Meniscal injury,a prevalent and challenging medical condition,is characterized by poor self-healing potential and a complex microenvironment.Tissue engineering scaffolds,particularly those made of silk fibroin(SF)/hya...Meniscal injury,a prevalent and challenging medical condition,is characterized by poor self-healing potential and a complex microenvironment.Tissue engineering scaffolds,particularly those made of silk fibroin(SF)/hyaluronic acid methacryloyl(HAMA)and encapsulating Mg^(2+),are promising options for meniscal repair.However,the inflammatory response following implantation is a significant concern.In this study,we prepared a composite SF/HAMA-Mg hydrogel scaffold,evaluated its physical and chemical properties,and detected its fibrochondrogenic differentiation effect in vitro and the healing effect in a rabbit meniscus defect model in vivo.Our results showed that the scaffold differentiates pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages after implantation,thereby reducing inflammation and facilitating the growth and repair of meniscus tissue.Further,the composite scaffold provided a conducive milieu for cell proliferation,anticipatory differentiation,and generation of extracellular matrix.In summary,composite SF/HAMA-Mg scaffolds exhibit exceptional biocompatibility and anti-inflammatory properties,demonstrating superior potential for meniscal repair.展开更多
1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many ...1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.展开更多
The effective and translational strategy to regenerate knee meniscal fibrocartilage remained challenging.Herein,we first identified vascular smooth muscle cells(VSMCs)transdifferentiated into fibrochondrocytes and par...The effective and translational strategy to regenerate knee meniscal fibrocartilage remained challenging.Herein,we first identified vascular smooth muscle cells(VSMCs)transdifferentiated into fibrochondrocytes and participated in spontaneous meniscal regeneration using smooth muscle cell lineage tracing transgenic mice meniscal defect model.Then,we identified low-intensity pulsed ultrasound(LIPUS)acoustic stimulus enhanced fibrochondrogenic transdifferentiation of VSMCs in vitro and in vivo.Mechanistically,LIPUS stimulus could up-regulate mechanosensitive ion channel Piezo1 expression and then activate the transforming growth factorβ1(TGFβ1)signal,following repression of the Notch signal,consequently enhancing fibrochondrogenic transdifferentiation of VSMCs.Finally,we demonstrated that the regular LIPUS stimulus enhanced anisotropic native-like meniscal fibrocartilage tissue regeneration in a beagle canine subtotal meniscectomy model at 6 months postoperatively.The single-cell RNA sequencing analysis confirmed the role of VSMC fibrochondrogenic transdifferentiation in meniscal regeneration.展开更多
Background:Visual input significantly influences cerebral activity related to locomotor navigation,although the underlying mechanism remains unclear.This study aimed to analyze the effects of chronic visual impairment...Background:Visual input significantly influences cerebral activity related to locomotor navigation,although the underlying mechanism remains unclear.This study aimed to analyze the effects of chronic visual impairment and its rehabilitation on sensorimotor integration during level walking in patients with age-related cataract.Methods:This prospective case series enrolled 14 female patients(68.4±4.7 years)with age-related cataract,scheduled for consecutive cataract surgeries at the Department of Ophthalmology in Peking University Third Hospital from June 2019 to June 2020.Electroencephalogram(EEG)signals during level walking were recorded using a portable EEG system before and 4 weeks after visual restoration.Walking speed was assessed using the Footscan system.Spectral power of the theta and alpha bands was analyzed with repeated-measures analysis of variance,with Assignment(rest and walking),Phase(preoperative and postoperative),and Electrode sites(F3,Fz,F4,O1,and O2)as within-subject factors.Results:Compared to the visual impairment state,theta band power significantly decreased after visual restoration(13.16±1.58μV^(2) vs.23.65±3.48μV^(2),P=0.018).Theta activity was notably reduced during walking(17.24±2.43μV^(2) vs.37.86±6.62μV^(2),P=0.017),while theta power at rest was not significantly different between the two phases(9.44±1.24μV^(2) vs.9.08±1.74µV^(2),P=0.864).Changes in walking speed were correlated with alterations in theta power at electrode sites of O1(r=-0.574,P=0.032)and O2(r=-0.648,P=0.012).Alpha band power remained stable during walking and was unaffected by visual status.Conclusions:Chronic visual impairment from age-related cataract triggers enhanced cerebral activation of sensorimotor integration to compensate for visual decline during locomotion.This cerebral over-activation is effectively alleviated by visual restoration.展开更多
