Due to the significant impact of carbon dioxide on global ecology,more efforts have been put into the exploration on CO_(2)capture and utilization.Porous organic framework materials,as a kind of materials with high po...Due to the significant impact of carbon dioxide on global ecology,more efforts have been put into the exploration on CO_(2)capture and utilization.Porous organic framework materials,as a kind of materials with high porosity and designable structure,have been considered as effective host materials for adsorbing carbon dioxide or separating it from other gases.This review gives a deep insight into the applications of metal-organic frameworks,covalent-organic frameworks,and other porous frameworks on CO_(2)capture,focusing on the enhanced capture performances originated from their high surface area with abundant porous structure,functional groups with specific heteroatoms modification,or other building unit interactions.Besides,the main challenges associated with porous frameworks for CO_(2)capture and proposed strategies to address these obstacles,including the structural design strategy or the capture mechanism exploration,have been demonstrated and emphasized.This review can contribute to further investigation on porous frameworks for gas capture and separation with enhanced performance and efficiency.展开更多
Reasonable field acquisition geometry can not only guide seismic exploration to obtain sufficient geological information of target body,but also reduce acquisition cost to the maximum.In this study,building on convent...Reasonable field acquisition geometry can not only guide seismic exploration to obtain sufficient geological information of target body,but also reduce acquisition cost to the maximum.In this study,building on conventional ray-based geometry design methods,we incorporate imaging results as a constraint to optimize the geometry design and evaluate its effectiveness.Firstly,the geological model of the target layer is established based on the geological data of the study area and surface seismic data combined with exploration tasks.Then,the ray-tracing method is employed to simulate and assess the proposed geometry design,verifying whether its parameters meet the exploration requirements.Finally,the imaging effect of the designed geometry on the target layer is tested by the cross-well seismic reverse time migration method.This methodology was applied to design the cross-well seismic acquisition geometry for offshore deviated wells in the X Oilfield.The simulation results demonstrate that the imaging-driven geometry design approach effectively guides field operations,enhances the imaging quality of the target layer,and reduces acquisition costs.展开更多
Warm dense plasmas are crucial for high-energy-density physics and inertial confinement fusion research.Experiments involving laser-irradiated copper(Cu)foil were performed at the Shenguang-II facility.A highly orient...Warm dense plasmas are crucial for high-energy-density physics and inertial confinement fusion research.Experiments involving laser-irradiated copper(Cu)foil were performed at the Shenguang-II facility.A highly oriented pyrolytic graphite crystal spectrometer measured the time-integrated spectral distribution of Cu under varying laser intensities.Using the two-dimensional radiation-hydrodynamics code FLASH and the spectral analysis code FLYCHK,we simulated the temporal evolution of plasma density and temperature distributions,as well as the emission intensities of spectral lines at different temperatures and densities.The simulation results revealed that the two-electron satellite lines(J)and the resonance line(W)emissions of Cu originate predominantly from the radiation region near the critical density surface,with a density range from approximately 0.5 nc to 1.0 nc,and radiate primarily during the laser irradiation period.By analyzing the J/W intensity ratio of the measured spectral lines,we estimated the electron temperatures near the critical-density surface under different laser intensities.展开更多
AIM:To develop models to predict hepatitis B e antigen(HBe Ag)seroconversion in response to interferon(IFN)-αtreatment in chronic hepatitis B patients.METHODS:We enrolled 147 treatment-nave HBe Agpositive chronic h...AIM:To develop models to predict hepatitis B e antigen(HBe Ag)seroconversion in response to interferon(IFN)-αtreatment in chronic hepatitis B patients.METHODS:We enrolled 147 treatment-nave HBe Agpositive chronic hepatitis B patients in China and analyzed variables after initiating IFN-α1b treatment.Patients were tested for serum alanine aminotransferase(ALT),hepatitis B virus-DNA,hepatitis B surface antigen(HBs Ag),antibody to hepatitis B surface antigen,HBe Ag,antibody to hepatitis B e antigen(anti-HBe),and antibody to hepatitis B core antigen(anti-HBc)at baseline and 12 wk,24 wk,and 52 wk after initiating