A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rot...A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants.展开更多
Seedling stage is an important period for forestry.The aim of this study was to estimate the growth trend of six local precious species and consider their implications for silviculture on forestry.We assessed height,d...Seedling stage is an important period for forestry.The aim of this study was to estimate the growth trend of six local precious species and consider their implications for silviculture on forestry.We assessed height,diameter near ground and crown width at 1,4,6 and 8-month.The variance analysis indicated that there were significant differences between species on all traits except diameter near ground and crown width at 8-month.There were no significant differences on height and crown width at all ages among replicates whereas there were significant differences on diameter near ground at 1 and 4 months,differences on diameter near ground at 6 months and no difference on diameter near ground at 8-month.The significant differences among interaction of species and replicates on diameter near ground at 1-months,4-month,6-month and crown width at 8-month were also found.Dalbergia odorifera had a higher growth period after 6-month.Aquilaria sinensis(Lour.)Spreng,Swietenia mahagoni(L.)Jacq.,Hopea hainanensis Merr.et Chun,Homalium hainanense Gagnep.and Cassia siamea Lam.had the same growth trend on all traits at the whole time.展开更多
Silviculture is the major procedures in forest research.Silviculture is traditionally focused on various aspects of tree planting,such as tree selection,site preparation,irrigation and fertilization and so on,and the ...Silviculture is the major procedures in forest research.Silviculture is traditionally focused on various aspects of tree planting,such as tree selection,site preparation,irrigation and fertilization and so on,and the role of silviculture at that time is to manage forests scientifically for continuous production of goods and services while meeting biological and economic requirements.During the past three decades,an increase in research on silviculture has improved Eucalyptus productivity and on wood properties.But,very little information about this procedure on the review of Eucalyptus grown in China has been published even though this species was introduced many years.This paper reviews the available information regarding research history and progress of silviculture under Chinese ecological conditions and to outline some suggestions to them.展开更多
基金supported by National Health Commission of the People’s Republic of China (grant number:2019ZX09302059)sponsored and funded by Wuhan Institute of Biological Products Co.,Ltd.,Hubei,China
文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants.
文摘Seedling stage is an important period for forestry.The aim of this study was to estimate the growth trend of six local precious species and consider their implications for silviculture on forestry.We assessed height,diameter near ground and crown width at 1,4,6 and 8-month.The variance analysis indicated that there were significant differences between species on all traits except diameter near ground and crown width at 8-month.There were no significant differences on height and crown width at all ages among replicates whereas there were significant differences on diameter near ground at 1 and 4 months,differences on diameter near ground at 6 months and no difference on diameter near ground at 8-month.The significant differences among interaction of species and replicates on diameter near ground at 1-months,4-month,6-month and crown width at 8-month were also found.Dalbergia odorifera had a higher growth period after 6-month.Aquilaria sinensis(Lour.)Spreng,Swietenia mahagoni(L.)Jacq.,Hopea hainanensis Merr.et Chun,Homalium hainanense Gagnep.and Cassia siamea Lam.had the same growth trend on all traits at the whole time.
文摘Silviculture is the major procedures in forest research.Silviculture is traditionally focused on various aspects of tree planting,such as tree selection,site preparation,irrigation and fertilization and so on,and the role of silviculture at that time is to manage forests scientifically for continuous production of goods and services while meeting biological and economic requirements.During the past three decades,an increase in research on silviculture has improved Eucalyptus productivity and on wood properties.But,very little information about this procedure on the review of Eucalyptus grown in China has been published even though this species was introduced many years.This paper reviews the available information regarding research history and progress of silviculture under Chinese ecological conditions and to outline some suggestions to them.
