Pulmonary fibrosis(PF)is a progressive,fatal fibrotic disease caused by respiratory conditions.The condition can ultimately lead to severe organ failure and mortality,and is associated with multiple risk factors.Growi...Pulmonary fibrosis(PF)is a progressive,fatal fibrotic disease caused by respiratory conditions.The condition can ultimately lead to severe organ failure and mortality,and is associated with multiple risk factors.Growing evidence highlights the immune system’s role in PF,with various immune components participating in inflammatory and fibrotic processes.Different immune cells,including neutrophils,lymphocytes,and macrophages,demonstrate distinct effects on PF progression and development.Furthermore,key immune system cytokines,including the interleukin(IL)family,tumor necrosis factor(TNF)-α,interferon(IFN)-γ,transforming growth factor(TGF)-β,and connective tissue growth factor(CTGF),contribute to PF initiation and progression through independent mechanisms and mutual regulation.Currently,limited effective treatments exist for PF,with several treatments causing severe adverse reactions.Natural products,characterized by multi-target effects,holistic regulation,and low toxicity,have emerged as a research focus.This review compiles the mechanisms,therapeutic potential,and active components of various natural products.These compounds can ameliorate pulmonary inflammation,epithelial-mesenchymal transition,and collagen deposition through diverse immune mechanisms,acting at specific stages or throughout the fibrotic process,thereby supporting PF management.This review examines current scientific understanding of natural products’immunological effects in PF,which is crucial for developing future anti-PF therapeutics.展开更多
Solid-solution based luminescent materials have been widely explored due to their tunable optical properties in recent years. In this work, instead of more common cation-substitution approach, we investigated the lumi...Solid-solution based luminescent materials have been widely explored due to their tunable optical properties in recent years. In this work, instead of more common cation-substitution approach, we investigated the luminescence properties of Eu^2＋ and Mn^2 ＋ co-doped halophosphate solid solution Ca5（PO4）3（F0.8Cl0.2） via anion substitution synthesized by high temperature solid state reaction method. The formation of the solid solution was confirmed by X-ray diffraction （XRD） characterization, which indicates that the introduction of certain proportion of CI will not make significant change on the CaB（PO4）3F lattice, We also studied the energy transfer from Eu^2＋ to Mn^2＋ in the host so as to obtain white light emission via adjusting the doping concentrations of Eu^2＋ and Mn^2＋, The white light emission was achieved through combination of Eu^2＋ blue emission and Mn^2＋ red-orange emission with appropriate proportions. The results suggest that Ca5（PO4）3（F0.8Cl0.2）：0.01Eu^2＋＋,0.18Mn^2＋ could be a potential WLED phosphor working under ultraviolet excitation,展开更多
基金supported by the National Natural Science Foundation of China(No.82260820)the Natural Science Foundation of Jilin Province,Jilin,China(No.YDZJ202201ZYTS155).
文摘Pulmonary fibrosis(PF)is a progressive,fatal fibrotic disease caused by respiratory conditions.The condition can ultimately lead to severe organ failure and mortality,and is associated with multiple risk factors.Growing evidence highlights the immune system’s role in PF,with various immune components participating in inflammatory and fibrotic processes.Different immune cells,including neutrophils,lymphocytes,and macrophages,demonstrate distinct effects on PF progression and development.Furthermore,key immune system cytokines,including the interleukin(IL)family,tumor necrosis factor(TNF)-α,interferon(IFN)-γ,transforming growth factor(TGF)-β,and connective tissue growth factor(CTGF),contribute to PF initiation and progression through independent mechanisms and mutual regulation.Currently,limited effective treatments exist for PF,with several treatments causing severe adverse reactions.Natural products,characterized by multi-target effects,holistic regulation,and low toxicity,have emerged as a research focus.This review compiles the mechanisms,therapeutic potential,and active components of various natural products.These compounds can ameliorate pulmonary inflammation,epithelial-mesenchymal transition,and collagen deposition through diverse immune mechanisms,acting at specific stages or throughout the fibrotic process,thereby supporting PF management.This review examines current scientific understanding of natural products’immunological effects in PF,which is crucial for developing future anti-PF therapeutics.
基金Project supported by the National Natural Science Foundation of China(11574298,61635012)the National Key Research and Development Program of China(2016YFB0701001)
文摘Solid-solution based luminescent materials have been widely explored due to their tunable optical properties in recent years. In this work, instead of more common cation-substitution approach, we investigated the luminescence properties of Eu^2＋ and Mn^2 ＋ co-doped halophosphate solid solution Ca5（PO4）3（F0.8Cl0.2） via anion substitution synthesized by high temperature solid state reaction method. The formation of the solid solution was confirmed by X-ray diffraction （XRD） characterization, which indicates that the introduction of certain proportion of CI will not make significant change on the CaB（PO4）3F lattice, We also studied the energy transfer from Eu^2＋ to Mn^2＋ in the host so as to obtain white light emission via adjusting the doping concentrations of Eu^2＋ and Mn^2＋, The white light emission was achieved through combination of Eu^2＋ blue emission and Mn^2＋ red-orange emission with appropriate proportions. The results suggest that Ca5（PO4）3（F0.8Cl0.2）：0.01Eu^2＋＋,0.18Mn^2＋ could be a potential WLED phosphor working under ultraviolet excitation,