treatment.We performed univariate analysis to identify response predictors among the variables.Multivariate models to predict treatment response were constructed at baseline,12 wk,and 24 wk.RESULTS:At baseline,the 3 factors correlating most with HBe Ag seroconversion were serum ALT level>4×the upper limit of normal(ULN),HBe Ag≤500 S/CO,and anti-HBc>11.4 S/CO.At 12 wk,the 3 factors most associated with HBe Ag seroconversion were HBe Ag level≤250 S/CO,decline in HBe Ag>1 log10 S/CO,and anti-HBc>11.8 S/CO.At 24 wk,the 3 factors most associated with HBe Ag seroconversion were HBe Ag level≤5 S/CO,anti-HBc>11.4 S/CO,and decline in HBe Ag>2 log10 S/CO.Each variable was assigned a score of1,a score of 0 was given if patients did not have any of the 3 variables.The 3 factors most strongly correlating with HBe Ag seroconversion at each time point were used to build models to predict the outcome after IFN-αtreatment.When the score was 3,the response rates at the 3 time points were 57.7%,83.3%,and 84.0%,respectively.When the score was 0,the response rates were 2.9%,0.0%,and 2.1%,respectively.CONCLUSION:Models with good negative and positive predictive values were developed to calculate the probability of response to IFN-αtherapy.展开更多
The Chinese HαSolar Explorer(CHASE)is designed to test a newly developed satellite platform and conduct solar observations.The scientific payload of the satellite is an Hαimaging spectrograph(HIS),which can,for the ...The Chinese HαSolar Explorer(CHASE)is designed to test a newly developed satellite platform and conduct solar observations.The scientific payload of the satellite is an Hαimaging spectrograph(HIS),which can,for the first time,acquire full-disk spectroscopic solar observations in the Hαwaveband.This paper briefly introduces CHASE/HIS including its scientific objectives,technical parameters,scientific application system,etc.The CHASE mission is scheduled to launch in 2021.It will complement the observations by on-orbit solar spacecraft(such as SDO,IRIS,STEREO and PSP),as well as future solar missions of the Solar Orbiter and Advanced Space-based Solar Observatory(ASO-S).展开更多
Disinfectants are commonly applied to control the growth of microorganisms in drinking water distribution systems. However, the effect of disinfection on drinking water microbial community remains poorly understood. T...Disinfectants are commonly applied to control the growth of microorganisms in drinking water distribution systems. However, the effect of disinfection on drinking water microbial community remains poorly understood. The present study investigated the impacts of different disinfectants（chlorine and chloramine） and dosages on biofilm bacterial community in bench-scale pipe section reactors. Illumina MiS eq sequencing illustrated that disinfection strategy could affect both bacterial diversity and community structure of drinking water biofilm. Proteobacteria tended to predominate in chloraminated drinking water biofilms, while Firmicutes in chlorinated and unchlorinated biofilms. The major proteobacterial groups were influenced by both disinfectant type and dosage. In addition, chloramination had a more profound impact on bacterial community than chlorination.展开更多
Chinese bayberry Myrica rubra is a very popular fruit in southeastern China.In spite of its wide consumption,no allergies to this fruit have been reported previously.Here we report on a 40-year-old woman suffering fro...Chinese bayberry Myrica rubra is a very popular fruit in southeastern China.In spite of its wide consumption,no allergies to this fruit have been reported previously.Here we report on a 40-year-old woman suffering from anaphylaxis to Chinese bayberry fruit.Prick-prick skin tests revealed strong reactions to fresh Chinese bayberry fruits as well as to peach,and weaker reactions to some other fruits including apple,melon,and banana.ImmunoCAP analysis revealed identical titers of specific IgE(4.3 kU A /L) to peach extract and its lipid transfer protein(LTP,rPru p 3),which was confirmed by detection of a 9 kD band following immunoblotting.Immunoblot analysis with Chinese bayberry extract gave bands of 22,45,and 90 kD,but no 9 kD band was recognized.There was also no evidence of LTP recognition for loquat(36 kD) or melon(24 kD).This first report of a severe allergic reaction to Chinese bayberry fruit in a patient with LTP-mediated peach allergy indicates that other as yet unidentified non-pollen related fruit allergens are involved in this new severe fruit allergy.展开更多
