The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restrain...The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restraint device through existing detection methods in actual inspections,making it difficult to obtain the impact of changes in the performance of the restraint device on the bridge structure.In this paper,a random vehicle load model is firstly established based on the WIM data of Jiangyin Bridge,and the displacement of girder end under the actual traffic flow is simulated by using finite element dynamic time history analysis.On this basis,according to the performance test data of the bearings and dampers,the performance degradation laws of the above two restraint devices are summarized,and the performance degradation process of the two restraint devices and the effects of different restraint parameters on the bridge structure are simulated.The results show that the performance degradation of the damper will significantly reduce the damping force at low speed,resulting in a significant increase in the cumulative displacement of the girder end;in the presence of longitudinal dampers,the increase in the friction coefficient caused by the deterioration of the bearing sliding plate has little effect on the cumulative displacement,but excessive wear of the bearing sliding plate adversely affects the structural dynamic performance.展开更多
肉苁蓉为列当科植物肉苁蓉Cistanche deserticola Y. C. Ma或管花肉苁蓉C. tubulosa (Schenk) R.Wight的干燥带鳞叶的肉质茎,具有补肾阳、益精血、润肠通便等功效,为著名的补益中药。现代药理学研究证实,肉苁蓉具有显著的神经保护作用,...肉苁蓉为列当科植物肉苁蓉Cistanche deserticola Y. C. Ma或管花肉苁蓉C. tubulosa (Schenk) R.Wight的干燥带鳞叶的肉质茎,具有补肾阳、益精血、润肠通便等功效,为著名的补益中药。现代药理学研究证实,肉苁蓉具有显著的神经保护作用,其抗抑郁作用也于近年来得到证实,但其抗抑郁活性物质基础及机制尚未得到充分阐明。我们依据肉苁蓉的传统功效进行了抑郁活性及体内外代谢研究,在此进行研究思路总结,为后期肉苁蓉抗抑郁功效相关药物开发提供数据和参考。展开更多
Objective:To quantitatively analyze global research trends on the gut microbiota and cardiovascular disease(CVD)from 2005–2025,identifying publication output,core themes,influential articles,and emerging research hot...Objective:To quantitatively analyze global research trends on the gut microbiota and cardiovascular disease(CVD)from 2005–2025,identifying publication output,core themes,influential articles,and emerging research hotspots.Methods:We retrieved publications related to gut microbiota and CVD from 2005–2025 using standard bibliographic databases.A bibliometric analysis was conducted to evaluate annual output growth,leading journals,country and institutional contributions,author collaborations,citation networks,and keyword co-occurrence patterns.Descriptive statistics and visualization tools were used to map the developmental trajectory and research hotspots of this field.Results:The analysis included a sharp rise in publications over the past two decades,with especially rapid growth after 2015.Collaborative networks highlighted a few key countries and research centers driving the field.Highly cited papers clustered around themes such as microbiota-derived metabolites such as trimethylamine N-oxide,inflammation,and the“gut-heart axis.”Keyword analysis indicated evolving focus from early descriptive studies to recent mechanistic and clinical translational research.Conclusion:Research linking gut microbiota and CVD has expanded exponentially in 2005–2025,transitioning from correlation studies to mechanistic and therapeutic explorations.The bibliometric trends underscore the gut-heart axis as an emerging interdisciplinary domain in cardiovascular research,with potential to inform novel preventive and therapeutic strategies.展开更多
Oral ulcers(OUs)are among the most common lesions of the oral mucosa,typically associated with pain and burning sensations,and remain clinically challenging due to the scarcity of effective treatment options.Cy_(RL-QN...Oral ulcers(OUs)are among the most common lesions of the oral mucosa,typically associated with pain and burning sensations,and remain clinically challenging due to the scarcity of effective treatment options.Cy_(RL-QN15),a novel ultra-short cyclic heptapeptide recently shown to promote skin repair,diabetic wound healing,and follicle neogenesis,was evaluated for its therapeutic potential in mucosal repair.Using a rat OU model and a primary oral epithelial cell inflammation model,Cy_(RL-QN15)significantly accelerated wound closure through coordinated modulation of immune-epithelial crosstalk,including suppression of inflammatory cytokine release from macrophages and neutrophils,reduction of pro-inflammatory factor secretion by oral epithelial cells,and enhancement of their proliferation and migration.Mechanistic studies employing alanine scanning mutagenesis and microscale thermophoresis revealed that Cy_(RL-QN15)directly interacted with Toll-like receptor 4(TLR4)via a methionine-dependent binding interface(K_(d)=2.64μmol/L),thereby inhibiting downstream MyD88/NF-κB signaling.As the first ultra-short cyclic heptapeptide identified to antagonize TLR4,Cy_(RL-QN15)represents a mechanistically distinct immunomodulatory scaffold that restores mucosal homeostasis and offers a promising therapeutic candidate for TLR4-based OU intervention.展开更多
