Background The comorbidity of cardiovascular disease(CVD)and depression has been well established,as depression usually presents simultaneously with CVD risk factors.However,the potential association between cumulativ...Background The comorbidity of cardiovascular disease(CVD)and depression has been well established,as depression usually presents simultaneously with CVD risk factors.However,the potential association between cumulative exposure to CVD risk and depression remains unclear,so we conducted the current investigation.To our knowledge,this is the first study that employs the cumulative risk model to examine the effect of CVD risk factors on depression using nationally representative population and gender,age and CVD status-stratified subpopulations.Aims To systematically study the possible individual and cumulative effect of 18 CVD risk factors on depression.Methods A cross-sectional,secondary analysis investigated associations between 18 CVD risk factors and depression.The interaction effect between CVD risk factors and age,gender and CVD status was also examined.Enrolment included 20816 participants from the US National Health and Nutrition Examination Survey 2005–2016.Participants with Patient Health Questionnaire-9 scores over 15 or who were using an antidepressant were considered depressive;18 known cardiovascular risk factors were incorporated in the present study.Results At the individual risk factor level,smoking,drinking,living alone,sleep quality,body mass index,waist circumference and diabetes status had differential associations with depression risk according to the gender,age or CVD status of the participants.Most importantly,gender-stratified cumulative risk analysis indicated that similar depression risk was found in both genders with a small number of CVD risk factors(odds ratio(OR)adjusted=1.32;95%confidence interval(CI):0.87 to 1.99),but females had a significantly higher depression risk compared with males under high cumulative risk exposure(ORadjusted=2.86;95%CI:1.79 to 4.59).Conclusions Clarifying the association of numerous CVD risk factors with depression according to gender,age and overall CVD status may be beneficial for risk stratification and the prevention of depression in clinical practice.Moreover,the observed novel evidence of high cumulative risk exposure-mediated gender disparities in depression risk may shed light on the underlying mechanism of females’greater vulnerability to depression.展开更多
Malignant glioblastoma(GBM)is prone to relapse due to the inevitable tumor cells residue by surgery.During the tumor resection surgery in brain,addressing bleeding and superbug infections is also full of challenges.Cu...Malignant glioblastoma(GBM)is prone to relapse due to the inevitable tumor cells residue by surgery.During the tumor resection surgery in brain,addressing bleeding and superbug infections is also full of challenges.Currently,no method or material in clinical craniotomy can simultaneously solve these three problems.Herein,Chitosan composite nanofibers embed-ded with CuSe nanoparticles were prepared by green electrospinning method,in which the CuSe nanoparticles have strong absorption in the second near-infrared(NIR-II)window.Immediately after removing the tumor in craniotomy,nanofibers were electrospun and deposited directly onto the resection site with high precision(>90%)to achieve rapid hemostasis(<8 s).Moreover,evidenced by the deeper penetration depth of NIR-II light(1064 nm)both in the scalp and skull than NIR-I light(808 nm),photothermal and photodynamic therapy induced by NIR-II exhibits efficient superbug-killing rate(>99%)and effectively induces cell apoptosis of residual tumor thereby to inhibit tumor recurrence.Only using the same material,a tril-ogy of intracranial hemostasis,killing superbug and residual cancer cells is simultaneously achieved.The short operation time reduces the risk of craniotomy.This electrospinning strategy could combine with craniotomy and minimally invasive surgery,which may provide novel perspectives in clinical operation besides craniotomy.展开更多
This study investigated the co-inoculation of Lactobacillus plantarum B8 and Staphylococcus edaphicus F for fermenting Mandarin fish(Siniperca chuatsi)to enhance product quality and safety.On the seventh day of fermen...This study investigated the co-inoculation of Lactobacillus plantarum B8 and Staphylococcus edaphicus F for fermenting Mandarin fish(Siniperca chuatsi)to enhance product quality and safety.On the seventh day of fermentation,the results demonstrated that co-inoculation significantly improved the textural properties of fermented fish and increased the content of umami-and sweet-flavored amino acids.Compared to spontaneous fermentation,co-inoculation reduced total volatile base nitrogen(TVB-N)by 25.53%,thiobarbituric acid reactive substances(TBARS)by 62.82%,and total biogenic amines(BAs)by 27.91%,indicating enhanced freshness,suppressed lipid oxidation,and mitigated safety risks.Furthermore,the co-inoculated samples exhibited significantly lower levels of sulfur-and nitrogen-containing volatile compounds,contributing to a milder flavor profile and superior sensory attributes.Microbial analysis revealed a notable reduction in Vibrio abundance,which correlated with decreased indole and sulfide production,thereby improving odor characteristics.Principal component analysis(PCA)and partial least squares-discriminant analysis(PLS-DA)highlighted the synergistic interactions between microbial communities and their positive impacts on the quality and flavor development of fermented fish.In conclusion,co-inoculation with L.plantarum B8 and S.edaphicus F not only enhances the safety and nutritional value of the products but also improves their sensory properties,making them more appealing to consumers.展开更多
基金This study was supported by the National Natural Science Foundation of China(grant no.81973698 and 81703942)the Young Elite Scientists Sponsorship Program by CACM(grant no.2019-QNRC2-B08)+2 种基金the BUCM Precision Cultivation Program(grant no.JZPY-202205)the Science Fund for Distinguished Young Scholars in BUCM(grant no.BUCM-2019-JCRC004)the BUCM Research Development Fund(grant no.2021-ZXFZJJ-052).
