Sorafenib(Sora)not only has an inhibitory effect on angiogenesis via indirectly inhibiting tumor growth through antiangiogenesis,but also can inactivate the glutathione peroxidase 4(GPX4)to induce ferroptosis.Nonethel...Sorafenib(Sora)not only has an inhibitory effect on angiogenesis via indirectly inhibiting tumor growth through antiangiogenesis,but also can inactivate the glutathione peroxidase 4(GPX4)to induce ferroptosis.Nonetheless,the therapeutic efficacy is hampered by a plethora of factors,including low bioavailability and tumor microenvironment(TME).Of particular note is the hypoxic and reductive TME,which acts as a significant impediment and poses formidable challenges to attain the most optimal treatment outcomes.Herein,we developed a novel therapeutic platform based on Sora-loaded mesoporous ferromanganese nanoparticles(PMFNs@Sora).PMFNs mimics both catalase and GPX activities.The self-sustained catalase activity enables continuous decomposition of hydrogen peroxide to generate oxygen,which alleviates hypoxia microenvironment.The GPX activity simultaneously amplifies the therapeutic efficacy of Sora.The as-synthesized PMFNs@Sora demonstrates significantly enhanced antitumor effect in vitro through apoptosis-ferroptosis,revealed by Western blot.Furthermore,PMFNs@Sora also showed effective tumor growth inhibition in vivo.This multifunctional nanoplatform offers a promising strategy for modulating the TME and enhancing cancer treatment in clinical application.展开更多
The classification of the Northeast China Cold Vortex(NCCV)activity paths is an important way to analyze its characteristics in detail.Based on the daily precipitation data of the northeastern China(NEC)region,and the...The classification of the Northeast China Cold Vortex(NCCV)activity paths is an important way to analyze its characteristics in detail.Based on the daily precipitation data of the northeastern China(NEC)region,and the atmospheric circulation field and temperature field data of ERA-Interim for every six hours,the NCCV processes during the early summer(June)seasons from 1979 to 2018 were objectively identified.Then,the NCCV processes were classified using a machine learning method(k-means)according to the characteristic parameters of the activity path information.The rationality of the classification results was verified from two aspects,as follows:(1)the atmospheric circulation configuration of the NCCV on various paths;and(2)its influences on the climate conditions in the NEC.The obtained results showed that the activity paths of the NCCV could be divided into four types according to such characteristics as the generation origin,movement direction,and movement velocity of the NCCV.These included the generation-eastward movement type in the east of the Mongolia Plateau(eastward movement type or type A);generation-southeast longdistance movement type in the upstream of the Lena River(southeast long-distance movement type or type B);generationeastward less-movement type near Lake Baikal(eastward less-movement type or type C);and the generation-southward less-movement type in eastern Siberia(southward less-movement type or type D).There were obvious differences observed in the atmospheric circulation configuration and the climate impact of the NCCV on the four above-mentioned types of paths,which indicated that the classification results were reasonable.展开更多
The Northeast China cold vortex(NCCV)during late summer(from July to August)is identified and classified into three types in terms of its movement path using machine learning.The relationships of the three types of NC...The Northeast China cold vortex(NCCV)during late summer(from July to August)is identified and classified into three types in terms of its movement path using machine learning.The relationships of the three types of NCCV intensity with atmospheric circulations in late summer,the sea surface temperature(SST),and Arctic sea ice concentration(SIC)in the preceding months,are analyzed.The sensitivity tests by the Community Atmosphere Model version 5.3(CAM5.3)are used to verify the statistical results.The results show that the coordination pattern of East Asia-Pacific(EAP)and Lake Baikal high pressure forced by SST anomalies in the North Indian Ocean dipole mode(NIOD)during the preceding April and SIC anomalies in the Nansen Basin during the preceding June results in an intensity anomaly for the first type of NCCV.While the pattern of high pressure over the Urals and Okhotsk Sea and low pressure over Lake Baikal during late summer-which is forced by SST anomalies in the South Indian Ocean dipole mode(SIOD)in the preceding June and SIC anomalies in the Barents Sea in the preceding April-causes the intensity anomaly of the second type.The third type is atypical and is not analyzed in detail.Sensitivity tests,jointly forced by the SST and SIC in the preceding period,can well reproduce the observations.In contrast,the results forced separately by the SST and SIC are poor,indicating that the NCCV during late summer is likely influenced by the coordinated effects of both SST and SIC in the preceding months.展开更多