Schottky contacts have attracted widespread attention from both the electronic device industry and researchers since their discovery.The Schottky characteristics make these contacts highly suitable for use in field-ef...Schottky contacts have attracted widespread attention from both the electronic device industry and researchers since their discovery.The Schottky characteristics make these contacts highly suitable for use in field-effect transistors(FETs),photodetectors(PDs),solar cells(SCs),resistive-switching memories(RSMs),thin-film transistors(TFTs),etc.However,how do Schottky contacts affect the device performance?The answer lies simply in the Schottky parameters.This review focuses on the extraction of Schottky parameters,i.e.,the Schottky barrier height(SBH),ideality factor(IF),and series resistance(SR),from the current-voltage(I−V)curve to understand and analyze the characteristics of Schottky devices.First,the current research progress in this field and the principles of Schottky contacts are presented.Second,this article delves into some classic and widely used extraction methods as well as the latest extraction methods,providing an objective evaluation based on their practical effectiveness.Then,several research applications,including studies that require extraction,simple extraction,and delicate extraction,are enumerated to demonstrate the necessity and importance of Schottky parameter analysis.Finally,an outlook and future research prospects are discussed based on recent progress,and a comprehensive summary is given.展开更多
To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engi...To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engineering case for finite element analysis.This bridge employs an unprecedented tower-girder constraintmethod,with all vertical supports placed at the transition piers at both ends.This paper aims to study the characteristics of longitudinal displacement control at the girder ends under this novel structure,relying on finite element(FE)analysis.Initially,based on the Weigh In Motion(WIM)data,a random vehicle load model is generated and applied to the finite elementmodel.Several longitudinal constraint systems are proposed,and their effects on the structural response of the bridge are compared.The most reasonable system,balancing girder-end displacement and transitional pier stress,is selected.Subsequently,the study examines the impact of different viscous damper parameters on key structural response indicators,including cumulative longitudinal displacement at the girder ends,maximum longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,maximum longitudinal displacement at the pier tops,longitudinal acceleration at the pier tops,and maximum bending moment at the pier bottoms.Finally,the coefficient of variation(CV)-TOPSIS method is used to optimize the viscous damper parameters for multiple objectives.The results show that adding viscous dampers at the side towers,in addition to the existing longitudinal limit bearings at the central tower,can most effectively reduce the response of structural indicators.The changes in these indicators are not entirely consistent with variations in damping coefficient and velocity exponent.The damper parameters significantly influence cumulative longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,and maximum bending moments at the pier bottoms.The optimal damper parameters are found to be a damping coefficient of 5000 kN/(m/s)0.2 and a velocity exponent of 0.2.展开更多
Combining the background of modern construction engineering site safety management,this article analyzes the real-time monitoring and alarm strategies for site construction safety under the integration of BIM and AI.T...Combining the background of modern construction engineering site safety management,this article analyzes the real-time monitoring and alarm strategies for site construction safety under the integration of BIM and AI.This includes the analysis of BIM and AI technologies and their integration advantages,real-time monitoring and alarm strategies for construction site safety based on BIM and AI integration,as well as the development direction of BIM and AI integration in real-time monitoring and alarm for construction site safety.It is hoped that through this analysis,a scientific reference can be provided for the digital and intelligent management of construction site safety,promoting the digital and intelligent development of its safety management work.展开更多
