Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)recon...Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)reconstruction remains a significant challenge.In this study,black tantalic oxide(BTO)submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide(WTO)through magnesium thermal reduction(MTR)method,and BTO was coated on polyetheretherketone(PEEK)fibers(PKF),which were woven into fabrics(PBT)as artificial ligaments.PBT with BTO coating exhibited excellent photothermal performance,which possessed not only antibac-terial effects in vitro but also anti-infective ability in vivo.PBT with optimized surface properties(e.g.,submicro-topography and hydrophilicity)not only significantly facilitated rat bone mesenchymal stem cells(BMSC)responses(e.g.,proliferation and osteogenic differentiation)in vitro but also stimulated new bone formation for ligament-bone healing in vivo.The presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial effect.In summary,BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection,thereby promoting ligament-bone healing.Therefore,PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction.展开更多
基金supported by the National Natu-ral Science Foundation of China(Nos.32171340,81772343 and 81771990)the Key Medical Program of Science and Technol-ogy Development of Shanghai(No.20S31900400)the National Science Foundation of Shanghai(No.21ZR1447900).
文摘Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)reconstruction remains a significant challenge.In this study,black tantalic oxide(BTO)submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide(WTO)through magnesium thermal reduction(MTR)method,and BTO was coated on polyetheretherketone(PEEK)fibers(PKF),which were woven into fabrics(PBT)as artificial ligaments.PBT with BTO coating exhibited excellent photothermal performance,which possessed not only antibac-terial effects in vitro but also anti-infective ability in vivo.PBT with optimized surface properties(e.g.,submicro-topography and hydrophilicity)not only significantly facilitated rat bone mesenchymal stem cells(BMSC)responses(e.g.,proliferation and osteogenic differentiation)in vitro but also stimulated new bone formation for ligament-bone healing in vivo.The presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial effect.In summary,BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection,thereby promoting ligament-bone healing.Therefore,PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction.
