Alterations in the mesenchymal-epithelial transition factor(MET)gene are critical drivers of non-small cell lung cancer(NSCLC).In recent years advances in precision therapies targeting MET alterations have significant...Alterations in the mesenchymal-epithelial transition factor(MET)gene are critical drivers of non-small cell lung cancer(NSCLC).In recent years advances in precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients.These alterations include MET exon 14 skipping mutations(MET exon 14 skipping),MET gene amplifications,MET point mutations(primarily kinase domain mutations),and MET protein overexpression.Accurate identification of these alterations and appropriate selection of patient populations and targeted therapies are essential for improving clinical outcomes.The East China Lung Cancer Group,Youth Committee(ECLUNG YOUNG,Yangtze River Delta Lung Cancer Cooperation Group)has synthesized insights from China’s innovative drug development landscape and clinical practice to formulate an expert consensus on the diagnosis and treatment of NSCLC patients with MET alterations.This consensus addresses key areas,such as optimal testing timing,testing methods,testing strategies,quality control measures,and treatment approaches.By offering standardized recommendations,this guidance aims to streamline diagnostic and therapeutic processes and enhance clinical decision-making for NSCLC with MET alterations.展开更多
[Objectives]To explore the effects of high soil temperature stress on microorganisms utilizing different carbon sources in the rhizosphere of pepper seedlings.[Methods]Using seedlings of the main pepper cultivar‘Reyi...[Objectives]To explore the effects of high soil temperature stress on microorganisms utilizing different carbon sources in the rhizosphere of pepper seedlings.[Methods]Using seedlings of the main pepper cultivar‘Reyin 1’as experimental materials,five soil temperature gradients(25,30,35,40,and 45℃)were established.After a 96 d cultivation,soil nutrient content and soil microbial functional diversity were measured to elucidate the impact of high soil temperature on the soil microenvironment.[Results]As soil temperature increased,the contents of total nitrogen,alkaline hydrolyzable nitrogen,available phosphorus,and rapidly available potassium generally showed a decreasing trend.However,under the 45℃ treatment,the contents of total nitrogen,available phosphorus,and rapidly available potassium were the highest among all treatments,although the alkaline hydrolyzable nitrogen content was significantly lower compared to the other treatments.BIOLOG analysis revealed that with increasing soil temperature,the average soil microbial absorbance value and the Shannon diversity index decreased significantly.In contrast,the Shannon evenness index and the Simpson dominance index showed no significant differences across the different temperature treatments.This indicates that as soil temperature rises,the carbon source utilization capacity of the soil microbial community decreases,leading to reduced overall carbon metabolic activity and microbial functional diversity,while the dominant microbial populations remained unchanged during this process.Principal component analysis further confirmed effective separation among the different temperature treatments,suggesting that high soil stress significantly altered the structure of the soil microbial community.[Conclusions]In practical production,appropriate measures should be taken to decrease soil temperature to create a favorable rhizosphere microenvironment and thereby promote crop growth.展开更多
This paper explores a UAV-mounted active Reconfigurable Intelligent Surface(aRIS)network designed to enhance secure downlink communication for multiple users while mitigating the impact of multiple Eavesdroppers(EVs)....This paper explores a UAV-mounted active Reconfigurable Intelligent Surface(aRIS)network designed to enhance secure downlink communication for multiple users while mitigating the impact of multiple Eavesdroppers(EVs).The focus is on optimizing the UAV’s trajectory,the Base Station’s(BS)transmit beamforming,and the power-Amplified Programmable Reflecting Elements(APREs)of the aRIS to maximize the minimum secrecy rate in the presence of EVs.This is a complex non-convex problem due to multiple optimization variables,high-dimensional matrix operations,and log-determinant objective functions,which makes it challenging to solve.Hence,a Successive Convex Approximation(SCA)-based optimization strategy is developed to efficiently solve the subproblems related to the UAV’s trajectory,aRIS’s APREs,and BS’s beamforming.By leveraging slack variables and approximation techniques,we solve the nonconvex subproblems by a sequence of convex subproblems.Simulation results demonstrate that the proposed UAV-aRIS network significantly outperforms its passive RIS counterpart in improving communication security,highlighting the effectiveness of the optimization strategy.展开更多
