High-precision magnetic field measurements are crucial for understanding Earth’s internal structure,space environment,and dynamic geomagnetic variations.Data from the Fluxgate Magnetometer (FGM) on the Macao Science ...High-precision magnetic field measurements are crucial for understanding Earth’s internal structure,space environment,and dynamic geomagnetic variations.Data from the Fluxgate Magnetometer (FGM) on the Macao Science Satellite-1A (MSS-1A),added to data from other space-based magnetometers,should increase significantly the ability of scientists to observe changes in Earth’s magnetic field over time and space.Additionally,the MSS-1A’s FGM is intended to help identify magnetic disturbances affecting the spacecraft itself.This report focuses on the in-flight calibration of the MSS-1 FGM.A scalar calibration,independent of geomagnetic field models,was performed to correct offsets,sensitivities,and misalignment angles of the FGM.Using seven months of data,we find that the in-flight calibration parameters show good stability.We determined Euler angles describing the rotational relationship between the FGM and the Advanced Stellar Compass (ASC) coordinate system using two approaches:calibration with the CHAOS-7 geomagnetic field model,and simultaneous estimation of Euler angles and Gaussian spherical harmonic coefficients through self-consistent modeling.The accuracy of Euler angles describing the rotation was better than 18 arcsec.The calibrated FGM data exhibit good agreement with the calibrated data of the Vector Field Magnetometer (VFM),which is the primary vector magnetometer of the satellite.These calibration efforts have significantly improved the accuracy of the FGM measurements,which are now providing reliable data for geomagnetic field studies that promise to advance our understanding of the Earth’s magnetic environment.展开更多
Phthalate esters(PAEs),recognized as endocrine disruptors,are released into the environment during usage,thereby exerting adverse ecological effects.This study investigates the occurrence,sources,and risk assessment o...Phthalate esters(PAEs),recognized as endocrine disruptors,are released into the environment during usage,thereby exerting adverse ecological effects.This study investigates the occurrence,sources,and risk assessment of PAEs in surface water obtained from 36 sampling points within the Yellow River and Yangtze River basins.The total concentration of PAEs in the Yellow River spans from124.5 to 836.5 ng/L,with Dimethyl phthalate(DMP)(75.4±102.7 ng/L)and Diisobutyl phthalate(DiBP)(263.4±103.1 ng/L)emerging as the predominant types.Concentrations exhibit a pattern of upstream(512.9±202.1 ng/L)>midstream(344.5±135.3 ng/L)>downstream(177.8±46.7 ng/L).In the Yangtze River,the total concentration ranges from 81.9 to 441.6 ng/L,with DMP(46.1±23.4 ng/L),Diethyl phthalate(DEP)(93.3±45.2 ng/L),and DiBP(174.2±67.6 ng/L)as the primary components.Concentration levels follow a midstream(324.8±107.3 ng/L)>upstream(200.8±51.8 ng/L)>downstream(165.8±71.6 ng/L)pattern.Attention should be directed towards the moderate ecological risks of DiBP in the upstream of HH,and both the upstream and midstream of CJ need consideration for the moderate ecological risks associated with Di-n-octyl phthalate(DNOP).Conversely,in other regions,the associated risk with PAEs is either low or negligible.The main source of PAEs in Yellow River is attributed to the release of construction land,while in the Yangtze River Basin,it stems from the accumulation of pollutants in lakes and forests discharged into the river.These findings are instrumental for pinpointing sources of PAEs pollution and formulating control strategies in the Yellow and Yangtze Rivers,providing valuable insights for global PAEs research in other major rivers.展开更多
The security of the seed industry is crucial for ensuring national food security.Currently,developed countries in Europe and America,along with international seed industry giants,have entered the Breeding 4.0 era.This...The security of the seed industry is crucial for ensuring national food security.Currently,developed countries in Europe and America,along with international seed industry giants,have entered the Breeding 4.0 era.This era integrates biotechnology,artificial intelligence(AI),and big data information technology.In contrast,China is still in a transition period between stages 2.0 and 3.0,which primarily relies on conventional selection and molecular breeding.In the context of increasingly complex international situations,accurately identifying core issues in China's seed industry innovation and seizing the frontier of international seed technology are strategically important.These efforts are essential for ensuring food security and revitalizing the seed industry.This paper systematically analyzes the characteristics of crop breeding data from artificial selection to intelligent design breeding.It explores the applications and development trends of AI and big data in modern crop breeding from several key perspectives.These include highthroughput phenotype acquisition and analysis,multiomics big data database and management system construction,AI-based multiomics integrated analysis,and the development of intelligent breeding software tools based on biological big data and AI technology.Based on an in-depth analysis of the current status and challenges of China's seed industry technology development,we propose strategic goals and key tasks for China's new generation of AI and big data-driven intelligent design breeding.These suggestions aim to accelerate the development of an intelligent-driven crop breeding engineering system that features large-scale gene mining,efficient gene manipulation,engineered variety design,and systematized biobreeding.This study provides a theoretical basis and practical guidance for the development of China's seed industry technology.展开更多
Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ...Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the urgent need to explore new treatment strategies for epilepsy, recent research has highlighted the potential of targeting gliosis, metabolic disturbances, and neural circuit abnormalities as therapeutic strategies. Astrocytes, the largest group of nonneuronal cells in the central nervous system, play several crucial roles in maintaining ionic and energy metabolic homeostasis in neurons, regulating neurotransmitter levels, and modulating synaptic plasticity. This article briefly reviews the critical role of astrocytes in maintaining balance within the central nervous system. Building on previous research, we discuss how astrocyte dysfunction contributes to the onset and progression of epilepsy through four key aspects: the imbalance between excitatory and inhibitory neuronal signaling, dysregulation of metabolic homeostasis in the neuronal microenvironment, neuroinflammation, and the formation of abnormal neural circuits. We summarize relevant basic research conducted over the past 5 years that has focused on modulating astrocytes as a therapeutic approach for epilepsy. We categorize the therapeutic targets proposed by these studies into four areas: restoration of the excitation–inhibition balance, reestablishment of metabolic homeostasis, modulation of immune and inflammatory responses, and reconstruction of abnormal neural circuits. These targets correspond to the pathophysiological mechanisms by which astrocytes contribute to epilepsy. Additionally, we need to consider the potential challenges and limitations of translating these identified therapeutic targets into clinical treatments. These limitations arise from interspecies differences between humans and animal models, as well as the complex comorbidities associated with epilepsy in humans. We also highlight valuable future research directions worth exploring in the treatment of epilepsy and the regulation of astrocytes, such as gene therapy and imaging strategies. The findings presented in this review may help open new therapeutic avenues for patients with drugresistant epilepsy and for those suffering from other central nervous system disorders associated with astrocytic dysfunction.展开更多
Lactate serves as a key energy metabolite in the central nervous system,facilitating essential brain functions,including energy supply,signaling,and epigenetic modulation.Moreover,it links epigenetic modifications wit...Lactate serves as a key energy metabolite in the central nervous system,facilitating essential brain functions,including energy supply,signaling,and epigenetic modulation.Moreover,it links epigenetic modifications with metabolic reprogramming.Nonetheless,the specific mechanisms and roles of this connection in astrocytes remain unclear.Therefore,this review aims to explore the role and specific mechanisms of lactate in the metabolic reprogramming of astrocytes in the central nervous system.The close relationship between epigenetic modifications and metabolic reprogramming was discussed.Therapeutic strategies for targeting metabolic reprogramming in astrocytes in the central nervous system were also outlined to guide future research in central nervous system diseases.In the nervous system,lactate plays an essential role.However,its mechanism of action as a bridge between metabolic reprogramming and epigenetic modifications in the nervous system requires future investigation.The involvement of lactate in epigenetic modifications is currently a hot research topic,especially in lactylation modification,a key determinant in this process.Lactate also indirectly regulates various epigenetic modifications,such as N6-methyladenosine,acetylation,ubiquitination,and phosphorylation modifications,which are closely linked to several neurological disorders.In addition,exploring the clinical applications and potential therapeutic strategies of lactic acid provides new insights for future neurological disease treatments.展开更多
Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various phy...Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various physiological functions)and“Yin”(it represents the material foundation of the human body.It plays a role in nourishing,moistening,and cooling the body).Notoginseng Radix et Rhizoma(NRR)is recognized for its properties of resolving blood stasis(it refers to a pathological condition characterized by impaired or stagnant blood circulation within the body).Changes in the compatibility ratio of these herbs often lead to variations in their chemical composition and efficacy.However,the specific alterations in chemical composition and efficacy resulting from compatibility adjustments remain unclear.We aimed to compare the material basis and their effects of different compatibility ratios of PQR and NRR on“Qi”deficiency and blood stasis syndrome(QBS).Methods:This study employed UPLC-Q/TOF-MS to identify