Thorium dioxide(ThO_(2))fibers exhibit exceptional structural stability,low density and superior flexibility,coupled with a remarkably high melting point,positioning them as promising candidates for thermal protection...Thorium dioxide(ThO_(2))fibers exhibit exceptional structural stability,low density and superior flexibility,coupled with a remarkably high melting point,positioning them as promising candidates for thermal protection applications.Additionally,their commendable secondary processing characteristics enable the development of diverse composite materials when integrated with other materials,significantly broadening the potential utilization of ThO_(2)materials and thorium resources in industrial fields.In this work,the ThO_(2)fiber was fabricated by the sol-gel precursor method,and the precursor with good spinnability and excellent stability was synthesized for the first time.The ThO_(2)fiber with a mean diameter of 868 nm is both highly flexible and strong(max.tensile strength 2.21 MPa),capable of bending freely across a wide temperature range from-196℃(in liquid nitrogen)to 1200℃.Meanwhile,it exhibits excellent temperature stability and heat insulation properties.The ThO_(2)nanofiber membranes with layered structure have low density(32-37 mg·cm^(-3)),low thermal conductivity(27.3-30.1 mW·m^(-1)·K^(-1)@25℃).The ThO_(2)nanofiber membranes with 15 mm thickness can reduce the temperature from 1200 to 282℃and maintain a high aspect ratio and bendability after 1200℃@90 min.The results show that the ThO_(2)fiber can be used as a new kind of high-temperature resistant material.展开更多
AIM： To examine the sensitivity and accuracy of real-time polymerase chain reaction （PCR） for the quantification of hepatitis B virus （HBV） DNA in semen. METHODS： Hepatitis B viral DNA was isolated from HBV carr...AIM： To examine the sensitivity and accuracy of real-time polymerase chain reaction （PCR） for the quantification of hepatitis B virus （HBV） DNA in semen. METHODS： Hepatitis B viral DNA was isolated from HBV carriers＇ semen and sera using phenol extraction method and QIAamp DNA blood mini kit （Qiagen, Germany）. HBV DNA was detected by conventional PCR and quantified by TaqMan technology-based real-time PCR （quantitative polymerase chain reaction （qPCR））. The detection threshold was 200 copies of HBV DNA for conventional PCR and 10 copies of HBV DNA for real time PCR per reaction. RESULTS： Both methods of phenol extraction and QIAamp DNA blood mini kit were suitable for isolating HBV DNA from semen. The value of the detection thresholds was 500 copies of HBV DNA per mL in the semen. The viral loads were 7.5×10^7 and 1.67×10^7 copies of HBV DNA per mL in two HBV infected patients＇ sera, while 2.14×10^5 and 3.02×10^5 copies of HBV DNA per mL in the semen. CONCLUSION： Real-time PCR is a more sensitive and accurate method to detect and quantify HBV DNA in the semen.展开更多
The purpose of the present study was to investigate the association between admission clinical characteristics and outcomes at discharge among acute ischemic stroke patients in the Chinese population. A total of 2,673...The purpose of the present study was to investigate the association between admission clinical characteristics and outcomes at discharge among acute ischemic stroke patients in the Chinese population. A total of 2,673 patients with acute ischemic stroke were included in the present study. The clinical characteristics at admission and other study variables were collected for all patients. The study outcome was defined as neurological deficiency （National Institute of Health Stroke Scale score ≥ 10） at discharge or in-hospital death. Compared with the subjects without neurological deficiency at discharge or in-hospital death, the subjects with neurological deficiency at discharge or in-hospital death had a significantly higher prevalence of hyperglycemia or history of atrial fibrillation at admission. Age ≥ 80 years, hyperglycemia, hypertension, and history of atrial fibrillation were significantly associated with neurological deficiency at discharge or in-hospital death after adjustment for other variables. It is concluded that old age （ ≥ 80 years）, hyperglycemia, hypertension and history of atrial fibrillation are significantly associated with neurological deficiency at discharge or in-hospital death among patients with acute ischemic stroke.展开更多
基金supported by the National Key Research and Development Program of China(No.2022YFB3706704)the Academician Special Science Research Project of CCCC(No.YSZX-03-2022-01-B).
