目的运用孟德尔随机化分析研究免疫细胞与宫颈癌(CC)的因果关系。方法通过双向孟德尔随机化分析,利用全基因组关联研究(GWAS)数据集,探讨多种免疫细胞与宫颈癌之间的正反因果关系。研究中以逆方差加权法(IVW)分析为主,MR Egger法、加权...目的运用孟德尔随机化分析研究免疫细胞与宫颈癌(CC)的因果关系。方法通过双向孟德尔随机化分析,利用全基因组关联研究(GWAS)数据集,探讨多种免疫细胞与宫颈癌之间的正反因果关系。研究中以逆方差加权法(IVW)分析为主,MR Egger法、加权中位数法(WM)、simple model法、weighted mode法分析为辅,同时运用敏感性分析综合评估结果的异质性和水平多效性。结果正向孟德尔随机化分析IVW法发现了4种与宫颈癌风险相关的免疫细胞亚型,包括CD39+activated CD4 Treg%activated CD4 Treg(OR=1.2459,95%CI:1.0646~1.4580,P=0.0061),CD25 on switched memory B cell(OR=0.8646,95%CI:0.7826~0.9551,P=0.0042),CD66b on CD66b++myeloid cell(OR=1.1050,95%CI:1.0327~1.1823,P=0.0038),CD28 on CD45RA-CD4 not regulatory T cell(OR=1.1822,95%CI:1.0429~1.3400,P=0.0089)。反向孟德尔随机化分析IVW法发现宫颈癌可对6种免疫细胞亚型产生影响,包括Unswitched memory B cell%B cell(OR=0.9154,95%CI:0.8568~0.9780,P=0.0088),CD62L-HLA DR++monocyte Absolute Count(OR=1.1065,95%CI:1.0261~1.1931,P=0.0085),CD62L-HLA DR++monocyte%monocyte(OR=1.1064,95%CI:1.0308~1.1875,P=0.0051),CD39+activated CD4 Treg%activated CD4 Treg(OR=1.1691,95%CI:1.0398~1.3145,P=0.0090),CD33dim HLA DR+CD11b-Absolute Count(OR=1.1266,95%CI:1.0369~1.2239,P=0.0048),CD3 on Central CD8+T cell(OR=1.1168,95%CI:1.0407~1.1984,P=0.0022)。结论本研究为免疫细胞与宫颈癌之间的因果关系提供了证据,对临床诊断和治疗指导了方向。展开更多
Tilted metasurface nanostructures,with excellent physical properties and enormous application potential,pose an urgent need for manufacturing methods.Here,electric-field-driven generative-nanoimprinting technique is p...Tilted metasurface nanostructures,with excellent physical properties and enormous application potential,pose an urgent need for manufacturing methods.Here,electric-field-driven generative-nanoimprinting technique is proposed.The electric field applied between the template and the substrate drives the contact,tilting,filling,and holding processes.By accurately controlling the introduced included angle between the flexible template and the substrate,tilted nanostructures with a controllable angle are imprinted onto the substrate,although they are vertical on the template.By flexibly adjusting the electric field intensity and the included angle,large-area uniform-tilted,gradient-tilted,and high-angle-tilted nanostructures are fabricated.In contrast to traditional replication,the morphology of the nanoimprinting structure is extended to customized control.This work provides a cost-effective,efficient,and versatile technology for the fabrication of various large-area tilted metasurface structures.As an illustration,a tilted nanograting with a high coupling efficiency is fabricated and integrated into augmented reality displays,demonstrating superior imaging quality.展开更多
文摘目的运用孟德尔随机化分析研究免疫细胞与宫颈癌(CC)的因果关系。方法通过双向孟德尔随机化分析,利用全基因组关联研究(GWAS)数据集,探讨多种免疫细胞与宫颈癌之间的正反因果关系。研究中以逆方差加权法(IVW)分析为主,MR Egger法、加权中位数法(WM)、simple model法、weighted mode法分析为辅,同时运用敏感性分析综合评估结果的异质性和水平多效性。结果正向孟德尔随机化分析IVW法发现了4种与宫颈癌风险相关的免疫细胞亚型,包括CD39+activated CD4 Treg%activated CD4 Treg(OR=1.2459,95%CI:1.0646~1.4580,P=0.0061),CD25 on switched memory B cell(OR=0.8646,95%CI:0.7826~0.9551,P=0.0042),CD66b on CD66b++myeloid cell(OR=1.1050,95%CI:1.0327~1.1823,P=0.0038),CD28 on CD45RA-CD4 not regulatory T cell(OR=1.1822,95%CI:1.0429~1.3400,P=0.0089)。反向孟德尔随机化分析IVW法发现宫颈癌可对6种免疫细胞亚型产生影响,包括Unswitched memory B cell%B cell(OR=0.9154,95%CI:0.8568~0.9780,P=0.0088),CD62L-HLA DR++monocyte Absolute Count(OR=1.1065,95%CI:1.0261~1.1931,P=0.0085),CD62L-HLA DR++monocyte%monocyte(OR=1.1064,95%CI:1.0308~1.1875,P=0.0051),CD39+activated CD4 Treg%activated CD4 Treg(OR=1.1691,95%CI:1.0398~1.3145,P=0.0090),CD33dim HLA DR+CD11b-Absolute Count(OR=1.1266,95%CI:1.0369~1.2239,P=0.0048),CD3 on Central CD8+T cell(OR=1.1168,95%CI:1.0407~1.1984,P=0.0022)。结论本研究为免疫细胞与宫颈癌之间的因果关系提供了证据,对临床诊断和治疗指导了方向。
基金supported by National Natural Science Foundation of China(No.52025055 and 52275571)Basic Research Operation Fund of China(No.xzy012024024).
文摘Tilted metasurface nanostructures,with excellent physical properties and enormous application potential,pose an urgent need for manufacturing methods.Here,electric-field-driven generative-nanoimprinting technique is proposed.The electric field applied between the template and the substrate drives the contact,tilting,filling,and holding processes.By accurately controlling the introduced included angle between the flexible template and the substrate,tilted nanostructures with a controllable angle are imprinted onto the substrate,although they are vertical on the template.By flexibly adjusting the electric field intensity and the included angle,large-area uniform-tilted,gradient-tilted,and high-angle-tilted nanostructures are fabricated.In contrast to traditional replication,the morphology of the nanoimprinting structure is extended to customized control.This work provides a cost-effective,efficient,and versatile technology for the fabrication of various large-area tilted metasurface structures.As an illustration,a tilted nanograting with a high coupling efficiency is fabricated and integrated into augmented reality displays,demonstrating superior imaging quality.