effective compounds in the compatibility of PQR and NRR and utilized UPLC-TQ-MS/MS to analyze the dissolution of 16 saponins in PQR and NRR at 9 different ratios.A rat model of QBS was established,and the efficacy of PQR and NRR in treating this syndrome was assessed using hemorheology and coagulation analyses.Results:The study results show that PQR and NRR exhibit significant efficacy,effectively reducing blood viscosity induced by platelet aggregation and lowering inflammatory markers such as IL-6,IL-10,TXB2 and ET associated with vascular injury.Moreover,this combination regulates ATP and ADP levels,enhances energy metabolism,and promotes overall health.A total of 104 compounds in the compatibility of PQR and NRR were identified.The ratios of 1:2 and 1:3 showed the highest total saponin content,but the ratio of 1:1 demonstrated a superior pharmacological effect for the treatment of QBS.Conclusion:In summary,the compatibility of PQR and NRR not only shows the complex interactions between traditional Chinese medicinal materials,but also provides a new idea and method for the treatment of QBS.展开更多
Stomata are tiny pores on the plant leaf surface that regulate the exchange of water and gases between the plant and the external environment.They are crucial for photosynthesis,water use efficiency(WUE),and the plant...Stomata are tiny pores on the plant leaf surface that regulate the exchange of water and gases between the plant and the external environment.They are crucial for photosynthesis,water use efficiency(WUE),and the plant’s ability to adapt to environmental changes.Stomatal movement is vital for understanding how plants adapt to environmental stress and optimize resource utilization.Changes in environmental conditions,especially the quality and intensity of light throughout the day,affect stomatal dynamics and diurnal behavior,which in turn impact photosynthetic efficiency and water-use efficiency.In this review,we summarize the biophysical principles and mechanisms of stomatal movement regulated by ion transport at the plasma membrane,vacuolar membrane and metabolic activity through persulfidation or S-nitrosylation modifications.Specifically,we focus on recent progress in the regulation of stomatal movement by different light qualities,and summarize the photochemical and biochemical events underlying photoreceptors as well as the knowledge of novel regulatory functions and signaling in the multilayer control of stomatal movement and environmental adaptation.Furthermore,as rising global temperatures and increased water needs of farming methods are expected to escalate future crop losses,we explore the potential of smart LED lighting and gene editing technology in enhancing photosynthetic efficiency and water-use efficiency,leading to increased crop biomass and higher crop yields.展开更多
This paper introduces a new method based on deep belief networks(DBNs)to integrate intrinsic vibration information and assess the similarity of subspaces established on the Grassmann manifold for intelligent fault dia...This paper introduces a new method based on deep belief networks(DBNs)to integrate intrinsic vibration information and assess the similarity of subspaces established on the Grassmann manifold for intelligent fault diagnosis of a reciprocating compressor(RC).Initially,raw vibration signals undergo empirical mode decomposition to break them down into multiple intrinsic mode functions(IMFs).This operation can reveal inherent vibration patterns of fault and other components hidden in the original signals.Subsequently,features are refined from all the IMFs and concatenated into a high-dimensional representative vector,offering localized and comprehensive insights into RC operation.Through DBN,the fault-sensitive information is further refined from the features to enhance their performance in fault identification.Finally,similarities among subspaces on the Grassmann manifold are computed to match fault types.The efficacy of the method is validated usingfield data.Comparative analysis with traditional approaches for feature dimension reduction,feature extraction,and Euclidean distance-based fault identification underscores the effectiveness and superiority of the proposed method in RC fault diagnosis.展开更多
Effective vegetation reconstruction plays a vital role in the restoration of desert ecosystems.However,in reconstruction of different vegetation types,the community characteristics,assembly processes,and functions of ...Effective vegetation reconstruction plays a vital role in the restoration of desert ecosystems.However,in reconstruction of different vegetation types,the community characteristics,assembly processes,and functions of different soil microbial taxa under environmental changes are still disputed,which limits the understanding of the sustainability of desert restoration.Hence,we investigated the soil microbial community characteristics and functional attributes of grassland desert(GD),desert steppe(DS),typical steppe(TS),and artificial forest(AF)in the Mu Us Desert,China.Our findings confirmed the geographical conservation of soil microbial composition but highlighted decreased microbial diversity in TS.Meanwhile,the abundance of rare taxa and microbial community stability in TS improved.Heterogeneous and homogeneous selection determined the assembly of rare and abundant bacterial taxa,respectively,with both being significantly influenced by soil moisture.In contrast,fungal communities displayed stochastic processes and exhibited sensitivity to soil nutrient conditions.Furthermore,our investigation revealed a noteworthy augmentation in bacterial metabolic functionality in TS,aligning with improved vegetation restoration and the assemblage of abundant bacterial taxa.However,within nutrient-limited soils(GD,DS,and AF),the assembly dynamics of rare fungal taxa assumed a prominent role in augmenting their metabolic capacity and adaptability to desert ecosystems.These results highlighted the variations in the assembly processes and metabolic functions of soil microorganisms during vegetation reestablishment and provided corresponding theoretical support for anthropogenic revegetation of desert ecosystems.展开更多