Knowledge of sediment variation processes is essential to understand the evolution mechanism of beach morphology changes.Thus,a field measurement was conducted at the Heisha Beach,located on the west coast of the Zhuj...Knowledge of sediment variation processes is essential to understand the evolution mechanism of beach morphology changes.Thus,a field measurement was conducted at the Heisha Beach,located on the west coast of the Zhujiang River(Pearl River)Estuary,to investigate the short-term variation in suspended sediment concentrations(SSCs)and the relationship between the SSC and turbulent kinetic energy,bottom shear stress(BSS),and relative wave height.Based on extreme event analysis results,extreme events have a greater influence on turbulent kinetic energy than SSC.Although a portion of the turbulent kinetic energy dissipates directly into the water column,it plays an important role in suspended sediment motion.Most of the time,the wave-current interaction is strong enough to drive sediment incipience and resuspension.When combined,the wave-current interaction and wave-induced BSSs have a greater influence on suspended sediment transport and SSC variation than current-induced BSS alone.The relative wave height also has a strong correlation with SSC,indicating that the combined effect of water depth and wave height significantly impacts SSC variation.Water depth is mainly controlled by the tide on the beaches;thus,the effects of tides and waves should be conjunctively considered when analyzing the factors influencing SSC.展开更多
Anthropogenic disturbances associated with the rapid development of coastal cities have drastically influenced the hydrodynamics and sediment transport processes in many large estuaries globally.Lingdingyang Estuary(L...Anthropogenic disturbances associated with the rapid development of coastal cities have drastically influenced the hydrodynamics and sediment transport processes in many large estuaries globally.Lingdingyang Estuary(LE),located in the central and southern part of the Pearl River Delta,southern China with a long history of high-intensity anthropogenic disturbances,was studied to explore the contribution rate and mechanism underlying the alteration in hydrodynamics and sediment transport under each phase of human activity.A state-of-the-art modeling tool(TELEMAC-2D),was used to study the variations in the hydrodynamics and sediment transport,accounting for reclamation-induced shoreline and dredging-induced topography changes.The results indicated that:i)under the influence of successive land reclamation,the general distribution of the Confluence Hydrodynamic Zone(CHZ)in LE varied from scattered to concentrated,and these zones moved 3–5 km seaward.ii)Large-scale channel dredging weakened the residual flow in LE,decreasing the residual flow in the Inner-Lingding Estuary(ILE)by 62.45%.This was initiated by the enhancement of tidal dynamics through changes in the bottom friction caused by dredging in the ILE.In contrast,massive reclamation decreased the residual flow in the ILE by 17.55%and increased that in the Outer-Lingding Estuary(OLE).iii)Despite disturbances related to land reclamation and dredging,the estuarine jet flow in LE remained a turbulent jet system,and the estuarine jet flow became more asymmetrical.In addition,the position of the estuarine jet source moved 6–13 km seaward.iv)Both reclamation and dredging decreased the SSC in the ILE and increased the SSC in the OLE.Reclamation weakened the SSC in the ILE by 62.19%,whereas dredging enhanced the SSC in the OLE by 49%.Spatially,reclamation resulted in an increase in the SSC near the outlets and a decrease in the SSC in the northern portion of the Western Channel.Dredging mainly increased the SSC in the northern part of the OLE.v)The increase in the barotropic pressure gradient was the main factor driving the enhancement of the residual flow and SSC near the outlets.Moreover,the southward location of the“artificial outlets”favored the transport of suspended sediments to the OLE,which was one of the primary reasons for the increase in the SSC in the OLE.Finally,the tidal dynamics of the ILE intensified due to massive reclamation and dredging.The findings of this study indicate that hydrodynamics and sediment transport in LE have greatly changed over the last decades,with reclamation and dredging being the crucial drivers.The insights obtained from this study can serve as a reference for the comprehensive management of the Pearl River Estuary and other large estuaries experiencing similar anthropogenic forcing.展开更多
