How the subduction direction of the Paleo-Pacific plate beneath the Eurasian plate changes in the Early Cretaceous remains highly controversial due to the disappearance of the subducted oceanic plate.Intraplate deform...How the subduction direction of the Paleo-Pacific plate beneath the Eurasian plate changes in the Early Cretaceous remains highly controversial due to the disappearance of the subducted oceanic plate.Intraplate deformation structures in the east Asian continent,however,provide excellent opportunities for reconstructing paleostress fields in continental interior in relation to the Paleo-Pacific/Eurasian plate interaction.Anisotropy of magnetic susceptibility(AMS),geological,and geochronological analyses of post-kinematic mafic dykes intruding the detachment fault zone of the Wulian metamorphic core complex(WL MCC)in Jiaodong Peninsula exemplify emplacement of mantle-sourced dykes in a WNW-ESE(301°-121°)oriented tectonic extensional setting at ca.120 Ma.In combination with the results from our previous kinematic analysis of the MCC,a ca.21°clockwise change in the direction of intraplate extension is obtained for early(135-122 Ma)extensional exhumation of the MCC to late(122-108 Ma)emplacement of the dykes.Such a change is suggested to be related to the variation in subduction direction of the Paleo-Pacific plate beneath the Eurasian plate,from westward(pre-122 Ma)to west-northwestward(post-122 Ma).展开更多
This research reports a novel heterogeneous Fenton-like catalyst which could freely move through the model sediments and easily seize the pollutants in addition to efficiently catalyze H2O2,well suitable for soil and ...This research reports a novel heterogeneous Fenton-like catalyst which could freely move through the model sediments and easily seize the pollutants in addition to efficiently catalyze H2O2,well suitable for soil and groundwater remediation.Herein,submicron y-Fe2O3/C spheres were synthesized through a facile one-step aerosol-based process.In a series of column tests,these spheres exhibit better transport ability due to their optimal size,conforming to the prediction by the Tufenkji-Elimelech filtration theo ry.Meanwhile,y-Fe2O3/C spheres could act as a strong adsorbent for organic pollutants owing to the presence of carbon,thereby providing a driving force to gather contaminants into their vicinity and facilitating the reaction.In addition,immobilization of y-Fe2O3 nanoparticles into carbon spheres protects iron oxides from aggregation,and thus retains the number of active sites for catalytic decomposition of H2O2.Hence,the system containing the as-prepared y-Fe2O3/C spheres and H2O2 shows the high removal efficiency and degradation efficiency in the remediation of recalcitrant organic contaminants such as methylene blue and sulfamethoxazole.展开更多
Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging ...Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging due to the great differences in the diagnosis and treatment of gastric cancer in different regions.The Gastric Cancer Expert Committee of the National Cancer Quality Control Center(NCQCC)identified a lack of authoritative quality control standards as an opportunity to utilize its multidisciplinary membership to improve the standardized diagnosis and treatment of gastric cancer.The Gastric Cancer Expert Committee of the NCQCC aims to promote quality control and national standardization,uniformity,and normalization of gastric cancer diagnosis and treatment,which ultimately improved the survival rate and quality of life of gastric cancer patients.A panel of experts with gastrointestinal cancer surgery,gastrointestinal cancer medicine,medical imaging,pathology and radiotherapy were drawn together and determined the quality control standards for the standardized diagnosis and treatment of gastric cancer.The authors then utilized a modified Delphi approach to generate consensus recommendations.展开更多
Objective:To investigate the role of Runx3 protein and TGF-β_1 in the pathogenesis of irritable bowel syndrome(IBS),as well as the correlation of these two proteins.Methods:Colonic tissue was collected from patients ...Objective:To investigate the role of Runx3 protein and TGF-β_1 in the pathogenesis of irritable bowel syndrome(IBS),as well as the correlation of these two proteins.Methods:Colonic tissue was collected from patients with IBS and normal persons.The colonic expression of Runx3 protein and TGF-β_1 was detected with immunohislochemistry method.Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.Results:Compared with their counterparts,patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β_1(P>0.05).Interestingly,there was a significant correlation between Runx3 protein and TGF-β_1 in patients with IBS(P<0.05).Conclusions:The role of Runx3 protein and TGF-β_1 in the pathogenesis of IBS remains to be further studied.展开更多
