Interact of Things has received much attention over the past de cade. With the rapid increase in the use of smart devices, we are now able to collect big data on a daily basis. The data we are gather ing and related p...Interact of Things has received much attention over the past de cade. With the rapid increase in the use of smart devices, we are now able to collect big data on a daily basis. The data we are gather ing and related problems arc becoming more complex and uncer tain. Researchers have therefore turned to AI as an efficient way of dealing with the problems created by big data.展开更多
[Objectives]To explore the effects of Radix Salviae Miltiorrhizae water extract and Semen Ziziphi Spinosae compound on theβ-secretase activity in mice exposed to aluminum maltolate.[Methods]A total of 60 healthy,clea...[Objectives]To explore the effects of Radix Salviae Miltiorrhizae water extract and Semen Ziziphi Spinosae compound on theβ-secretase activity in mice exposed to aluminum maltolate.[Methods]A total of 60 healthy,clean-grade SPF mice were randomly assigned to four groups based on their body weight,with each group consisting of 15 mice.The groups included a control group,a model group,treatment group 1,and treatment group 2.The control group received an equivalent dose of normal saline,while the model group and treatment groups 1 and 2 were intraperitoneally injected with 0.3 mg/kg of aluminum maltolate solution for 60 d.Additionally,treatment groups 1 and 2 were injected with 0.3 mg/kg of Radix Salviae Miltiorrhizae water extract and 0.3 mg/kg of Semen Ziziphi Spinosae compound,respectively,starting from the 31 st day for a total of 30 d.The cognitive functions of mice,specifically their learning and memory capabilities,were assessed using the Y-shaped water maze test at three distinct time points:prior to,during,and following the experimental procedure.Serum samples were collected for the analysis of various biochemical markers,including hemoglobin(Hb),total cholesterol(TC),triglycerides(TG),total protein(TP),alanine aminotransferase(ALT),and blood urea nitrogen(BUN).Additionally,brain tissues were harvested to evaluate the levels of glutathione peroxidase(GSH-PX)and acetylcholinesterase(AChE)in both serum and brain samples.The expression levels ofα-secretase,β-secretase,andγ-secretase in mouse serum were quantified using enzyme-linked immunosorbent assay(ELISA).[Results]According to the final results of the Y-shaped water maze test,the administration of therapeutic drugs to mice resulted in a gradual reduction in both the swimming time and the distance traveled to reach the platform in treatment groups 1 and 2.Additionally,the number of errors made by these treatment groups was significantly greater than that observed in the control group,with statistically significant differences(P<0.01).Among the three groups subjected to subchronic aluminum exposure,statistically significant differences were observed in the levels of Hb,TC,TG,TP,ALT,BUN,brain GSH-PX,and brain AChE(P<0.05).Furthermore,with the increasing duration of therapeutic drug administration,the levels ofβ-secretase in the brains of mice in both the treatment groups and the model group exhibited a significant decrease,while the levels ofα-secretase showed a significant increase.Additionally,the differences were statistically significant when compared to the control group(P<0.05).[Conclusions]Radix Salviae Miltiorrhizae water extract and Semen Ziziphi Spinosae compound will decrease the expression level ofβ-secretase activity in mice exposed to aluminum maltolate.展开更多
Research into lactylation modifications across various target organs in both health and disease has gained significant attention.Many essential life processes and the onset of diseases are not only related to protein ...Research into lactylation modifications across various target organs in both health and disease has gained significant attention.Many essential life processes and the onset of diseases are not only related to protein abundance but are also primarily regulated by various post-translational protein modifications.Lactate,once considered merely a byproduct of anaerobic metabolism,has emerged as a crucial energy substrate and signaling molecule involved in both physiological and pathological processes within the nervous system.Furthermore,recent studies have emphasized the significant role of lactate in numerous neurological diseases,including Alzheimer's disease,Parkinson's disease,acute cerebral ischemic stroke,multiple sclerosis,Huntington's disease,and myasthenia gravis.The purpose of this review is to synthesize the current research on lactate and lactylation modifications in neurological diseases,aiming to clarify their mechanisms of action and identify potential therapeutic targets.As such,this work provides an overview of the metabolic regulatory roles of lactate in various disorders,emphasizing its involvement in the regulation of brain function.Additionally,the specific mechanisms of brain lactate metabolism are discussed,suggesting the unique roles of lactate in modulating brain function.As a critical aspect of lactate function,lactylation modifications,including both histone and non-histone lactylation,are explored,with an emphasis on recent advancements in identifying the key regulatory enzymes of such modifications,such as lactylation writers and erasers.The effects and specific mechanisms of abnormal lactate metabolism in diverse neurological diseases are summarized,revealing that lactate acts as a signaling molecule in the regulation of brain functions and that abnormal lactate metabolism is implicated in the progression of various neurological disorders.Future research should focus on further elucidating the molecular mechanisms underlying lactate and lactylation modifications and exploring their potential as therapeutic targets for neurological diseases.展开更多