To better understand the epidemiological characteristics of human adenovirus(HAdv)infections in China during and after the coronavirus disease 2019(COvVID-19)pandemic,respiratory specimens were collected from 17,562 e...To better understand the epidemiological characteristics of human adenovirus(HAdv)infections in China during and after the coronavirus disease 2019(COvVID-19)pandemic,respiratory specimens were collected from 17,562 enrolled patients with acute respiratory infections(ARIs)in 14 sentinel surveillance provinces during 2020-2023.Eight common respiratory viruses were detected using commercially available nucleic acid detection kits.HAdV-positive cases were statistically analyzed for detection rates,geographic distribution,seasonal patterns,demographic characteristics,and co-infection status.The results of this study showed that the overall HAdV detection rate was 5.09%(894/17,562)during 2020-2023,with a gradual decrease in the annual detection rate from 6.66%in 2020 to 3.89%in 2022 and a rebound in 2023(5.19%).The overall HAdV detection rate was significantly higher in the southern region(6.15%)than in the northern region(4.76%)(P<0.001).The median age of patients with HAdv infection was 3 years,with infants aged 0-2 years accounting for the majority(41.39%).HAdV-positive cases were detected throughout the year,with no clear seasonal pattern,and the HAdV epidemic in China during 2020-2023 may have been driven primarily by the virus infection in the southern region.Co-infections were frequent in HAdV-positive cases(overall rate:36.01%),primarily consisting of dual infections(79.28%),with human rhinovirus and human respiratory syncytial virus being the most common coinfecting pathogens.In conclusion,this study suggested the significant regional and temporal variation in HAdV detection rate in China during 2020-2023,and thus ongoing surveillance should be conducted to elucidate the epidemiological dynamics of HAdV infections.展开更多
With the rapid development of white LEDs,the research of new and efficient white light emitting materials has attracted increasing attention.Zero dimensional(0D)organic–inorganic hybrid metal halide perovskites with ...With the rapid development of white LEDs,the research of new and efficient white light emitting materials has attracted increasing attention.Zero dimensional(0D)organic–inorganic hybrid metal halide perovskites with superior luminescent property are promising candidates for LED application,due to their abundant and tailorable structure.Herein,[(CH_(3))_(3)S]_(2)SnCl_(6)・H_(2)O is synthesized as a host for dopant ions Bi^(3+)and Sb^(3+).The Sb^(3+)doped,or Bi^(3+)/Sb^(3+)co-doped,[(CH_(3))3S]_(2)SnCl_(6)・H_(2)O has a tunable optical emission spectrum by means of varying dopant ratio and excitation wavelength.As a result,we can achieve single-phase materials suitable for emission ranging from cold white light to warm white light.The intrinsic mechanism is examined in this work,to clarify the dopant effect on the optical properties.The high stability of title crystalline material,against water,oxygen and heat,makes it promising for further application.展开更多
Using the hindcasts provided by the Ensemble-Based Predictions of Climate Changes and Their Impacts(ENSEMBLES) project for the period of 1980–2005, the forecast capability of spring climate in China is assessed mainl...Using the hindcasts provided by the Ensemble-Based Predictions of Climate Changes and Their Impacts(ENSEMBLES) project for the period of 1980–2005, the forecast capability of spring climate in China is assessed mainly from the aspects of precipitation, 2-m air temperature, and atmospheric circulations. The ENSEMBELS can reproduce the climatology and dominant empirical orthogonal function(EOF) modes of precipitation and 2-m air temperature, with some differences arising from different initialization months. The multi-model ensemble(MME) forecast of interannual variability is of good performance in some regions such as eastern China with February initialization.The spatial patterns of the MME interannual and inter-member spreads for precipitation and 2-m air temperature are consistent with those of the observed interannual spread, indicating that internal dynamic processes have major impacts on the interannual anomaly of spring climate in China. We have identified two coupled modes between intermember anomalies of the 850-hPa vorticity in spring and sea surface temperature(SST) both in spring and at a lead of 2 months, of which the first mode shows a significant impact on the spring climate in China, with an anomalous anticyclone located over Northwest Pacific and positive precipitation and southwesterly anomalies in eastern China.Our results also suggest that the SST at a lead of two months may be a predictor for the spring climate in eastern China. A better representation of the ocean–atmosphere interaction over the tropical Pacific, Northwest Pacific, and Indian Ocean can improve the forecast skill of the spring climate in eastern China.展开更多
