We eomputationally study the possible effects of thermosensitive transient receptor potential （TRP） channels on the spontaneous calcium oscillations in astrocytes at various temperatures. Based on the previous model...We eomputationally study the possible effects of thermosensitive transient receptor potential （TRP） channels on the spontaneous calcium oscillations in astrocytes at various temperatures. Based on the previous model and the result of thermosensitive TRP channels＇ open probabilities, some meaningful conclusions are obtained. It is shown that the occurrence of calcium oscillations depends on temperature and the molar heat capacity difference between the closed and open channels （ACp ）. The data indicate that calcium oscillations in astrocytes occurred in the ranges of 7℃-11 ℃ and 27℃-30℃ when/kgp is 16 kJ· mol- 1·K- 1, and ca/cium oscillations only occur in the range of 27℃-30℃ when Agp is 2kJ·mol-1·K-1. In this study, the frequency decreases rapidly at temperatures ranging from 7℃ to 11℃, and there is a contrary result in the range of 27℃-30℃.展开更多
Considering an elastically coupled Brownian motors system in a two-dimensional traveling-wave potential, we investigate the effects of the angular frequency of the traveling wave, wavelength, coupling strength, free l...Considering an elastically coupled Brownian motors system in a two-dimensional traveling-wave potential, we investigate the effects of the angular frequency of the traveling wave, wavelength, coupling strength, free length of the spring, and the noise intensity on the current of the system. It is found that the traveling wave is the essential condition of the directed transport. The current is dominated by the traveling wave and varies nonmonotonically with both the angular frequency and the wavelength. At an optimal angular frequency or wavelength, the current can be optimized. The coupling strength and the free length of the spring can locally modulate the current, especially at small angular frequencies. Moreover, the current decreases rapidly with the increase of the noise intensity, indicating the interference effect of noise on the directed transport.展开更多
Considering a double-headed Brownian motor moving with both translational and rotational degrees of freedom,we investigate the directed transport properties of the system in a traveling-wave potential.It is found that...Considering a double-headed Brownian motor moving with both translational and rotational degrees of freedom,we investigate the directed transport properties of the system in a traveling-wave potential.It is found that the traveling wave provides the essential condition of the directed transport for the system,and at an appropriate angular frequency,the positive current can be optimized.A general current reversal appears by modulating the angular frequency of the traveling wave,noise intensity,external driving force and the rod length.By transforming the dynamical equation in traveling-wave potential into that in a tilted potential,the mechanism of current reversal is analyzed.For both cases of Gaussian and Lévy noises,the currents show similar dependence on the parameters.Moreover,the current in the tilted potential shows a typical stochastic resonance effect.The external driving force has also a resonance-like effect on the current in the tilted potential.But the current in the traveling-wave potential exhibits the reverse behaviors of that in the tilted potential.Besides,the currents obviously depend on the stability index of the Lévy noise under certain conditions.展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 11175055 and 11547013the Natural Science Foundation of Hebei Province under Grant No A2015202268
文摘We eomputationally study the possible effects of thermosensitive transient receptor potential （TRP） channels on the spontaneous calcium oscillations in astrocytes at various temperatures. Based on the previous model and the result of thermosensitive TRP channels＇ open probabilities, some meaningful conclusions are obtained. It is shown that the occurrence of calcium oscillations depends on temperature and the molar heat capacity difference between the closed and open channels （ACp ）. The data indicate that calcium oscillations in astrocytes occurred in the ranges of 7℃-11 ℃ and 27℃-30℃ when/kgp is 16 kJ· mol- 1·K- 1, and ca/cium oscillations only occur in the range of 27℃-30℃ when Agp is 2kJ·mol-1·K-1. In this study, the frequency decreases rapidly at temperatures ranging from 7℃ to 11℃, and there is a contrary result in the range of 27℃-30℃.
基金Project supported by the National Natural Science Foundation of China(Grant No.11875135)Quanzhou Scientific and Technological Foundation,China(Grant No.2018C085R)+1 种基金the Key Project of Beijing Institute of Graphic Communication,China(Grant No.Ea201702)the International Ability Improvement Project of Teaching Staff of Beijing Institute of Graphic Communication,China(Grant No.12000400001).
文摘Considering an elastically coupled Brownian motors system in a two-dimensional traveling-wave potential, we investigate the effects of the angular frequency of the traveling wave, wavelength, coupling strength, free length of the spring, and the noise intensity on the current of the system. It is found that the traveling wave is the essential condition of the directed transport. The current is dominated by the traveling wave and varies nonmonotonically with both the angular frequency and the wavelength. At an optimal angular frequency or wavelength, the current can be optimized. The coupling strength and the free length of the spring can locally modulate the current, especially at small angular frequencies. Moreover, the current decreases rapidly with the increase of the noise intensity, indicating the interference effect of noise on the directed transport.
基金the Key Project of Beijing Institute of Graphic Communication,Beijing,China(No.Ea201702)the International Ability Improvement Project of Teaching Staff of Beijing Institute of Graphic Communication,Beijing,China(No.12000400001)+2 种基金the National Natural Science Foundation of China(Grant No.11875135)Quanzhou Scientific and Technological Foundation(No.2018C085R)the Innovation Teams in Functional Materials and Structural Mechanics of Hebei University of Architecture(No.TD202011).
文摘Considering a double-headed Brownian motor moving with both translational and rotational degrees of freedom,we investigate the directed transport properties of the system in a traveling-wave potential.It is found that the traveling wave provides the essential condition of the directed transport for the system,and at an appropriate angular frequency,the positive current can be optimized.A general current reversal appears by modulating the angular frequency of the traveling wave,noise intensity,external driving force and the rod length.By transforming the dynamical equation in traveling-wave potential into that in a tilted potential,the mechanism of current reversal is analyzed.For both cases of Gaussian and Lévy noises,the currents show similar dependence on the parameters.Moreover,the current in the tilted potential shows a typical stochastic resonance effect.The external driving force has also a resonance-like effect on the current in the tilted potential.But the current in the traveling-wave potential exhibits the reverse behaviors of that in the tilted potential.Besides,the currents obviously depend on the stability index of the Lévy noise under certain conditions.