System logs record detailed information about system operation and areimportant for analyzing the system's operational status and performance. Rapidand accurate detection of system anomalies is of great significan...System logs record detailed information about system operation and areimportant for analyzing the system's operational status and performance. Rapidand accurate detection of system anomalies is of great significance to ensure system stability. However, large-scale distributed systems are becoming more andmore complex, and the number of system logs gradually increases, which bringschallenges to analyze system logs. Some recent studies show that logs can beunstable due to the evolution of log statements and noise introduced by log collection and parsing. Moreover, deep learning-based detection methods take a longtime to train models. Therefore, to reduce the computational cost and avoid loginstability we propose a new Word2Vec-based log unsupervised anomaly detection method (LogUAD). LogUAD does not require a log parsing step and takesoriginal log messages as input to avoid the noise. LogUAD uses Word2Vec togenerate word vectors and generates weighted log sequence feature vectors withTF-IDF to handle the evolution of log statements. At last, a computationally effi-cient unsupervised clustering is exploited to detect the anomaly. We conductedextensive experiments on the public dataset from Blue Gene/L (BGL). Experimental results show that the F1-score of LogUAD can be improved by 67.25%compared to LogCluster.展开更多
Spin engineering is recognized as a promising strategy that modulates the association between d‐orbital electrons and the oxygenated species,and enhances the catalytic kinetics.However,few efforts have been made to c...Spin engineering is recognized as a promising strategy that modulates the association between d‐orbital electrons and the oxygenated species,and enhances the catalytic kinetics.However,few efforts have been made to clarify whether spin engineering could make a considerable enhancement for electrocatalytic water oxidation.Herein,we report the spin engineering of a nanocage‐structured(Co,Ni)Se_(2)/C@FeOOH,that showed significant oxygen evolution reaction(OER)activity.Magnetization measurement presented that the(Co,Ni)Se_(2)/C@FeOOH sample possesses higher polarization spin number(μb=6.966μB/f.u.)compared with that of the(Co,Ni)Se_(2)/C sample(μb=6.398μB/f.u.),for which the enlarged spin polarization number favors the adsorption and desorption energy of the intermediate oxygenated species,as confirmed by surface valance band spectra.Consequently,the(Co,Ni)Se_(2)/C@FeOOH affords remarkable OER product with a low overpotential of 241 mV at a current of 10 mA cm^(-2) and small Tafel slope of 44 mV dec^(-1) in 1.0 mol/L KOH alkaline solution,significantly surpassing the parent(Co,Ni)Se_(2)/C catalyst.This work will trigger a solid step for the design of highly‐efficient OER electrocatalysts.展开更多
The visual cortex is an essential part of the brain for processing visual information.It exhibits structural and functional plasticity,which is crucial for adapting to complex visual environments.The quintessential ma...The visual cortex is an essential part of the brain for processing visual information.It exhibits structural and functional plasticity,which is crucial for adapting to complex visual environments.The quintessential manifestation of visual cortical plasticity is ocular dominance plasticity during the critical period,which involves numerous cellular and molecular events.While previous studies have emphasized the role of visual cortical neurons and their associated functional molecules in visual plasticity,recent findings have revealed that structural factors such as the extracellular matrix and glia are also involved.Investigating how these molecules interact to form a complex network that facilitates plasticity in the visual cortex is crucial to our understanding of the development of the visual system and the advancement of therapeutic strategies for visual disorders like amblyopia.展开更多
This study presents an inversion method to recover the tidal flow velocity using tidal signals extracted from geomagnetic satellite dataset.By integrating the latest Earth conductivity profile and the Earth's magn...This study presents an inversion method to recover the tidal flow velocity using tidal signals extracted from geomagnetic satellite dataset.By integrating the latest Earth conductivity profile and the Earth's magnetic field model,the limited memory quasi-Newton method(L-BFGS)is used to directly invert seawater flow velocities.We used the radial component of the induced magnetic field as the observed data,constructed an L_(2)-norm-based data misfit term using theoretical response and observed data,and applied smoothness constraints to the ocean flow velocity.The results agree well with the widely used HAMTIDE model in low-and mid-latitude regions,which is attributed to Macao Science Satellite-1's(MSS-1)unique low-inclination orbit of full coverage in these areas.These findings underscore MSS-1's potential to advance research on tidal-induced magnetic fields and their applications in ocean dynamics studies.展开更多
Throughout the lifespan,an animal can encounter predators frequently,thus the ability to avoid attacks from predators is crucial for its survival.The chances of evading danger can be greatly improved if the animal can...Throughout the lifespan,an animal can encounter predators frequently,thus the ability to avoid attacks from predators is crucial for its survival.The chances of evading danger can be greatly improved if the animal can respond immediately to the threat.Therefore,when an animal detects a threat through its visual system,it must quickly direct its gaze and attention toward the source of danger,assess the threat level,and take appropriate action.展开更多
To address the issues of slow diagnostic speed,low accuracy,and poor generalization performance in traditional rolling bearing fault diagnosis methods,we propose a rolling bearing fault diagnosis method based on Marko...To address the issues of slow diagnostic speed,low accuracy,and poor generalization performance in traditional rolling bearing fault diagnosis methods,we propose a rolling bearing fault diagnosis method based on Markov Transition Field(MTF)image encoding combined with a lightweight convolutional neural network that integrates a Convolutional Block Attention Module(CBAM-LCNN).Specifically,we first use the Markov Transition Field to convert the original one-dimensional vibration signals of rolling bearings into two-dimensional images.Then,we construct a lightweight convolutional neural network incorporating the convolutional attention module(CBAM-LCNN).Finally,the two-dimensional images obtained from MTF mapping are fed into the CBAM-LCNN network for image feature extraction and fault diagnosis.We validate the effectiveness of the proposed method on the bearing fault datasets from Guangdong University of Petrochemical Technology’s multi-stage centrifugal fan and Case Western Reserve University.Experimental results show that,compared to other advanced baseline methods,the proposed rolling bearing fault diagnosis method offers faster diagnostic speed and higher diagnostic accuracy.In addition,we conducted experiments on the Xi’an Jiaotong University rolling bearing dataset,achieving excellent results in bearing fault diagnosis.These results validate the strong generalization performance of the proposed method.The method presented in this paper not only effectively diagnoses faults in rolling bearings but also serves as a reference for fault diagnosis in other equipment.展开更多