As an important atmospheric circulation system in the mid-high latitudes of East Asia,the Northeast China cold vortex(NCCV)substantially influences weather and climate in this region.So far,systematic assessment on th...As an important atmospheric circulation system in the mid-high latitudes of East Asia,the Northeast China cold vortex(NCCV)substantially influences weather and climate in this region.So far,systematic assessment on the performance of numerical prediction of the NCCVs has not been carried out.Based on the Beijing Climate Centre(BCC)and the ECMWF model hindcast and forecast data that participated in the Sub-seasonal to Seasonal(S2S)Prediction Project,this study systematically examines the performance of both models in simulating and forecasting the NCCVs at the sub-seasonal timescale.The results demonstrate that the two models can effectively capture the seasonal variations in the intensity,active days,and spatial distribution of NCCVs;however,the duration of NCCVs is shorter and the intensity is weaker in the models than in the observations.Diagnostic analysis shows that the differences in the intensity and location of the East Asian subtropical westerly jet and the wave train pattern from North Atlantic to East Asia may be responsible for the deficient simulation of NCCV events in the S2S models.Nonetheless,in the deterministic forecasts,BCC and ECMWF provide skillful prediction on the anomalous numbers of NCCV days and intensity at a lead time of 4-5(5-6)pentads,and the skill limit of the ensemble mean is 1-2 pentads longer than that of individual members.In the probabilistic forecasts of daily NCCV activities,BCC and ECMWF exhibit a forecasting skill of approximately 7 and 11 days,respectively;both models show seasonal dependency in the simulation performance and forecast skills of NCCV events,with better performance in winter than in summer.The results from this study provide helpful references for further improvement of the S2S prediction of NCCVs.展开更多
The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor treatment.However,research on alleviating metabolic diseases,such as hyperglycemia,has not been reported.Herein,we found t...The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor treatment.However,research on alleviating metabolic diseases,such as hyperglycemia,has not been reported.Herein,we found that the single-atom Ce-N_(4)-C-(OH)_(2)(SACe-N_(4)-C-(OH)_(2))nanozyme promoted glucose absorption in lysosomes,resulting in increased reactive oxygen species production in HepG2 cells.Furthermore,the SACe-N_(4)-C-(OH)_(2)nanozyme initiated a cascade reaction involving superoxide dismutase-,oxidase-,catalase-,and peroxidase-like activity to overcome the limitations associated with the substrate and produce•OH,thus improving glucose intolerance and insulin resistance by increasing the phosphorylation of protein kinase B and glycogen synthase kinase 3β,and the expression of glycogen synthase,promoting glycogen synthesis to improve glucose intolerance and insulin resistance in high-fat diet-induced hyperglycemic mice.Altogether,these results demonstrated that the novel nanozyme SACeN_(4)-C-(OH)_(2)alleviated the effects of hyperglycemia without evident toxicity,demonstrating its excellent clinical application potential.展开更多
Correction:Frontiers of Optoelectronics(2024)17:6 https://doi.org/10.1007/s12200-024-00109-3 Following publication of the original article[1],the authors reported the errors,which need to be corrected:1.The sentence i...Correction:Frontiers of Optoelectronics(2024)17:6 https://doi.org/10.1007/s12200-024-00109-3 Following publication of the original article[1],the authors reported the errors,which need to be corrected:1.The sentence in Results and discussion section has been updated from"The crystal belongs to the Fm-3 m space group with a unit cell length of 12.43 A."to"The crystal belongs to the Pa-3 space group with a unit cell length of 12.42 A."A cif file has been added as a Supplementary file for comparison with other readers.展开更多
基金the financial support by National Natural Science Foundation of China(No.82171997)the Guangdong Basic and Applied Basic Research Fund Foundation(No.2023B1515120073)+2 种基金the Science and Technology Planning Project of Guangdong Province(No.2023B1212060013)Guangzhou Science and Technology Bureau(No.2023A03J0708)Shenzhen Science and Technology Program(Nos.JCYJ20230807111120043,JCYJ20220818102014028)。
文摘Sorafenib(Sora)not only has an inhibitory effect on angiogenesis via indirectly inhibiting tumor growth through antiangiogenesis,but also can inactivate the glutathione peroxidase 4(GPX4)to induce ferroptosis.Nonetheless,the therapeutic efficacy is hampered by a plethora of factors,including low bioavailability and tumor microenvironment(TME).Of particular note is the hypoxic and reductive TME,which acts as a significant impediment and poses formidable challenges to attain the most optimal treatment outcomes.Herein,we developed a novel therapeutic platform based on Sora-loaded mesoporous ferromanganese nanoparticles(PMFNs@Sora).PMFNs mimics both catalase and GPX activities.The self-sustained catalase activity enables continuous decomposition of hydrogen peroxide to generate oxygen,which alleviates hypoxia microenvironment.The GPX activity simultaneously amplifies the therapeutic efficacy of Sora.The as-synthesized PMFNs@Sora demonstrates significantly enhanced antitumor effect in vitro through apoptosis-ferroptosis,revealed by Western blot.Furthermore,PMFNs@Sora also showed effective tumor growth inhibition in vivo.This multifunctional nanoplatform offers a promising strategy for modulating the TME and enhancing cancer treatment in clinical application.