This review explored the application and effectiveness of and research gaps in integrative psychological support in patients undergoing cardiac surgery during the perioperative period.These patients often encounter ps...This review explored the application and effectiveness of and research gaps in integrative psychological support in patients undergoing cardiac surgery during the perioperative period.These patients often encounter psychological issues such as anxiety and depression,which affect their postoperative recovery and quality of life.Previous research indicated that preoperative psychological assessments and interventions significantly enhance patients’psychological states and posto-perative outcomes.Interventions,including preoperative education,mindfulness-based stress reduction,and cognitive training,have proven effective in reducing the incidence of postoperative delirium and anxiety.Intraoperative environment optimization(e.g.,music therapy)and postoperative psychological support(e.g.,family visits and psychological interventions in intensive care unit psychological interventions)positively influence patient recovery.Furthermore,theory-based nursing interventions and digital health tools(e.g.,remote monitoring applica-tions)offer new directions for psychological support.However,challenges,inclu-ding fragmented psychological support,insufficient cross-stage integration,and inadequate training,remain in current nursing practices.Future research should focus on developing standardized psychological support pathways,enhancing multidisciplinary collaboration,and verifying the long-term effects of digital the-rapeutics.展开更多
This study investigated the effect of konjac glucomannan(KGM)on the flotation separation of calcite and scheelite.Micro-flotation tests showed that under the action of 50 mg/L KGM,the floatability of calcite notably d...This study investigated the effect of konjac glucomannan(KGM)on the flotation separation of calcite and scheelite.Micro-flotation tests showed that under the action of 50 mg/L KGM,the floatability of calcite notably decreased,while the impact on scheelite was negligible,resulting in a recovery difference of 82.53%.Fourier transform infrared(FTIR)spectroscopy and atomic force micro-scopy(AFM)analyses indicated the selective adsorption of KGM on the calcite surface.Test results of the zeta potential and UV-visible absorption spectroscopy revealed that KGM prevented the adsorption of sodium oleate on the calcite surface.X-ray photoelectron spec-troscopy(XPS)analysis further confirmed the chemical adsorption of KGM on the calcite surface and the formation of Ca(OH)_(2).The density functional theory(DFT)simulation results were consistent with the flotation tests,demonstrating the strong adsorption perform-ance of KGM on the calcite surface.This study offers a pathway for highly sustainable and cost-effective mineral processing by utilizing the unique properties of biopolymers such as KGM to separate valuable minerals from gangue minerals.展开更多
文摘High-precision magnetic field measurements are crucial for understanding Earth’s internal structure,space environment,and dynamic geomagnetic variations.Data from the Fluxgate Magnetometer (FGM) on the Macao Science Satellite-1A (MSS-1A),added to data from other space-based magnetometers,should increase significantly the ability of scientists to observe changes in Earth’s magnetic field over time and space.Additionally,the MSS-1A’s FGM is intended to help identify magnetic disturbances affecting the spacecraft itself.This report focuses on the in-flight calibration of the MSS-1 FGM.A scalar calibration,independent of geomagnetic field models,was performed to correct offsets,sensitivities,and misalignment angles of the FGM.Using seven months of data,we find that the in-flight calibration parameters show good stability.We determined Euler angles describing the rotational relationship between the FGM and the Advanced Stellar Compass (ASC) coordinate system using two approaches:calibration with the CHAOS-7 geomagnetic field model,and simultaneous estimation of Euler angles and Gaussian spherical harmonic coefficients through self-consistent modeling.The accuracy of Euler angles describing the rotation was better than 18 arcsec.The calibrated FGM data exhibit good agreement with the calibrated data of the Vector Field Magnetometer (VFM),which is the primary vector magnetometer of the satellite.These calibration efforts have significantly improved the accuracy of the FGM measurements,which are now providing reliable data for geomagnetic field studies that promise to advance our understanding of the Earth’s magnetic environment.