This paper reports the chemical synthesis of tungsten carbide/cobalt (WC/Co) nanocomposite powders via a unique chemical processing technique, involving the using of all water soluble solution of W-, Co- and C-precurs...This paper reports the chemical synthesis of tungsten carbide/cobalt (WC/Co) nanocomposite powders via a unique chemical processing technique, involving the using of all water soluble solution of W-, Co- and C-precursors. In the actual synthesis, large quantities of commercial-scale WC-Co nanocomposite powders are made by an unique combination of converting a molecularly mixed W-, Co-, and C-containing solutions into a complex inorganic polymeric powder precursor, conversion of the inorganic polymeric precursor powder into a W-Co-C-O containing powder intermediates using a belt furnace with temperature at about 500°C - 600°C in an inert atmosphere, followed by carburization in a rotary furnace at temperature less than 1000°C in nitrogen. Liquid phase sintering technique is used to consolidate the WC/Co nanocomposite powder into sintered bulk parts. The sintered parts have excellent hardness in excess of 93 HRA, with WC grains in the order of 200 - 300 nm, while Co phase is uniformly distributed on the grain boundaries of the WC nanoparticles. We also report the presence of cobalt Co precipitates inside tungsten carbide WC nanograins in the composites of the consolidated bulk parts. EDS is used to identify the presence of these precipitates and micro-micro-diffraction technique is employed to determine the nature of these precipitates.展开更多
A new multi-wavelength solar telescope, the Optical and Near-infrared Solar Eruption Tracer （ONSET） of Nanjing University, has been constructed. It was fabricated at the Nanjing Institute of Astronomical Optics ＆ T...A new multi-wavelength solar telescope, the Optical and Near-infrared Solar Eruption Tracer （ONSET） of Nanjing University, has been constructed. It was fabricated at the Nanjing Institute of Astronomical Optics ＆ Technology, and the oper- ation is jointly administered with Yunnan Astronomical Observatory. ONSET is able to observe the Sun in three wavelength windows： He I 10830 A, Ha and white-light at 3600 A and 4250 A, which are selected in order to simultaneously record the dynam- ics of the corona, chromosphere and photosphere respectively. Full-disk or partial-disk solar images with a field of 10~ at three wavelengths can be obtained nearly simultane- ously. It is designed to trace solar eruptions with high spatial and temporal resolutions. This telescope was installed at a new solar observing site near Fuxian Lake in Yunnan Province, southwest China. The site is located at E102N24, with an altitude of 1722 m. The seeing is stable and has high quality. We give a brief description of the scientific objectives and the basic structure of ONSET. Some preliminary results are also pre- sented.展开更多
Microorganisms are involved in a variety of biogeochemical processes in natural environments.The differences between bacterial communities in freshwaters and upslope soils remain unclear. The present study investigate...Microorganisms are involved in a variety of biogeochemical processes in natural environments.The differences between bacterial communities in freshwaters and upslope soils remain unclear. The present study investigated the bacterial distribution in a plateau freshwater lake,Erhai Lake（southwestern China）, and its upslope soils. Illumina MiS eq sequencing illustrated high bacterial diversity in lake sediments and soils. Sediment and soil bacterial communities were mainly composed of Proteobacteria, Acidobacteria, Actinobacteria,Bacteroidetes, Chloroflexi and Planctomycetes. However, a distinctive difference in bacterial community structure was found between soil and sediment ecosystems. Water content, nitrogen and p H affected the distribution of the bacterial community across Erhai Lake and its upslope soils. Moreover, the soil bacterial community might also be shaped by plant types. This work could provide some new insights into plateau aquatic and terrestrial microbial ecology.展开更多
BACKGROUND Sarcopenia may be associated with hepatocellular carcinoma(HCC)following hepatectomy.But traditional single clinical variables are still insufficient to predict recurrence.We still lack effective prediction...BACKGROUND Sarcopenia may be associated with hepatocellular carcinoma(HCC)following hepatectomy.But traditional single clinical variables are still insufficient to predict recurrence.We still lack effective prediction models for recent recurrence(time to recurrence<2 years)after hepatectomy for HCC.AIM To establish an interventable prediction model to estimate recurrence-free survival(RFS)after hepatectomy for HCC based on sarcopenia.METHODS We retrospectively analyzed 283 hepatitis B-related HCC patients who underwent curative hepatectomy for the first time,and the skeletal muscle index at the third lumbar spine was measured by preoperative computed tomography.94 of these patients were enrolled for external validation.Cox multivariate analysis was per-formed to identify the risk factors of postoperative recurrence in training cohort.A nomogram model was developed to predict the RFS of HCC patients,and its predictive