In this study,a strategy is proposed to use the congestion index as a new input feature.This approach can reveal more deeply the complex effects of traffic conditions on variations in particulate matter(PM_(2.5))conce...In this study,a strategy is proposed to use the congestion index as a new input feature.This approach can reveal more deeply the complex effects of traffic conditions on variations in particulate matter(PM_(2.5))concentrations.To assess the effectiveness of this strategy,we conducted an ablation experiment on the congestion index and implemented a multi-scale input model.Compared with conventional models,the strategy reduces the root mean square error(RMSE)of all benchmark models by>6.07%on average,and the bestperforming model reduces it by 12.06%,demonstrating excellent performance improvement.In addition,evenwith high traffic emissions,the RMSE during peak hours is still below 9.83μg/m^(3),which proves the effectiveness of the strategy by effectively addressing pollution hotspots.This study provides new ideas for improving urban environmental quality and public health and anticipates inspiring further research in this domain.展开更多
In this paper,we propose a new non-Gaussian quantum state,termed the photon-modulated displaced thermal state(DTS).Using the operator ordering method,we obtain the normal ordering product of its density operator and t...In this paper,we propose a new non-Gaussian quantum state,termed the photon-modulated displaced thermal state(DTS).Using the operator ordering method,we obtain the normal ordering product of its density operator and then investigate its normalization,the negativity of its Wigner function and its non-Gaussianity.展开更多
Passive bistatic radar(PBR)frequently experiences interference from direct signal waves when detecting maritime targets,which can completely mask target echoes,particularly for distant targets or weak targets with low...Passive bistatic radar(PBR)frequently experiences interference from direct signal waves when detecting maritime targets,which can completely mask target echoes,particularly for distant targets or weak targets with low radar cross-section(RCS).To mitigate this,the paper proposes a direct signal interference(DSI)suppression method.The approach involves dual-channel reception of digital video broadcast satellites(DVB-S)signals from the China Sat-9,followed by signal pre-processing.The reference and surveillance channel signals are then segmented.After segmentation,the signals undergo fast Fourier transformation(FFT),and an adaptive filtering clutter suppres-sion method is applied at each frequency point.Finally,an inverse fast Fourier transform(IFFT)is performed on the suppressed signals to obtain the DSI-suppressed output.Compared to traditional clutter suppression techniques,this method is not only faster but also achieves more effective sup-pression.Simulation experiments involving both single and multiple targets validate the superiority of the proposed algorithm.展开更多
City metro tunnels are usually constructed as twin-parallel tunnels and their adjacent construction may lead to surface deformation,affecting the surface environment and the safety of the tunnels.Due to its strong dis...City metro tunnels are usually constructed as twin-parallel tunnels and their adjacent construction may lead to surface deformation,affecting the surface environment and the safety of the tunnels.Due to its strong dispersion,sandy cobble strata can be easily disturbed by shield tunneling.Based on the project of the Chengdu Metro Line 1,field and model tests were carried out to study the surface settlement caused by shield tunneling in sandy cobble strata by measuring surface settlement curves,ground loss ratios and construction influence zones.The discrete element method(DEM) was used to study the factors affecting the formation of ground arches in sandy cobble strata at the microscopic level.Results show that the shape of the surface settlement curve in sandy cobble strata is different from that in soft soil.The buried depth and clear spacing of the two tunnels had a significant impact on the formation of ground arches.展开更多
