Dear Editor,We reported the case of idiopathic uveal effusion syndrome(IUES)with increased intraocular pressure.IUES is a disease caused by an abnormal increase in serous exudation of the choriocapillaris in the eye f...Dear Editor,We reported the case of idiopathic uveal effusion syndrome(IUES)with increased intraocular pressure.IUES is a disease caused by an abnormal increase in serous exudation of the choriocapillaris in the eye for unknown reasons;it accumulates in the choroid and subretinal space,leading to choroidal and ciliary body detachment and nonrhegmatogenous retinal detachment[1].The diagnosis of IUES requires the exclusion of other causes of uveal effusion,such as choroidal tumors,uveitis,and surgical causes[2-3].展开更多
Whether long non-coding RNA myocardial infarction-associated transcript is involved in oxygen-induced retinopathy remains poorly understood. To validate this hypothesis, we established a newborn mouse model of oxygen-...Whether long non-coding RNA myocardial infarction-associated transcript is involved in oxygen-induced retinopathy remains poorly understood. To validate this hypothesis, we established a newborn mouse model of oxygen-induced retinopathy by feeding in an oxygen concentration of 75 ± 2% from postnatal day 8 to postnatal day 12, followed by in normal air. On postnatal day 11, the mice were injected with the myocardial infarction-associated transcript siRNA plasmid via the vitreous cavity to knockdown long non-coding RNA myocardial infarction-associated transcript. Myocardial infarction-associated transcript siRNA transcription significantly inhibited myocardial infarctionassociated transcript mRNA expression, reduced the phosphatidylinosital-3-kinase, phosphorylated Akt and vascular endothelial growth factor immunopositivities, protein and mRNA expression, and alleviated the pathological damage to the retina of oxygen-induced retinopathy mouse models. These findings suggest that myocardial infarction-associated transcript is likely involved in the retinal neovascularization in retinopathy of prematurity and that inhibition of myocardial infarction-associated transcript can downregulate phosphatidylinosital-3-kinase, phosphorylated Akt and vascular endothelial growth factor expression levels and inhibit neovascularization. This study was approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University, China(approval No. 2016 PS074 K) on February 25, 2016.展开更多
Long noncoding RNA(lncRNA)regulates the proliferation and migration of human retinal endothelial cells,as well as retinal neovascularization in diabetic retinopathy.Based on similarities between the pathogenesis of re...Long noncoding RNA(lncRNA)regulates the proliferation and migration of human retinal endothelial cells,as well as retinal neovascularization in diabetic retinopathy.Based on similarities between the pathogenesis of retinopathy of prematurity(ROP)and diabetic retinopathy,lncRNA may also play a role in ROP.Seven-day-old mice were administered 75±2% oxygen for 5 days and normoxic air for another 5 days to establish a ROP model.Expression of lncRNA and mRNA in the retinal tissue of mice was detected by high-throughput sequencing technology,and biological functions of the resulted differentially expressed RNAs were evaluated by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses.The results showed that compared with the control group,57 lncRNAs were differentially expressed,including 43 upregulated and 14 downregulated,in the retinal tissue of ROP mice.Compared with control mice,42 mRNAs were differentially expressed in the retinal tissue of ROP mice,including 24 upregulated and 18 downregulated mRNAs.Differentially expressed genes were involved in ocular development and related metabolic pathways.The differentially expressed lncRNAs may regulate ROP in mice via microRNAs and multiple signaling pathways.Our results revealed that these differentially expressed lncRNAs may be therapeutic targets for ROP treatment.This study was approved by the Medical Ethics Committee of Shengjing Hospital of China Medical University on February 25,2016(approval No.2016PS074K).展开更多
非阻塞性颗粒阻尼(non-obstructive particle damper,NOPD)腔体几何形状会显著改变颗粒层间的压力分布特性,从而影响其振动抑制性能。采用离散元数值方法(discrete element method,DEM)分析了圆锥腔体NOPD的动力学特性。首先,构建了NOP...非阻塞性颗粒阻尼(non-obstructive particle damper,NOPD)腔体几何形状会显著改变颗粒层间的压力分布特性,从而影响其振动抑制性能。采用离散元数值方法(discrete element method,DEM)分析了圆锥腔体NOPD的动力学特性。首先,构建了NOPD基于离散元的数值模型,并进行了实验测试,结合实验结果验证了模型的可靠性。重点讨论了圆锥腔体NOPD结构参数如颗粒填充比、体积比参数(单个颗粒体积与腔体容积之比)及壁倾角等对其减振性能的影响机制。分析结果表明,圆锥腔体NOPD在0.6的填充比时呈现最佳阻尼效果,且该最优值与壁倾角无关。然后,通过对比分析发现在填充比低于0.6时,圆锥腔体NOPD增加了颗粒间碰撞耗能而表现出优于圆柱形腔体NOPD的减振性能;但当填充比超过0.6时,圆锥结构导致颗粒运动受限反而使其性能下降。参数优化计算显示,锥壁最佳倾斜角度区间为45°~55°,同时确定了最优体积占比参数为0.00032。展开更多
The structural design of housing architecture is the core part of housing architecture design, and the overall design effect is directly related to the safety and stability of the building, as well as the life and pro...The structural design of housing architecture is the core part of housing architecture design, and the overall design effect is directly related to the safety and stability of the building, as well as the life and property safety of users. With the rapid development of China's economy, users have a higher demand for the structural design of housing construction. The basic structural design is also a key part of the building architecture design. Therefore, we need to pay more attention to the building architecture design to ensure the rationality and scientificity of the overall design, so as to comprehensively improve the overall level of building architecture design.展开更多
基金Supported by the National Natural Science Foundation of China(No.81600747)Foundation of Liaoning Province Education Administration(No.JYTMS20230089)Joint Project Planned by the Department of Science and Technology of Liaoning Province(No.2023JH2/101700129).