performance was validated.The predictive efficacy of this model was evaluated using the receiver operating characteristic curve.RESULTS Multivariate analysis showed that sarcopenia[Hazard ratio(HR)=1.767,95%CI:1.166-2.678,P<0.05],alpha-fetoprotein≥40 ng/mL(HR=1.984,95%CI:1.307-3.011,P<0.05),the maximum diameter of tumor>5 cm(HR=2.222,95%CI:1.285-3.842,P<0.05),and hepatitis B virus DNA level≥2000 IU/mL(HR=2.1,95%CI:1.407-3.135,P<0.05)were independent risk factors associated with postoperative recurrence of HCC.Based on the sarcopenia to assess the RFS model of hepatectomy with hepatitis B-related liver cancer disease(SAMD)was established combined with other the above risk factors.The area under the curve of the SAMD model was 0.782(95%CI:0.705-0.858)in the training cohort(sensitivity 81%,specificity 63%)and 0.773(95%CI:0.707-0.838)in the validation cohort.Besides,a SAMD score≥110 was better to distinguish the high-risk group of postoperative recurrence of HCC.CONCLUSION Sarcopenia is associated with recent recurrence after hepatectomy for hepatitis B-related HCC.A nutritional status-based prediction model is first established for postoperative recurrence of hepatitis B-related HCC,which is superior to other models and contributes to prognosis prediction.展开更多
The necessity to explore high-efficiency and high-value utilization strategy for biomass-waste is desirable.Herein,the strategy for direct conversion biomass-waste(rice husks) to Si/C composite structure anode was bui...The necessity to explore high-efficiency and high-value utilization strategy for biomass-waste is desirable.Herein,the strategy for direct conversion biomass-waste(rice husks) to Si/C composite structure anode was built.The Si/C composite materials were successfully obtained via the typical thermal reduction with magnesium,and the Si nanopa rticle was uniformly embedded in carbon frame,as revealed by Raman,X-ray diffraction(XRD) and transmission electron microscope(TEM) measurement.The carbon structure among rice husks was effectively used as a protective layer to accommodate the volume variation of Si anode during the repeated lithiation/delithiation process.Benefitting from the structure design,the batteries show a superior electrochemical stability with the capacity retention rate above 90% after 150 cycles at the charge/discha rge rate of 0.5 C(1 C=600 mAh/g),and hold a high charge capacity of 420.7 mAh/g at the rate of 3 C.Therefore,our finding not only provides a promising design strategy for directly conversion biomass-waste to electrochemical storage materials but broadens the high-efficiency utilization method for other biomass by-products.展开更多
Objective： Airway inflammation and airway hyper-responsiveness（AHR） are principle pathological manifestations of asthma. Cluster of differentiation 69（CD69） is a well-known co-stimulatory factor associated with t...Objective： Airway inflammation and airway hyper-responsiveness（AHR） are principle pathological manifestations of asthma. Cluster of differentiation 69（CD69） is a well-known co-stimulatory factor associated with the activation, proliferation as well as apoptosis of immune cells. This study aims to examine the effect of anti-CD69 monoclonal antibody（m Ab） on the pathophysiology of a mouse model of asthma. Methods： A murine model of ovalbumin（OVA）-induced allergic airway inflammation was used in this study. Briefly, mice were injected with 20 μg chicken OVA intraperitoneally on Days 0 and 14, followed by aerosol provocation with 1%（0.01 g/ml） OVA on Days 24, 25, and 26. Anti-CD69 m Ab or isotype Ig G was injected intraperitoneally after OVA challenge; dexamethasone（DXM） was administrated either before or after OVA challenge. AHR, mucus production, and eosinophil infiltration in the peribronchial area were examined. The levels of granulocyte-macrophage colony-stimulating factor（GM-CSF） and interleukin-5（IL-5） in bronchoalveolar lavage fluid（BALF） were also assayed as indices of airway inflammation on Day 28 following OVA injection. Results： Pretreatment with DXM together with anti-CD69 m Ab treatment after OVA provocation completely inhibited AHR, eosinophil infiltration and mucus overproduction, and significantly reduced BALF IL-5. However, treatment with DXM alone after OVA challenge only partially inhibited AHR, eosinophil infiltration and mucus overproduction, and did not diminish BALF IL-5. Treatment with either DXM or anti-CD69 m Ab did not alter the concentration of BALF GM-CSF. Conclusions： Anti-CD69 m Ab treatment inhibits established airway inflammation as effectively as DXM pretreatment. This study provides a potential alternative therapeutic opportunity for the clinical management of asthma and its exacerbation.展开更多
基金the Natural Science Foundation of Shanghai(23ZR1422600)the Innovative research team of high-level local university in Shanghai for their financial support.