基金supported by the Ministry of Science and Technology of China(Nos.2021YFC3200904 and 2022YFC3203705)the National Natural Science Foundation of China(Nos.52270012 and 52070184).
文摘Phthalate esters(PAEs),recognized as endocrine disruptors,are released into the environment during usage,thereby exerting adverse ecological effects.This study investigates the occurrence,sources,and risk assessment of PAEs in surface water obtained from 36 sampling points within the Yellow River and Yangtze River basins.The total concentration of PAEs in the Yellow River spans from124.5 to 836.5 ng/L,with Dimethyl phthalate(DMP)(75.4±102.7 ng/L)and Diisobutyl phthalate(DiBP)(263.4±103.1 ng/L)emerging as the predominant types.Concentrations exhibit a pattern of upstream(512.9±202.1 ng/L)>midstream(344.5±135.3 ng/L)>downstream(177.8±46.7 ng/L).In the Yangtze River,the total concentration ranges from 81.9 to 441.6 ng/L,with DMP(46.1±23.4 ng/L),Diethyl phthalate(DEP)(93.3±45.2 ng/L),and DiBP(174.2±67.6 ng/L)as the primary components.Concentration levels follow a midstream(324.8±107.3 ng/L)>upstream(200.8±51.8 ng/L)>downstream(165.8±71.6 ng/L)pattern.Attention should be directed towards the moderate ecological risks of DiBP in the upstream of HH,and both the upstream and midstream of CJ need consideration for the moderate ecological risks associated with Di-n-octyl phthalate(DNOP).Conversely,in other regions,the associated risk with PAEs is either low or negligible.The main source of PAEs in Yellow River is attributed to the release of construction land,while in the Yangtze River Basin,it stems from the accumulation of pollutants in lakes and forests discharged into the river.These findings are instrumental for pinpointing sources of PAEs pollution and formulating control strategies in the Yellow and Yangtze Rivers,providing valuable insights for global PAEs research in other major rivers.
基金partially supported by the Construction of Collaborative Innovation Center of Beijing Academy of Agricultural and Forestry Sciences(KJCX20240406)the Beijing Natural Science Foundation(JQ24037)+1 种基金the National Natural Science Foundation of China(32330075)the Earmarked Fund for China Agriculture Research System(CARS-02 and CARS-54)。
文摘The security of the seed industry is crucial for ensuring national food security.Currently,developed countries in Europe and America,along with international seed industry giants,have entered the Breeding 4.0 era.This era integrates biotechnology,artificial intelligence(AI),and big data information technology.In contrast,China is still in a transition period between stages 2.0 and 3.0,which primarily relies on conventional selection and molecular breeding.In the context of increasingly complex international situations,accurately identifying core issues in China's seed industry innovation and seizing the frontier of international seed technology are strategically important.These efforts are essential for ensuring food security and revitalizing the seed industry.This paper systematically analyzes the characteristics of crop breeding data from artificial selection to intelligent design breeding.It explores the applications and development trends of AI and big data in modern crop breeding from several key perspectives.These include highthroughput phenotype acquisition and analysis,multiomics big data database and management system construction,AI-based multiomics integrated analysis,and the development of intelligent breeding software tools based on biological big data and AI technology.Based on an in-depth analysis of the current status and challenges of China's seed industry technology development,we propose strategic goals and key tasks for China's new generation of AI and big data-driven intelligent design breeding.These suggestions aim to accelerate the development of an intelligent-driven crop breeding engineering system that features large-scale gene mining,efficient gene manipulation,engineered variety design,and systematized biobreeding.This study provides a theoretical basis and practical guidance for the development of China's seed industry technology.