基金This research was jointly supported by the National Natural Science Foundation of China(Grant No.42005037)the Liaoning Provincial Natural Science Foundation Project(PhD Start-up Research Fund 2019-BS-214),the Special Scientific Research Project for the Forecaster(Grant No.CMAYBY2018-018)+2 种基金a Key Technical Project of Liaoning Meteorological Bureau(Grant No.LNGJ201903)the National Key Research and Development Project(Grant No.2018YFC1505601)the Open Foundation Project of the Institute of Atmospheric Environment,China Meteorological Administration(Grant Nos.2020SYIAE08 and 2020SYIAEZD5).
文摘The classification of the Northeast China Cold Vortex(NCCV)activity paths is an important way to analyze its characteristics in detail.Based on the daily precipitation data of the northeastern China(NEC)region,and the atmospheric circulation field and temperature field data of ERA-Interim for every six hours,the NCCV processes during the early summer(June)seasons from 1979 to 2018 were objectively identified.Then,the NCCV processes were classified using a machine learning method(k-means)according to the characteristic parameters of the activity path information.The rationality of the classification results was verified from two aspects,as follows:(1)the atmospheric circulation configuration of the NCCV on various paths;and(2)its influences on the climate conditions in the NEC.The obtained results showed that the activity paths of the NCCV could be divided into four types according to such characteristics as the generation origin,movement direction,and movement velocity of the NCCV.These included the generation-eastward movement type in the east of the Mongolia Plateau(eastward movement type or type A);generation-southeast longdistance movement type in the upstream of the Lena River(southeast long-distance movement type or type B);generationeastward less-movement type near Lake Baikal(eastward less-movement type or type C);and the generation-southward less-movement type in eastern Siberia(southward less-movement type or type D).There were obvious differences observed in the atmospheric circulation configuration and the climate impact of the NCCV on the four above-mentioned types of paths,which indicated that the classification results were reasonable.
基金jointly supported by the National Natural Science Foundation of China (Grant No. 42005037)Special Project of Innovative Development, CMA (CXFZ2021J022, CXFZ2022J008, and CXFZ2021J028)+1 种基金Liaoning Provincial Natural Science Foundation Project (Ph.D. Start-up Research Fund 2019-BS214)Research Project of the Institute of Atmospheric Environment, CMA (2021SYIAEKFMS08, 2020SYIAE08 and 2021SYIAEKFMS09)
文摘The Northeast China cold vortex(NCCV)during late summer(from July to August)is identified and classified into three types in terms of its movement path using machine learning.The relationships of the three types of NCCV intensity with atmospheric circulations in late summer,the sea surface temperature(SST),and Arctic sea ice concentration(SIC)in the preceding months,are analyzed.The sensitivity tests by the Community Atmosphere Model version 5.3(CAM5.3)are used to verify the statistical results.The results show that the coordination pattern of East Asia-Pacific(EAP)and Lake Baikal high pressure forced by SST anomalies in the North Indian Ocean dipole mode(NIOD)during the preceding April and SIC anomalies in the Nansen Basin during the preceding June results in an intensity anomaly for the first type of NCCV.While the pattern of high pressure over the Urals and Okhotsk Sea and low pressure over Lake Baikal during late summer-which is forced by SST anomalies in the South Indian Ocean dipole mode(SIOD)in the preceding June and SIC anomalies in the Barents Sea in the preceding April-causes the intensity anomaly of the second type.The third type is atypical and is not analyzed in detail.Sensitivity tests,jointly forced by the SST and SIC in the preceding period,can well reproduce the observations.In contrast,the results forced separately by the SST and SIC are poor,indicating that the NCCV during late summer is likely influenced by the coordinated effects of both SST and SIC in the preceding months.
