Introduction:Hypertension and left ventricular hypertrophy(LVH)have emerged as significant risk factors forcardiovascular events and all-cause mortality.Inflammation and nutrition play critical roles in the developmen...Introduction:Hypertension and left ventricular hypertrophy(LVH)have emerged as significant risk factors forcardiovascular events and all-cause mortality.Inflammation and nutrition play critical roles in the development of hypertension and damage to target organs.The HALP Score,which assesses levels of hemoglobin,albumin,lympho-cytes,and platelets,is an index closely associated with inflammation and nutrition,and has been demonstrated to be particularly effective in the older population.Hence,the objective of this study was to examine the correlation between the HALP Score and LVH in older patients with hypertension.Methods:We collected and retrospectively analyzed data from 234 older patients,including clinical data,and routine blood,liver function,kidney function,and cardiac ultrasound parameters.All patients were categorized into a non-left ventricular hypertrophy(NLVH)group(n=131)or an LVH group(n=103).The association between the HALP Score and LVH was investigated,and potential influencing factors were considered.Results:The LVH group had a significantly lower HALP Score than the NLVH group.Logistic regression analysis revealed that a lower HALP Score and female sex were independent factors associated with LVH in older patients with hypertension(OR=0.944,9.962,95%CI:0.910–0.979,3.866–24.300,P=0.002,<0.001).The area under the curve for the HALP Score in diagnosing LVH in older patients with hypertension was 0.708(95%CI:0.641–0.776,P=0.002).Conclusion:The HALP Score is significantly associated with LVH in older patients with hypertension:lower scores indicate a greater likelihood of LVH.The HALP Score has moderate diagnostic value for LVH in this population.展开更多
Cell death programmes including apoptosis, pyroptosis, autophagy, oncosis and necroptosis were defined dependent on distinct biochemical mechanism and genetic pathways. Pyroptosis is an inflammatory form of programmed...Cell death programmes including apoptosis, pyroptosis, autophagy, oncosis and necroptosis were defined dependent on distinct biochemical mechanism and genetic pathways. Pyroptosis is an inflammatory form of programmed cell death characterized by the activation of inflammatory caspases, cell swelling, pore formation on plasma mem- brane and rapid cellular rupture which cause the release of cell contents followed by robust inflammatory responses （Cookson and Brennan, 2001; Jorgensen and Miao, 2015）.展开更多
TANK-binding kinase 1(TBK1)is an important enzyme in the regulation of cellular antiviral effects.TBK1 regulates the activity of the interferon regulatory factors IRF3 and IRF7,thereby playing a key role in type I int...TANK-binding kinase 1(TBK1)is an important enzyme in the regulation of cellular antiviral effects.TBK1 regulates the activity of the interferon regulatory factors IRF3 and IRF7,thereby playing a key role in type I interferon(IFN)signaling pathways.The structure of TBK1 consists of an N-terminal kinase domain,a middle ubiquitin-like domain(ULD),and a C-terminal elongated helical domain.It has been reported that the ULD of TBK1 regulates kinase activity,playing an important role in signaling and mediating interactions with other molecules in the IFN pathway.In this study,we present the crystal structure of the ULD of human TBK1 and identify several con-served residues by multiple sequence alignment.We found that a hydrophobic patch in TBK1,containing residues Leu316,Ile353,and Val382,corresponding to the“Ile44 hydrophobic patch”observed in ubiquitin,was conserved in TBK1,IκB kinase epsilon(IKKε/IKKi),IκB kinase alpha(IKKα),and IκB kinase beta(IKKβ).In com-parison with the structure of the IKKβULD domain of Xenopus laevis,we speculate that the Ile44 hydrophobic patch of TBK1 is present in an intramolecular binding surface between ULD and the C-terminal elongated heli-ces.The varying surface charge distributions in the ULD domains of IKK and IKK-related kinases may be relevant to their specificity for specific partners.展开更多
基金This work was supported by the Key Research and Development Project of Hebei Province(19277787D)Hebei Province Innovation Capability Improvement Program(199776249D)Medical Science Research Project of Hebei Province(20220061).
文摘Introduction:Hypertension and left ventricular hypertrophy(LVH)have emerged as significant risk factors forcardiovascular events and all-cause mortality.Inflammation and nutrition play critical roles in the development of hypertension and damage to target organs.The HALP Score,which assesses levels of hemoglobin,albumin,lympho-cytes,and platelets,is an index closely associated with inflammation and nutrition,and has been demonstrated to be particularly effective in the older population.Hence,the objective of this study was to examine the correlation between the HALP Score and LVH in older patients with hypertension.Methods:We collected and retrospectively analyzed data from 234 older patients,including clinical data,and routine blood,liver function,kidney function,and cardiac ultrasound parameters.All patients were categorized into a non-left ventricular hypertrophy(NLVH)group(n=131)or an LVH group(n=103).The association between the HALP Score and LVH was investigated,and potential influencing factors were considered.Results:The LVH group had a significantly lower HALP Score than the NLVH group.Logistic regression analysis revealed that a lower HALP Score and female sex were independent factors associated with LVH in older patients with hypertension(OR=0.944,9.962,95%CI:0.910–0.979,3.866–24.300,P=0.002,<0.001).The area under the curve for the HALP Score in diagnosing LVH in older patients with hypertension was 0.708(95%CI:0.641–0.776,P=0.002).Conclusion:The HALP Score is significantly associated with LVH in older patients with hypertension:lower scores indicate a greater likelihood of LVH.The HALP Score has moderate diagnostic value for LVH in this population.
文摘Cell death programmes including apoptosis, pyroptosis, autophagy, oncosis and necroptosis were defined dependent on distinct biochemical mechanism and genetic pathways. Pyroptosis is an inflammatory form of programmed cell death characterized by the activation of inflammatory caspases, cell swelling, pore formation on plasma mem- brane and rapid cellular rupture which cause the release of cell contents followed by robust inflammatory responses （Cookson and Brennan, 2001; Jorgensen and Miao, 2015）.
基金supported by grants from the State Key Development Program for Basic Research of the Ministry of Science and Technology of China(973 Program)(Grant Nos.2011CB910304 and 2012CB910204)to YLthe National Natural Science Foundation of China(Grant Nos.30925011,31030024 and 31021062).
文摘TANK-binding kinase 1(TBK1)is an important enzyme in the regulation of cellular antiviral effects.TBK1 regulates the activity of the interferon regulatory factors IRF3 and IRF7,thereby playing a key role in type I interferon(IFN)signaling pathways.The structure of TBK1 consists of an N-terminal kinase domain,a middle ubiquitin-like domain(ULD),and a C-terminal elongated helical domain.It has been reported that the ULD of TBK1 regulates kinase activity,playing an important role in signaling and mediating interactions with other molecules in the IFN pathway.In this study,we present the crystal structure of the ULD of human TBK1 and identify several con-served residues by multiple sequence alignment.We found that a hydrophobic patch in TBK1,containing residues Leu316,Ile353,and Val382,corresponding to the“Ile44 hydrophobic patch”observed in ubiquitin,was conserved in TBK1,IκB kinase epsilon(IKKε/IKKi),IκB kinase alpha(IKKα),and IκB kinase beta(IKKβ).In com-parison with the structure of the IKKβULD domain of Xenopus laevis,we speculate that the Ile44 hydrophobic patch of TBK1 is present in an intramolecular binding surface between ULD and the C-terminal elongated heli-ces.The varying surface charge distributions in the ULD domains of IKK and IKK-related kinases may be relevant to their specificity for specific partners.