文摘Dear Editor,We reported the case of idiopathic uveal effusion syndrome(IUES)with increased intraocular pressure.IUES is a disease caused by an abnormal increase in serous exudation of the choriocapillaris in the eye for unknown reasons;it accumulates in the choroid and subretinal space,leading to choroidal and ciliary body detachment and nonrhegmatogenous retinal detachment[1].The diagnosis of IUES requires the exclusion of other causes of uveal effusion,such as choroidal tumors,uveitis,and surgical causes[2-3].
基金supported by the National Natural Science Foundation of China,No.81600747(to YD)the Start-Up Foundation for Doctors of Liaoning Province,China,No.201501020(to YD)。
文摘Whether long non-coding RNA myocardial infarction-associated transcript is involved in oxygen-induced retinopathy remains poorly understood. To validate this hypothesis, we established a newborn mouse model of oxygen-induced retinopathy by feeding in an oxygen concentration of 75 ± 2% from postnatal day 8 to postnatal day 12, followed by in normal air. On postnatal day 11, the mice were injected with the myocardial infarction-associated transcript siRNA plasmid via the vitreous cavity to knockdown long non-coding RNA myocardial infarction-associated transcript. Myocardial infarction-associated transcript siRNA transcription significantly inhibited myocardial infarctionassociated transcript mRNA expression, reduced the phosphatidylinosital-3-kinase, phosphorylated Akt and vascular endothelial growth factor immunopositivities, protein and mRNA expression, and alleviated the pathological damage to the retina of oxygen-induced retinopathy mouse models. These findings suggest that myocardial infarction-associated transcript is likely involved in the retinal neovascularization in retinopathy of prematurity and that inhibition of myocardial infarction-associated transcript can downregulate phosphatidylinosital-3-kinase, phosphorylated Akt and vascular endothelial growth factor expression levels and inhibit neovascularization. This study was approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University, China(approval No. 2016 PS074 K) on February 25, 2016.
基金supported by the National Natural Science Foundation of China,No.81600747(to YD)Startup Foundation for Doctors of Liaoning Province,China,No.201501020(to YD)
文摘Long noncoding RNA(lncRNA)regulates the proliferation and migration of human retinal endothelial cells,as well as retinal neovascularization in diabetic retinopathy.Based on similarities between the pathogenesis of retinopathy of prematurity(ROP)and diabetic retinopathy,lncRNA may also play a role in ROP.Seven-day-old mice were administered 75±2% oxygen for 5 days and normoxic air for another 5 days to establish a ROP model.Expression of lncRNA and mRNA in the retinal tissue of mice was detected by high-throughput sequencing technology,and biological functions of the resulted differentially expressed RNAs were evaluated by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses.The results showed that compared with the control group,57 lncRNAs were differentially expressed,including 43 upregulated and 14 downregulated,in the retinal tissue of ROP mice.Compared with control mice,42 mRNAs were differentially expressed in the retinal tissue of ROP mice,including 24 upregulated and 18 downregulated mRNAs.Differentially expressed genes were involved in ocular development and related metabolic pathways.The differentially expressed lncRNAs may regulate ROP in mice via microRNAs and multiple signaling pathways.Our results revealed that these differentially expressed lncRNAs may be therapeutic targets for ROP treatment.This study was approved by the Medical Ethics Committee of Shengjing Hospital of China Medical University on February 25,2016(approval No.2016PS074K).
文摘非阻塞性颗粒阻尼(non-obstructive particle damper,NOPD)腔体几何形状会显著改变颗粒层间的压力分布特性,从而影响其振动抑制性能。采用离散元数值方法(discrete element method,DEM)分析了圆锥腔体NOPD的动力学特性。首先,构建了NOPD基于离散元的数值模型,并进行了实验测试,结合实验结果验证了模型的可靠性。重点讨论了圆锥腔体NOPD结构参数如颗粒填充比、体积比参数(单个颗粒体积与腔体容积之比)及壁倾角等对其减振性能的影响机制。分析结果表明,圆锥腔体NOPD在0.6的填充比时呈现最佳阻尼效果,且该最优值与壁倾角无关。然后,通过对比分析发现在填充比低于0.6时,圆锥腔体NOPD增加了颗粒间碰撞耗能而表现出优于圆柱形腔体NOPD的减振性能;但当填充比超过0.6时,圆锥结构导致颗粒运动受限反而使其性能下降。参数优化计算显示,锥壁最佳倾斜角度区间为45°~55°,同时确定了最优体积占比参数为0.00032。
文摘The structural design of housing architecture is the core part of housing architecture design, and the overall design effect is directly related to the safety and stability of the building, as well as the life and property safety of users. With the rapid development of China's economy, users have a higher demand for the structural design of housing construction. The basic structural design is also a key part of the building architecture design. Therefore, we need to pay more attention to the building architecture design to ensure the rationality and scientificity of the overall design, so as to comprehensively improve the overall level of building architecture design.
