Perchlorate and chlorate are ubiquitous pollutants that can adversely affect the thyroid function in humans.This study assessed the potential health risks associated with the dietary exposure of infants and young chil...Perchlorate and chlorate are ubiquitous pollutants that can adversely affect the thyroid function in humans.This study assessed the potential health risks associated with the dietary exposure of infants and young children to perchlorate and chlorate present in infant formulas available in Shanghai.The assessment was based on risk monitoring data from 150 samples of infant formulas in Shanghai between 2020 and 2022,along with the dietary consumption data of infants and young children.The detection rates of perchlorate and chlorate in infant formulas were 46.0%and 98.7%,with mean contents of 9.98μg/kg and 112.01μg/kg,and the maximum values of 151.00μg/kg and 1475.00μg/kg,respectively.The mean and 95th percentile(P95)values of daily perchlorate exposure of 0-36-month-old infant and young children via infant formulas were 0.07 and 0.17μg/kg body weight(bw)per day,respectively,which were lower than the tolerable daily intake(TDI)of perchlorate(0.3μg/kg bw per day).The mean and P95 values of chlorate exposure via infant formulas in 0-36-month-old infants and young children were 0.83 and 1.89μg/kg bw per day,which were lower than the TDI of chlorate(3μg/kg bw per day).The P95 exposure of different age groups(0-6 months,7-12 months and 13-36 months)of infants and young children to perchlorate and chlorate in infant formulas was below the TDI.Therefore,the risk associated with the exposure of 0-36-month-old infants and young children to perchlorate and chlorate from infant formulas in Shanghai is considered acceptable.Prioritizing environmental pollution control efforts to reduce the levels of perchlorate and chlorate in food products is important to safeguard the health of the infants and children under the One Health concept.展开更多
基金The Guizhou Province Biological and Pharmaceutical Engineering Research Center(Grant No.QJHKY2019051)the Discipline and Master’s Site Construction Project of Guiyang University by Guiyang City Financial Support Guiyang University(Grant No.SY-2020)the Guizhou Science and Technology Support Program(Grant No.Qiankehe 2021-138)。
基金supported by Science and Technology Project of Shanghai Municipal Administration for Market Regulation in 2022(No.2022-67).
文摘Perchlorate and chlorate are ubiquitous pollutants that can adversely affect the thyroid function in humans.This study assessed the potential health risks associated with the dietary exposure of infants and young children to perchlorate and chlorate present in infant formulas available in Shanghai.The assessment was based on risk monitoring data from 150 samples of infant formulas in Shanghai between 2020 and 2022,along with the dietary consumption data of infants and young children.The detection rates of perchlorate and chlorate in infant formulas were 46.0%and 98.7%,with mean contents of 9.98μg/kg and 112.01μg/kg,and the maximum values of 151.00μg/kg and 1475.00μg/kg,respectively.The mean and 95th percentile(P95)values of daily perchlorate exposure of 0-36-month-old infant and young children via infant formulas were 0.07 and 0.17μg/kg body weight(bw)per day,respectively,which were lower than the tolerable daily intake(TDI)of perchlorate(0.3μg/kg bw per day).The mean and P95 values of chlorate exposure via infant formulas in 0-36-month-old infants and young children were 0.83 and 1.89μg/kg bw per day,which were lower than the TDI of chlorate(3μg/kg bw per day).The P95 exposure of different age groups(0-6 months,7-12 months and 13-36 months)of infants and young children to perchlorate and chlorate in infant formulas was below the TDI.Therefore,the risk associated with the exposure of 0-36-month-old infants and young children to perchlorate and chlorate from infant formulas in Shanghai is considered acceptable.Prioritizing environmental pollution control efforts to reduce the levels of perchlorate and chlorate in food products is important to safeguard the health of the infants and children under the One Health concept.
