-based spatial metabolomics as a promising approach for the risk assessment of agents in medical care.展开更多
目的通过迁移学习方法构建李素卿教授治疗反复呼吸道感染智能处方模型。方法首先使用李素卿教授的大量医案数据作为源域知识数据,基于长短期记忆网络(Long Short-Term Memory,LSTM)的端到端(Sequence to Sequence,seq2seq)算法,融合了...目的通过迁移学习方法构建李素卿教授治疗反复呼吸道感染智能处方模型。方法首先使用李素卿教授的大量医案数据作为源域知识数据,基于长短期记忆网络(Long Short-Term Memory,LSTM)的端到端(Sequence to Sequence,seq2seq)算法,融合了症状和药物关注的两种注意机制,对模型进行预训练,再以李素卿教授典型医案作为目标域知识数据进行迁移学习训练。结果图灵测试结果显示各类参与评估的中医医生的误差率均超过30%,其中长期跟诊李素卿教授的医生误差率最低。进一步的定性与定量评价显示,采用迁移学习方法的模型平均分为6.14,与李素卿教授原始处方模型得分6.50非常接近,而单一的LSTM模型评分较低。结论预训练迁移学习方法在模拟名老中医的处方用药思路上表现出色,为中医人工智能辅助决策系统提供了有效的解决方案,展示了深度学习在传统医学领域的巨大应用潜力。展开更多
基金supported by the Open Project of Basic Research of Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai(Grant No.AMGM2023F08)Open Fund Project of National United Engineering Laboratory for Advanced Bearing Tribology(No.202301).
文摘Waterborne polyurethane(WPU)is attracting widespread attention in the friction field,but pure WPU cannot meet the wear resistance requirements due to poor thermal and self-lubricating properties.Herein,a novel cellulose/BNNSs-AgNPs aerogel(CBAg)composed of zero-dimensional silver nanoparticles(AgNPs),onedimensional cellulose and two-dimensional boron nitride nanosheets(BNNSs)was successfully fabricated.Specifically,AgNPs were loaded onto the surface of BNNSs,which could serve as bridges to connect adjacent BNNSs.Cellulose was used to construct a 3D skeleton structure for stabilizing better dispersion of inorganic fillers.Finally,the thermal and tribological properties of CBAg-WPU were improved compared to pure WPU,with a 69%increase in thermal conductivity and an 89%reduction in wear rate.This was attributed to the load-bearing capacity of cellulose and outstanding thermal and lubricant capability of BNNSs-AgNPs.In addition,BNNSs and AgNPs inside the aerogel were transferred to the sliding interface and participated in the formation of high-quality friction transfer film,further endowing CBAg-WPU composites prominent tribological performance.Therefore,the novel design of 3D hybrid aerogels provided a promising avenue to improve the tribological performance of WPU composites.
基金supported by the National Natural Science Foundation of China(Grant No.:82074235)the Central Universities in China(Grant No.:2023-JYB-JBQN-041)。
文摘Ischemic heart disease(IHD)is associated with high morbidity and mortality rates.Reperfusion therapy is the best treatment option for this condition.However,reperfusion can aggravate myocardial damage through a phenomenon known as myocardial ischemia/reperfusion(I/R)injury,which has recently gained the attention of researchers.Several studies have shown that Chinese herbal medicines and their natural monomeric components exert therapeutic effects against I/R injury.This review outlines the current knowledge on the pathological mechanisms through which mitochondria participate in I/R injury,focusing on the issues related to energy metabolism,mitochondrial quality control disorders,oxidative stress,and calcium.The mechanisms by which mitochondria mediate cell death have also been discussed.To develop a resource for the prevention and management of clinical myocardial I/R damage,we compiled the most recent research on the effects of Chinese herbal remedies and their monomer components.
基金supported by the science and technology foundation of Guizhou province[2022]general 013the science and technology foundation of Guizhou province[2022]general 014+1 种基金the science and technology foundation of Guizhou province GCC[2022]016-1the educational technology foundation of Guizhou province[2022]043.
