It is well known that alcohol consumption leads to substantially increased free radical levels and health risks,which lacks effective treatment besides alcohol abstinence.Here,we compared different static magnetic fie...It is well known that alcohol consumption leads to substantially increased free radical levels and health risks,which lacks effective treatment besides alcohol abstinence.Here,we compared different static magnetic field(SMF)settings and found that a downward quasi-uniform SMF of~0.1 to 0.2 T could effectively alleviate alcohol-induced liver damage and lipid accumulation and improve hepatic function.SMFs of two different directions can reduce the inflammation,reactive oxygen species levels,and oxidative stress in the liver,while the downward SMF had more obvious effects.Moreover,we found that the upward direction SMF of~0.1 to 0.2 T could inhibit DNA synthesis and regeneration in hepatocytes,which caused detrimental effects on the lifespan of"heavy drinking"mice.In contrast,the downward SMF prolongs survival of"heavy drinking"mice.On one hand,our study shows that~0.1 to 0.2 T moderate quasi-uniform SMFs with a downward direction have great promises to be developed into a physical method to reduce alcohol-induced liver damage;on the other hand,although the internationally recognized upper limit for SMF public exposure is 0.4 T,people should also pay extra attention to SMF strength,direction,and inhomogeneity that could generate harmful effects on specific severe pathological conditions.展开更多
Type 2 diabetes(T2D)is a metabolic disorder with high prevalence and severe complications that has recently been indicated to be treatable by a combined static magnetic field(SMF)and electric field.We systematically c...Type 2 diabetes(T2D)is a metabolic disorder with high prevalence and severe complications that has recently been indicated to be treatable by a combined static magnetic field(SMF)and electric field.We systematically compared four types of SMFs and found that a downward SMF of100 mT could effectively reduce the development of hyperglycemia,fatty liver,weight gain,and tissue injury in high-fat-diet(HFD)/streptozocin-induced T2D mice,but not the upward SMF.The downward SMF markedly restored the Bacteroidetes population and reversed the iron complex outer membrane receptor gene reduction in the mice gut microbiota,and reduced iron deposition in the pancreas.SMF also reduced the labile iron and reactive oxygen species level in pancreatic Min6 cells in vitro and prevented palmitate-induced Min6 cell number reduction.Therefore,this simple SMF setting could partially prevent HFD-induced T2D development and ameliorate related symptoms,which could provide a low-cost and non-invasive physical method to prevent and/or treat T2D in the future.展开更多
基金The work was supported by National Natural Science Foundation of China(U21A20148)International Partnership Program of Chinese Academy of Sciences(116134KYSB20210052)+1 种基金the CASHIPS Director’s Fund(BJPY2021A06 and YZJJ2021QN32)Heye Health Technology Chong Ming Project(HYCMP2021010).
文摘It is well known that alcohol consumption leads to substantially increased free radical levels and health risks,which lacks effective treatment besides alcohol abstinence.Here,we compared different static magnetic field(SMF)settings and found that a downward quasi-uniform SMF of~0.1 to 0.2 T could effectively alleviate alcohol-induced liver damage and lipid accumulation and improve hepatic function.SMFs of two different directions can reduce the inflammation,reactive oxygen species levels,and oxidative stress in the liver,while the downward SMF had more obvious effects.Moreover,we found that the upward direction SMF of~0.1 to 0.2 T could inhibit DNA synthesis and regeneration in hepatocytes,which caused detrimental effects on the lifespan of"heavy drinking"mice.In contrast,the downward SMF prolongs survival of"heavy drinking"mice.On one hand,our study shows that~0.1 to 0.2 T moderate quasi-uniform SMFs with a downward direction have great promises to be developed into a physical method to reduce alcohol-induced liver damage;on the other hand,although the internationally recognized upper limit for SMF public exposure is 0.4 T,people should also pay extra attention to SMF strength,direction,and inhomogeneity that could generate harmful effects on specific severe pathological conditions.
基金This work was supported by the National Key R&D Program of China(grant 2016YFA0400900)the Chinese Academy of Sciences Hefei Institutes of Physical Science Director's Fund(YZJJ201704)the Chinese National Natural Science Foundations(grant31800051).We would like to thank Heye Health Technology for providing the magnetic plates for the alternating magnetic field in Figure 1B.A portion of this work was supported by the High Magnetic Field Laboratory of Anhui Province.The authors have a patent pending related to this work.
文摘Type 2 diabetes(T2D)is a metabolic disorder with high prevalence and severe complications that has recently been indicated to be treatable by a combined static magnetic field(SMF)and electric field.We systematically compared four types of SMFs and found that a downward SMF of100 mT could effectively reduce the development of hyperglycemia,fatty liver,weight gain,and tissue injury in high-fat-diet(HFD)/streptozocin-induced T2D mice,but not the upward SMF.The downward SMF markedly restored the Bacteroidetes population and reversed the iron complex outer membrane receptor gene reduction in the mice gut microbiota,and reduced iron deposition in the pancreas.SMF also reduced the labile iron and reactive oxygen species level in pancreatic Min6 cells in vitro and prevented palmitate-induced Min6 cell number reduction.Therefore,this simple SMF setting could partially prevent HFD-induced T2D development and ameliorate related symptoms,which could provide a low-cost and non-invasive physical method to prevent and/or treat T2D in the future.