The effects of Manganese （Mn） incorporation on a precipitated iron-based Fischer-Tropsch synthesis （FTS） catalyst were investigated using N2 physical adsorption, air differential thermal analysis （DTA）, H2 tempe...The effects of Manganese （Mn） incorporation on a precipitated iron-based Fischer-Tropsch synthesis （FTS） catalyst were investigated using N2 physical adsorption, air differential thermal analysis （DTA）, H2 temperature-programmed reduction （TPR）, and Mǒssbauer spectroscopy. The FTS performances of the catalysts were tested in a slurry phase reactor. The characterization results indicated that Mn increased the surface area of the catalyst, and improved the dispersion of （α-Fe2O3 and reduced its crystallite size as a result of the high dispersion effect of Mn and the Fe-Mn interaction. The Fe-Mn interaction also suppressed the reduction of （α-Fe2O3 to Fe3O4, stabilized the FeO phase, and （or） decreased the carburization degree of the catalysts in the H2 and syngas reduction processes. In addition, incorporated Mn decreased the initial catalyst activity, but improved the catalyst stability because Mn restrained the reoxidation of iron carbides to Fe3O4, and improved further carburization of the catalysts. Manganese suppressed the formation of CH4 and increased the selectivity to light olefins （C2-4^=）, but it had little effect on the selectivities to heavy （C5＋） hydrocarbons. All these results indicated that the strong Fe-Mn interaction suppressed the chemisorptive effect of the Mn as an electronic promoter, to some extent, in the precipitated iron-manganese catalyst system.展开更多
Objective： Accurate estimation of lymph node metastasis （LNM） in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate comb...Objective： Accurate estimation of lymph node metastasis （LNM） in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate combined clinicopathological features to predict the presence of LNM. Methods： A retrospective review of data from 386 intramucosaL gastric cancer patients who underwent gastrectomy with extended lymphadenectomy from 2003 to 2010 was conducted. The mutual relation between clinicopathological characteristics and LNM was analyzed. Results： LNM was detected in 40 （10.4%） of the 386 patients. Histological typeand vascular or lymphatic invasion presence showed a positive correlation with LNM occurrence by univariate analysis. Multivariate analysis revealed that histological type was the only factor associated with LNM. Combined clinicopathologic characteristics would be more predictable for LNM. We found no LNM when we used combined clinicopathological characteristics conforming to Japanese absolute indications for endoscopic therapy. The LNM rate was as high as 8.7% when Japanese expanded criteria were used. Univariate analysis in cancer conformity to expand endoscopic submucosal dissection （ESD） indication also revealed that the undifferential type was the only significant factor for LNM. Conclusions： It was possible to predict intramucosal gastric cancer cases without LNM using combined clinicopathological characteristic analysis. Extended indication for ESD should be cautiously used for intramucosal gastric cancer patients.展开更多
Inflammatory myofibroblastic tumors are usually treated by surgical resection. We herein report two cases of intra-abdominal inflammatory myofibroblastic tumors that were unresectable and underwent spontaneous regress...Inflammatory myofibroblastic tumors are usually treated by surgical resection. We herein report two cases of intra-abdominal inflammatory myofibroblastic tumors that were unresectable and underwent spontaneous regression without any treatment. Our case report and literature review show that regression is more common in the middle-aged and older male populations. Abdominal discomfort and fever were the most common symptoms, but the majority of patients had no obvious physical signs. There was no specific indicator for diagnosis. The majority of the lesions regressed within3 mo and nearly all of the masses completely resolved within 1 year. We conclude that the clinical characteristics of inflammatory myofibroblastic tumors are variable and, accordingly, the disease needs to be subdivided and treated on an individual basis. Surgery is always the first-line treatment; however, for those masses assessed as unresectable, conservative therapy with in-tense follow-up should be considered.展开更多