文摘Integrated-energy systems(IESs)are key to advancing renewable-energy utilization and addressing environmental challenges.Key components of IESs include low-carbon,economic dispatch and demand response,for maximizing renewable-energy consumption and supporting sustainable-energy systems.User participation is central to demand response;however,many users are not inclined to engage actively;therefore,the full potential of demand response remains unrealized.User satisfaction must be prioritized in demand-response assessments.This study proposed a two-stage,capacity-optimization configuration method for user-level energy systems con-sidering thermal inertia and user satisfaction.This method addresses load coordination and complementary issues within the IES and seeks to minimize the annual,total cost for determining equipment capacity configurations while introducing models for system thermal inertia and user satisfaction.Indoor heating is adjusted,for optimizing device output and load profiles,with a focus on typical,daily,economic,and environmental objectives.The studyfindings indicate that the system thermal inertia optimizes energy-system scheduling considering user satisfaction.This optimization mitigates environmental concerns and enhances clean-energy integration.
基金the financial support from National Natural Science Foundation of China (Nos. 62192771, 12374344, 12221004)National Key Research and Development Program of China (2022YFA1204700, 2020YFA0710100)+1 种基金Natural Science Foundation of Shanghai (Grant No. 23dz2260100)China Postdoctoral Science Foundation 2021TQ0077
文摘On-chip devices for generating pre-designed vectorial optical fields(VOFs)under surface wave(SW)excitations are highly desired in integrated photonics.However,conventional devices are usually of large footprints,low efficiencies,and limited wave-control capabilities.Here,we present a generic approach to design ultra-compact on-chip devices that can efficiently generate pre-designed VOFs under SW excitations,and experimentally verify the concept in terahertz(THz)regime.We first describe how to design SW-excitation metasurfaces for generating circularly polarized complex beams,and experimentally demonstrate two meta-devices to realize directional emission and focusing of THz waves with oppo-site circular polarizations,respectively.We then establish a systematic approach to construct an integrated device via merging two carefully designed metasurfaces,which,under SW excitations,can separately produce pre-designed far-field patterns with different circular polarizations and generate target VOF based on their interference.As a proof of con-cept,we demonstrate experimentally a meta-device that can generate a radially polarized Bessel beam under SW excita-tion at~0.4 THz.Experimental results agree well with full-wave simulations,collectively verifying the performance of our device.Our study paves the road to realizing highly integrated on-chip functional THz devices,which may find many ap-plications in biological sensing,communications,displays,image multiplexing,and beyond.
文摘Objective:To understand the current situation of career planning awareness and readiness of freshman medical students with a background in digital medicine,and to provide references for optimizing the medical education system and career guidance.Methods:A cross-sectional study was conducted on freshman medical students at a university in Yunnan Province using questionnaire survey.Results:A total of 272 questionnaires were distributed and 264 valid questionnaires were returned,yielding an effective response rate of 97.10%.The average score of digital medical awareness of freshman medical students was(70.50±8.81),and 63.63%of the students had a high awareness(score≧70);The average score of career planning awareness and readiness of freshman medical students was(91.76±14.87),and 60.63%of students had high awareness and readiness(score≧90).Pearson correlation analysis showed that the total score of digital medical awareness was positively correlated with the total score of career planning awareness and readiness(r=0.13,P<0.05).Conclusion:Freshman medical students’career planning awareness and readiness are generally good,but their practical application of digital medical-related skills still needs improvement.It is suggested that schools strengthen the integration of interdisciplinary curriculum,introduce digital vocational training modules,and formulate differentiated guidance strategies for different majors to enhance students’professional competitiveness in the digital medical era.
基金supported by the National MCF Energy Research and Development Program(Grant Nos.2024YFE03190001,2024YFE03190004,2022YFE03030001,and 2019YFE03030002)the National Natural Science Foundation of China(Grant Nos.12405257,12475215,and 12475219)+2 种基金the Natural Science Foundation of Sichuan Province,China(Grant Nos.2023NSFSC1289 and 2025ZNSFSC0066)the Nuclear Technology Research and Development Program(Grant No.HJSYF2024(02))the Innovation Program of Southwestern Institute of Physics(Grant No.202301XWCX001)。
文摘The isotope effect on zonal flows(ZFs)and turbulence remains a key issue that is not completely solved in fusion plasmas.This paper presents the first experimental results of the ab initio prediction of causal relation between geodesic acoustic mode(GAM)and ambient turbulence at different isotope masses in the edge of HL-2A tokamak,where transfer entropy method based on information-theoretical approach is utilized as a quantified indicator of causality.Analysis shows that GAM is more pronounced in deuterium plasmas than in hydrogen,leading to a lower heat transport as well as more peaked profiles in the former situation.The causal impact of GAM on conductive heat flux component is stronger than on the convective component,which is resulted from a larger causal influence of zonal flow on temperature fluctuation.While a stronger GAM in deuterium plasmas has larger influence on all flux components,the relative change in temperature fluctuation and coefficient is more obvious when the ion mass varies.These findings not only offer an in-depth understanding of the real causality between zonal flow and turbulence in the present isotope experiments,but also provide useful ways for the physical understandings of transport and zonal flow dynamics in future deuterium-tritium fusion plasmas.