文摘Due to the significant impact of carbon dioxide on global ecology,more efforts have been put into the exploration on CO_(2)capture and utilization.Porous organic framework materials,as a kind of materials with high porosity and designable structure,have been considered as effective host materials for adsorbing carbon dioxide or separating it from other gases.This review gives a deep insight into the applications of metal-organic frameworks,covalent-organic frameworks,and other porous frameworks on CO_(2)capture,focusing on the enhanced capture performances originated from their high surface area with abundant porous structure,functional groups with specific heteroatoms modification,or other building unit interactions.Besides,the main challenges associated with porous frameworks for CO_(2)capture and proposed strategies to address these obstacles,including the structural design strategy or the capture mechanism exploration,have been demonstrated and emphasized.This review can contribute to further investigation on porous frameworks for gas capture and separation with enhanced performance and efficiency.
基金funded by the Young Scientists Fund of the National Natural Science Foundation of China(42304135)the scientific research project of Gansu Coal Geology Bureau(2023-07).
文摘Reasonable field acquisition geometry can not only guide seismic exploration to obtain sufficient geological information of target body,but also reduce acquisition cost to the maximum.In this study,building on conventional ray-based geometry design methods,we incorporate imaging results as a constraint to optimize the geometry design and evaluate its effectiveness.Firstly,the geological model of the target layer is established based on the geological data of the study area and surface seismic data combined with exploration tasks.Then,the ray-tracing method is employed to simulate and assess the proposed geometry design,verifying whether its parameters meet the exploration requirements.Finally,the imaging effect of the designed geometry on the target layer is tested by the cross-well seismic reverse time migration method.This methodology was applied to design the cross-well seismic acquisition geometry for offshore deviated wells in the X Oilfield.The simulation results demonstrate that the imaging-driven geometry design approach effectively guides field operations,enhances the imaging quality of the target layer,and reduces acquisition costs.
基金Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA25051000,XDA25010100,XDA25010300,XDA25030100,and XDA25030200)。
文摘Warm dense plasmas are crucial for high-energy-density physics and inertial confinement fusion research.Experiments involving laser-irradiated copper(Cu)foil were performed at the Shenguang-II facility.A highly oriented pyrolytic graphite crystal spectrometer measured the time-integrated spectral distribution of Cu under varying laser intensities.Using the two-dimensional radiation-hydrodynamics code FLASH and the spectral analysis code FLYCHK,we simulated the temporal evolution of plasma density and temperature distributions,as well as the emission intensities of spectral lines at different temperatures and densities.The simulation results revealed that the two-electron satellite lines(J)and the resonance line(W)emissions of Cu originate predominantly from the radiation region near the critical density surface,with a density range from approximately 0.5 nc to 1.0 nc,and radiate primarily during the laser irradiation period.By analyzing the J/W intensity ratio of the measured spectral lines,we estimated the electron temperatures near the critical-density surface under different laser intensities.
基金supported by the Jiangxi Provincial Natural Science Foundation,China(No.20192BAB216009)the Science and Technology Planning Project of Hunan Province,China(No.2019WK2051)Science and Technology Project of Changsha,Hunan,China(No.kh2003023)。
基金Supported by Specialized Research Fund for the Doctoral Program of Higher Education of China,No.20093420120005National Science Foundation of China,No.30771907
文摘AIM:To develop models to predict hepatitis B e antigen(HBe Ag)seroconversion in response to interferon(IFN)-αtreatment in chronic hepatitis B patients.METHODS:We enrolled 147 treatment-nave HBe Agpositive chronic hepatitis B patients in China and analyzed variables after initiating IFN-α1b treatment.Patients were tested for serum alanine aminotransferase(ALT),hepatitis B virus-DNA,hepatitis B surface antigen(HBs Ag),antibody to hepatitis B surface antigen,HBe Ag,antibody to hepatitis B e antigen(anti-HBe),and antibody to hepatitis B core antigen(anti-HBc)at baseline and 12 wk,24 wk,and 52 wk after initiating treatment.We performed univariate analysis to identify response predictors among the variables.Multivariate models to predict treatment response were constructed at baseline,12 wk,and 24 wk.RESULTS:At baseline,the 3 factors correlating most with HBe Ag seroconversion were serum ALT level>4×the upper limit of normal(ULN),HBe Ag≤500 S/CO,and anti-HBc>11.4 S/CO.At 12 wk,the 3 factors most associated with HBe Ag seroconversion were HBe Ag level≤250 S/CO,decline in HBe Ag>1 log10 S/CO,and anti-HBc>11.8 S/CO.At 24 wk,the 3 factors most associated with HBe Ag seroconversion were HBe Ag level≤5 S/CO,anti-HBc>11.4 S/CO,and decline in HBe Ag>2 log10 S/CO.Each variable was assigned a score of1,a score of 0 was given if patients did not have any of the 3 variables.The 3 factors most strongly correlating with HBe Ag seroconversion at each time point were used to build models to predict the outcome after IFN-αtreatment.When the score was 3,the response rates at the 3 time points were 57.7%,83.3%,and 84.0%,respectively.When the score was 0,the response rates were 2.9%,0.0%,and 2.1%,respectively.CONCLUSION:Models with good negative and positive predictive values were developed to calculate the probability of response to IFN-αtherapy.
