Stroke results from a sudden interruption of blood supply to the brain,causing ischemia,hypoxia,and subsequent brain tissue damage.It is the second leading cause of death worldwide and a major contributor to disabilit...Stroke results from a sudden interruption of blood supply to the brain,causing ischemia,hypoxia,and subsequent brain tissue damage.It is the second leading cause of death worldwide and a major contributor to disability.Despite significant advancements in cerebral ischemia-reperfusion strategies,patients remain vulnerable to ischemia/reperfusion injury,with neuroinflammation playing a central role.Evidence suggests that neuroinflammatory responses persist throughout the entire course of ischemic stroke.This review explores the diverse immune cell types and mechanisms involved in neuroinflammation,highlighting their neurotoxic and neuroprotective effects.Additionally,it examines various therapeutic approaches targeting neuroinflammation,offering a comprehensive reference for related research efforts.展开更多
Ischemic stroke(IS)is the main killer that endangers the health and life of middle-aged and elderly people worldwide.Inflammatory response plays a key regulatory role in the pathogenesis of IS.After cerebral ischemia,...Ischemic stroke(IS)is the main killer that endangers the health and life of middle-aged and elderly people worldwide.Inflammatory response plays a key regulatory role in the pathogenesis of IS.After cerebral ischemia,leukocytes rapidly accumulate,penetrate blood vessels and infiltrate brain tissue,thereby activating pro-inflammatory factors in the infarct area to exacerbate nerve damage.Neutrophil extracellular traps(NETs)are fibrous mesh structures released by activated neutrophils outside the cell,which can clear pathogens and cell debris,induce inflammatory responses and exacerbate cerebral ischemia-reperfusion(CI/R)injury.Various traditional Chinese medicines and their main components can improve neurological function defects after IS,and inhibit the formation of NETs,which opens up a new direction for the study of traditional Chinese medicines in the prevention and treatment of IS.展开更多
基金supported by the National Science Foundation of Foundation of Hebei Province China(H2024110042).
文摘Stroke results from a sudden interruption of blood supply to the brain,causing ischemia,hypoxia,and subsequent brain tissue damage.It is the second leading cause of death worldwide and a major contributor to disability.Despite significant advancements in cerebral ischemia-reperfusion strategies,patients remain vulnerable to ischemia/reperfusion injury,with neuroinflammation playing a central role.Evidence suggests that neuroinflammatory responses persist throughout the entire course of ischemic stroke.This review explores the diverse immune cell types and mechanisms involved in neuroinflammation,highlighting their neurotoxic and neuroprotective effects.Additionally,it examines various therapeutic approaches targeting neuroinflammation,offering a comprehensive reference for related research efforts.
文摘Ischemic stroke(IS)is the main killer that endangers the health and life of middle-aged and elderly people worldwide.Inflammatory response plays a key regulatory role in the pathogenesis of IS.After cerebral ischemia,leukocytes rapidly accumulate,penetrate blood vessels and infiltrate brain tissue,thereby activating pro-inflammatory factors in the infarct area to exacerbate nerve damage.Neutrophil extracellular traps(NETs)are fibrous mesh structures released by activated neutrophils outside the cell,which can clear pathogens and cell debris,induce inflammatory responses and exacerbate cerebral ischemia-reperfusion(CI/R)injury.Various traditional Chinese medicines and their main components can improve neurological function defects after IS,and inhibit the formation of NETs,which opens up a new direction for the study of traditional Chinese medicines in the prevention and treatment of IS.