基金The National Key Research and Development Program of China under contract No.2016YFC0402603the Guangdong Provincial Department of Natural Resources Project under contract No.42090038the Guangdong Provincial Department of Ocean and Fisheries Project under contract No.42090033.
文摘Knowledge of sediment variation processes is essential to understand the evolution mechanism of beach morphology changes.Thus,a field measurement was conducted at the Heisha Beach,located on the west coast of the Zhujiang River(Pearl River)Estuary,to investigate the short-term variation in suspended sediment concentrations(SSCs)and the relationship between the SSC and turbulent kinetic energy,bottom shear stress(BSS),and relative wave height.Based on extreme event analysis results,extreme events have a greater influence on turbulent kinetic energy than SSC.Although a portion of the turbulent kinetic energy dissipates directly into the water column,it plays an important role in suspended sediment motion.Most of the time,the wave-current interaction is strong enough to drive sediment incipience and resuspension.When combined,the wave-current interaction and wave-induced BSSs have a greater influence on suspended sediment transport and SSC variation than current-induced BSS alone.The relative wave height also has a strong correlation with SSC,indicating that the combined effect of water depth and wave height significantly impacts SSC variation.Water depth is mainly controlled by the tide on the beaches;thus,the effects of tides and waves should be conjunctively considered when analyzing the factors influencing SSC.
基金funded by the National Natural Science Foundation of China(Grant Nos.42201104,41376101,and 42071123)China Postdoctoral Research Foundation(Grant No.2023M730758)Guangdong Provincial Special Key Project of Six Marine Industries in 2022“Research on Three-dimensional Efficient Utilization of Marine Spatial Resources in Guangdong-Hong Kong-Macao Greater Bay Area”([2022]49).
文摘Anthropogenic disturbances associated with the rapid development of coastal cities have drastically influenced the hydrodynamics and sediment transport processes in many large estuaries globally.Lingdingyang Estuary(LE),located in the central and southern part of the Pearl River Delta,southern China with a long history of high-intensity anthropogenic disturbances,was studied to explore the contribution rate and mechanism underlying the alteration in hydrodynamics and sediment transport under each phase of human activity.A state-of-the-art modeling tool(TELEMAC-2D),was used to study the variations in the hydrodynamics and sediment transport,accounting for reclamation-induced shoreline and dredging-induced topography changes.The results indicated that:i)under the influence of successive land reclamation,the general distribution of the Confluence Hydrodynamic Zone(CHZ)in LE varied from scattered to concentrated,and these zones moved 3–5 km seaward.ii)Large-scale channel dredging weakened the residual flow in LE,decreasing the residual flow in the Inner-Lingding Estuary(ILE)by 62.45%.This was initiated by the enhancement of tidal dynamics through changes in the bottom friction caused by dredging in the ILE.In contrast,massive reclamation decreased the residual flow in the ILE by 17.55%and increased that in the Outer-Lingding Estuary(OLE).iii)Despite disturbances related to land reclamation and dredging,the estuarine jet flow in LE remained a turbulent jet system,and the estuarine jet flow became more asymmetrical.In addition,the position of the estuarine jet source moved 6–13 km seaward.iv)Both reclamation and dredging decreased the SSC in the ILE and increased the SSC in the OLE.Reclamation weakened the SSC in the ILE by 62.19%,whereas dredging enhanced the SSC in the OLE by 49%.Spatially,reclamation resulted in an increase in the SSC near the outlets and a decrease in the SSC in the northern portion of the Western Channel.Dredging mainly increased the SSC in the northern part of the OLE.v)The increase in the barotropic pressure gradient was the main factor driving the enhancement of the residual flow and SSC near the outlets.Moreover,the southward location of the“artificial outlets”favored the transport of suspended sediments to the OLE,which was one of the primary reasons for the increase in the SSC in the OLE.Finally,the tidal dynamics of the ILE intensified due to massive reclamation and dredging.The findings of this study indicate that hydrodynamics and sediment transport in LE have greatly changed over the last decades,with reclamation and dredging being the crucial drivers.The insights obtained from this study can serve as a reference for the comprehensive management of the Pearl River Estuary and other large estuaries experiencing similar anthropogenic forcing.