文摘The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restraint device through existing detection methods in actual inspections,making it difficult to obtain the impact of changes in the performance of the restraint device on the bridge structure.In this paper,a random vehicle load model is firstly established based on the WIM data of Jiangyin Bridge,and the displacement of girder end under the actual traffic flow is simulated by using finite element dynamic time history analysis.On this basis,according to the performance test data of the bearings and dampers,the performance degradation laws of the above two restraint devices are summarized,and the performance degradation process of the two restraint devices and the effects of different restraint parameters on the bridge structure are simulated.The results show that the performance degradation of the damper will significantly reduce the damping force at low speed,resulting in a significant increase in the cumulative displacement of the girder end;in the presence of longitudinal dampers,the increase in the friction coefficient caused by the deterioration of the bearing sliding plate has little effect on the cumulative displacement,but excessive wear of the bearing sliding plate adversely affects the structural dynamic performance.
文摘肉苁蓉为列当科植物肉苁蓉Cistanche deserticola Y. C. Ma或管花肉苁蓉C. tubulosa (Schenk) R.Wight的干燥带鳞叶的肉质茎,具有补肾阳、益精血、润肠通便等功效,为著名的补益中药。现代药理学研究证实,肉苁蓉具有显著的神经保护作用,其抗抑郁作用也于近年来得到证实,但其抗抑郁活性物质基础及机制尚未得到充分阐明。我们依据肉苁蓉的传统功效进行了抑郁活性及体内外代谢研究,在此进行研究思路总结,为后期肉苁蓉抗抑郁功效相关药物开发提供数据和参考。
基金Medical and Health Research Project of Yichang(Project No.:A23-1-006)。
文摘Objective:To quantitatively analyze global research trends on the gut microbiota and cardiovascular disease(CVD)from 2005–2025,identifying publication output,core themes,influential articles,and emerging research hotspots.Methods:We retrieved publications related to gut microbiota and CVD from 2005–2025 using standard bibliographic databases.A bibliometric analysis was conducted to evaluate annual output growth,leading journals,country and institutional contributions,author collaborations,citation networks,and keyword co-occurrence patterns.Descriptive statistics and visualization tools were used to map the developmental trajectory and research hotspots of this field.Results:The analysis included a sharp rise in publications over the past two decades,with especially rapid growth after 2015.Collaborative networks highlighted a few key countries and research centers driving the field.Highly cited papers clustered around themes such as microbiota-derived metabolites such as trimethylamine N-oxide,inflammation,and the“gut-heart axis.”Keyword analysis indicated evolving focus from early descriptive studies to recent mechanistic and clinical translational research.Conclusion:Research linking gut microbiota and CVD has expanded exponentially in 2005–2025,transitioning from correlation studies to mechanistic and therapeutic explorations.The bibliometric trends underscore the gut-heart axis as an emerging interdisciplinary domain in cardiovascular research,with potential to inform novel preventive and therapeutic strategies.
基金supported by the National Natural Science Foundation of China(32301054,82404582,32360138,32060212)First-Class Discipline Team of Skin&Mucosal Regenerative Medicine of Kunming Medical University(2024XKTDTS10)+2 种基金Key Program of Yunnan Fundamental Research Project(202301AS070036)Open Research Fund of Yunnan Characteristic Plant Extraction Laboratory(YKKF2024003)Project of Yunnan Applied Basic Research Project-Kunming Medical University Union Foundation(202301AY070001-301,202401AY070001-028,202301AY070001-012,202401AY070001-068,202301AY070001-169)。
文摘Oral ulcers(OUs)are among the most common lesions of the oral mucosa,typically associated with pain and burning sensations,and remain clinically challenging due to the scarcity of effective treatment options.Cy_(RL-QN15),a novel ultra-short cyclic heptapeptide recently shown to promote skin repair,diabetic wound healing,and follicle neogenesis,was evaluated for its therapeutic potential in mucosal repair.Using a rat OU model and a primary oral epithelial cell inflammation model,Cy_(RL-QN15)significantly accelerated wound closure through coordinated modulation of immune-epithelial crosstalk,including suppression of inflammatory cytokine release from macrophages and neutrophils,reduction of pro-inflammatory factor secretion by oral epithelial cells,and enhancement of their proliferation and migration.Mechanistic studies employing alanine scanning mutagenesis and microscale thermophoresis revealed that Cy_(RL-QN15)directly interacted with Toll-like receptor 4(TLR4)via a methionine-dependent binding interface(K_(d)=2.64μmol/L),thereby inhibiting downstream MyD88/NF-κB signaling.As the first ultra-short cyclic heptapeptide identified to antagonize TLR4,Cy_(RL-QN15)represents a mechanistically distinct immunomodulatory scaffold that restores mucosal homeostasis and offers a promising therapeutic candidate for TLR4-based OU intervention.