The section of shield tunnel of the Chengdu Metro line passes primarily through sandy cobble strata. There are many buildings with spread foundations along the lines. Shield tunnel construction will disturb the ground...The section of shield tunnel of the Chengdu Metro line passes primarily through sandy cobble strata. There are many buildings with spread foundations along the lines. Shield tunnel construction will disturb the ground, causing displacement or stress to adjacent spread foundations. Based on the similarity theory, a laboratory model test of shield tunnel driving was carried out to study the influence of shield tunnel excavation on the displace ment of adjacent spread foundation. The results show that foundation closer to the tunnel has greater displacement or settlement than that further away. The horizontal dis placement is small and is influenced greatly by the cutting face. The displacement along the machine driving direction is bigger and is significantly affected by the thrust force. Settlement occurs primarily when shield machine passes close to the foundation and is the greatest at that time. Uneven settlement at the bottom of the spread foundation reaches a maximum after the excavation ends. In a numerical simulation, a particle flow model was con structed to study the impact of shield tunnel excavation on the stresses in the ground. The model showed stress con centration at the bottom of the spread foundation. With the increasing ground loss ratio, a loose area appears in the tunnel dome where the contact force dropped. Above the loose area, the contact force increases, forming an arch shaped soil area which prevents the loose area from expanding to the ground surface. The excavation also changed the pressure distribution around spread foundation.展开更多
To provide precise prediction of tunnelling-induced deformation of the surrounding geomaterials,a framework for derivation of rigorous large-strain solutions of unified spherical and cylindrical cavity contraction is ...To provide precise prediction of tunnelling-induced deformation of the surrounding geomaterials,a framework for derivation of rigorous large-strain solutions of unified spherical and cylindrical cavity contraction is presented for description of confinement-convergence responses for deep tunnels in geomaterials.Considering the tunnelling-induced large deformation,logarithmic strains are adopted for cavity contraction analyses in linearly elastic,non-associated Mohr-Coulomb,and brittle Hoek-Brown media.Compared with approximate solutions,the approximation error indicates the importance of release of small-strain restrictions for estimating tunnel convergence profiles,especially in terms of the scenarios with high stress condition and stiffness degradation under large deformation.The ground reaction curve is therefore predicted to describe the volume loss and stress relaxation around the tunnel walls.The stiffness of circular lining is calculated from the geometry and equivalent modulus of the supporting structure,and a lining installation factor is thus introduced to indicate the time of lining installation based on the prediction of spherical cavity contraction around the tunnel opening face.This study also provides a general approach for solutions using other sophisticated geomaterial models,and serves as benchmarks for analytical developments in consideration of nonlinear large-deformation behaviour and for numerical analyses of underground excavation.展开更多
文摘Alterations in the mesenchymal-epithelial transition factor(MET)gene are critical drivers of non-small cell lung cancer(NSCLC).In recent years advances in precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients.These alterations include MET exon 14 skipping mutations(MET exon 14 skipping),MET gene amplifications,MET point mutations(primarily kinase domain mutations),and MET protein overexpression.Accurate identification of these alterations and appropriate selection of patient populations and targeted therapies are essential for improving clinical outcomes.The East China Lung Cancer Group,Youth Committee(ECLUNG YOUNG,Yangtze River Delta Lung Cancer Cooperation Group)has synthesized insights from China’s innovative drug development landscape and clinical practice to formulate an expert consensus on the diagnosis and treatment of NSCLC patients with MET alterations.This consensus addresses key areas,such as optimal testing timing,testing methods,testing strategies,quality control measures,and treatment approaches.By offering standardized recommendations,this guidance aims to streamline diagnostic and therapeutic processes and enhance clinical decision-making for NSCLC with MET alterations.
基金Supported by Natural Science Foundation of Hainan Province(320MS108)Scientific and Technological Innovation Team of the National Center for Tropical Agricultural Science,Chinese Academy of Tropical Agricultural Sciences(CATASCXTD202303)Key Laboratory of Genetic Resources Utilization of Spice and Beverage Crops,Ministry of Agriculture and Rural Affairs,Hainan Provincial Key Laboratory of Genetic Improvement and Quality Regulation for Tropical Spice and Beverage Crops,or Hainan Provincial Engineering Research Center for Tropical Spice and Beverage Crops(2019xys007).