In 1955,Professor Mianyu Qu,the founder of Chinese sports medicine,and the older generation of sports medicine practitioners,founded China’s sports medicine in response to the needs of the development of national spo...In 1955,Professor Mianyu Qu,the founder of Chinese sports medicine,and the older generation of sports medicine practitioners,founded China’s sports medicine in response to the needs of the development of national sports and health.In therst 30 years of the establishment of sports medicine,they played an important role in the academic development,talent cultivation,international communication,construction of the society and organization,national Olympic glory,and nationaltness.Their contributions established a solid foundation for the rapid development of China’s sports medicine in the following 30 years.展开更多
Background:Osteoarthritis(OA)is a debilitating joint disorder characterized by pro-gressive cartilage degeneration.During OA,subchondral bone undergoes micro-structural and molecular changes that precede cartilage deg...Background:Osteoarthritis(OA)is a debilitating joint disorder characterized by pro-gressive cartilage degeneration.During OA,subchondral bone undergoes micro-structural and molecular changes that precede cartilage degradation.However,spe-cific mechanisms underlying metabolic dysregulation of the bone-cartilage unit remain unclear.This study aims to investigate the role of receptor-interacting protein kinase-3(RIP3)in OA progression,focusing on bone-cartilage metabolic homeostasis.Methods:RIP3-mediated pathological and metabolic alterations in chondrocytes,os-teoblasts,and bone marrow-derived macrophages(BMMs)were evaluated.RIP3-mediated OA manifestations in cartilage and,more importantly,subchondral bone were determined by intra-articular overexpression of RIP3 in rats.The protective effect of RIP3 deficiency on the bone-cartilage unit during OA was systematically investigated using Rip3 knockout mice.The CMap database was used to screen for compounds that abrogate RIP3-induced OA pathological changes.Results:RIP3 was upregulated in the cartilage and subchondral bone of OA patients and post-traumatic OA mouse model.RIP3 overexpression not only inhibited extra-cellular matrix(ECM)anabolism in chondrocytes but also attenuated osteoblast differentiation,whereas RIP3 deficiency blunted receptor activator of NF-kappaB ligand-mediated osteoclastogenesis of BMMs.Intra-articular RIP3 overexpression induced the imbalance of SP7+osteoblasts/tartrate-resistant acid phosphatase(TRAP)+osteoclasts within the subchondral bone in addition to cartilage degen-eration in rats,while Rip3 deletion significantly improved structural outcomes of the bone-cartilage unit,and achieved pain relief as well as functional improvement in surgery-induced and spontaneous OA mouse models.Mechanistically,RIP3 initiates OA by perturbing critical events,including cartilage metabolism,inflammatory re-sponses,senescence,and osteoclast differentiation.Clofibrate,a hypolipidemic drug,was identified as a novel RIP3 inhibitor that reverses ECM catabolism in OA.Conclusions:RIP3 is an essential governor of whole joint metabolic homeostasis by regulating both cartilage metabolism and subchondral bone remodeling.Reconstruction of the bone-cartilage unit by targeting RIP3 might provide a two-birds-one-stone approach for the development of future OA therapies.展开更多
Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-domi...Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy.展开更多
To the Editor:Many physical examination tests are used to diagnose femoroacetabular impingement(FAI).The sensitivity and specificity of the flexion,abduction,and external rotation(FABER)test and the flexion,adduction,...To the Editor:Many physical examination tests are used to diagnose femoroacetabular impingement(FAI).The sensitivity and specificity of the flexion,abduction,and external rotation(FABER)test and the flexion,adduction,and internal rotation(FADIR)test for FAI diagnosis are quite different.Therefore,based on clinical practice,we proposed the possibility of adding a physical examination test to improve the accuracy of the traditional physical examinations.展开更多
Fatigue has a tremendously adverse impact on pilot performance.This study aims to explore the Biceps Brachii(BB),Rectus Femoris(RF),Flexor Carpi Radialis(FCR),and Tibialis Anterior(TA)activities of fighter pilots in t...Fatigue has a tremendously adverse impact on pilot performance.This study aims to explore the Biceps Brachii(BB),Rectus Femoris(RF),Flexor Carpi Radialis(FCR),and Tibialis Anterior(TA)activities of fighter pilots in the early and late combat stages,and the target hitting time.A total of 13 volunteers were recruited to conduct simulated combats inside a real fighter cockpit.The surface Electromyography(sEMG)was collected from all volunteers in the initial and final 20s of flight,and the target hitting time during three simulated combats was recorded.The root mean square(RMS)values of right BB and TA were significantly higher than the left side values(p<0.001),while insignificant differences were found in the RMS values between the bilateral RF and FCR.Compared to the early flight period,the median frequency(MF)values of BB and TA were significantly lower during the late flight period,and the RMS values were significantly higher(p<0.047).Contrastively,the RMS values of FCR and RF differed insignificantly during the late flight period.Regarding the target hitting time,a significant difference was noted between task 1 and rask3.Subjects exhibit varying levels of muscle fatigue for different muscle groups before and after the flight.The muscle fatigue levels are asymmetrical on the left and right sides.Muscle fatigue might reduce the pilots'operational ability.This study provides a reference for fighter pilot fatigue protection and treatment.展开更多
