Vitiligo is a common skin depigmentation disease and affects the mental health of myriad populations around the world.The pathogenesis is multifactorial and the exact driving factor remains unclear.There is much evide...Vitiligo is a common skin depigmentation disease and affects the mental health of myriad populations around the world.The pathogenesis is multifactorial and the exact driving factor remains unclear.There is much evidence that the changes in microbiome play an important role in the pathogenesis of vitiligo,they affect immune homeostasis,oxidative stress,skin barrier,and gene expression in vitiligo.The restoration of microbiome is a promising preventive and therapeutic strategy for vitiligo.Herein,we have reviewed recent studies on the vitiligo-related microbiome in an attempt to confidently identify the“core”microbiome of vitiligo patients,understand the role of microbiome in the pathogenesis of vitiligo,and explore new therapeutic strategies for vitiligo through microbial intervention.展开更多
Transdermal drug delivery systems(TDDs)have the advantages on good local targeting,controlled and sustainable drug delivery.Hoewever,the stratum corneum,as the main skin barrier,severely limits the transdermal penetra...Transdermal drug delivery systems(TDDs)have the advantages on good local targeting,controlled and sustainable drug delivery.Hoewever,the stratum corneum,as the main skin barrier,severely limits the transdermal penetration of drugs and reduces bioavailability,which also limits their application.Microneedles(MNS)penetrate the stratum corneum and create several reversible microchannels in a minimally invasive manner to significantly improve the penetration of therapeutic agents,and are considered a milestone for effective transdermal drug delivery.As an emerging drug delivery modality,microneedle transdermal drug delivery systems have the advantages of being minimally invasive,safe,efficient,economical and convenient.In addition to the extensive research on microneedles for improving transdermal drug delivery,there is a growing interest in using them to manage and treat dermatological conditions.Being the largest organ in the human body,the skin acts as a barrier between the body and the external environment,while having an immense influence on appearance and self-confidence.Indeed,there is now a considerable body of evidence on how dermatological conditions can lead to psychological problems and a reduced quality of life.The utilisation of microneedle transdermal drug delivery systems for the management and treatment of dermatological conditions is of great therapeutic and commercial value.The principleof microneedle transdermal drug delivery systems and the progress of its clinical application in dermatology are reviewed here.展开更多
Skin is the largest organ of human body and it protects the organism from external stimuli.Skin will age as the organism ages in normal circumstances.Skin photoaging refers to the accumulation of ultraviolet radiation...Skin is the largest organ of human body and it protects the organism from external stimuli.Skin will age as the organism ages in normal circumstances.Skin photoaging refers to the accumulation of ultraviolet radiation due to long-term exposure to sunlight,which results in the premature aging of skin,wrinkles,pigmentation,skin laxity,and other signs of aging.The increase in the level of reactive oxygen species(ROS)induced by ultraviolet radiation,which causes the oxidation of cells,proteins,lipids,and other components,is an important cause of accelerated photoaging of skin.For this reason,the skin's antioxidant system will further play an antioxidant role to reduce oxidative damage by inhibiting ROS production,breaking down ROS,and degrading oxides.Therefore,it is important to understand the mechanism of skin damage caused by Ultraviolet radiation,the effects of reactive oxygen species and how the body's antioxidant system exerts its antioxidant effect.This will not only deepen the understanding of skin photoaging but also provide a scientific basis for the research on how to prevent and treat photoaging.展开更多
文摘Vitiligo is a common skin depigmentation disease and affects the mental health of myriad populations around the world.The pathogenesis is multifactorial and the exact driving factor remains unclear.There is much evidence that the changes in microbiome play an important role in the pathogenesis of vitiligo,they affect immune homeostasis,oxidative stress,skin barrier,and gene expression in vitiligo.The restoration of microbiome is a promising preventive and therapeutic strategy for vitiligo.Herein,we have reviewed recent studies on the vitiligo-related microbiome in an attempt to confidently identify the“core”microbiome of vitiligo patients,understand the role of microbiome in the pathogenesis of vitiligo,and explore new therapeutic strategies for vitiligo through microbial intervention.
基金Yunnan Provincial Science and Technology Department University Joint Project:Effect and mechanism of microneedle transdermal administration of Periplaneta Americana extract on aging skin of mice(202001BA070001-214).
文摘Transdermal drug delivery systems(TDDs)have the advantages on good local targeting,controlled and sustainable drug delivery.Hoewever,the stratum corneum,as the main skin barrier,severely limits the transdermal penetration of drugs and reduces bioavailability,which also limits their application.Microneedles(MNS)penetrate the stratum corneum and create several reversible microchannels in a minimally invasive manner to significantly improve the penetration of therapeutic agents,and are considered a milestone for effective transdermal drug delivery.As an emerging drug delivery modality,microneedle transdermal drug delivery systems have the advantages of being minimally invasive,safe,efficient,economical and convenient.In addition to the extensive research on microneedles for improving transdermal drug delivery,there is a growing interest in using them to manage and treat dermatological conditions.Being the largest organ in the human body,the skin acts as a barrier between the body and the external environment,while having an immense influence on appearance and self-confidence.Indeed,there is now a considerable body of evidence on how dermatological conditions can lead to psychological problems and a reduced quality of life.The utilisation of microneedle transdermal drug delivery systems for the management and treatment of dermatological conditions is of great therapeutic and commercial value.The principleof microneedle transdermal drug delivery systems and the progress of its clinical application in dermatology are reviewed here.
基金supported by Yunnan Provincial Department of Education Science Research Fund Project(2021Y426/2018JS411).
文摘Skin is the largest organ of human body and it protects the organism from external stimuli.Skin will age as the organism ages in normal circumstances.Skin photoaging refers to the accumulation of ultraviolet radiation due to long-term exposure to sunlight,which results in the premature aging of skin,wrinkles,pigmentation,skin laxity,and other signs of aging.The increase in the level of reactive oxygen species(ROS)induced by ultraviolet radiation,which causes the oxidation of cells,proteins,lipids,and other components,is an important cause of accelerated photoaging of skin.For this reason,the skin's antioxidant system will further play an antioxidant role to reduce oxidative damage by inhibiting ROS production,breaking down ROS,and degrading oxides.Therefore,it is important to understand the mechanism of skin damage caused by Ultraviolet radiation,the effects of reactive oxygen species and how the body's antioxidant system exerts its antioxidant effect.This will not only deepen the understanding of skin photoaging but also provide a scientific basis for the research on how to prevent and treat photoaging.
