Carbon dots(CDs)-based composites have shown impressive performance in fields of information encryption and sensing,however,a great challenge is to simultaneously implement multi-mode luminescence and room-temperature...Carbon dots(CDs)-based composites have shown impressive performance in fields of information encryption and sensing,however,a great challenge is to simultaneously implement multi-mode luminescence and room-temperature phosphorescence(RTP)detection in single system due to the formidable synthesis.Herein,a multifunctional composite of Eu&CDs@p RHO has been designed by co-assembly strategy and prepared via a facile calcination and impregnation treatment.Eu&CDs@p RHO exhibits intense fluorescence(FL)and RTP coming from two individual luminous centers,Eu3+in the free pores and CDs in the interrupted structure of RHO zeolite.Unique four-mode color outputs including pink(Eu^(3+),ex.254 nm),light violet(CDs,ex.365 nm),blue(CDs,254 nm off),and green(CDs,365 nm off)could be realized,on the basis of it,a preliminary application of advanced information encoding has been demonstrated.Given the free pores of matrix and stable RTP in water of confined CDs,a visual RTP detection of Fe^(3+)ions is achieved with the detection limit as low as 9.8μmol/L.This work has opened up a new perspective for the strategic amalgamation of luminous vips with porous zeolite to construct the advanced functional materials.展开更多
Background:The available evidence regarding the benefits of percutaneous coronary intervention(PCI)on patients receiving dialysis with coronary artery disease(CAD)is limited and inconsistent.This study aimed to evalua...Background:The available evidence regarding the benefits of percutaneous coronary intervention(PCI)on patients receiving dialysis with coronary artery disease(CAD)is limited and inconsistent.This study aimed to evaluate the association between PCI and clinical outcomes as compared with medical therapy alone in patients undergoing dialysis with CAD in China.Methods:This multicenter,retrospective study was conducted in 30 tertiary medical centers across 12 provinces in China from January 2015 to June 2021 to include patients on dialysis with CAD.The primary outcome was major adverse cardiovascular events(MACE),defined as a composite of cardiovascular death,non-fatal myocardial infarction,and non-fatal stroke.Secondary outcomes included all-cause death,the individual components of MACE,and Bleeding Academic Research Consortium criteria types 2,3,or 5 bleeding.Multivariable Cox proportional hazard models were used to assess the association between PCI and outcomes.Inverse probability of treatment weighting(IPTW)and propensity score matching(PSM)were performed to account for potential between-group differences.Results:Of the 1146 patients on dialysis with significant CAD,821(71.6%)underwent PCI.After a median follow-up of 23.0 months,PCI was associated with a 43.0%significantly lower risk for MACE(33.9%[n=278]vs.43.7%[n=142];adjusted hazards ratio 0.57,95%confidence interval 0.45-0.71),along with a slightly increased risk for bleeding outcomes that did not reach statistical significance(11.1%vs.8.3%;adjusted hazards ratio 1.31,95%confidence interval,0.82-2.11).Furthermore,PCI was associated with a significant reduction in all-cause and cardiovascular mortalities.Subgroup analysis did not modify the association of PCI with patient outcomes.These primary findings were consistent across IPTW,PSM,and competing risk analyses.Conclusion:This study indicated that PCI in patients on dialysis with CAD was significantly associated with lower MACE and mortality when comparing with those with medical therapy alone,albeit with a slightly increased risk for bleeding events that did not reach statistical significance.展开更多
Hypertension(HT)is the most common public-health challenge andshows a high inci-dence around the world.Cardiovascular diseases are the leadingcause of mortality and morbidity among the elderly(age>65 years)in the U...Hypertension(HT)is the most common public-health challenge andshows a high inci-dence around the world.Cardiovascular diseases are the leadingcause of mortality and morbidity among the elderly(age>65 years)in the UnitedStates.Now,there is widespread acceptanceof the causal link between HT and acute myocardial infarction(MI).This is the first data-mining study to identify co-expressed differentially expressed genes(Co-DEGs)between HT and MI(rela-tive to nommal control)and to uncover potential biomarkers and therapeutic targets of HT-related MI.In thismanuscript,HT-specfcDEGs andMl-specific DEGs and dffretially expressed microRNAs(DE-miRNAs)were identifhed in Gene Expression Omnibus(GEO)datasets GSE24752,GSE60993,GSE62646,and GSE24548 after data consolidation and batch correction.Subse-quently,enichmentin Gene Ontology(GO)terms and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways as well as protein-protein interaction networks were identified,and single-gene gene set enrichment analysis was performed to determine the affected biological cate-gories and networks.Cross-matching of the results on cCo-DE-miRNAs and predicted miRNAs tar-geting the Co-DEGs wasconducted and discussed as well.We found thatMYC and HIST1H2BO may be associatedwith HT,whereas FCGR 1A,FYN,KLRD1,KLRB1,and FOLR3 may be implicated in MI.Moreover,Co-DEGs FOLR3 and NFE2 with predicted miRNAs and DE-miRNAs,especially miR-7 and miR-548,may be significantly associated and show huge potential as a new set of novel bio-markers and important molecular targets in the course of HT-related MI.展开更多
基金supported by the National Natural Science Foundation of China(No.22288101)the 111 Project(No.B17020)。
文摘Carbon dots(CDs)-based composites have shown impressive performance in fields of information encryption and sensing,however,a great challenge is to simultaneously implement multi-mode luminescence and room-temperature phosphorescence(RTP)detection in single system due to the formidable synthesis.Herein,a multifunctional composite of Eu&CDs@p RHO has been designed by co-assembly strategy and prepared via a facile calcination and impregnation treatment.Eu&CDs@p RHO exhibits intense fluorescence(FL)and RTP coming from two individual luminous centers,Eu3+in the free pores and CDs in the interrupted structure of RHO zeolite.Unique four-mode color outputs including pink(Eu^(3+),ex.254 nm),light violet(CDs,ex.365 nm),blue(CDs,254 nm off),and green(CDs,365 nm off)could be realized,on the basis of it,a preliminary application of advanced information encoding has been demonstrated.Given the free pores of matrix and stable RTP in water of confined CDs,a visual RTP detection of Fe^(3+)ions is achieved with the detection limit as low as 9.8μmol/L.This work has opened up a new perspective for the strategic amalgamation of luminous vips with porous zeolite to construct the advanced functional materials.