基金financially supported by Guangxi Science and Technology Plan Project(Nos.AD21220150,2023GXNSFBA026216,AD21220056,and 2023JJG170001)the National Natural Sci-ence Foundation of China(Nos.51802032,52262022,52061009,62174041,and 62361022)the Yunnan Province Major Science and Technology Projects(No.202102AB080008-2).
文摘Schottky contacts have attracted widespread attention from both the electronic device industry and researchers since their discovery.The Schottky characteristics make these contacts highly suitable for use in field-effect transistors(FETs),photodetectors(PDs),solar cells(SCs),resistive-switching memories(RSMs),thin-film transistors(TFTs),etc.However,how do Schottky contacts affect the device performance?The answer lies simply in the Schottky parameters.This review focuses on the extraction of Schottky parameters,i.e.,the Schottky barrier height(SBH),ideality factor(IF),and series resistance(SR),from the current-voltage(I−V)curve to understand and analyze the characteristics of Schottky devices.First,the current research progress in this field and the principles of Schottky contacts are presented.Second,this article delves into some classic and widely used extraction methods as well as the latest extraction methods,providing an objective evaluation based on their practical effectiveness.Then,several research applications,including studies that require extraction,simple extraction,and delicate extraction,are enumerated to demonstrate the necessity and importance of Schottky parameter analysis.Finally,an outlook and future research prospects are discussed based on recent progress,and a comprehensive summary is given.
基金supported by the National Key Research and Development Program of China(No.2022YFB3706704)the Academician Special Science Research Project of CCCC(No.YSZX-03-2022-01-B).
文摘To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engineering case for finite element analysis.This bridge employs an unprecedented tower-girder constraintmethod,with all vertical supports placed at the transition piers at both ends.This paper aims to study the characteristics of longitudinal displacement control at the girder ends under this novel structure,relying on finite element(FE)analysis.Initially,based on the Weigh In Motion(WIM)data,a random vehicle load model is generated and applied to the finite elementmodel.Several longitudinal constraint systems are proposed,and their effects on the structural response of the bridge are compared.The most reasonable system,balancing girder-end displacement and transitional pier stress,is selected.Subsequently,the study examines the impact of different viscous damper parameters on key structural response indicators,including cumulative longitudinal displacement at the girder ends,maximum longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,maximum longitudinal displacement at the pier tops,longitudinal acceleration at the pier tops,and maximum bending moment at the pier bottoms.Finally,the coefficient of variation(CV)-TOPSIS method is used to optimize the viscous damper parameters for multiple objectives.The results show that adding viscous dampers at the side towers,in addition to the existing longitudinal limit bearings at the central tower,can most effectively reduce the response of structural indicators.The changes in these indicators are not entirely consistent with variations in damping coefficient and velocity exponent.The damper parameters significantly influence cumulative longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,and maximum bending moments at the pier bottoms.The optimal damper parameters are found to be a damping coefficient of 5000 kN/(m/s)0.2 and a velocity exponent of 0.2.