文摘[Objectives]To explore the effects of high soil temperature stress on microorganisms utilizing different carbon sources in the rhizosphere of pepper seedlings.[Methods]Using seedlings of the main pepper cultivar‘Reyin 1’as experimental materials,five soil temperature gradients(25,30,35,40,and 45℃)were established.After a 96 d cultivation,soil nutrient content and soil microbial functional diversity were measured to elucidate the impact of high soil temperature on the soil microenvironment.[Results]As soil temperature increased,the contents of total nitrogen,alkaline hydrolyzable nitrogen,available phosphorus,and rapidly available potassium generally showed a decreasing trend.However,under the 45℃ treatment,the contents of total nitrogen,available phosphorus,and rapidly available potassium were the highest among all treatments,although the alkaline hydrolyzable nitrogen content was significantly lower compared to the other treatments.BIOLOG analysis revealed that with increasing soil temperature,the average soil microbial absorbance value and the Shannon diversity index decreased significantly.In contrast,the Shannon evenness index and the Simpson dominance index showed no significant differences across the different temperature treatments.This indicates that as soil temperature rises,the carbon source utilization capacity of the soil microbial community decreases,leading to reduced overall carbon metabolic activity and microbial functional diversity,while the dominant microbial populations remained unchanged during this process.Principal component analysis further confirmed effective separation among the different temperature treatments,suggesting that high soil stress significantly altered the structure of the soil microbial community.[Conclusions]In practical production,appropriate measures should be taken to decrease soil temperature to create a favorable rhizosphere microenvironment and thereby promote crop growth.
基金co-supported by Technology Key Project of Guangdong Province,China(No.HZJBGS-2021001)the Shanghai Sailing Scholar,China(No.23YF1412700)+1 种基金the National Natural Science Foundation of China(No.61901254)the Shanghai Technical Service Computing Center of Science and Engineering,Shanghai University,China.
文摘This paper explores a UAV-mounted active Reconfigurable Intelligent Surface(aRIS)network designed to enhance secure downlink communication for multiple users while mitigating the impact of multiple Eavesdroppers(EVs).The focus is on optimizing the UAV’s trajectory,the Base Station’s(BS)transmit beamforming,and the power-Amplified Programmable Reflecting Elements(APREs)of the aRIS to maximize the minimum secrecy rate in the presence of EVs.This is a complex non-convex problem due to multiple optimization variables,high-dimensional matrix operations,and log-determinant objective functions,which makes it challenging to solve.Hence,a Successive Convex Approximation(SCA)-based optimization strategy is developed to efficiently solve the subproblems related to the UAV’s trajectory,aRIS’s APREs,and BS’s beamforming.By leveraging slack variables and approximation techniques,we solve the nonconvex subproblems by a sequence of convex subproblems.Simulation results demonstrate that the proposed UAV-aRIS network significantly outperforms its passive RIS counterpart in improving communication security,highlighting the effectiveness of the optimization strategy.
基金supported by the Enterprises Research Project(Nos.W2021JSKF0922 and W2023JSKF0116)the Key industrialization Projects of Intelligent Manufacturing Institute,Hefei University of Technology(No.IMICZ2019001).
文摘In this study,a strategy is proposed to use the congestion index as a new input feature.This approach can reveal more deeply the complex effects of traffic conditions on variations in particulate matter(PM_(2.5))concentrations.To assess the effectiveness of this strategy,we conducted an ablation experiment on the congestion index and implemented a multi-scale input model.Compared with conventional models,the strategy reduces the root mean square error(RMSE)of all benchmark models by>6.07%on average,and the bestperforming model reduces it by 12.06%,demonstrating excellent performance improvement.In addition,evenwith high traffic emissions,the RMSE during peak hours is still below 9.83μg/m^(3),which proves the effectiveness of the strategy by effectively addressing pollution hotspots.This study provides new ideas for improving urban environmental quality and public health and anticipates inspiring further research in this domain.
基金supported by the Collaborative Innovation Project of University,Anhui Province(Grant No.GXXT-2022-088)。
文摘In this paper,we propose a new non-Gaussian quantum state,termed the photon-modulated displaced thermal state(DTS).Using the operator ordering method,we obtain the normal ordering product of its density operator and then investigate its normalization,the negativity of its Wigner function and its non-Gaussianity.
基金supported in part by Shanghai Sailing Scholar(No.23YF1412700)in part by the Key Laboratory Innova-tion and Development Fund Project,China(No.61424132006).