基金funded by the “Integration of Space and Ground Based Instruments” project of the China National Space Administrationthe National Natural Science Foundation of China (Grant Nos. 11673012, 11533005 and 11733003)
文摘The Chinese HαSolar Explorer(CHASE)is designed to test a newly developed satellite platform and conduct solar observations.The scientific payload of the satellite is an Hαimaging spectrograph(HIS),which can,for the first time,acquire full-disk spectroscopic solar observations in the Hαwaveband.This paper briefly introduces CHASE/HIS including its scientific objectives,technical parameters,scientific application system,etc.The CHASE mission is scheduled to launch in 2021.It will complement the observations by on-orbit solar spacecraft(such as SDO,IRIS,STEREO and PSP),as well as future solar missions of the Solar Orbiter and Advanced Space-based Solar Observatory(ASO-S).
基金financially supported by the State Environmental Protection Key Laboratory of Microorganism Application and Risk Control (No. MARC2012D010)the National Water Special Program (No. 2012ZX07404-002)the International Science & Technology Cooperation Program of China (No. 2010DFA91830)
文摘Disinfectants are commonly applied to control the growth of microorganisms in drinking water distribution systems. However, the effect of disinfection on drinking water microbial community remains poorly understood. The present study investigated the impacts of different disinfectants（chlorine and chloramine） and dosages on biofilm bacterial community in bench-scale pipe section reactors. Illumina MiS eq sequencing illustrated that disinfection strategy could affect both bacterial diversity and community structure of drinking water biofilm. Proteobacteria tended to predominate in chloraminated drinking water biofilms, while Firmicutes in chlorinated and unchlorinated biofilms. The major proteobacterial groups were influenced by both disinfectant type and dosage. In addition, chloramination had a more profound impact on bacterial community than chlorination.
基金Project (Nos. 30971970 and 30600266) supported by the National Natural Science Foundation of China
文摘Chinese bayberry Myrica rubra is a very popular fruit in southeastern China.In spite of its wide consumption,no allergies to this fruit have been reported previously.Here we report on a 40-year-old woman suffering from anaphylaxis to Chinese bayberry fruit.Prick-prick skin tests revealed strong reactions to fresh Chinese bayberry fruits as well as to peach,and weaker reactions to some other fruits including apple,melon,and banana.ImmunoCAP analysis revealed identical titers of specific IgE(4.3 kU A /L) to peach extract and its lipid transfer protein(LTP,rPru p 3),which was confirmed by detection of a 9 kD band following immunoblotting.Immunoblot analysis with Chinese bayberry extract gave bands of 22,45,and 90 kD,but no 9 kD band was recognized.There was also no evidence of LTP recognition for loquat(36 kD) or melon(24 kD).This first report of a severe allergic reaction to Chinese bayberry fruit in a patient with LTP-mediated peach allergy indicates that other as yet unidentified non-pollen related fruit allergens are involved in this new severe fruit allergy.