基金National High Level Hospital Clinical Research Funding(No.2024-NHLHCRF-YS-01)Capital’s Founds for Health Improvement and Research(No.2022-1-4062)+5 种基金Beijing Research Ward Construction Clinical Research Project(No.2022-YJXBF-04-03)Science Foundation of China-Japan Friendship Hospital(No.2020-HX-40)National Natural Science Foundation of China(No.82270352)National High Level Hospital Clinical Research Funding(No.2024-NHLHCRF-JBGS-WZ-06)Chinese Society of Cardiology’s Foundation(No.CSCF2021B02)National Key Clinical Specialty Construction Project(No.2020-QTL-009)
文摘Background:The available evidence regarding the benefits of percutaneous coronary intervention(PCI)on patients receiving dialysis with coronary artery disease(CAD)is limited and inconsistent.This study aimed to evaluate the association between PCI and clinical outcomes as compared with medical therapy alone in patients undergoing dialysis with CAD in China.Methods:This multicenter,retrospective study was conducted in 30 tertiary medical centers across 12 provinces in China from January 2015 to June 2021 to include patients on dialysis with CAD.The primary outcome was major adverse cardiovascular events(MACE),defined as a composite of cardiovascular death,non-fatal myocardial infarction,and non-fatal stroke.Secondary outcomes included all-cause death,the individual components of MACE,and Bleeding Academic Research Consortium criteria types 2,3,or 5 bleeding.Multivariable Cox proportional hazard models were used to assess the association between PCI and outcomes.Inverse probability of treatment weighting(IPTW)and propensity score matching(PSM)were performed to account for potential between-group differences.Results:Of the 1146 patients on dialysis with significant CAD,821(71.6%)underwent PCI.After a median follow-up of 23.0 months,PCI was associated with a 43.0%significantly lower risk for MACE(33.9%[n=278]vs.43.7%[n=142];adjusted hazards ratio 0.57,95%confidence interval 0.45-0.71),along with a slightly increased risk for bleeding outcomes that did not reach statistical significance(11.1%vs.8.3%;adjusted hazards ratio 1.31,95%confidence interval,0.82-2.11).Furthermore,PCI was associated with a significant reduction in all-cause and cardiovascular mortalities.Subgroup analysis did not modify the association of PCI with patient outcomes.These primary findings were consistent across IPTW,PSM,and competing risk analyses.Conclusion:This study indicated that PCI in patients on dialysis with CAD was significantly associated with lower MACE and mortality when comparing with those with medical therapy alone,albeit with a slightly increased risk for bleeding events that did not reach statistical significance.
基金This work was supported by the Postgraduate Research&Practice Innovation Program of Jiangsu Province(grant number KYCX18_1462)Nanjing Health Youth Talent Training Project in in 13th Five-Year(grant number QRX17113)+1 种基金Nanjing Medical Science and technique Devel-opment Foundation(grant number QRX17057)the Natural Science Foundation of China(grant numbers 81700392 and 81601539).
文摘Hypertension(HT)is the most common public-health challenge andshows a high inci-dence around the world.Cardiovascular diseases are the leadingcause of mortality and morbidity among the elderly(age>65 years)in the UnitedStates.Now,there is widespread acceptanceof the causal link between HT and acute myocardial infarction(MI).This is the first data-mining study to identify co-expressed differentially expressed genes(Co-DEGs)between HT and MI(rela-tive to nommal control)and to uncover potential biomarkers and therapeutic targets of HT-related MI.In thismanuscript,HT-specfcDEGs andMl-specific DEGs and dffretially expressed microRNAs(DE-miRNAs)were identifhed in Gene Expression Omnibus(GEO)datasets GSE24752,GSE60993,GSE62646,and GSE24548 after data consolidation and batch correction.Subse-quently,enichmentin Gene Ontology(GO)terms and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways as well as protein-protein interaction networks were identified,and single-gene gene set enrichment analysis was performed to determine the affected biological cate-gories and networks.Cross-matching of the results on cCo-DE-miRNAs and predicted miRNAs tar-geting the Co-DEGs wasconducted and discussed as well.We found thatMYC and HIST1H2BO may be associatedwith HT,whereas FCGR 1A,FYN,KLRD1,KLRB1,and FOLR3 may be implicated in MI.Moreover,Co-DEGs FOLR3 and NFE2 with predicted miRNAs and DE-miRNAs,especially miR-7 and miR-548,may be significantly associated and show huge potential as a new set of novel bio-markers and important molecular targets in the course of HT-related MI.