基金supported by the National Key Research and Development Program of China,No. 2023YFF0714200 (to CW)the National Natural Science Foundation of China,Nos. 82472038 and 82202224 (both to CW)+3 种基金the Shanghai Rising-Star Program,No. 23QA1407700 (to CW)the Construction Project of Shanghai Key Laboratory of Molecular Imaging,No. 18DZ2260400 (to CW)the National Science Foundation for Distinguished Young Scholars,No. 82025019 (to CL)the Greater Bay Area Institute of Precision Medicine (Guangzhou)(to CW)。
文摘Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the urgent need to explore new treatment strategies for epilepsy, recent research has highlighted the potential of targeting gliosis, metabolic disturbances, and neural circuit abnormalities as therapeutic strategies. Astrocytes, the largest group of nonneuronal cells in the central nervous system, play several crucial roles in maintaining ionic and energy metabolic homeostasis in neurons, regulating neurotransmitter levels, and modulating synaptic plasticity. This article briefly reviews the critical role of astrocytes in maintaining balance within the central nervous system. Building on previous research, we discuss how astrocyte dysfunction contributes to the onset and progression of epilepsy through four key aspects: the imbalance between excitatory and inhibitory neuronal signaling, dysregulation of metabolic homeostasis in the neuronal microenvironment, neuroinflammation, and the formation of abnormal neural circuits. We summarize relevant basic research conducted over the past 5 years that has focused on modulating astrocytes as a therapeutic approach for epilepsy. We categorize the therapeutic targets proposed by these studies into four areas: restoration of the excitation–inhibition balance, reestablishment of metabolic homeostasis, modulation of immune and inflammatory responses, and reconstruction of abnormal neural circuits. These targets correspond to the pathophysiological mechanisms by which astrocytes contribute to epilepsy. Additionally, we need to consider the potential challenges and limitations of translating these identified therapeutic targets into clinical treatments. These limitations arise from interspecies differences between humans and animal models, as well as the complex comorbidities associated with epilepsy in humans. We also highlight valuable future research directions worth exploring in the treatment of epilepsy and the regulation of astrocytes, such as gene therapy and imaging strategies. The findings presented in this review may help open new therapeutic avenues for patients with drugresistant epilepsy and for those suffering from other central nervous system disorders associated with astrocytic dysfunction.
基金supported by the National Natural Science Foundation of China,Nos.82071383,82371392(to BN)the Natural Science Foundation of Shandong Province of China(Key Project),No.ZR2020KH007(to BN)+1 种基金“Taishan Scholar Distinguished Expert Program”of Shandong Province,No.tstp20231257(to BN)Health Commission Science and Technology Plan Project of Jinan,No.2023-1-8(to YZ).
文摘Lactate serves as a key energy metabolite in the central nervous system,facilitating essential brain functions,including energy supply,signaling,and epigenetic modulation.Moreover,it links epigenetic modifications with metabolic reprogramming.Nonetheless,the specific mechanisms and roles of this connection in astrocytes remain unclear.Therefore,this review aims to explore the role and specific mechanisms of lactate in the metabolic reprogramming of astrocytes in the central nervous system.The close relationship between epigenetic modifications and metabolic reprogramming was discussed.Therapeutic strategies for targeting metabolic reprogramming in astrocytes in the central nervous system were also outlined to guide future research in central nervous system diseases.In the nervous system,lactate plays an essential role.However,its mechanism of action as a bridge between metabolic reprogramming and epigenetic modifications in the nervous system requires future investigation.The involvement of lactate in epigenetic modifications is currently a hot research topic,especially in lactylation modification,a key determinant in this process.Lactate also indirectly regulates various epigenetic modifications,such as N6-methyladenosine,acetylation,ubiquitination,and phosphorylation modifications,which are closely linked to several neurological disorders.In addition,exploring the clinical applications and potential therapeutic strategies of lactic acid provides new insights for future neurological disease treatments.
基金funded by the Entrusted service project of Shaanxi Administration of Traditional Chinese Medicine(ZYJXG-L23001)2023 Sanqin Talent Special Support Program Innovation and Entrepreneurship Team Project,and Sci-Tech Innovation Talent System Construction Program of Shaanxi University of Chinese Medicine(2023).