Dear Editor,Autism spectrum disorders(ASDs)are neurodevelopmen-tal disorders with phenotypic and genetic heterogeneity,and are among the most heritable of neurodevelopmental disorders[1].Rare single nucleotide variant...Dear Editor,Autism spectrum disorders(ASDs)are neurodevelopmen-tal disorders with phenotypic and genetic heterogeneity,and are among the most heritable of neurodevelopmental disorders[1].Rare single nucleotide variants(SNVs)of genes and/or rare copy number variants(CNVs)involving gene variants and/or genomic imbalances play an important role in ASD,but their molecular pathogenic mechanisms remain indistinct[2].Over the decades,genetic and neurobiological studies mainly involving severe ASD comorbid with intellectual disability(ID)or developmental delay(DD)have indicated that loss of function affects neural development[3].展开更多
We perform a computational simulation of light emissions from two sonoluminescent bubbles in water. Our simulation includes the radii of two bubbles, radiation acoustic pressures, and light emission spectra by numeric...We perform a computational simulation of light emissions from two sonoluminescent bubbles in water. Our simulation includes the radii of two bubbles, radiation acoustic pressures, and light emission spectra by numerically solving the pulsing equations of a two-bubble system and the equations of gas dynamics. The simulation results demonstrate that the motion of each bubble in the two-bubble system is restrained because of the radiation acoustic pressures from the other pulsing bubble. The restrained oscillation of a bubble with a small ambient radius is stronger than that of a bubble with a large ambient radius under the same driving acoustic pressure. This effect increases when the distance between the two bubbles decreases. When compared to single-bubble sonoluminescence, the interaction between two bubbles leads to generation of different spectral characteristics.展开更多
The most recent spectroscopic studies of moving-single bubble sonoluminescence(MSBSL)and multi-bubble sonoluminescence(MBSL)have revealed that hydrated electrons(e^(-)_(aq))are generated in MSBSL but absent in MBSL.To...The most recent spectroscopic studies of moving-single bubble sonoluminescence(MSBSL)and multi-bubble sonoluminescence(MBSL)have revealed that hydrated electrons(e^(-)_(aq))are generated in MSBSL but absent in MBSL.To explore the mechanism of this phenomenon,we numerically simulate the ionization processes in single-and multi-bubble sonoluminescence in aqueous solution of terbium chloride(TbCl_(3)).The results show that the maximum degree of ionization of single-bubble sonoluminescence(SBSL)is approximately 10000 times greater than that of MBSL under certain special physical parameters.The hydrated electrons(e^(-)_(aq))formed in SBSL are far more than those in MBSL provided these electrons are ejected from a bubble into a liquid.Therefore,the quenching of e^(-)_(aq)to SBSL spectrum is stronger than that of the MBSL spectrum.This may be the reason that the trivalent terbium[Tb(Ⅲ)]ion line intensities from SBSL in the TbCl_(3) aqueous solutions with the acceptor of e^(-)_(aq)are stronger than those of TbCl_(3) aqueous solutions without the acceptor of e^(-)_(aq).Whereas the Tb(Ⅲ)ion line intensities from MBSL are not variational,which is significant for exploring the mechanism behind the cavitation and sonoluminescence.展开更多
Molecular imaging(MI)is a novel imaging discipline that has been continuously developed in recent years.It combines biochemistry,multimodal imaging,biomathematics,bioinformatics,cell&molecular physiology,biophysic...Molecular imaging(MI)is a novel imaging discipline that has been continuously developed in recent years.It combines biochemistry,multimodal imaging,biomathematics,bioinformatics,cell&molecular physiology,biophysics,and pharmacology,and it provides a new technology platform for the early diagnosis and quantitative analysis of diseases,treatment monitoring and evaluation,and the development of comprehensive physiology.Fluorescence Molecular Tomography(FMT)is a type of optical imaging modality in MI that captures the three-dimensional distribution of fluorescence within a biological tissue generated by a specific molecule of fluorescent material within a biological tissue.Compared with other optical molecular imaging methods,FMT has the characteristics of high sensitivity,low cost,and safety and reliability.It has become the research frontier and research hotspot of optical molecular imaging technology.This paper took an overview of the recent methodology advances in FMT,mainly focused on the photon propagation model of FMT based on the radiative transfer equation(RTE),and the reconstruction problem solution consist of forward problem and inverse problem.We introduce the detailed technologies utilized in reconstruction of FMT.Finally,the challenges in FMT were discussed.This survey aims at summarizing current research hotspots in methodology of FMT,fromwhich future research may benefit.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos:42130801,41430211,90814006,and 42072226)the“Deep-time Digital Earth”Science and Technology Leading Talents Team Funds for the Central Universities for the Frontiers Science Center for Deep-time Digital Earth,CUGB(Fundamental Research Funds for the Central UniversitiesGrant No:2652023001).
