Understanding the influencing factors of ecosystem services(ESs)and their relationships is essential for sustainable ecosystem management in degraded alpine ecosystems.There is a lack of integrated multi-model approac...Understanding the influencing factors of ecosystem services(ESs)and their relationships is essential for sustainable ecosystem management in degraded alpine ecosystems.There is a lack of integrated multi-model approaches to explore the multidimensional influences on ESs and their relationships in alpine ecosystems.Taking the Daxing'anling forest area,Inner Mongolia(DFAIM)as a case study,this study used the integrated valuation of ecosystem services and trade-offs(InVEST)model to quantify four ESs—soil conservation(SC),water yield(WY),carbon storage(CS),and habitat quality(HQ)—from 2013 to 2018.We adopted root mean square deviation(RMSD)and coupling coordination degree models(CCDM)to analyze their relationships,and integrated three complementary approaches—optimal parameter-based geographical detector model(OPGDM),gradient boosting regression tree model(GBRTM),and quantile regression model(QRM)—to reveal multidimensional influencing factors.Key findings include the following:(1)From 2013 to 2018,WY,SC,and HQ declined while CS increased.WY was primarily influenced by mean annual precipitation(MAP),forest ratio(RF),and soil bulk density(SBD);CS and HQ by RF and population density(PD);and SC by slope(S),RF,and MAP.Mean annual temperature(MAT),gross domestic product(GDP),and road network density(RND)showed increasing negative impacts.(2)Low trade-off intensity(TI<0.15)dominated all ES pairs,with RF,MAP,PD,and normalized difference vegetation index(NDVI)being the dominant factors.The factor interactions primarily showed two-factor enhancement patterns.(3)The average coupling coordination degree(CCD)of the four ESs was low and declined over time,with low-CCD areas becoming increasingly prevalent.RF,S,SBD,and NDVI positively influenced CCD,while PD,MAT,GDP,and RND had increasing negative impacts,with over 62%of the factor interactions exceeding the individual factor effects.In summary,ES supply generally decreased.Local relationships showed moderate coordination,while overall relationships indicated primary dysfunction.Land use and natural factors primarily shaped these ES and their relationships,while climate and socioeconomic changes diminished ES supply and intensified competition.We recommend enhancing the resilience of natural systems rather than replacing them,establishing climate adaptation monitoring systems,and promoting conservation tillage and cross-departmental coordination mechanisms for collaborative ES optimization.These results provide valuable insights into the sustainable management of alpine ecosystems.展开更多
Objective:To investigate whether the mTOR inhibitor rapamycin can enhance the growth suppression effect of 5-fluorouracil(5-FU)on colon cancer cells.Methods:CCK8 assays were used to examine cell survival.Flow cytometr...Objective:To investigate whether the mTOR inhibitor rapamycin can enhance the growth suppression effect of 5-fluorouracil(5-FU)on colon cancer cells.Methods:CCK8 assays were used to examine cell survival.Flow cytometry and Western blotting were employed to detect cell proliferation,apoptosis,and related markers.Results:The combination of rapamycin and 5-FU exhibited greater cytotoxicity in cells compared to rapamycin or 5-FU alone.Notably,cells in the G0/G1 phase increased while cells in the S phase decreased in the combination group,consistent with changes in the levels of Cyclin D1 and PCNA.Rapamycin enhanced 5-FU-induced apoptosis in vitro by inducing caspase-dependent apoptosis,which is Bax/Bcl-2 related.Conclusion:The combination of rapamycin and 5-FU showed a significant synergistic anticancer effect by enhancing autophagy.This study supports that the combination of rapamycin with 5-FU is an effective and feasible approach for colorectal cancer treatment.展开更多
County forestry economy is a strong power for regional green economic development,and an important way to improve farmers' income and promote living environment in urban and rural areas. According to the investiga...County forestry economy is a strong power for regional green economic development,and an important way to improve farmers' income and promote living environment in urban and rural areas. According to the investigation of ten typical counties or cities with forestry industrial advantage,this paper sums up the elementary experiences of county forestry economy,analyzes its prominent problems. Countermeasures are brought forward to improve the development of county forestry economy.展开更多
基金funded primarily by the Central Public Welfare Research Institutes Basic Research Business Funds to Support the Administration’s Central Work Project(Grant No.CAFYBB2023ZA003-4)the National Natural Science Foundation of China(Grant Nos.31170593 and 31570633)National Forestry and Grassland Administration Forestry Under the Project“Forestry Major Issues Research”(Grant Nos.500102-1776 and 500102-5110).