文摘Passive bistatic radar(PBR)frequently experiences interference from direct signal waves when detecting maritime targets,which can completely mask target echoes,particularly for distant targets or weak targets with low radar cross-section(RCS).To mitigate this,the paper proposes a direct signal interference(DSI)suppression method.The approach involves dual-channel reception of digital video broadcast satellites(DVB-S)signals from the China Sat-9,followed by signal pre-processing.The reference and surveillance channel signals are then segmented.After segmentation,the signals undergo fast Fourier transformation(FFT),and an adaptive filtering clutter suppres-sion method is applied at each frequency point.Finally,an inverse fast Fourier transform(IFFT)is performed on the suppressed signals to obtain the DSI-suppressed output.Compared to traditional clutter suppression techniques,this method is not only faster but also achieves more effective sup-pression.Simulation experiments involving both single and multiple targets validate the superiority of the proposed algorithm.
基金Project supported by the National Basic Research(973)Program of China(No.2010CB732105)the National Natural Science Foundation of China(Nos.50908193,50925830,and 51208432)
文摘City metro tunnels are usually constructed as twin-parallel tunnels and their adjacent construction may lead to surface deformation,affecting the surface environment and the safety of the tunnels.Due to its strong dispersion,sandy cobble strata can be easily disturbed by shield tunneling.Based on the project of the Chengdu Metro Line 1,field and model tests were carried out to study the surface settlement caused by shield tunneling in sandy cobble strata by measuring surface settlement curves,ground loss ratios and construction influence zones.The discrete element method(DEM) was used to study the factors affecting the formation of ground arches in sandy cobble strata at the microscopic level.Results show that the shape of the surface settlement curve in sandy cobble strata is different from that in soft soil.The buried depth and clear spacing of the two tunnels had a significant impact on the formation of ground arches.
基金Foundation item:the National Outstanding Young Scientists Foundation of China(20625620)the National Key Basic Research Program of China(973 Program,2007CB216401)+1 种基金the National Natural Science Foundation of China(20590360)the Natural Science Foundation of Shanxi Province(2006021014).
文摘The effects of Manganese （Mn） incorporation on a precipitated iron-based Fischer-Tropsch synthesis （FTS） catalyst were investigated using N2 physical adsorption, air differential thermal analysis （DTA）, H2 temperature-programmed reduction （TPR）, and Mǒssbauer spectroscopy. The FTS performances of the catalysts were tested in a slurry phase reactor. The characterization results indicated that Mn increased the surface area of the catalyst, and improved the dispersion of （α-Fe2O3 and reduced its crystallite size as a result of the high dispersion effect of Mn and the Fe-Mn interaction. The Fe-Mn interaction also suppressed the reduction of （α-Fe2O3 to Fe3O4, stabilized the FeO phase, and （or） decreased the carburization degree of the catalysts in the H2 and syngas reduction processes. In addition, incorporated Mn decreased the initial catalyst activity, but improved the catalyst stability because Mn restrained the reoxidation of iron carbides to Fe3O4, and improved further carburization of the catalysts. Manganese suppressed the formation of CH4 and increased the selectivity to light olefins （C2-4^=）, but it had little effect on the selectivities to heavy （C5＋） hydrocarbons. All these results indicated that the strong Fe-Mn interaction suppressed the chemisorptive effect of the Mn as an electronic promoter, to some extent, in the precipitated iron-manganese catalyst system.
文摘Objective： Accurate estimation of lymph node metastasis （LNM） in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate combined clinicopathological features to predict the presence of LNM. Methods： A retrospective review of data from 386 intramucosaL gastric cancer patients who underwent gastrectomy with extended lymphadenectomy from 2003 to 2010 was conducted. The mutual relation between clinicopathological characteristics and LNM was analyzed. Results： LNM was detected in 40 （10.4%） of the 386 patients. Histological typeand vascular or lymphatic invasion presence showed a positive correlation with LNM occurrence by univariate analysis. Multivariate analysis revealed that histological type was the only factor associated with LNM. Combined clinicopathologic characteristics would be more predictable for LNM. We found no LNM when we used combined clinicopathological characteristics conforming to Japanese absolute indications for endoscopic therapy. The LNM rate was as high as 8.7% when Japanese expanded criteria were used. Univariate analysis in cancer conformity to expand endoscopic submucosal dissection （ESD） indication also revealed that the undifferential type was the only significant factor for LNM. Conclusions： It was possible to predict intramucosal gastric cancer cases without LNM using combined clinicopathological characteristic analysis. Extended indication for ESD should be cautiously used for intramucosal gastric cancer patients.