Neutral beam injection(NBI)has been proven as a reliable heating and current drive method for fusion plasma.For the high-energy NBI system(particle energy>150 ke V)of large-scale fusion devices,the negative ion sou...Neutral beam injection(NBI)has been proven as a reliable heating and current drive method for fusion plasma.For the high-energy NBI system(particle energy>150 ke V)of large-scale fusion devices,the negative ion source neutral beam injection(NNBI)system is inevitable,which can obtain an acceptable neutralization efficiency(>55%).But the NNBI system is very complex and challengeable.To explore and master the key NNBI technology for future fusion reactor in China,an NNBI test facility is under development in the framework of the Comprehensive Research Facility for Fusion Technology(CRAFT).The initial goal of CRAFT NNBI facility is to achieve a 2 MW hydrogen neutral beam at the energy of 200–400 ke V for lasting 100 s.In the first operation of the CRAFT NNBI facility,a negative ion source with dual RF drivers was developed and tested.By using the 50 keV accelerator,the long-pulse and highcurrent extractions of negative hydrogen ions have been achieved and the typical values were 55.4 keV,7.3 A(~123 A/m^(2)),105 s and 55.0 keV,14.7 A(~248 A/m^(2)),30 s,respectively.By using the 200 keV accelerator,the megawatt-class negative hydrogen beam has also been achieved(135.9 keV,8.9 A,8 s).The whole process of the gas neutralization of negative ion beam,electric removal of residual ions,and beam transport have been demonstrated experimentally.展开更多
The visibility characteristics and meteorological conditions of a sea fog process on 27</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-fa...The visibility characteristics and meteorological conditions of a sea fog process on 27</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> February, 2016 are analyzed and the heavy fog process is simulated by the Weather Research and Forecasting (WRF) model in this paper. The forecast results show that the visibility in Qingdao coastal area is light fog on the night of the 26</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;">. In the WRF simulation, it can be observed from the sea-level pressure that the wind direction of Qingdao and the coastal area turned southerly with the eastward movement of the low pressure system on surface from 1200 UTC to 1800 UTC on the 26</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;">. A large amount of water vapor brought by easterly and southerly wind provides sufficient water vapor conditions for the formation and development of the sea fog. At 975 hPa, there is a strong warm tongue over Shandong Peninsula at 0600 UTC on the 26</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;">, w</span><span><span style="font-family:Verdana;">hile the offshore is affected by the cold tongue, where the horizontal temperature gradient is large and there is a strong baroclinicity. At 850 hPa, there is a weak warm ridge over Qingdao at 1200 UTC on the 26</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;">, which means that it is an inversion layer, which is conducive to the maintenance of fog.展开更多
37 μm × 37 μm array of metamaterial-based microbolometers was designed and successfully fa-bricated by conventional MEMS technology. FTIR measurements reveal that the as-designed mi-crobolometers exhibit a high...37 μm × 37 μm array of metamaterial-based microbolometers was designed and successfully fa-bricated by conventional MEMS technology. FTIR measurements reveal that the as-designed mi-crobolometers exhibit a high absorption of ~31.5% at 3.93 THz. In contrast, no response can be detected from those microbolometers without metamaterials. The experimental results have been confirmed by simulations.展开更多
Polyvinylpyrrolidone-reduced graphene oxide was prepared by modified hummers method and was used as adsorbent for removing Cu ions from wastewater. The effects of contact time and ions concentration on adsorption capa...Polyvinylpyrrolidone-reduced graphene oxide was prepared by modified hummers method and was used as adsorbent for removing Cu ions from wastewater. The effects of contact time and ions concentration on adsorption capacity were examined. The maximum adsorption capacity of 1689 mg/g was observed at an initial p H value of 3.5 after agitating for 10 min. It was demonstrated that polyvinylpyrrolidone-reduced graphene oxide had a huge adsorption capacity for Cu ions, which was 10 times higher than maximal value reported in previous works. The adsorption mechanism was also discussed by density functional theory. It demonstrates that Cu ions are attracted to surface of reduced graphene oxide by C atoms in reduced graphene oxide modified by polyvinylpyrrolidone through physisorption processes, which may be responsible for the higher adsorption capacity. Our results suggest that polyvinylpyrrolidone-reduced graphene oxide is an effective adsorbent for removing Cu ions in wastewater. It also provides a new way to improve the adsorption capacity of reduced graphene oxide for dealing with the heavy metal ion in wastewater.展开更多