文摘This paper reports the chemical synthesis of tungsten carbide/cobalt (WC/Co) nanocomposite powders via a unique chemical processing technique, involving the using of all water soluble solution of W-, Co- and C-precursors. In the actual synthesis, large quantities of commercial-scale WC-Co nanocomposite powders are made by an unique combination of converting a molecularly mixed W-, Co-, and C-containing solutions into a complex inorganic polymeric powder precursor, conversion of the inorganic polymeric precursor powder into a W-Co-C-O containing powder intermediates using a belt furnace with temperature at about 500°C - 600°C in an inert atmosphere, followed by carburization in a rotary furnace at temperature less than 1000°C in nitrogen. Liquid phase sintering technique is used to consolidate the WC/Co nanocomposite powder into sintered bulk parts. The sintered parts have excellent hardness in excess of 93 HRA, with WC grains in the order of 200 - 300 nm, while Co phase is uniformly distributed on the grain boundaries of the WC nanoparticles. We also report the presence of cobalt Co precipitates inside tungsten carbide WC nanograins in the composites of the consolidated bulk parts. EDS is used to identify the presence of these precipitates and micro-micro-diffraction technique is employed to determine the nature of these precipitates.
基金Supported by the National Natural Science Foundation of China
文摘A new multi-wavelength solar telescope, the Optical and Near-infrared Solar Eruption Tracer （ONSET） of Nanjing University, has been constructed. It was fabricated at the Nanjing Institute of Astronomical Optics ＆ Technology, and the oper- ation is jointly administered with Yunnan Astronomical Observatory. ONSET is able to observe the Sun in three wavelength windows： He I 10830 A, Ha and white-light at 3600 A and 4250 A, which are selected in order to simultaneously record the dynam- ics of the corona, chromosphere and photosphere respectively. Full-disk or partial-disk solar images with a field of 10~ at three wavelengths can be obtained nearly simultane- ously. It is designed to trace solar eruptions with high spatial and temporal resolutions. This telescope was installed at a new solar observing site near Fuxian Lake in Yunnan Province, southwest China. The site is located at E102N24, with an altitude of 1722 m. The seeing is stable and has high quality. We give a brief description of the scientific objectives and the basic structure of ONSET. Some preliminary results are also pre- sented.
基金financially supported by the National Natural Science Foundation of China (Nos. 41571444, 51279001)the National Basic Research Program of China (2015CB458900)the Special Fund of State Key Joint Laboratory of Environment Simulation and Pollution Control (No. 14Y02ESPCP)
文摘Microorganisms are involved in a variety of biogeochemical processes in natural environments.The differences between bacterial communities in freshwaters and upslope soils remain unclear. The present study investigated the bacterial distribution in a plateau freshwater lake,Erhai Lake（southwestern China）, and its upslope soils. Illumina MiS eq sequencing illustrated high bacterial diversity in lake sediments and soils. Sediment and soil bacterial communities were mainly composed of Proteobacteria, Acidobacteria, Actinobacteria,Bacteroidetes, Chloroflexi and Planctomycetes. However, a distinctive difference in bacterial community structure was found between soil and sediment ecosystems. Water content, nitrogen and p H affected the distribution of the bacterial community across Erhai Lake and its upslope soils. Moreover, the soil bacterial community might also be shaped by plant types. This work could provide some new insights into plateau aquatic and terrestrial microbial ecology.
基金Supported by Guizhou Provincial Science and Technology Projects,No.[2021]013 and No.[2021]053Doctor Foundation of Guizhou Provincial People's Hospital,No.GZSYBS[2021]07.
文摘BACKGROUND Sarcopenia may be associated with hepatocellular carcinoma(HCC)following hepatectomy.But traditional single clinical variables are still insufficient to predict recurrence.We still lack effective prediction models for recent recurrence(time to recurrence<2 years)after hepatectomy for HCC.AIM To establish an interventable prediction model to estimate recurrence-free survival(RFS)after hepatectomy for HCC based on sarcopenia.METHODS We retrospectively analyzed 283 hepatitis B-related HCC patients who underwent curative hepatectomy for the first time,and the skeletal muscle index at the third lumbar spine was measured by preoperative computed tomography.94 of these patients were enrolled for external validation.Cox multivariate analysis was per-formed to identify the risk factors of postoperative recurrence in training cohort.A nomogram model was developed to predict the RFS of HCC patients,and its predictive performance was validated.The predictive efficacy of this model was evaluated using the receiver operating characteristic curve.RESULTS Multivariate analysis showed that sarcopenia[Hazard ratio(HR)=1.767,95%CI:1.166-2.678,P<0.05],alpha-fetoprotein≥40 ng/mL(HR=1.984,95%CI:1.307-3.011,P<0.05),the maximum diameter of tumor>5 cm(HR=2.222,95%CI:1.285-3.842,P<0.05),and hepatitis B virus DNA level≥2000 IU/mL(HR=2.1,95%CI:1.407-3.135,P<0.05)were independent risk factors associated with postoperative recurrence of HCC.Based on the sarcopenia to assess the RFS model of hepatectomy with hepatitis B-related liver cancer disease(SAMD)was established combined with other the above risk factors.The area under the curve of the SAMD model was 0.782(95%CI:0.705-0.858)in the training cohort(sensitivity 81%,specificity 63%)and 0.773(95%CI:0.707-0.838)in the validation cohort.Besides,a SAMD score≥110 was better to distinguish the high-risk group of postoperative recurrence of HCC.CONCLUSION Sarcopenia is associated with recent recurrence after hepatectomy for hepatitis B-related HCC.A nutritional status-based prediction model is first established for postoperative recurrence of hepatitis B-related HCC,which is superior to other models and contributes to prognosis prediction.