文摘How the subduction direction of the Paleo-Pacific plate beneath the Eurasian plate changes in the Early Cretaceous remains highly controversial due to the disappearance of the subducted oceanic plate.Intraplate deformation structures in the east Asian continent,however,provide excellent opportunities for reconstructing paleostress fields in continental interior in relation to the Paleo-Pacific/Eurasian plate interaction.Anisotropy of magnetic susceptibility(AMS),geological,and geochronological analyses of post-kinematic mafic dykes intruding the detachment fault zone of the Wulian metamorphic core complex(WL MCC)in Jiaodong Peninsula exemplify emplacement of mantle-sourced dykes in a WNW-ESE(301°-121°)oriented tectonic extensional setting at ca.120 Ma.In combination with the results from our previous kinematic analysis of the MCC,a ca.21°clockwise change in the direction of intraplate extension is obtained for early(135-122 Ma)extensional exhumation of the MCC to late(122-108 Ma)emplacement of the dykes.Such a change is suggested to be related to the variation in subduction direction of the Paleo-Pacific plate beneath the Eurasian plate,from westward(pre-122 Ma)to west-northwestward(post-122 Ma).
基金supported by the National Natural Science Foundation of China(NSFC,Nos.21876022,31400840)the Fundamental Research Funds for the Central Universities(No.DUT16ZD226)PetroChina Innovation Foundation(No.2017D5007-0609)。
文摘This research reports a novel heterogeneous Fenton-like catalyst which could freely move through the model sediments and easily seize the pollutants in addition to efficiently catalyze H2O2,well suitable for soil and groundwater remediation.Herein,submicron y-Fe2O3/C spheres were synthesized through a facile one-step aerosol-based process.In a series of column tests,these spheres exhibit better transport ability due to their optimal size,conforming to the prediction by the Tufenkji-Elimelech filtration theo ry.Meanwhile,y-Fe2O3/C spheres could act as a strong adsorbent for organic pollutants owing to the presence of carbon,thereby providing a driving force to gather contaminants into their vicinity and facilitating the reaction.In addition,immobilization of y-Fe2O3 nanoparticles into carbon spheres protects iron oxides from aggregation,and thus retains the number of active sites for catalytic decomposition of H2O2.Hence,the system containing the as-prepared y-Fe2O3/C spheres and H2O2 shows the high removal efficiency and degradation efficiency in the remediation of recalcitrant organic contaminants such as methylene blue and sulfamethoxazole.
基金supported by“Beijing Municipal Administration of Hospitals Incubating Program”(No.PX2018043)。
文摘Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging due to the great differences in the diagnosis and treatment of gastric cancer in different regions.The Gastric Cancer Expert Committee of the National Cancer Quality Control Center(NCQCC)identified a lack of authoritative quality control standards as an opportunity to utilize its multidisciplinary membership to improve the standardized diagnosis and treatment of gastric cancer.The Gastric Cancer Expert Committee of the NCQCC aims to promote quality control and national standardization,uniformity,and normalization of gastric cancer diagnosis and treatment,which ultimately improved the survival rate and quality of life of gastric cancer patients.A panel of experts with gastrointestinal cancer surgery,gastrointestinal cancer medicine,medical imaging,pathology and radiotherapy were drawn together and determined the quality control standards for the standardized diagnosis and treatment of gastric cancer.The authors then utilized a modified Delphi approach to generate consensus recommendations.
基金Supported by Natural Scienee Foundation of Hainan Province(No 30855)
文摘Objective:To investigate the role of Runx3 protein and TGF-β_1 in the pathogenesis of irritable bowel syndrome(IBS),as well as the correlation of these two proteins.Methods:Colonic tissue was collected from patients with IBS and normal persons.The colonic expression of Runx3 protein and TGF-β_1 was detected with immunohislochemistry method.Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.Results:Compared with their counterparts,patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β_1(P>0.05).Interestingly,there was a significant correlation between Runx3 protein and TGF-β_1 in patients with IBS(P<0.05).Conclusions:The role of Runx3 protein and TGF-β_1 in the pathogenesis of IBS remains to be further studied.