基金supported by the Key Program of Natural Science Basic Research Plan in Shaanxi Province of China(Grant No.2021JZ-13)。
文摘Gibberellin(GA)is one of the major plant hormones that promote parthenocarpy,a highly valuable agronomic trait.Here,we demonstrated that exogenous GA3application triggered the formation of parthenocarpic fruits with smaller size but unchanged shape in tomato(Solanum lycopersicum).These fruits exhibited a thicker pericarp,undeveloped ovules,and few jelly tissues,leading to smaller locules with empty cavities.Histological investigation showed that GA treatment produced more cell layers with larger cells in the pericarp,suggesting its promotion in both cell division and expansion.Transcriptomic analyses between GA-3and mock-treated unpollinated ovaries/fruits identified a large number of differentially expressed genes related to hormones,cell division,cell expansion,and transcription factors,implying that they coordinately regulated parthenocarpy conferred by GA.In particular,the downregulation of five reported repressors of tomato parthenocarpy,including two auxin signaling components,AUXIN RESPONSE FACTOR5(SlARF5)and Sl ARF7,and three MADS-box genes,TOMATO APETALA3(TAP3),TOMATO PISTILLATA(TPI),and AGAMOUS-LIKE6(SlAGL6),after GA treatment might play a key role in this process.Furthermore,we found that the knockdown of a GA signaling factor SlMYB33,which was depressed by GA treatment,induced parthenocarpic fruit set in tomato,an effect that might have been achieved by enhancing GA biosynthesis and decreasing the expression of some repressors of tomato parthenocarpy.Thus,our results provide a basis for understanding the regulatory mechanism of GA in tomato parthenocarpy.
基金the National Natural Science Foundation of China(No.52173059)the National Key Research and Development Program of China(No.2022YFB3805803)+1 种基金the Key Research and Development Program of Jiangsu Province(No.21KJA540002)China National Textile and Apparel Council Science and Technology Guidance Project(No.2020116).
文摘Due to their potential use in creating advanced electronic textiles for wearable technology,functional fibers have garnered enormous interests.The presence of stretchable smart fibers has significantly expanded the application scenarios of intelligent fibers.However,preparing fibers that possess both excellent electrical performance and high stretchability remains a formidable challenge.The fabrication of stretchable multifunctional fiber-based sensors employing a scalable method is reported here.Using a thermal drawing process,the collaborative interplay between the hollow confined channels of superelastic poly(styrene-b-(ethylene-co-butylene)-b-styrene)(SEBS)thermally drawn fibers and the high fluidity of liquid metal(LM)ensures the exceptional electrical performance of the fibers.Simultaneously,the presence of a helical structure further enhances both the sensing and mechanical properties.The helical two LM channel fiber-based sensors are capable of displaying more than 1000%strain,high stability over 1000 cycles,a quick pressure response and release time of 30.45 and 45.35 ms,and outstanding electrical conductivity of 8.075×10^(5)S/m.In addition,the electrical conductivity of this fiber increases with strain level,reaching 3×10^(6)S/m when the strain is 500%.Furthermore,due to their superior tension and compression sensing capabilities,flexible helical sensors offer considerable potential for use in wearable electronics applications such as human motion detection,Morse code compilation,multichannel sensing,and more.
文摘Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for ophthalmologists.Because nanophthalmos patients who have undergone filtration surgery or other intraocular procedures are more susceptible to severe complications,including choroidal effusion,malignant glaucoma,and explosive choroidal hemorrhage,all of which can lead to vision loss[1].This dilemma is particularly pronounced in patients with shorter axial lengths.Micropulse transscleral laser therapy(M-TLT),also known as micropulse transscleral cyclophotocoagulation(MP-TSCPC),is a nonincisional laser therapy surgery for glaucoma[2].In 2015,Golan and Kurtz[3]were the first to report four patients with secondary angle-closure glaucoma in nanophthalmos with axial lengths ranging between 17 and 19 mm(mean 18 mm)who were successfully treated with M-TLT,and choroidal detachment was observed in all patients(recovery spontaneously in two patients and recovery after systemic steroid treatment in the other two),of which two had a slight decrease in visual acuity.