Background:Visual inputs are critical for locomotor navigation and sensorimotor integration in the elderly;however,the mechanism needs to be explored intensively.The present study assessed the gait pattern after catar...Background:Visual inputs are critical for locomotor navigation and sensorimotor integration in the elderly;however,the mechanism needs to be explored intensively.The present study assessed the gait pattern after cataract surgery to investigate the effects of visual restoration on locomotion.Methods:The prospective study recruited 32 patients(70.1±5.2 years)with bilateral age-related cataracts in the Department of Ophthalmology at Peking University Third Hospital from October 2016 to December 2019.The temporal-spatial gait parameters and kinematic parameters were measured by the Footscan system and inertial measurement units.Paired t-test was employed to compare data normally distributed and Wilcoxon rank-sum test for non-normally distributed.Results:After visual restoration,the walking speed increased by 9.3%(1.19±0.40 m/s vs.1.09±0.34 m/s,P=0.008)and exhibited an efficient gait pattern with significant decrease in gait cycle(1.02±0.08 s vs.1.04±0.07 s,P=0.012),stance time(0.66±0.06 s vs.0.68±0.06 s,P=0.045),and single support time(0.36±0.03 s vs.0.37±0.02 s,P=0.011).High amplitude of joint motion was detected in the sagittal plane in the left hip(37.6°±5.3°vs.35.5°±6.2°,P=0.014),left thigh(38.0°±5.2°vs.36.4°±5.8°,P=0.026),left shank(71.9°±5.7°vs.70.1°±5.6°,P=0.031),and right knee(59.1°±4.8°vs.56.4°±4.8°,P=0.001).The motor symmetry of thigh improved from 8.35±5.30%to 6.30±4.73%(P=0.042).Conclusions:The accelerated gait in response to visual restoration is characterized by decreased stance time and increased range of joint motion.Training programs for improving muscle strength of lower extremities might be helpful to facilitate the adaptation to these changes in gait.展开更多
基金supported by grants from the Beijing Natural Science Foundation,China(No.7244431)the Postdoctoral Science Foundation of China(No.2022M710260)the National Natural Science Foundation of China(No.82202723).
文摘Meniscal injury,a prevalent and challenging medical condition,is characterized by poor self-healing potential and a complex microenvironment.Tissue engineering scaffolds,particularly those made of silk fibroin(SF)/hyaluronic acid methacryloyl(HAMA)and encapsulating Mg^(2+),are promising options for meniscal repair.However,the inflammatory response following implantation is a significant concern.In this study,we prepared a composite SF/HAMA-Mg hydrogel scaffold,evaluated its physical and chemical properties,and detected its fibrochondrogenic differentiation effect in vitro and the healing effect in a rabbit meniscus defect model in vivo.Our results showed that the scaffold differentiates pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages after implantation,thereby reducing inflammation and facilitating the growth and repair of meniscus tissue.Further,the composite scaffold provided a conducive milieu for cell proliferation,anticipatory differentiation,and generation of extracellular matrix.In summary,composite SF/HAMA-Mg scaffolds exhibit exceptional biocompatibility and anti-inflammatory properties,demonstrating superior potential for meniscal repair.
文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.
基金supported by the National Natural Science Foundation of China(no.82172420)China Postdoctoral Science Foundation(2022M710260)Peking University Medicine Sailing Program for Young Scholars’Scientific&Technological Innovation(BMU2023YFJHMX008 and BMU2023YFJHPY023).
文摘The effective and translational strategy to regenerate knee meniscal fibrocartilage remained challenging.Herein,we first identified vascular smooth muscle cells(VSMCs)transdifferentiated into fibrochondrocytes and participated in spontaneous meniscal regeneration using smooth muscle cell lineage tracing transgenic mice meniscal defect model.Then,we identified low-intensity pulsed ultrasound(LIPUS)acoustic stimulus enhanced fibrochondrogenic transdifferentiation of VSMCs in vitro and in vivo.Mechanistically,LIPUS stimulus could up-regulate mechanosensitive ion channel Piezo1 expression and then activate the transforming growth factorβ1(TGFβ1)signal,following repression of the Notch signal,consequently enhancing fibrochondrogenic transdifferentiation of VSMCs.Finally,we demonstrated that the regular LIPUS stimulus enhanced anisotropic native-like meniscal fibrocartilage tissue regeneration in a beagle canine subtotal meniscectomy model at 6 months postoperatively.The single-cell RNA sequencing analysis confirmed the role of VSMC fibrochondrogenic transdifferentiation in meniscal regeneration.