To increase spatial resolution and signal-to-noise ratio in PET imaging,we present in this paper the design and performance evaluation of a PET detector module combining both depth-of-interaction(DOI) and time-offligh...To increase spatial resolution and signal-to-noise ratio in PET imaging,we present in this paper the design and performance evaluation of a PET detector module combining both depth-of-interaction(DOI) and time-offlight(TOF) capabilities.The detector module consists of a staggered dual-layer LYSO block with2 mm × 2 mm × 7 mm crystals.MR-compatible SiPM sensors(MicroFJ-30035-TSV,SensL) are assembled into an 8× 8 array.SiPM signals from both fast and slow outputs are read out by a 128-channel ASIC chip.To test its performance,a flood histogram is acquired with a ^(22)Na point source on top of the detector,and the energy resolution and the coincidence resolving time(CRT) value for each individual crystal are measured.The flood histogram shows excellent crystal separation in both layers.The average energy resolution at 511 keV is 14.0 and 12.7%at the bottom and top layers,respectively.The average CRT of a single crystal is 635 and 565 ps at the bottom and top layers,respectively.In conclusion,the compact DOI-TOF PET detector module is of excellent crystal identification capability,good energy resolution and reasonable time resolution and has promising application prospective in clinical TOF PET,PET/MRI,and brain PET systems.展开更多
Polysaccharides are widely present in herbs with multiple activities,especially immunity regulation and metabolic benefits for metabolic disorders.However,the underlying mechanisms are not well under-stood.Functional ...Polysaccharides are widely present in herbs with multiple activities,especially immunity regulation and metabolic benefits for metabolic disorders.However,the underlying mechanisms are not well under-stood.Functional metabolomics is increasingly used to investigate systemic effects on the host by iden-tifying metabolites with particular functions.This study explores the mechanisms underlying the metabolic benefits of Astragalus polysaccharides(APS)by adopting a functional metabolomics strategy.The effects of APS were determined in eight-week high-fat diet(HFD)-fed obese mice.Then,gas chromatography–time-of-flight mass spectrometry(GC–TOFMS)-based untargeted metabolomics was performed for an analysis of serum and liver tissues,and liquid chromatography–tandem mass spectrom-etry(LC–MS/MS)-based targeted metabolomics was performed.The potential functions of the metabo-lites were tested with in vitro and in vivo models of metabolic disorders.Our results first confirmed the metabolic benefits of APS in obese mice.Then,metabolomics analysis revealed that APS supplemen-tation reversed the HFD-induced metabolic changes,and identified 2-hydroxybutyric acid(2-HB)as a potential functional metabolite for APS activity that was significantly decreased by a HFD and reversed by APS.Further study indicated that 2-HB inhibited oleic acid(OA)-induced triglyceride(TG)accumula-tion.It was also found to stimulate the expression of proteins in lipid degradation in hepatocytes and TG lipolysis in 3T3-L1 cells.Moreover,it was found to reduce serum TG and regulate the proteins involved in lipid degradation in high-fat and high-sucrose(HFHS)-fed mice.In conclusion,our study demonstrates that the metabolic benefits of APS are at least partially due to 2-HB generation,which modulated lipid metabolism both in vitro and in vivo.Our results also highlight that functional metabolomics is practical for investigating the mechanism underlying the systemic benefits of plant polysaccharides.展开更多
Cell discontinuous transmission(Cell DTx)is a key technology to mitigate inter-cell interference(ICI)in ultra-dense networks(UDNs).The aim of this work is to understand the impact of Cell DTx on physical-layer sum rat...Cell discontinuous transmission(Cell DTx)is a key technology to mitigate inter-cell interference(ICI)in ultra-dense networks(UDNs).The aim of this work is to understand the impact of Cell DTx on physical-layer sum rates of SBSs and link-layer quality-of-service(QoS)performance in multiuser UDNs.In this work,we develop a cross-layer framework for capacity analysis in multiuser UDNs with Cell DTx.In particular,we first extend the traditional one-dimensional effective capacity model to a new multidimensional effective capacity model to derive the sum rate and the effective capacity.Moreover,we propose a new iterative bisection search algorithm that is capable of approximating QoS performance.The convergence of this new algorithm to a unique QoS exponent vector is later proved.Finally,we apply this framework to the round-robin and the max-C/I scheduling policies.Simulation results show that our framework is accurate in approximating 1)queue length distribution,2)delay distribution and 3)sum rates under the above two scheduling policies,and further show that with the Cell DTx,systems have approximately 30% higher sum rate and 35% smaller average delay than those in full-buffer scenarios.展开更多
Membrane fouling is always the biggest problem in the practice of membrane separation technologies,which strongly impacts their applicability,separation efficiency,cost effectiveness,and service lifespan.Herein,a simp...Membrane fouling is always the biggest problem in the practice of membrane separation technologies,which strongly impacts their applicability,separation efficiency,cost effectiveness,and service lifespan.Herein,a simple but effective 3D modification approach was designed for permanently functionalizing polymeric membranes by directly cross-linking polyvinyl alcohol(PVA)under gamma-ray irradiation at room temperature without any additives.After the modification,a PVA layer was constructed on the membrane surface and the pore inner surface of polyvinylidene fluoride(PVDF)membranes.This endowed them with good hydrophilicity,low adsorption of protein model foulants,and easy recoverability properties.In addition,the pore size and distribution were customized by controlling the PVA concentration,which enhanced the rejection ability of the resultant membranes and converted them from microfiltration to ultrafiltration.The crosslinked PVA layer was equipped with the resultant membranes with good resistance to chemical cleaning by acidic,alkaline,and oxidative reagents,which could greatly prolong the membrane service lifetime.Furthermore,this approach was demonstrated as a universal method to modify PVDF membranes with other hydrophilic macromolecular modifiers,including polyethylene glycol,sodium alginate,and polyvinyl pyrrolidone.This modification of the membranes effectively endowed them with good hydrophilicity and antifouling properties,as expected.展开更多
文摘Interact of Things has received much attention over the past de cade. With the rapid increase in the use of smart devices, we are now able to collect big data on a daily basis. The data we are gather ing and related problems arc becoming more complex and uncer tain. Researchers have therefore turned to AI as an efficient way of dealing with the problems created by big data.