基金supported by the Strategic Cooperation Technology Projects of CNPC and CUPB(No.ZLZX2020-02)the National Science and Technology Special(No.2017ZX05049-006-001)+1 种基金the National Natural Science Foundation of China(No.41602137)Science Foundation of China University of Petroleum,Beijing(No.2462020YXZZ022).
文摘The tight tuff reservoir is an unusual type of unconventional reservoir with strong heterogeneity.However,there is a lack of research on the microscopic pore structure that causes the heterogeneity of tuff reservoirs.Using the Chang 7 Formation in Ordos Basin,China as a case study,carbon-dioxide gas adsorption,nitrogen gas adsorption and high-pressure mercury injection are integrated to investigate the multi-scale pore structure characteristics of tuff reservoirs.Meanwhile,the fractal dimension is introduced to characterize the complexity of pore structure in tuff reservoirs.By this multi-experimental method,the quantitative characterizations of the full-range pore size distribution of four tuff types were obtained and compared in the size ranges of micropores,mesopores and macropores.Fractal dimension curves derived from full-range pores are divided into six segments as D1,D2,D3,D4,D5 and D6 corresponding to fractal characteristics of micropores,smaller mesopores,larger mesopores,smaller macropores,medium macropores and larger macropores,respectively.The macropore volume,average macropore radius and fractal dimension D5 significantly control petrophysical properties.The larger macropore volume,average macropore radius and D5 correspond to favorable pore structure and good reservoir quality,which provides new indexes for the tuff reservoir evaluation.This study enriches the understanding of the heterogeneity of pore structures and contributes to unconventional oil and gas exploration and development.
基金supported by the National Natural Science Foundation of China (Nos.22036001, 22276034 and 22106130)。
文摘Cancer cell spheroids(CCS) are a valuable three-dimensional cell model in cancer studies because they could replicate numerous characteristics of solid tumors. Increasing researches have used matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI) to investigate the spatial distribution of endogenous compounds(e.g., lipids) in CCS. However, only limited lipid species can be detected owing to a low ion yield by using MALDI. Besides, it is still challenging to fully characterize the structural diversity of lipids due to the existence of isomeric/isobaric species. Here, we carried out the initial application of MALDI coupled with laser-postionization(MALDI-2) and trapped ion mobility spectrometry(TIMS) imaging in HCT116 colon CCS to address these challenges. We demonstrated that MALDI-2 is capable of detecting more number and classes of lipids in HCT116 colon CCS with higher signal intensities than MALDI. TIMS could successfully separate numerous isobaric/isomeric species of lipids in CCS. Interestingly, we found that some isomeric/isobaric species have totally different spatial distributions in colon CCS. Further MS/MS imaging analysis was employed to determine the compositions of fatty acid chains for isomeric species by examining disparities in signal intensities and spatial distributions of product ions. This work stresses the robust ability of TIMS and MALDI-2 imaging in analyzing endogenous lipids in CCS, which could potentially become powerful tools for future cancer studies.
基金supported by the National Natural Science Foundation of China (No. 41971377 & No. 41901346)the Fundamental Research Funds for the Central Universities, Peking University。
文摘Global inland surface water bodies such as lakes and reservoirs,important components of the hydrosphere and ecosphere,are increasingly affected by climate change.Generating bathymetric volume-areaheight (BVAH) curves for global inland surface water bodies can enhance our understanding of their topography and climate impacts.However,accurately quantifying the topographic patterns of these water bodies remains challenging due to the difficulties in collecting comprehensive bathymetric data.Therefore,we collected and processed over 2000 bathymetric maps of global water bodies from over 50 different data sources and then developed the BVAH model.Finally,the BVAH hydrological curves of 16671 global inland surface water bodies (larger than 10 km~2) were generated.The results include but are not limited to (1) For most targeted water bodies,area (A) and volume (V) exhibit significant power function relationships with surface heights (H),with optimal power values quantified as 1.42 for A and 2.42 for V.(2) The BVAH model outperforms GLOBathy in estimating area and volume changes,achieving higher correlation coefficients (CC) of approximately 0.962 for the area and 0.991 for volume,and demonstrating lower percentages of root mean squared errors (PRMSE) around 10.9% for the area and 4.8% for volume.(3) In the case study of the Xizang Plateau and various large global reservoirs,the BVAH curve database can capture dynamic volume changes.As a unified simulation of the bathymetric topographical patterns,our bathymetric dataset and corresponding BVAH curve database have great potential to contribute to effective water resource management and ecological conservation efforts worldwide.
