Hepatitis B virus(HBV) is a major cause of hepatocellular carcinoma(HCC). Its chronic infection can lead to chronic liver inflammation and the accumulation of genetic alterations to result in the oncogenic transformat...Hepatitis B virus(HBV) is a major cause of hepatocellular carcinoma(HCC). Its chronic infection can lead to chronic liver inflammation and the accumulation of genetic alterations to result in the oncogenic transformation of hepatocytes. HBV can also sensitize hepatocytes to oncogenic transformation by causing genetic and epigenetic changes of the host chromosomes. HBV DNA can insert into host chromosomes and recent large-scale whole-genome sequencing studies revealed recurrent HBV DNA integrations sites that may play important roles in the initiation of hepatocellular carcinogenesis. HBV can also cause epigenetic changes by altering the methylation status of cellular DNA, the post-translational modification of histones, and the expression of micro RNAs. These changes can also lead to the eventual hepatocellular transformation. These recent findings on the genetic and epigenetic alterations of the host chromosomes induced by HBV opened a new avenue for the development of novel diagnosis and treatments for HBV-induced HCC.展开更多
Despite an effective p-type dopant for PbTe, the low solubility of Na limits the fully optimization of thermoelectric properties of Na-doped PbTe. In this work, Na-doped PbTe was synthesized under high pressure. The f...Despite an effective p-type dopant for PbTe, the low solubility of Na limits the fully optimization of thermoelectric properties of Na-doped PbTe. In this work, Na-doped PbTe was synthesized under high pressure. The formation of the desired rocksalt phase with substantially increased Na content leads to a high carrier concentration of 3.2×10^20 cm^-3 for Na0.03Pb0.97Te. Moreover, dense in-grain dislocations are identified from the microstructure analysis. Benefited from the improved power factor and greatly suppressed lattice thermal conductivity, the maximal ZT of 1.7 is achieved in the optimal Na0.03Pb0.97Te. Current work thus designates the advantage of high pressure in synthesizing PbTe-based thermoelectric materials.展开更多
基金supported by the NIH grants DK100257 and DK177337
文摘Hepatitis B virus(HBV) is a major cause of hepatocellular carcinoma(HCC). Its chronic infection can lead to chronic liver inflammation and the accumulation of genetic alterations to result in the oncogenic transformation of hepatocytes. HBV can also sensitize hepatocytes to oncogenic transformation by causing genetic and epigenetic changes of the host chromosomes. HBV DNA can insert into host chromosomes and recent large-scale whole-genome sequencing studies revealed recurrent HBV DNA integrations sites that may play important roles in the initiation of hepatocellular carcinogenesis. HBV can also cause epigenetic changes by altering the methylation status of cellular DNA, the post-translational modification of histones, and the expression of micro RNAs. These changes can also lead to the eventual hepatocellular transformation. These recent findings on the genetic and epigenetic alterations of the host chromosomes induced by HBV opened a new avenue for the development of novel diagnosis and treatments for HBV-induced HCC.
基金supported by the National Natural Science Foundation of China (51525205, 51421091, and 51722209)the Key Basic Research Project of Hebei (14961013D)
文摘Despite an effective p-type dopant for PbTe, the low solubility of Na limits the fully optimization of thermoelectric properties of Na-doped PbTe. In this work, Na-doped PbTe was synthesized under high pressure. The formation of the desired rocksalt phase with substantially increased Na content leads to a high carrier concentration of 3.2×10^20 cm^-3 for Na0.03Pb0.97Te. Moreover, dense in-grain dislocations are identified from the microstructure analysis. Benefited from the improved power factor and greatly suppressed lattice thermal conductivity, the maximal ZT of 1.7 is achieved in the optimal Na0.03Pb0.97Te. Current work thus designates the advantage of high pressure in synthesizing PbTe-based thermoelectric materials.