基金Supported by Undergraduate Innovation and Entrepreneurship Training Program(202410599042).
文摘[Objectives]To explore the effects of Radix Salviae Miltiorrhizae water extract and Semen Ziziphi Spinosae compound on theβ-secretase activity in mice exposed to aluminum maltolate.[Methods]A total of 60 healthy,clean-grade SPF mice were randomly assigned to four groups based on their body weight,with each group consisting of 15 mice.The groups included a control group,a model group,treatment group 1,and treatment group 2.The control group received an equivalent dose of normal saline,while the model group and treatment groups 1 and 2 were intraperitoneally injected with 0.3 mg/kg of aluminum maltolate solution for 60 d.Additionally,treatment groups 1 and 2 were injected with 0.3 mg/kg of Radix Salviae Miltiorrhizae water extract and 0.3 mg/kg of Semen Ziziphi Spinosae compound,respectively,starting from the 31 st day for a total of 30 d.The cognitive functions of mice,specifically their learning and memory capabilities,were assessed using the Y-shaped water maze test at three distinct time points:prior to,during,and following the experimental procedure.Serum samples were collected for the analysis of various biochemical markers,including hemoglobin(Hb),total cholesterol(TC),triglycerides(TG),total protein(TP),alanine aminotransferase(ALT),and blood urea nitrogen(BUN).Additionally,brain tissues were harvested to evaluate the levels of glutathione peroxidase(GSH-PX)and acetylcholinesterase(AChE)in both serum and brain samples.The expression levels ofα-secretase,β-secretase,andγ-secretase in mouse serum were quantified using enzyme-linked immunosorbent assay(ELISA).[Results]According to the final results of the Y-shaped water maze test,the administration of therapeutic drugs to mice resulted in a gradual reduction in both the swimming time and the distance traveled to reach the platform in treatment groups 1 and 2.Additionally,the number of errors made by these treatment groups was significantly greater than that observed in the control group,with statistically significant differences(P<0.01).Among the three groups subjected to subchronic aluminum exposure,statistically significant differences were observed in the levels of Hb,TC,TG,TP,ALT,BUN,brain GSH-PX,and brain AChE(P<0.05).Furthermore,with the increasing duration of therapeutic drug administration,the levels ofβ-secretase in the brains of mice in both the treatment groups and the model group exhibited a significant decrease,while the levels ofα-secretase showed a significant increase.Additionally,the differences were statistically significant when compared to the control group(P<0.05).[Conclusions]Radix Salviae Miltiorrhizae water extract and Semen Ziziphi Spinosae compound will decrease the expression level ofβ-secretase activity in mice exposed to aluminum maltolate.
基金supported by Applied Basic Research Joint Fund Project of Yunnan Province,No.202301AY070001-200Middle-aged Academic and Technical Training Project for High-Level Talents,No.202105AC160065+1 种基金Yunnan Clinical Medical Center for Neurological and Cardiovascular Diseases,No.YWLCYXZX2023300077Key Clinical Specialty of Neurology in Yunnan Province,No.300064(all to CL)。
文摘Research into lactylation modifications across various target organs in both health and disease has gained significant attention.Many essential life processes and the onset of diseases are not only related to protein abundance but are also primarily regulated by various post-translational protein modifications.Lactate,once considered merely a byproduct of anaerobic metabolism,has emerged as a crucial energy substrate and signaling molecule involved in both physiological and pathological processes within the nervous system.Furthermore,recent studies have emphasized the significant role of lactate in numerous neurological diseases,including Alzheimer's disease,Parkinson's disease,acute cerebral ischemic stroke,multiple sclerosis,Huntington's disease,and myasthenia gravis.The purpose of this review is to synthesize the current research on lactate and lactylation modifications in neurological diseases,aiming to clarify their mechanisms of action and identify potential therapeutic targets.As such,this work provides an overview of the metabolic regulatory roles of lactate in various disorders,emphasizing its involvement in the regulation of brain function.Additionally,the specific mechanisms of brain lactate metabolism are discussed,suggesting the unique roles of lactate in modulating brain function.As a critical aspect of lactate function,lactylation modifications,including both histone and non-histone lactylation,are explored,with an emphasis on recent advancements in identifying the key regulatory enzymes of such modifications,such as lactylation writers and erasers.The effects and specific mechanisms of abnormal lactate metabolism in diverse neurological diseases are summarized,revealing that lactate acts as a signaling molecule in the regulation of brain functions and that abnormal lactate metabolism is implicated in the progression of various neurological disorders.Future research should focus on further elucidating the molecular mechanisms underlying lactate and lactylation modifications and exploring their potential as therapeutic targets for neurological diseases.
基金funded by the Researchers Supporting Project No.(RSP.2021/102)King Saud University,Riyadh,Saudi ArabiaThis work was supported in part by the National Natural Science Foundation of China under Grant 61802030+2 种基金Natural Science Foundation of Hunan Province under Grant 2020JJ5602the Research Foundation of Education Bureau of Hunan Province under Grant 19B005the International Cooperative Project for“Double First-Class”,CSUST under Grant 2018IC24.