基金“Research on AI-Intelligent Management Technology for Construction Safety Based on BIM Technology and Smart Construction Site Scenarios”(Project No.:KJQN202401904)“Research on Intelligent Monitoring System for Construction Quality and Safety Based on BIM and AI Technologies”(Project No.:202412608006)。
文摘Combining the background of modern construction engineering site safety management,this article analyzes the real-time monitoring and alarm strategies for site construction safety under the integration of BIM and AI.This includes the analysis of BIM and AI technologies and their integration advantages,real-time monitoring and alarm strategies for construction site safety based on BIM and AI integration,as well as the development direction of BIM and AI integration in real-time monitoring and alarm for construction site safety.It is hoped that through this analysis,a scientific reference can be provided for the digital and intelligent management of construction site safety,promoting the digital and intelligent development of its safety management work.
基金supported by the National Natural Science Foundation of China(No.52202090)the Fundamental Research Funds for the Central Universities(No.2082019014).
文摘Thorium dioxide(ThO_(2))fibers exhibit exceptional structural stability,low density and superior flexibility,coupled with a remarkably high melting point,positioning them as promising candidates for thermal protection applications.Additionally,their commendable secondary processing characteristics enable the development of diverse composite materials when integrated with other materials,significantly broadening the potential utilization of ThO_(2)materials and thorium resources in industrial fields.In this work,the ThO_(2)fiber was fabricated by the sol-gel precursor method,and the precursor with good spinnability and excellent stability was synthesized for the first time.The ThO_(2)fiber with a mean diameter of 868 nm is both highly flexible and strong(max.tensile strength 2.21 MPa),capable of bending freely across a wide temperature range from-196℃(in liquid nitrogen)to 1200℃.Meanwhile,it exhibits excellent temperature stability and heat insulation properties.The ThO_(2)nanofiber membranes with layered structure have low density(32-37 mg·cm^(-3)),low thermal conductivity(27.3-30.1 mW·m^(-1)·K^(-1)@25℃).The ThO_(2)nanofiber membranes with 15 mm thickness can reduce the temperature from 1200 to 282℃and maintain a high aspect ratio and bendability after 1200℃@90 min.The results show that the ThO_(2)fiber can be used as a new kind of high-temperature resistant material.
基金Supported by Research Fund for the Control of Infectious Diseases and Research Grant Committee of Hong Kong Government
文摘AIM： To examine the sensitivity and accuracy of real-time polymerase chain reaction （PCR） for the quantification of hepatitis B virus （HBV） DNA in semen. METHODS： Hepatitis B viral DNA was isolated from HBV carriers＇ semen and sera using phenol extraction method and QIAamp DNA blood mini kit （Qiagen, Germany）. HBV DNA was detected by conventional PCR and quantified by TaqMan technology-based real-time PCR （quantitative polymerase chain reaction （qPCR））. The detection threshold was 200 copies of HBV DNA for conventional PCR and 10 copies of HBV DNA for real time PCR per reaction. RESULTS： Both methods of phenol extraction and QIAamp DNA blood mini kit were suitable for isolating HBV DNA from semen. The value of the detection thresholds was 500 copies of HBV DNA per mL in the semen. The viral loads were 7.5×10^7 and 1.67×10^7 copies of HBV DNA per mL in two HBV infected patients＇ sera, while 2.14×10^5 and 3.02×10^5 copies of HBV DNA per mL in the semen. CONCLUSION： Real-time PCR is a more sensitive and accurate method to detect and quantify HBV DNA in the semen.
文摘The purpose of the present study was to investigate the association between admission clinical characteristics and outcomes at discharge among acute ischemic stroke patients in the Chinese population. A total of 2,673 patients with acute ischemic stroke were included in the present study. The clinical characteristics at admission and other study variables were collected for all patients. The study outcome was defined as neurological deficiency （National Institute of Health Stroke Scale score ≥ 10） at discharge or in-hospital death. Compared with the subjects without neurological deficiency at discharge or in-hospital death, the subjects with neurological deficiency at discharge or in-hospital death had a significantly higher prevalence of hyperglycemia or history of atrial fibrillation at admission. Age ≥ 80 years, hyperglycemia, hypertension, and history of atrial fibrillation were significantly associated with neurological deficiency at discharge or in-hospital death after adjustment for other variables. It is concluded that old age （ ≥ 80 years）, hyperglycemia, hypertension and history of atrial fibrillation are significantly associated with neurological deficiency at discharge or in-hospital death among patients with acute ischemic stroke.