基金The National Natural Science Foundation of China(Nos.51803054,51772093)the Natural Science Foundation of Hunan province(Nos.2019JJ20010,2020JJ3022,2019JJ50223)+1 种基金the“Double first-class”School Construction Project(No.SYL201802008)Outstanding Youth Foundation(No.19B270)from Education Department of Hunan Province。
文摘The necessity to explore high-efficiency and high-value utilization strategy for biomass-waste is desirable.Herein,the strategy for direct conversion biomass-waste(rice husks) to Si/C composite structure anode was built.The Si/C composite materials were successfully obtained via the typical thermal reduction with magnesium,and the Si nanopa rticle was uniformly embedded in carbon frame,as revealed by Raman,X-ray diffraction(XRD) and transmission electron microscope(TEM) measurement.The carbon structure among rice husks was effectively used as a protective layer to accommodate the volume variation of Si anode during the repeated lithiation/delithiation process.Benefitting from the structure design,the batteries show a superior electrochemical stability with the capacity retention rate above 90% after 150 cycles at the charge/discha rge rate of 0.5 C(1 C=600 mAh/g),and hold a high charge capacity of 420.7 mAh/g at the rate of 3 C.Therefore,our finding not only provides a promising design strategy for directly conversion biomass-waste to electrochemical storage materials but broadens the high-efficiency utilization method for other biomass by-products.
基金Project supported by the National Natural Science Foundation of China(No.30600266)the Zhejiang Provincial Science and Technology Project(No.2011C37073)+2 种基金the Zhejiang Provincial Natural Science Foundation(No.LQ12H16012)the National Key Clinical Project of Allergy of Chinathe National Key Clinical Specialist Construction Programs of China
文摘Objective： Airway inflammation and airway hyper-responsiveness（AHR） are principle pathological manifestations of asthma. Cluster of differentiation 69（CD69） is a well-known co-stimulatory factor associated with the activation, proliferation as well as apoptosis of immune cells. This study aims to examine the effect of anti-CD69 monoclonal antibody（m Ab） on the pathophysiology of a mouse model of asthma. Methods： A murine model of ovalbumin（OVA）-induced allergic airway inflammation was used in this study. Briefly, mice were injected with 20 μg chicken OVA intraperitoneally on Days 0 and 14, followed by aerosol provocation with 1%（0.01 g/ml） OVA on Days 24, 25, and 26. Anti-CD69 m Ab or isotype Ig G was injected intraperitoneally after OVA challenge; dexamethasone（DXM） was administrated either before or after OVA challenge. AHR, mucus production, and eosinophil infiltration in the peribronchial area were examined. The levels of granulocyte-macrophage colony-stimulating factor（GM-CSF） and interleukin-5（IL-5） in bronchoalveolar lavage fluid（BALF） were also assayed as indices of airway inflammation on Day 28 following OVA injection. Results： Pretreatment with DXM together with anti-CD69 m Ab treatment after OVA provocation completely inhibited AHR, eosinophil infiltration and mucus overproduction, and significantly reduced BALF IL-5. However, treatment with DXM alone after OVA challenge only partially inhibited AHR, eosinophil infiltration and mucus overproduction, and did not diminish BALF IL-5. Treatment with either DXM or anti-CD69 m Ab did not alter the concentration of BALF GM-CSF. Conclusions： Anti-CD69 m Ab treatment inhibits established airway inflammation as effectively as DXM pretreatment. This study provides a potential alternative therapeutic opportunity for the clinical management of asthma and its exacerbation.