文摘System logs record detailed information about system operation and areimportant for analyzing the system's operational status and performance. Rapidand accurate detection of system anomalies is of great significance to ensure system stability. However, large-scale distributed systems are becoming more andmore complex, and the number of system logs gradually increases, which bringschallenges to analyze system logs. Some recent studies show that logs can beunstable due to the evolution of log statements and noise introduced by log collection and parsing. Moreover, deep learning-based detection methods take a longtime to train models. Therefore, to reduce the computational cost and avoid loginstability we propose a new Word2Vec-based log unsupervised anomaly detection method (LogUAD). LogUAD does not require a log parsing step and takesoriginal log messages as input to avoid the noise. LogUAD uses Word2Vec togenerate word vectors and generates weighted log sequence feature vectors withTF-IDF to handle the evolution of log statements. At last, a computationally effi-cient unsupervised clustering is exploited to detect the anomaly. We conductedextensive experiments on the public dataset from Blue Gene/L (BGL). Experimental results show that the F1-score of LogUAD can be improved by 67.25%compared to LogCluster.
文摘Spin engineering is recognized as a promising strategy that modulates the association between d‐orbital electrons and the oxygenated species,and enhances the catalytic kinetics.However,few efforts have been made to clarify whether spin engineering could make a considerable enhancement for electrocatalytic water oxidation.Herein,we report the spin engineering of a nanocage‐structured(Co,Ni)Se_(2)/C@FeOOH,that showed significant oxygen evolution reaction(OER)activity.Magnetization measurement presented that the(Co,Ni)Se_(2)/C@FeOOH sample possesses higher polarization spin number(μb=6.966μB/f.u.)compared with that of the(Co,Ni)Se_(2)/C sample(μb=6.398μB/f.u.),for which the enlarged spin polarization number favors the adsorption and desorption energy of the intermediate oxygenated species,as confirmed by surface valance band spectra.Consequently,the(Co,Ni)Se_(2)/C@FeOOH affords remarkable OER product with a low overpotential of 241 mV at a current of 10 mA cm^(-2) and small Tafel slope of 44 mV dec^(-1) in 1.0 mol/L KOH alkaline solution,significantly surpassing the parent(Co,Ni)Se_(2)/C catalyst.This work will trigger a solid step for the design of highly‐efficient OER electrocatalysts.
基金supported by the National Natural Science Foundation of China(81770956,81371049,32471055 and 82171090)Project of Tianjin 131 Innovative Talent Team(201936)+4 种基金the Science and Technology Planning Project of Tianjin(21JCYBJC00780)the Science and Technology Fund for Health of Tianjin(TJWJ2023ZD008)Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)ZJLab,Shanghai Center for Brain Science and Brain-Inspired Technology,the Lingang Laboratory(LG-QS-202203-12)Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK‑016A).
文摘The visual cortex is an essential part of the brain for processing visual information.It exhibits structural and functional plasticity,which is crucial for adapting to complex visual environments.The quintessential manifestation of visual cortical plasticity is ocular dominance plasticity during the critical period,which involves numerous cellular and molecular events.While previous studies have emphasized the role of visual cortical neurons and their associated functional molecules in visual plasticity,recent findings have revealed that structural factors such as the extracellular matrix and glia are also involved.Investigating how these molecules interact to form a complex network that facilitates plasticity in the visual cortex is crucial to our understanding of the development of the visual system and the advancement of therapeutic strategies for visual disorders like amblyopia.
基金financially supported by the National Natural Science Foundation of China(42250102,42250101)the Macao Foundation。
文摘This study presents an inversion method to recover the tidal flow velocity using tidal signals extracted from geomagnetic satellite dataset.By integrating the latest Earth conductivity profile and the Earth's magnetic field model,the limited memory quasi-Newton method(L-BFGS)is used to directly invert seawater flow velocities.We used the radial component of the induced magnetic field as the observed data,constructed an L_(2)-norm-based data misfit term using theoretical response and observed data,and applied smoothness constraints to the ocean flow velocity.The results agree well with the widely used HAMTIDE model in low-and mid-latitude regions,which is attributed to Macao Science Satellite-1's(MSS-1)unique low-inclination orbit of full coverage in these areas.These findings underscore MSS-1's potential to advance research on tidal-induced magnetic fields and their applications in ocean dynamics studies.
基金supported by the National Natural Science Foundation of China(32471055 and 82171090)Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)ZJLab,Shanghai Center for Brain Science and Brain-Inspired Technology,the Lingang Laboratory(LG-QS-202203-12).
文摘Throughout the lifespan,an animal can encounter predators frequently,thus the ability to avoid attacks from predators is crucial for its survival.The chances of evading danger can be greatly improved if the animal can respond immediately to the threat.Therefore,when an animal detects a threat through its visual system,it must quickly direct its gaze and attention toward the source of danger,assess the threat level,and take appropriate action.
基金supported by the National Natural Science Foundation of China(52001340)the Henan Province Science and Technology Key Research Project(242102110332)the Henan Province Teaching Reform Project(2022SYJXLX087).
