Dear Editor,SARS-CoV-2 rapidly evolves during the pandemic1 with many variants of concern(VoCs)lineages(Supplementary Fig.S1a).Omicron(B.1.1.529)and its sub-lineages led to multiple infection waves globally.2 Omicron ...Dear Editor,SARS-CoV-2 rapidly evolves during the pandemic1 with many variants of concern(VoCs)lineages(Supplementary Fig.S1a).Omicron(B.1.1.529)and its sub-lineages led to multiple infection waves globally.2 Omicron subvariants harbored a high number of mutations,especially in the spike(S)glycoprotein,and clustered in the receptor-binding domain(RBD)(Supplementary Fig.S1b,c;Supplemental Discussion).These subvariants drastically decrease the efficacy of current vaccinations and monoclonal antibody therapies.展开更多
基金LBMS is supported by the DOE Office of Biological and Environmental Research(KP1607011)We thank Drs.Lucas,Klein,L Chen,Müschen,Mr.Monteiro,and others for support+1 种基金This work is supported by DoD PRMRP IIAR(W81XWH-21-1-0019)discretionary funds to SC and NIH R01 AI163395 to Y.X.
文摘Dear Editor,SARS-CoV-2 rapidly evolves during the pandemic1 with many variants of concern(VoCs)lineages(Supplementary Fig.S1a).Omicron(B.1.1.529)and its sub-lineages led to multiple infection waves globally.2 Omicron subvariants harbored a high number of mutations,especially in the spike(S)glycoprotein,and clustered in the receptor-binding domain(RBD)(Supplementary Fig.S1b,c;Supplemental Discussion).These subvariants drastically decrease the efficacy of current vaccinations and monoclonal antibody therapies.
