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胸腔镜和开胸肺叶切除术对非小细胞肺癌患者免疫因子、炎性因子表达水平影响的研究 被引量:25
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作者 曹小庆 刘志东 +1 位作者 于大平 韩毅 《中国医刊》 CAS 2020年第12期1358-1361,共4页
目的探讨胸腔镜肺叶切除术和开胸肺叶切除术对非小细胞肺癌患者免疫因子、炎性因子表达的影响。方法选取2017年6月至2019年10月首都医科大学附属北京胸科医院收治的80例非小细胞肺癌患者为研究对象,按照交叉双盲法分为对照组(40例)和观... 目的探讨胸腔镜肺叶切除术和开胸肺叶切除术对非小细胞肺癌患者免疫因子、炎性因子表达的影响。方法选取2017年6月至2019年10月首都医科大学附属北京胸科医院收治的80例非小细胞肺癌患者为研究对象,按照交叉双盲法分为对照组(40例)和观察组(40例),对照组行开胸肺叶切除术治疗,观察组行胸腔镜肺叶切除术。根据用力肺活量(forced vital capacity,FVC),1秒量(forced expiratory volume in 1 second,FEV1)、每分钟最大通气量(maximum ventilatory volume,MVV)、1秒率(ratio of forced expiratory volume to forced vital capacity in 1 second,FEV1/FVC)等水平,比较两组患者术前、术后肺功能。通过CD4+、CD8+、CD16+CD56+、CD4+/CD8+等T细胞亚群水平,以及免疫球蛋白G、免疫球蛋白M、免疫球蛋白A等免疫球蛋白水平,比较两组患者免疫功能。同时评估C反应蛋白、白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α等水平,比较两组患者术前、术后炎性应激状态。结果两组患者淋巴结清扫数目差异无显著性(P>0.05),观察组手术时间、切口长度、术中出血量优于对照组,差异有显著性(P<0.05)。术前两组FVC、FEV1、MVV、FEV1/FVC等水平差异均无显著性(P>0.05);术后观察组肺功能指标水平优于对照组,差异有显著性(P<0.05)。术前两组CD4+、CD8+、CD16+CD56+、CD4+/CD8+等T细胞亚群水平及免疫球蛋白G、免疫球蛋白M、免疫球蛋白A等免疫球蛋白水平差异均无显著性(P>0.05);术后观察组各项免疫功能指标水平优于对照组,差异有显著性(P<0.05)。术前两组患者C反应蛋白、白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α等水平差异无显著性(P>0.05);术后观察组各项炎性因子水平优于对照组,差异有显著性(P<0.05)。结论相较于开胸肺叶切除术,胸腔镜肺叶切除术具有创伤小、出血少等优点,可以保留较好的肺功能,同时提高机体免疫功能并改善炎性应激状态。 展开更多
关键词 非小细胞肺癌 胸腔镜肺叶切除术 肺功能 免疫因子 炎性因子
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Catalyst Innovation for Reducing Olefin Content in MGG Gasoline
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作者 yu daping Qiu Zhonghong 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS 2010年第2期19-21,共3页
In order to reduce the olefin content in gasoline manufactured by the MGG (Maximizing Liquefied Gas and Gasoline) process while retaining the LPG yield, RIPP has developed a novel catalyst consisting of a more pore-... In order to reduce the olefin content in gasoline manufactured by the MGG (Maximizing Liquefied Gas and Gasoline) process while retaining the LPG yield, RIPP has developed a novel catalyst consisting of a more pore-opened matrix and the modified Y-zeolite and the ZRP zeolite modified with metal oxides. Test results have revealed that compared with the commercial catalyst RAG under comparable reaction conditions the reaction conversion rate and product distribution provided by the novel catalyst were similar, but the olefin content in gasoline obtained thereof was decreased with the octane rating unchanged along with a slight reduction of olefin content in the LPG fraction. The hydrothermal stability of the novel catalyst was better than the commercial catalyst RAG. 展开更多
关键词 CATALYST GASOLINE OCTANE hydrogen transfer reaction olefin selectivity
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FCC Catalysts to Meet Demand of New Era
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作者 yu daping 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS 2008年第1期9-15,共7页
The CGP series FCC catalysts for manufacture of clean gasoline and propylene and the catalyst RSC-2006 for processing inferior residuum with high yield of light distillates are novel catalysts jointly developed by Qil... The CGP series FCC catalysts for manufacture of clean gasoline and propylene and the catalyst RSC-2006 for processing inferior residuum with high yield of light distillates are novel catalysts jointly developed by Qilu Catalyst Branch Company of SINOPEC Corp. and the Research Institute of Petroleum Processing (RIPP). The results of commercial application of these catalysts have revealed that they can satisfactorily meet the requirements for environmental protection, good economic benefits and capability for processing inferior FCC feed under new circumstances. 展开更多
关键词 clean gasoline PROPYLENE inferior residuum catalytic cracking
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Gene expression profiles of ERCC1, TYMS, RRM1, TUBB3 and EGFR in tumor tissue from non-small cell lung cancer patients 被引量:7
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作者 yu daping Li Jie +5 位作者 Han Yi Liu Shuku Xiao Ning Li yunsong Sun Xiaojun Liu Zhidong 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第8期1464-1468,共5页
Background Personalized medicine becomes essential in lung cancer treatment, however lung-cancer-related gene expression profiles in Chinese patients remain unknown. In this study, the correlation of gene expression p... Background Personalized medicine becomes essential in lung cancer treatment, however lung-cancer-related gene expression profiles in Chinese patients remain unknown. In this study, the correlation of gene expression profiles and clinical characteristics in non-small-cell lung cancer (NSCLC) was investigated. Methods Seventy-six Chinese patients with NSCLC were enrolled in the study to investigate mRNA expression profiles of excision repair cross complement group 1 (ERCC1), thymidylate synthetase (TYMS), ribonucleotide reductase (RRM1), class Ill 13-tubulin (TUBB3), and epidermal growth factor receptor (EGFR) genes and their correlation with patient clinical characteristics. A novel liquidchip technology was used to detect mRNA expression levels in formalin fixed paraffin embedded tumor pathology samples. The relationships between gene expression and clinical characteristics were assessed using the Mann-Whitney test. Results ERCC1 mRNA levels were higher in tumors from patients with metastatic disease than patients with non- metastatic disease (P=-0.021), and higher in adenocarcinomas than squamous cell carcinomas (P=0.006). Increased TUBB3 mRNA expression levels were found in patients with performance status (PS) 1 in comparison with PS 0 (P=0.049), with poorly differentiated tumors in comparison with tumors that were moderately and well differentiated (P 〈0.000 1), and with advanced stage in comparison with early stage disease (P 〈0.000 1). Conclusions ERCC1 mRNA levels were higher in metastatic adenocarcinoma NSCLC; TUBB3 mRNA levels were significantly higher in poorly differentiated tumors and in advanced stage NSCLC, which indicates the poor prognosis. 展开更多
关键词 ERCC1 gene TYMS gene RRM1 gene TUBB3 gene EGFR gene liquidchip non-small cell lung cancer
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