基金supported by a grant from the National Natural Science Foundation of China(No.81600760).
文摘Background:Visual input significantly influences cerebral activity related to locomotor navigation,although the underlying mechanism remains unclear.This study aimed to analyze the effects of chronic visual impairment and its rehabilitation on sensorimotor integration during level walking in patients with age-related cataract.Methods:This prospective case series enrolled 14 female patients(68.4±4.7 years)with age-related cataract,scheduled for consecutive cataract surgeries at the Department of Ophthalmology in Peking University Third Hospital from June 2019 to June 2020.Electroencephalogram(EEG)signals during level walking were recorded using a portable EEG system before and 4 weeks after visual restoration.Walking speed was assessed using the Footscan system.Spectral power of the theta and alpha bands was analyzed with repeated-measures analysis of variance,with Assignment(rest and walking),Phase(preoperative and postoperative),and Electrode sites(F3,Fz,F4,O1,and O2)as within-subject factors.Results:Compared to the visual impairment state,theta band power significantly decreased after visual restoration(13.16±1.58μV^(2) vs.23.65±3.48μV^(2),P=0.018).Theta activity was notably reduced during walking(17.24±2.43μV^(2) vs.37.86±6.62μV^(2),P=0.017),while theta power at rest was not significantly different between the two phases(9.44±1.24μV^(2) vs.9.08±1.74µV^(2),P=0.864).Changes in walking speed were correlated with alterations in theta power at electrode sites of O1(r=-0.574,P=0.032)and O2(r=-0.648,P=0.012).Alpha band power remained stable during walking and was unaffected by visual status.Conclusions:Chronic visual impairment from age-related cataract triggers enhanced cerebral activation of sensorimotor integration to compensate for visual decline during locomotion.This cerebral over-activation is effectively alleviated by visual restoration.
文摘In 1955,Professor Mianyu Qu,the founder of Chinese sports medicine,and the older generation of sports medicine practitioners,founded China’s sports medicine in response to the needs of the development of national sports and health.In therst 30 years of the establishment of sports medicine,they played an important role in the academic development,talent cultivation,international communication,construction of the society and organization,national Olympic glory,and nationaltness.Their contributions established a solid foundation for the rapid development of China’s sports medicine in the following 30 years.
基金supported by the National Natural Science Foundation of China(32000923,82072486,and 81972101)Beijing Municipal Natural Science Foundation(7214304)Peking University Third Hospital Clinical Key Project Talent Program(BYSYZD2021039).
文摘Background:Osteoarthritis(OA)is a debilitating joint disorder characterized by pro-gressive cartilage degeneration.During OA,subchondral bone undergoes micro-structural and molecular changes that precede cartilage degradation.However,spe-cific mechanisms underlying metabolic dysregulation of the bone-cartilage unit remain unclear.This study aims to investigate the role of receptor-interacting protein kinase-3(RIP3)in OA progression,focusing on bone-cartilage metabolic homeostasis.Methods:RIP3-mediated pathological and metabolic alterations in chondrocytes,os-teoblasts,and bone marrow-derived macrophages(BMMs)were evaluated.RIP3-mediated OA manifestations in cartilage and,more importantly,subchondral bone were determined by intra-articular overexpression of RIP3 in rats.The protective effect of RIP3 deficiency on the bone-cartilage unit during OA was systematically investigated using Rip3 knockout mice.The CMap database was used to screen for compounds that abrogate RIP3-induced OA pathological changes.Results:RIP3 was upregulated in the cartilage and subchondral bone of OA patients and post-traumatic OA mouse model.RIP3 overexpression not only inhibited extra-cellular matrix(ECM)anabolism in chondrocytes but also attenuated osteoblast differentiation,whereas RIP3 deficiency blunted receptor activator of NF-kappaB ligand-mediated osteoclastogenesis of BMMs.Intra-articular RIP3 overexpression induced the imbalance of SP7+osteoblasts/tartrate-resistant acid phosphatase(TRAP)+osteoclasts within the subchondral bone in addition to cartilage degen-eration in rats,while Rip3 deletion significantly improved structural outcomes of the bone-cartilage unit,and achieved pain relief as well as functional improvement in surgery-induced and spontaneous OA mouse models.Mechanistically,RIP3 initiates OA by perturbing critical events,including cartilage metabolism,inflammatory re-sponses,senescence,and osteoclast differentiation.Clofibrate,a hypolipidemic drug,was identified as a novel RIP3 inhibitor that reverses ECM catabolism in OA.Conclusions:RIP3 is an essential governor of whole joint metabolic homeostasis by regulating both cartilage metabolism and subchondral bone remodeling.Reconstruction of the bone-cartilage unit by targeting RIP3 might provide a two-birds-one-stone approach for the development of future OA therapies.