基金the financial support through the National Natural Science Foundation of China(No.52271355)the Henan Provincial Science and Technology Research Joint Fund-Young Scientist Project(No.225200810108)+3 种基金the Basic Scientific Research Fund Project of Henan Academy of Sciences(No.230618023)the Research Startup Fund of Henan Academy of Sciences(Nos.231818027,232018001)the High-level Achievement Award and Cultivation Project of Henan Academy of Sciences(No.242218021)the Zhuhai City Industry-University-Research Cooperation Project(No.ZH22017001210148PWC).
文摘Self-repairing coatings hold promise for prolonging the lifespan of steel structures and reducing carbon dioxide emissions from metal corrosion.Reversible chemistry-based intrinsic self-repairing has emerged as a cutting-edge strategy for addressing material damage.However,achieving effective repair at damaged coating interfaces remains challenging due to adhesion limitations between the coating and substrate.In this study,we propose an innovative approach to efficiently repair coating damage using photothermal-induced confined solid-liquid transition.We developed a unique structured coating by incorporating ther-moplastic epoxy resin(EP)into a polyethersulfone(PES)network skeleton through controlled reaction-induced phase separation.Additionally,we synthesized visible-light transmittable copper sulfide(CuS)nanocrystals as photothermal fillers to impart PES/EP-CuS coating with colorability.Upon near-infrared(NIR)laser irradiation,the EP phase undergoes confined solid-liquid transition at the crack site,enabling it to flow through the PES skeleton and seal the crack.This process promotes contact between damaged interfaces and closes the crack through interfacial tension.The PES/EP-CuS coating exhibited exceptional anti-corrosion restoration during service,showcasing its robust self-repairing capability.
基金supported by National Natural Science Foundation of China(Grant Nos.:22036001 and 22276034).
文摘Triclocarban(TCC)is a common antimicrobial agent that has been widely used in medical care.Given the close association between TCC treatment and metabolic disorders,we assessed whether long-term treatment to TCC at a human-relevant concentration could induce nephrotoxicity by disrupting the metabolic levels in a mouse model.Matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI)was applied to investigate the alterations in the spatial distributions and abundances of TCC,endogenous and exogenous metabolites in the kidney after TCC treatment.The results showed that TCC treatment induced the changes in the organ weight,organ coefficient and histopathology of the mouse kidney.MSI data revealed that TCC accumulated in all regions of the kidney,while its five metabolites mainly distributed in the cortex regions.The abundances of 79 biomolecules associated with pathways of leukotriene E4 metabolism,biosynthesis and degradation of glycerophospholipids and glycerolipids,ceramide-to-sphingomyelin signaling were significantly altered in the kidney after TCC treatment.These biomolecules showed distinctive distributions in the kidney and displayed a favorable spatial correlation with the pathological damage.This work offers new insights into the related mechanisms of TCC-induced nephrotocicity and exhibits the potential of MALDI-MSI-based spatial metabolomics as a promising approach for the risk assessment of agents in medical care.
文摘目的通过迁移学习方法构建李素卿教授治疗反复呼吸道感染智能处方模型。方法首先使用李素卿教授的大量医案数据作为源域知识数据,基于长短期记忆网络(Long Short-Term Memory,LSTM)的端到端(Sequence to Sequence,seq2seq)算法,融合了症状和药物关注的两种注意机制,对模型进行预训练,再以李素卿教授典型医案作为目标域知识数据进行迁移学习训练。结果图灵测试结果显示各类参与评估的中医医生的误差率均超过30%,其中长期跟诊李素卿教授的医生误差率最低。进一步的定性与定量评价显示,采用迁移学习方法的模型平均分为6.14,与李素卿教授原始处方模型得分6.50非常接近,而单一的LSTM模型评分较低。结论预训练迁移学习方法在模拟名老中医的处方用药思路上表现出色,为中医人工智能辅助决策系统提供了有效的解决方案,展示了深度学习在传统医学领域的巨大应用潜力。