文摘Inflammatory myofibroblastic tumors are usually treated by surgical resection. We herein report two cases of intra-abdominal inflammatory myofibroblastic tumors that were unresectable and underwent spontaneous regression without any treatment. Our case report and literature review show that regression is more common in the middle-aged and older male populations. Abdominal discomfort and fever were the most common symptoms, but the majority of patients had no obvious physical signs. There was no specific indicator for diagnosis. The majority of the lesions regressed within3 mo and nearly all of the masses completely resolved within 1 year. We conclude that the clinical characteristics of inflammatory myofibroblastic tumors are variable and, accordingly, the disease needs to be subdivided and treated on an individual basis. Surgery is always the first-line treatment; however, for those masses assessed as unresectable, conservative therapy with in-tense follow-up should be considered.
基金funded by the National Natural Science Foundation of China (Nos. 51278422 and 50925830)the National 973 Plan Topics of China (No. 2010CB732105)+1 种基金the National Science and Technology Pillar Program of China (No. 2012BAG05B03)the Sichuan Youth Science and Technology Foundation, China (No. 2012JQ0021)
文摘The section of shield tunnel of the Chengdu Metro line passes primarily through sandy cobble strata. There are many buildings with spread foundations along the lines. Shield tunnel construction will disturb the ground, causing displacement or stress to adjacent spread foundations. Based on the similarity theory, a laboratory model test of shield tunnel driving was carried out to study the influence of shield tunnel excavation on the displace ment of adjacent spread foundation. The results show that foundation closer to the tunnel has greater displacement or settlement than that further away. The horizontal dis placement is small and is influenced greatly by the cutting face. The displacement along the machine driving direction is bigger and is significantly affected by the thrust force. Settlement occurs primarily when shield machine passes close to the foundation and is the greatest at that time. Uneven settlement at the bottom of the spread foundation reaches a maximum after the excavation ends. In a numerical simulation, a particle flow model was con structed to study the impact of shield tunnel excavation on the stresses in the ground. The model showed stress con centration at the bottom of the spread foundation. With the increasing ground loss ratio, a loose area appears in the tunnel dome where the contact force dropped. Above the loose area, the contact force increases, forming an arch shaped soil area which prevents the loose area from expanding to the ground surface. The excavation also changed the pressure distribution around spread foundation.
基金financial supports from the Foundation of Key Laboratory of Transportation Tunnel Engineering(Southwest Jiaotong University)Ministry of Education,China(Grant No.TTE2017-04)+1 种基金National Natural Science Foundation of China(Grant No.51908546)Natural Science Foundation of Jiangsu Province(Grant No.BK20170279)。
文摘To provide precise prediction of tunnelling-induced deformation of the surrounding geomaterials,a framework for derivation of rigorous large-strain solutions of unified spherical and cylindrical cavity contraction is presented for description of confinement-convergence responses for deep tunnels in geomaterials.Considering the tunnelling-induced large deformation,logarithmic strains are adopted for cavity contraction analyses in linearly elastic,non-associated Mohr-Coulomb,and brittle Hoek-Brown media.Compared with approximate solutions,the approximation error indicates the importance of release of small-strain restrictions for estimating tunnel convergence profiles,especially in terms of the scenarios with high stress condition and stiffness degradation under large deformation.The ground reaction curve is therefore predicted to describe the volume loss and stress relaxation around the tunnel walls.The stiffness of circular lining is calculated from the geometry and equivalent modulus of the supporting structure,and a lining installation factor is thus introduced to indicate the time of lining installation based on the prediction of spherical cavity contraction around the tunnel opening face.This study also provides a general approach for solutions using other sophisticated geomaterial models,and serves as benchmarks for analytical developments in consideration of nonlinear large-deformation behaviour and for numerical analyses of underground excavation.