基金support from the Natural Science Foundation of Beijing Municipality(No.7171014)National Natural Science Foundation of China(No.81871770,81802101,81802153)+1 种基金National Key Research and Development Program of China(No.2016YFC1101301,2018YFF0301100)Beijing Nova Program Z201100006820011.
文摘Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy.
基金National Natural Science Foundation of China(NFSCNo. 81672182)
文摘To the Editor:Many physical examination tests are used to diagnose femoroacetabular impingement(FAI).The sensitivity and specificity of the flexion,abduction,and external rotation(FABER)test and the flexion,adduction,and internal rotation(FADIR)test for FAI diagnosis are quite different.Therefore,based on clinical practice,we proposed the possibility of adding a physical examination test to improve the accuracy of the traditional physical examinations.
基金the National Military Commission Logistics Department[Grant number:BZZ18J004].
文摘Fatigue has a tremendously adverse impact on pilot performance.This study aims to explore the Biceps Brachii(BB),Rectus Femoris(RF),Flexor Carpi Radialis(FCR),and Tibialis Anterior(TA)activities of fighter pilots in the early and late combat stages,and the target hitting time.A total of 13 volunteers were recruited to conduct simulated combats inside a real fighter cockpit.The surface Electromyography(sEMG)was collected from all volunteers in the initial and final 20s of flight,and the target hitting time during three simulated combats was recorded.The root mean square(RMS)values of right BB and TA were significantly higher than the left side values(p<0.001),while insignificant differences were found in the RMS values between the bilateral RF and FCR.Compared to the early flight period,the median frequency(MF)values of BB and TA were significantly lower during the late flight period,and the RMS values were significantly higher(p<0.047).Contrastively,the RMS values of FCR and RF differed insignificantly during the late flight period.Regarding the target hitting time,a significant difference was noted between task 1 and rask3.Subjects exhibit varying levels of muscle fatigue for different muscle groups before and after the flight.The muscle fatigue levels are asymmetrical on the left and right sides.Muscle fatigue might reduce the pilots'operational ability.This study provides a reference for fighter pilot fatigue protection and treatment.
基金National Natural Science Foundation of China(No.81600760)
文摘Background:Visual inputs are critical for locomotor navigation and sensorimotor integration in the elderly;however,the mechanism needs to be explored intensively.The present study assessed the gait pattern after cataract surgery to investigate the effects of visual restoration on locomotion.Methods:The prospective study recruited 32 patients(70.1±5.2 years)with bilateral age-related cataracts in the Department of Ophthalmology at Peking University Third Hospital from October 2016 to December 2019.The temporal-spatial gait parameters and kinematic parameters were measured by the Footscan system and inertial measurement units.Paired t-test was employed to compare data normally distributed and Wilcoxon rank-sum test for non-normally distributed.Results:After visual restoration,the walking speed increased by 9.3%(1.19±0.40 m/s vs.1.09±0.34 m/s,P=0.008)and exhibited an efficient gait pattern with significant decrease in gait cycle(1.02±0.08 s vs.1.04±0.07 s,P=0.012),stance time(0.66±0.06 s vs.0.68±0.06 s,P=0.045),and single support time(0.36±0.03 s vs.0.37±0.02 s,P=0.011).High amplitude of joint motion was detected in the sagittal plane in the left hip(37.6°±5.3°vs.35.5°±6.2°,P=0.014),left thigh(38.0°±5.2°vs.36.4°±5.8°,P=0.026),left shank(71.9°±5.7°vs.70.1°±5.6°,P=0.031),and right knee(59.1°±4.8°vs.56.4°±4.8°,P=0.001).The motor symmetry of thigh improved from 8.35±5.30%to 6.30±4.73%(P=0.042).Conclusions:The accelerated gait in response to visual restoration is characterized by decreased stance time and increased range of joint motion.Training programs for improving muscle strength of lower extremities might be helpful to facilitate the adaptation to these changes in gait.