基金supported by the National Key R&D Program of China(2022YFC2305303).
文摘To better understand the epidemiological characteristics of human adenovirus(HAdv)infections in China during and after the coronavirus disease 2019(COvVID-19)pandemic,respiratory specimens were collected from 17,562 enrolled patients with acute respiratory infections(ARIs)in 14 sentinel surveillance provinces during 2020-2023.Eight common respiratory viruses were detected using commercially available nucleic acid detection kits.HAdV-positive cases were statistically analyzed for detection rates,geographic distribution,seasonal patterns,demographic characteristics,and co-infection status.The results of this study showed that the overall HAdV detection rate was 5.09%(894/17,562)during 2020-2023,with a gradual decrease in the annual detection rate from 6.66%in 2020 to 3.89%in 2022 and a rebound in 2023(5.19%).The overall HAdV detection rate was significantly higher in the southern region(6.15%)than in the northern region(4.76%)(P<0.001).The median age of patients with HAdv infection was 3 years,with infants aged 0-2 years accounting for the majority(41.39%).HAdV-positive cases were detected throughout the year,with no clear seasonal pattern,and the HAdV epidemic in China during 2020-2023 may have been driven primarily by the virus infection in the southern region.Co-infections were frequent in HAdV-positive cases(overall rate:36.01%),primarily consisting of dual infections(79.28%),with human rhinovirus and human respiratory syncytial virus being the most common coinfecting pathogens.In conclusion,this study suggested the significant regional and temporal variation in HAdV detection rate in China during 2020-2023,and thus ongoing surveillance should be conducted to elucidate the epidemiological dynamics of HAdV infections.
基金supported by the National Natural Science Foundation of China(NSFC)(Grant Nos.22373014 and 22371043)the Natural Science Foundation of Fujian Province(No.2022J06019)the Open Project Program of Wuhan National Laboratory for Optoelectronics(No.2020WNLOKF009).
文摘With the rapid development of white LEDs,the research of new and efficient white light emitting materials has attracted increasing attention.Zero dimensional(0D)organic–inorganic hybrid metal halide perovskites with superior luminescent property are promising candidates for LED application,due to their abundant and tailorable structure.Herein,[(CH_(3))_(3)S]_(2)SnCl_(6)・H_(2)O is synthesized as a host for dopant ions Bi^(3+)and Sb^(3+).The Sb^(3+)doped,or Bi^(3+)/Sb^(3+)co-doped,[(CH_(3))3S]_(2)SnCl_(6)・H_(2)O has a tunable optical emission spectrum by means of varying dopant ratio and excitation wavelength.As a result,we can achieve single-phase materials suitable for emission ranging from cold white light to warm white light.The intrinsic mechanism is examined in this work,to clarify the dopant effect on the optical properties.The high stability of title crystalline material,against water,oxygen and heat,makes it promising for further application.
基金Supported by the National Natural Science Foundation of China(41575077,41490643,and 41805051)National Key Research and Development Program of China(2017YFA0604102)+1 种基金Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)Startup Found for Introduced Talents of Nanjing University of Information Science&Technology(2017r057)
文摘Using the hindcasts provided by the Ensemble-Based Predictions of Climate Changes and Their Impacts(ENSEMBLES) project for the period of 1980–2005, the forecast capability of spring climate in China is assessed mainly from the aspects of precipitation, 2-m air temperature, and atmospheric circulations. The ENSEMBELS can reproduce the climatology and dominant empirical orthogonal function(EOF) modes of precipitation and 2-m air temperature, with some differences arising from different initialization months. The multi-model ensemble(MME) forecast of interannual variability is of good performance in some regions such as eastern China with February initialization.The spatial patterns of the MME interannual and inter-member spreads for precipitation and 2-m air temperature are consistent with those of the observed interannual spread, indicating that internal dynamic processes have major impacts on the interannual anomaly of spring climate in China. We have identified two coupled modes between intermember anomalies of the 850-hPa vorticity in spring and sea surface temperature(SST) both in spring and at a lead of 2 months, of which the first mode shows a significant impact on the spring climate in China, with an anomalous anticyclone located over Northwest Pacific and positive precipitation and southwesterly anomalies in eastern China.Our results also suggest that the SST at a lead of two months may be a predictor for the spring climate in eastern China. A better representation of the ocean–atmosphere interaction over the tropical Pacific, Northwest Pacific, and Indian Ocean can improve the forecast skill of the spring climate in eastern China.