文摘To address the issues of slow diagnostic speed,low accuracy,and poor generalization performance in traditional rolling bearing fault diagnosis methods,we propose a rolling bearing fault diagnosis method based on Markov Transition Field(MTF)image encoding combined with a lightweight convolutional neural network that integrates a Convolutional Block Attention Module(CBAM-LCNN).Specifically,we first use the Markov Transition Field to convert the original one-dimensional vibration signals of rolling bearings into two-dimensional images.Then,we construct a lightweight convolutional neural network incorporating the convolutional attention module(CBAM-LCNN).Finally,the two-dimensional images obtained from MTF mapping are fed into the CBAM-LCNN network for image feature extraction and fault diagnosis.We validate the effectiveness of the proposed method on the bearing fault datasets from Guangdong University of Petrochemical Technology’s multi-stage centrifugal fan and Case Western Reserve University.Experimental results show that,compared to other advanced baseline methods,the proposed rolling bearing fault diagnosis method offers faster diagnostic speed and higher diagnostic accuracy.In addition,we conducted experiments on the Xi’an Jiaotong University rolling bearing dataset,achieving excellent results in bearing fault diagnosis.These results validate the strong generalization performance of the proposed method.The method presented in this paper not only effectively diagnoses faults in rolling bearings but also serves as a reference for fault diagnosis in other equipment.
基金supported by the Comprehensive Research Facility for Fusion Technology Program of China(No.2018-000052-73-01-001228)。
文摘Neutral beam injection(NBI)has been proven as a reliable heating and current drive method for fusion plasma.For the high-energy NBI system(particle energy>150 ke V)of large-scale fusion devices,the negative ion source neutral beam injection(NNBI)system is inevitable,which can obtain an acceptable neutralization efficiency(>55%).But the NNBI system is very complex and challengeable.To explore and master the key NNBI technology for future fusion reactor in China,an NNBI test facility is under development in the framework of the Comprehensive Research Facility for Fusion Technology(CRAFT).The initial goal of CRAFT NNBI facility is to achieve a 2 MW hydrogen neutral beam at the energy of 200–400 ke V for lasting 100 s.In the first operation of the CRAFT NNBI facility,a negative ion source with dual RF drivers was developed and tested.By using the 50 keV accelerator,the long-pulse and highcurrent extractions of negative hydrogen ions have been achieved and the typical values were 55.4 keV,7.3 A(~123 A/m^(2)),105 s and 55.0 keV,14.7 A(~248 A/m^(2)),30 s,respectively.By using the 200 keV accelerator,the megawatt-class negative hydrogen beam has also been achieved(135.9 keV,8.9 A,8 s).The whole process of the gas neutralization of negative ion beam,electric removal of residual ions,and beam transport have been demonstrated experimentally.
文摘The visibility characteristics and meteorological conditions of a sea fog process on 27</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;"> February, 2016 are analyzed and the heavy fog process is simulated by the Weather Research and Forecasting (WRF) model in this paper. The forecast results show that the visibility in Qingdao coastal area is light fog on the night of the 26</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;">. In the WRF simulation, it can be observed from the sea-level pressure that the wind direction of Qingdao and the coastal area turned southerly with the eastward movement of the low pressure system on surface from 1200 UTC to 1800 UTC on the 26</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;">. A large amount of water vapor brought by easterly and southerly wind provides sufficient water vapor conditions for the formation and development of the sea fog. At 975 hPa, there is a strong warm tongue over Shandong Peninsula at 0600 UTC on the 26</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;">, w</span><span><span style="font-family:Verdana;">hile the offshore is affected by the cold tongue, where the horizontal temperature gradient is large and there is a strong baroclinicity. At 850 hPa, there is a weak warm ridge over Qingdao at 1200 UTC on the 26</span><sup><span style="font-family:Verdana;">th</span></sup><span style="font-family:Verdana;">, which means that it is an inversion layer, which is conducive to the maintenance of fog.
文摘37 μm × 37 μm array of metamaterial-based microbolometers was designed and successfully fa-bricated by conventional MEMS technology. FTIR measurements reveal that the as-designed mi-crobolometers exhibit a high absorption of ~31.5% at 3.93 THz. In contrast, no response can be detected from those microbolometers without metamaterials. The experimental results have been confirmed by simulations.
基金supported by the National Natu-ral Science Foundation of China(No.22002129,No.21972119,No.21991151,No.22202162,No.22102137,No.22072123)the China Post-doctoral Science Foundation(No.2019TQ0177,No.2022T150548,No.2022M722648).
基金the support by National Natural Science Foundation of China under grants (11202006)University’s Science and technology exploiture of Shangxi Province (20121010)the National Basic Research Program of China (G2010CB832701)
文摘Polyvinylpyrrolidone-reduced graphene oxide was prepared by modified hummers method and was used as adsorbent for removing Cu ions from wastewater. The effects of contact time and ions concentration on adsorption capacity were examined. The maximum adsorption capacity of 1689 mg/g was observed at an initial p H value of 3.5 after agitating for 10 min. It was demonstrated that polyvinylpyrrolidone-reduced graphene oxide had a huge adsorption capacity for Cu ions, which was 10 times higher than maximal value reported in previous works. The adsorption mechanism was also discussed by density functional theory. It demonstrates that Cu ions are attracted to surface of reduced graphene oxide by C atoms in reduced graphene oxide modified by polyvinylpyrrolidone through physisorption processes, which may be responsible for the higher adsorption capacity. Our results suggest that polyvinylpyrrolidone-reduced graphene oxide is an effective adsorbent for removing Cu ions in wastewater. It also provides a new way to improve the adsorption capacity of reduced graphene oxide for dealing with the heavy metal ion in wastewater.