文摘Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various physiological functions)and“Yin”(it represents the material foundation of the human body.It plays a role in nourishing,moistening,and cooling the body).Notoginseng Radix et Rhizoma(NRR)is recognized for its properties of resolving blood stasis(it refers to a pathological condition characterized by impaired or stagnant blood circulation within the body).Changes in the compatibility ratio of these herbs often lead to variations in their chemical composition and efficacy.However,the specific alterations in chemical composition and efficacy resulting from compatibility adjustments remain unclear.We aimed to compare the material basis and their effects of different compatibility ratios of PQR and NRR on“Qi”deficiency and blood stasis syndrome(QBS).Methods:This study employed UPLC-Q/TOF-MS to identify effective compounds in the compatibility of PQR and NRR and utilized UPLC-TQ-MS/MS to analyze the dissolution of 16 saponins in PQR and NRR at 9 different ratios.A rat model of QBS was established,and the efficacy of PQR and NRR in treating this syndrome was assessed using hemorheology and coagulation analyses.Results:The study results show that PQR and NRR exhibit significant efficacy,effectively reducing blood viscosity induced by platelet aggregation and lowering inflammatory markers such as IL-6,IL-10,TXB2 and ET associated with vascular injury.Moreover,this combination regulates ATP and ADP levels,enhances energy metabolism,and promotes overall health.A total of 104 compounds in the compatibility of PQR and NRR were identified.The ratios of 1:2 and 1:3 showed the highest total saponin content,but the ratio of 1:1 demonstrated a superior pharmacological effect for the treatment of QBS.Conclusion:In summary,the compatibility of PQR and NRR not only shows the complex interactions between traditional Chinese medicinal materials,but also provides a new idea and method for the treatment of QBS.
基金funded by the National Natural Science Foundation of China(Grant Nos.32272698,32441072,32122081)National Key Research and Development Program of China(Grant No.2023YFF1002000)+4 种基金Liaoning Province Youth Science Foundation A-Class Project(formerly Liaoning Natural Science Foundation Outstanding Youth Project,Grant No.2025-JQ-05)Liaoning Province’s Future Industry Frontier Technology Project(Grant Nos.2025JH2/101330184 and 2025JH2/101330185)National Postdoctoral Program for Innovative Talents(Grant No.BX20250016)Open Project Program of State Key Laboratory of Crop Stress Biology for Arid Areas of China(Grant No.SKLCSRHPKF2025017)HAAFS Science and Technology Innovation Special Project(Grant No.2023KJCXZX-JZS-10).
文摘Stomata are tiny pores on the plant leaf surface that regulate the exchange of water and gases between the plant and the external environment.They are crucial for photosynthesis,water use efficiency(WUE),and the plant’s ability to adapt to environmental changes.Stomatal movement is vital for understanding how plants adapt to environmental stress and optimize resource utilization.Changes in environmental conditions,especially the quality and intensity of light throughout the day,affect stomatal dynamics and diurnal behavior,which in turn impact photosynthetic efficiency and water-use efficiency.In this review,we summarize the biophysical principles and mechanisms of stomatal movement regulated by ion transport at the plasma membrane,vacuolar membrane and metabolic activity through persulfidation or S-nitrosylation modifications.Specifically,we focus on recent progress in the regulation of stomatal movement by different light qualities,and summarize the photochemical and biochemical events underlying photoreceptors as well as the knowledge of novel regulatory functions and signaling in the multilayer control of stomatal movement and environmental adaptation.Furthermore,as rising global temperatures and increased water needs of farming methods are expected to escalate future crop losses,we explore the potential of smart LED lighting and gene editing technology in enhancing photosynthetic efficiency and water-use efficiency,leading to increased crop biomass and higher crop yields.
文摘This paper introduces a new method based on deep belief networks(DBNs)to integrate intrinsic vibration information and assess the similarity of subspaces established on the Grassmann manifold for intelligent fault diagnosis of a reciprocating compressor(RC).Initially,raw vibration signals undergo empirical mode decomposition to break them down into multiple intrinsic mode functions(IMFs).This operation can reveal inherent vibration patterns of fault and other components hidden in the original signals.Subsequently,features are refined from all the IMFs and concatenated into a high-dimensional representative vector,offering localized and comprehensive insights into RC operation.Through DBN,the fault-sensitive information is further refined from the features to enhance their performance in fault identification.Finally,similarities among subspaces on the Grassmann manifold are computed to match fault types.The efficacy of the method is validated usingfield data.Comparative analysis with traditional approaches for feature dimension reduction,feature extraction,and Euclidean distance-based fault identification underscores the effectiveness and superiority of the proposed method in RC fault diagnosis.