基金Supported by the Research Project of China Meteorological Administration(CMA)Institute of Atmospheric Environment(2021SYI AEKFMS11)National Key Research and Development Program of China(2021YFA0718000)+3 种基金National Natural Science Foundation of China(42175052 and 42005037)Joint Research Project for Meteorological Capacity Improvement(22NLTSY008)CMA Special Project for Innovative Development(CXFZ2022J008)CMA Youth Innovation Team Fund(CMA2024QN06 and CMA2024QN05).
文摘As an important atmospheric circulation system in the mid-high latitudes of East Asia,the Northeast China cold vortex(NCCV)substantially influences weather and climate in this region.So far,systematic assessment on the performance of numerical prediction of the NCCVs has not been carried out.Based on the Beijing Climate Centre(BCC)and the ECMWF model hindcast and forecast data that participated in the Sub-seasonal to Seasonal(S2S)Prediction Project,this study systematically examines the performance of both models in simulating and forecasting the NCCVs at the sub-seasonal timescale.The results demonstrate that the two models can effectively capture the seasonal variations in the intensity,active days,and spatial distribution of NCCVs;however,the duration of NCCVs is shorter and the intensity is weaker in the models than in the observations.Diagnostic analysis shows that the differences in the intensity and location of the East Asian subtropical westerly jet and the wave train pattern from North Atlantic to East Asia may be responsible for the deficient simulation of NCCV events in the S2S models.Nonetheless,in the deterministic forecasts,BCC and ECMWF provide skillful prediction on the anomalous numbers of NCCV days and intensity at a lead time of 4-5(5-6)pentads,and the skill limit of the ensemble mean is 1-2 pentads longer than that of individual members.In the probabilistic forecasts of daily NCCV activities,BCC and ECMWF exhibit a forecasting skill of approximately 7 and 11 days,respectively;both models show seasonal dependency in the simulation performance and forecast skills of NCCV events,with better performance in winter than in summer.The results from this study provide helpful references for further improvement of the S2S prediction of NCCVs.
基金This work was supported by the Natural Science Foundation of China(Grant No.32001787)the 2115 Talent Development Program of China Agricultural University。
文摘The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor treatment.However,research on alleviating metabolic diseases,such as hyperglycemia,has not been reported.Herein,we found that the single-atom Ce-N_(4)-C-(OH)_(2)(SACe-N_(4)-C-(OH)_(2))nanozyme promoted glucose absorption in lysosomes,resulting in increased reactive oxygen species production in HepG2 cells.Furthermore,the SACe-N_(4)-C-(OH)_(2)nanozyme initiated a cascade reaction involving superoxide dismutase-,oxidase-,catalase-,and peroxidase-like activity to overcome the limitations associated with the substrate and produce•OH,thus improving glucose intolerance and insulin resistance by increasing the phosphorylation of protein kinase B and glycogen synthase kinase 3β,and the expression of glycogen synthase,promoting glycogen synthesis to improve glucose intolerance and insulin resistance in high-fat diet-induced hyperglycemic mice.Altogether,these results demonstrated that the novel nanozyme SACeN_(4)-C-(OH)_(2)alleviated the effects of hyperglycemia without evident toxicity,demonstrating its excellent clinical application potential.
文摘Correction:Frontiers of Optoelectronics(2024)17:6 https://doi.org/10.1007/s12200-024-00109-3 Following publication of the original article[1],the authors reported the errors,which need to be corrected:1.The sentence in Results and discussion section has been updated from"The crystal belongs to the Fm-3 m space group with a unit cell length of 12.43 A."to"The crystal belongs to the Pa-3 space group with a unit cell length of 12.42 A."A cif file has been added as a Supplementary file for comparison with other readers.