基金the National Natural Science Foundation of China(31671461,31301162,31625013,and 81941405)973 Program from the Ministry of Science and Technology of China(2013CB945404 and 2010CB529601)+2 种基金Shanghai Brain-Intelligence Project from STCSM(16JC1420501)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDBS01060200 and XDA16010310)the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05).
文摘Dear Editor,Autism spectrum disorders(ASDs)are neurodevelopmen-tal disorders with phenotypic and genetic heterogeneity,and are among the most heritable of neurodevelopmental disorders[1].Rare single nucleotide variants(SNVs)of genes and/or rare copy number variants(CNVs)involving gene variants and/or genomic imbalances play an important role in ASD,but their molecular pathogenic mechanisms remain indistinct[2].Over the decades,genetic and neurobiological studies mainly involving severe ASD comorbid with intellectual disability(ID)or developmental delay(DD)have indicated that loss of function affects neural development[3].
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11864007 and 11564006)the Science and Technology Planning Project of Guizhou Province of China(Grant No.[2018]5769).
文摘We perform a computational simulation of light emissions from two sonoluminescent bubbles in water. Our simulation includes the radii of two bubbles, radiation acoustic pressures, and light emission spectra by numerically solving the pulsing equations of a two-bubble system and the equations of gas dynamics. The simulation results demonstrate that the motion of each bubble in the two-bubble system is restrained because of the radiation acoustic pressures from the other pulsing bubble. The restrained oscillation of a bubble with a small ambient radius is stronger than that of a bubble with a large ambient radius under the same driving acoustic pressure. This effect increases when the distance between the two bubbles decreases. When compared to single-bubble sonoluminescence, the interaction between two bubbles leads to generation of different spectral characteristics.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11864007 and 11564006)。
文摘The most recent spectroscopic studies of moving-single bubble sonoluminescence(MSBSL)and multi-bubble sonoluminescence(MBSL)have revealed that hydrated electrons(e^(-)_(aq))are generated in MSBSL but absent in MBSL.To explore the mechanism of this phenomenon,we numerically simulate the ionization processes in single-and multi-bubble sonoluminescence in aqueous solution of terbium chloride(TbCl_(3)).The results show that the maximum degree of ionization of single-bubble sonoluminescence(SBSL)is approximately 10000 times greater than that of MBSL under certain special physical parameters.The hydrated electrons(e^(-)_(aq))formed in SBSL are far more than those in MBSL provided these electrons are ejected from a bubble into a liquid.Therefore,the quenching of e^(-)_(aq)to SBSL spectrum is stronger than that of the MBSL spectrum.This may be the reason that the trivalent terbium[Tb(Ⅲ)]ion line intensities from SBSL in the TbCl_(3) aqueous solutions with the acceptor of e^(-)_(aq)are stronger than those of TbCl_(3) aqueous solutions without the acceptor of e^(-)_(aq).Whereas the Tb(Ⅲ)ion line intensities from MBSL are not variational,which is significant for exploring the mechanism behind the cavitation and sonoluminescence.
基金supported by Ministry of Science and Technology of China under Grant No.2017YFA0205200,2016YFC0103702National Natural Science Foundation of China under Grant No.81227901,81527805‘Chinese Academy of Sciences under Grant No.GJJSTD20170004’Beijing Municipal Science&Technology Commission No.Z161100002616022by the General Financial Grant from the China Postdoctoral Science Foundation under Grant 2017 M620952.
文摘Molecular imaging(MI)is a novel imaging discipline that has been continuously developed in recent years.It combines biochemistry,multimodal imaging,biomathematics,bioinformatics,cell&molecular physiology,biophysics,and pharmacology,and it provides a new technology platform for the early diagnosis and quantitative analysis of diseases,treatment monitoring and evaluation,and the development of comprehensive physiology.Fluorescence Molecular Tomography(FMT)is a type of optical imaging modality in MI that captures the three-dimensional distribution of fluorescence within a biological tissue generated by a specific molecule of fluorescent material within a biological tissue.Compared with other optical molecular imaging methods,FMT has the characteristics of high sensitivity,low cost,and safety and reliability.It has become the research frontier and research hotspot of optical molecular imaging technology.This paper took an overview of the recent methodology advances in FMT,mainly focused on the photon propagation model of FMT based on the radiative transfer equation(RTE),and the reconstruction problem solution consist of forward problem and inverse problem.We introduce the detailed technologies utilized in reconstruction of FMT.Finally,the challenges in FMT were discussed.This survey aims at summarizing current research hotspots in methodology of FMT,fromwhich future research may benefit.