文摘Understanding the influencing factors of ecosystem services(ESs)and their relationships is essential for sustainable ecosystem management in degraded alpine ecosystems.There is a lack of integrated multi-model approaches to explore the multidimensional influences on ESs and their relationships in alpine ecosystems.Taking the Daxing'anling forest area,Inner Mongolia(DFAIM)as a case study,this study used the integrated valuation of ecosystem services and trade-offs(InVEST)model to quantify four ESs—soil conservation(SC),water yield(WY),carbon storage(CS),and habitat quality(HQ)—from 2013 to 2018.We adopted root mean square deviation(RMSD)and coupling coordination degree models(CCDM)to analyze their relationships,and integrated three complementary approaches—optimal parameter-based geographical detector model(OPGDM),gradient boosting regression tree model(GBRTM),and quantile regression model(QRM)—to reveal multidimensional influencing factors.Key findings include the following:(1)From 2013 to 2018,WY,SC,and HQ declined while CS increased.WY was primarily influenced by mean annual precipitation(MAP),forest ratio(RF),and soil bulk density(SBD);CS and HQ by RF and population density(PD);and SC by slope(S),RF,and MAP.Mean annual temperature(MAT),gross domestic product(GDP),and road network density(RND)showed increasing negative impacts.(2)Low trade-off intensity(TI<0.15)dominated all ES pairs,with RF,MAP,PD,and normalized difference vegetation index(NDVI)being the dominant factors.The factor interactions primarily showed two-factor enhancement patterns.(3)The average coupling coordination degree(CCD)of the four ESs was low and declined over time,with low-CCD areas becoming increasingly prevalent.RF,S,SBD,and NDVI positively influenced CCD,while PD,MAT,GDP,and RND had increasing negative impacts,with over 62%of the factor interactions exceeding the individual factor effects.In summary,ES supply generally decreased.Local relationships showed moderate coordination,while overall relationships indicated primary dysfunction.Land use and natural factors primarily shaped these ES and their relationships,while climate and socioeconomic changes diminished ES supply and intensified competition.We recommend enhancing the resilience of natural systems rather than replacing them,establishing climate adaptation monitoring systems,and promoting conservation tillage and cross-departmental coordination mechanisms for collaborative ES optimization.These results provide valuable insights into the sustainable management of alpine ecosystems.
文摘Objective:To investigate whether the mTOR inhibitor rapamycin can enhance the growth suppression effect of 5-fluorouracil(5-FU)on colon cancer cells.Methods:CCK8 assays were used to examine cell survival.Flow cytometry and Western blotting were employed to detect cell proliferation,apoptosis,and related markers.Results:The combination of rapamycin and 5-FU exhibited greater cytotoxicity in cells compared to rapamycin or 5-FU alone.Notably,cells in the G0/G1 phase increased while cells in the S phase decreased in the combination group,consistent with changes in the levels of Cyclin D1 and PCNA.Rapamycin enhanced 5-FU-induced apoptosis in vitro by inducing caspase-dependent apoptosis,which is Bax/Bcl-2 related.Conclusion:The combination of rapamycin and 5-FU showed a significant synergistic anticancer effect by enhancing autophagy.This study supports that the combination of rapamycin with 5-FU is an effective and feasible approach for colorectal cancer treatment.
文摘County forestry economy is a strong power for regional green economic development,and an important way to improve farmers' income and promote living environment in urban and rural areas. According to the investigation of ten typical counties or cities with forestry industrial advantage,this paper sums up the elementary experiences of county forestry economy,analyzes its prominent problems. Countermeasures are brought forward to improve the development of county forestry economy.