文摘Background The comorbidity of cardiovascular disease(CVD)and depression has been well established,as depression usually presents simultaneously with CVD risk factors.However,the potential association between cumulative exposure to CVD risk and depression remains unclear,so we conducted the current investigation.To our knowledge,this is the first study that employs the cumulative risk model to examine the effect of CVD risk factors on depression using nationally representative population and gender,age and CVD status-stratified subpopulations.Aims To systematically study the possible individual and cumulative effect of 18 CVD risk factors on depression.Methods A cross-sectional,secondary analysis investigated associations between 18 CVD risk factors and depression.The interaction effect between CVD risk factors and age,gender and CVD status was also examined.Enrolment included 20816 participants from the US National Health and Nutrition Examination Survey 2005–2016.Participants with Patient Health Questionnaire-9 scores over 15 or who were using an antidepressant were considered depressive;18 known cardiovascular risk factors were incorporated in the present study.Results At the individual risk factor level,smoking,drinking,living alone,sleep quality,body mass index,waist circumference and diabetes status had differential associations with depression risk according to the gender,age or CVD status of the participants.Most importantly,gender-stratified cumulative risk analysis indicated that similar depression risk was found in both genders with a small number of CVD risk factors(odds ratio(OR)adjusted=1.32;95%confidence interval(CI):0.87 to 1.99),but females had a significantly higher depression risk compared with males under high cumulative risk exposure(ORadjusted=2.86;95%CI:1.79 to 4.59).Conclusions Clarifying the association of numerous CVD risk factors with depression according to gender,age and overall CVD status may be beneficial for risk stratification and the prevention of depression in clinical practice.Moreover,the observed novel evidence of high cumulative risk exposure-mediated gender disparities in depression risk may shed light on the underlying mechanism of females’greater vulnerability to depression.
基金supported by a grant from the National Natural Science Foundation of China(11904193 and 51973100)State Key Laboratory of Bio-Fibers and Eco-Textiles,Qingdao University(RZ2000003334 and G2RC202022)the National Key Research and Development Program(2019YFC0121402).
文摘Malignant glioblastoma(GBM)is prone to relapse due to the inevitable tumor cells residue by surgery.During the tumor resection surgery in brain,addressing bleeding and superbug infections is also full of challenges.Currently,no method or material in clinical craniotomy can simultaneously solve these three problems.Herein,Chitosan composite nanofibers embed-ded with CuSe nanoparticles were prepared by green electrospinning method,in which the CuSe nanoparticles have strong absorption in the second near-infrared(NIR-II)window.Immediately after removing the tumor in craniotomy,nanofibers were electrospun and deposited directly onto the resection site with high precision(>90%)to achieve rapid hemostasis(<8 s).Moreover,evidenced by the deeper penetration depth of NIR-II light(1064 nm)both in the scalp and skull than NIR-I light(808 nm),photothermal and photodynamic therapy induced by NIR-II exhibits efficient superbug-killing rate(>99%)and effectively induces cell apoptosis of residual tumor thereby to inhibit tumor recurrence.Only using the same material,a tril-ogy of intracranial hemostasis,killing superbug and residual cancer cells is simultaneously achieved.The short operation time reduces the risk of craniotomy.This electrospinning strategy could combine with craniotomy and minimally invasive surgery,which may provide novel perspectives in clinical operation besides craniotomy.
基金supported by Anhui Provincial Key Research and Development Plan(202104a06020013)Major Science and Technology Special Projects in Anhui Province(2021d06050001)Open Research Project of the Rural Revitalization Collaborative Technical Service Center of Anhui Province(Huangshan University)(XCZXZD2301).
文摘This study investigated the co-inoculation of Lactobacillus plantarum B8 and Staphylococcus edaphicus F for fermenting Mandarin fish(Siniperca chuatsi)to enhance product quality and safety.On the seventh day of fermentation,the results demonstrated that co-inoculation significantly improved the textural properties of fermented fish and increased the content of umami-and sweet-flavored amino acids.Compared to spontaneous fermentation,co-inoculation reduced total volatile base nitrogen(TVB-N)by 25.53%,thiobarbituric acid reactive substances(TBARS)by 62.82%,and total biogenic amines(BAs)by 27.91%,indicating enhanced freshness,suppressed lipid oxidation,and mitigated safety risks.Furthermore,the co-inoculated samples exhibited significantly lower levels of sulfur-and nitrogen-containing volatile compounds,contributing to a milder flavor profile and superior sensory attributes.Microbial analysis revealed a notable reduction in Vibrio abundance,which correlated with decreased indole and sulfide production,thereby improving odor characteristics.Principal component analysis(PCA)and partial least squares-discriminant analysis(PLS-DA)highlighted the synergistic interactions between microbial communities and their positive impacts on the quality and flavor development of fermented fish.In conclusion,co-inoculation with L.plantarum B8 and S.edaphicus F not only enhances the safety and nutritional value of the products but also improves their sensory properties,making them more appealing to consumers.