基金supported by the National Natural Science Foundation of China(No.42007428)the National Forage Industry Technology System Program of China(No.CARS34)+1 种基金the Key Research and Development Program of Shaanxi,China(No.2022SF-285)Shaanxi Province Forestry Science and Technology Innovation Program,China(No.SXLK2022-02-14)。
文摘Effective vegetation reconstruction plays a vital role in the restoration of desert ecosystems.However,in reconstruction of different vegetation types,the community characteristics,assembly processes,and functions of different soil microbial taxa under environmental changes are still disputed,which limits the understanding of the sustainability of desert restoration.Hence,we investigated the soil microbial community characteristics and functional attributes of grassland desert(GD),desert steppe(DS),typical steppe(TS),and artificial forest(AF)in the Mu Us Desert,China.Our findings confirmed the geographical conservation of soil microbial composition but highlighted decreased microbial diversity in TS.Meanwhile,the abundance of rare taxa and microbial community stability in TS improved.Heterogeneous and homogeneous selection determined the assembly of rare and abundant bacterial taxa,respectively,with both being significantly influenced by soil moisture.In contrast,fungal communities displayed stochastic processes and exhibited sensitivity to soil nutrient conditions.Furthermore,our investigation revealed a noteworthy augmentation in bacterial metabolic functionality in TS,aligning with improved vegetation restoration and the assemblage of abundant bacterial taxa.However,within nutrient-limited soils(GD,DS,and AF),the assembly dynamics of rare fungal taxa assumed a prominent role in augmenting their metabolic capacity and adaptability to desert ecosystems.These results highlighted the variations in the assembly processes and metabolic functions of soil microorganisms during vegetation reestablishment and provided corresponding theoretical support for anthropogenic revegetation of desert ecosystems.
文摘This review explored the application and effectiveness of and research gaps in integrative psychological support in patients undergoing cardiac surgery during the perioperative period.These patients often encounter psychological issues such as anxiety and depression,which affect their postoperative recovery and quality of life.Previous research indicated that preoperative psychological assessments and interventions significantly enhance patients’psychological states and posto-perative outcomes.Interventions,including preoperative education,mindfulness-based stress reduction,and cognitive training,have proven effective in reducing the incidence of postoperative delirium and anxiety.Intraoperative environment optimization(e.g.,music therapy)and postoperative psychological support(e.g.,family visits and psychological interventions in intensive care unit psychological interventions)positively influence patient recovery.Furthermore,theory-based nursing interventions and digital health tools(e.g.,remote monitoring applica-tions)offer new directions for psychological support.However,challenges,inclu-ding fragmented psychological support,insufficient cross-stage integration,and inadequate training,remain in current nursing practices.Future research should focus on developing standardized psychological support pathways,enhancing multidisciplinary collaboration,and verifying the long-term effects of digital the-rapeutics.
基金supported by the National Natural Science Foundation of China(No.52164022).
文摘This study investigated the effect of konjac glucomannan(KGM)on the flotation separation of calcite and scheelite.Micro-flotation tests showed that under the action of 50 mg/L KGM,the floatability of calcite notably decreased,while the impact on scheelite was negligible,resulting in a recovery difference of 82.53%.Fourier transform infrared(FTIR)spectroscopy and atomic force micro-scopy(AFM)analyses indicated the selective adsorption of KGM on the calcite surface.Test results of the zeta potential and UV-visible absorption spectroscopy revealed that KGM prevented the adsorption of sodium oleate on the calcite surface.X-ray photoelectron spec-troscopy(XPS)analysis further confirmed the chemical adsorption of KGM on the calcite surface and the formation of Ca(OH)_(2).The density functional theory(DFT)simulation results were consistent with the flotation tests,demonstrating the strong adsorption perform-ance of KGM on the calcite surface.This study offers a pathway for highly sustainable and cost-effective mineral processing by utilizing the unique properties of biopolymers such as KGM to separate valuable minerals from gangue minerals.