基金supported in part by Fundamental Research Funds for the Central Universities(No.FRF-TP-15-114A1)National Natural Science Foundation of China(Nos.11375096,11505300)Tsinghua University Initiative Scientific Research Program(No.20131089289)
文摘To increase spatial resolution and signal-to-noise ratio in PET imaging,we present in this paper the design and performance evaluation of a PET detector module combining both depth-of-interaction(DOI) and time-offlight(TOF) capabilities.The detector module consists of a staggered dual-layer LYSO block with2 mm × 2 mm × 7 mm crystals.MR-compatible SiPM sensors(MicroFJ-30035-TSV,SensL) are assembled into an 8× 8 array.SiPM signals from both fast and slow outputs are read out by a 128-channel ASIC chip.To test its performance,a flood histogram is acquired with a ^(22)Na point source on top of the detector,and the energy resolution and the coincidence resolving time(CRT) value for each individual crystal are measured.The flood histogram shows excellent crystal separation in both layers.The average energy resolution at 511 keV is 14.0 and 12.7%at the bottom and top layers,respectively.The average CRT of a single crystal is 635 and 565 ps at the bottom and top layers,respectively.In conclusion,the compact DOI-TOF PET detector module is of excellent crystal identification capability,good energy resolution and reasonable time resolution and has promising application prospective in clinical TOF PET,PET/MRI,and brain PET systems.
基金funded by the National Natural Science Foundation of China (81673662 and 81873059)the Program for Professor of Special Appointment (Eastern Scholar)&Shuguang Scholar (16SG36) at the Shanghai Institutions of Higher Learning from Shanghai Municipal Education
文摘Polysaccharides are widely present in herbs with multiple activities,especially immunity regulation and metabolic benefits for metabolic disorders.However,the underlying mechanisms are not well under-stood.Functional metabolomics is increasingly used to investigate systemic effects on the host by iden-tifying metabolites with particular functions.This study explores the mechanisms underlying the metabolic benefits of Astragalus polysaccharides(APS)by adopting a functional metabolomics strategy.The effects of APS were determined in eight-week high-fat diet(HFD)-fed obese mice.Then,gas chromatography–time-of-flight mass spectrometry(GC–TOFMS)-based untargeted metabolomics was performed for an analysis of serum and liver tissues,and liquid chromatography–tandem mass spectrom-etry(LC–MS/MS)-based targeted metabolomics was performed.The potential functions of the metabo-lites were tested with in vitro and in vivo models of metabolic disorders.Our results first confirmed the metabolic benefits of APS in obese mice.Then,metabolomics analysis revealed that APS supplemen-tation reversed the HFD-induced metabolic changes,and identified 2-hydroxybutyric acid(2-HB)as a potential functional metabolite for APS activity that was significantly decreased by a HFD and reversed by APS.Further study indicated that 2-HB inhibited oleic acid(OA)-induced triglyceride(TG)accumula-tion.It was also found to stimulate the expression of proteins in lipid degradation in hepatocytes and TG lipolysis in 3T3-L1 cells.Moreover,it was found to reduce serum TG and regulate the proteins involved in lipid degradation in high-fat and high-sucrose(HFHS)-fed mice.In conclusion,our study demonstrates that the metabolic benefits of APS are at least partially due to 2-HB generation,which modulated lipid metabolism both in vitro and in vivo.Our results also highlight that functional metabolomics is practical for investigating the mechanism underlying the systemic benefits of plant polysaccharides.
文摘Cell discontinuous transmission(Cell DTx)is a key technology to mitigate inter-cell interference(ICI)in ultra-dense networks(UDNs).The aim of this work is to understand the impact of Cell DTx on physical-layer sum rates of SBSs and link-layer quality-of-service(QoS)performance in multiuser UDNs.In this work,we develop a cross-layer framework for capacity analysis in multiuser UDNs with Cell DTx.In particular,we first extend the traditional one-dimensional effective capacity model to a new multidimensional effective capacity model to derive the sum rate and the effective capacity.Moreover,we propose a new iterative bisection search algorithm that is capable of approximating QoS performance.The convergence of this new algorithm to a unique QoS exponent vector is later proved.Finally,we apply this framework to the round-robin and the max-C/I scheduling policies.Simulation results show that our framework is accurate in approximating 1)queue length distribution,2)delay distribution and 3)sum rates under the above two scheduling policies,and further show that with the Cell DTx,systems have approximately 30% higher sum rate and 35% smaller average delay than those in full-buffer scenarios.
基金This work was supported by the National Natural Science Foundation of China(Nos.11875313,12075153,and 11575277).
文摘Membrane fouling is always the biggest problem in the practice of membrane separation technologies,which strongly impacts their applicability,separation efficiency,cost effectiveness,and service lifespan.Herein,a simple but effective 3D modification approach was designed for permanently functionalizing polymeric membranes by directly cross-linking polyvinyl alcohol(PVA)under gamma-ray irradiation at room temperature without any additives.After the modification,a PVA layer was constructed on the membrane surface and the pore inner surface of polyvinylidene fluoride(PVDF)membranes.This endowed them with good hydrophilicity,low adsorption of protein model foulants,and easy recoverability properties.In addition,the pore size and distribution were customized by controlling the PVA concentration,which enhanced the rejection ability of the resultant membranes and converted them from microfiltration to ultrafiltration.The crosslinked PVA layer was equipped with the resultant membranes with good resistance to chemical cleaning by acidic,alkaline,and oxidative reagents,which could greatly prolong the membrane service lifetime.Furthermore,this approach was demonstrated as a universal method to modify PVDF membranes with other hydrophilic macromolecular modifiers,including polyethylene glycol,sodium alginate,and polyvinyl pyrrolidone.This modification of the membranes effectively endowed them with good hydrophilicity and antifouling properties,as expected.
