Ceramic aerogels(CAs)have emerged as a significant research frontier across various applications due to their lightweight,high porosity,and easily tunable structural characteristics.However,the intrinsic weak interact...Ceramic aerogels(CAs)have emerged as a significant research frontier across various applications due to their lightweight,high porosity,and easily tunable structural characteristics.However,the intrinsic weak interactions among the constituent nanoparticles,coupled with the limited toughness of traditional CAs,make them susceptible to structural collapse or even catastrophic failure when exposed to complex mechanical external forces.Unlike 0D building units,1D ceramic nanofibers(CNFs)possess a high aspect ratio and exceptional flexibility simultaneously,which are desirable building blocks for elastic CAs.This review presents the recent progress in electrospun ceramic nanofibrous aerogels(ECNFAs)that are constructed using ECNFs as building blocks,focusing on the various preparation methods and corresponding structural characteristics,strategies for optimizing mechanical performance,and a wide range of applications.The methods for preparing ECNFs and ECNFAs with diverse structures were initially explored,followed by the implementation of optimization strategies for enhancing ECNFAs,emphasizing the improvement of reinforcing the ECNFs,establishing the bonding effects between ECNFs,and designing the aggregate structures of the aerogels.Moreover,the applications of ECNFAs across various fields are also discussed.Finally,it highlights the existing challenges and potential opportunities for ECNFAs to achieve superior properties and realize promising prospects.展开更多
A modified electrospraying process is exploited to enhance the dissolution profiles of a poorly water-soluble drug. With polyvinylpyrrolidone (PVP) as a hydrophilic polymer matrix and ketoprofen (KET) as a model drug,...A modified electrospraying process is exploited to enhance the dissolution profiles of a poorly water-soluble drug. With polyvinylpyrrolidone (PVP) as a hydrophilic polymer matrix and ketoprofen (KET) as a model drug, polymer-drug composites in the form of nanoparticles were prepared and characterized. The surface morphologies, the physical status of the drug, and the drug-polymer interactions were studied using FESEM, DSC, XRD, and ATR-FTIR. FESEM observations demonstrated that the nanoparticles gradually decreased in size from 640 ± 350, to 530 ± 320, 460 ± 200 and 320 ± 160 nm as the KET content increased from 0, to 9.1%, 16.7% and 33.3% w/w, respectively. Results from DSC and XRD suggested that KET was distributed in the PVP matrix in an amorphous manner at the molecular level. This is thought to be due to their compatibility, arising through hydrogen bonding as demonstrated by ATR- FTIR spectra. In vitro dissolution tests showed that the nanoparticles released the incorporated KET within 1 min, evidencing markedly improved dissolution over pure KET and a KET-PVP physical mixture. Electrospraying can hence offer a facile route to develop new polymer composites for biomedical applications, in particular for improving dissolution rate of poorly water-soluble drugs.展开更多
Development of exquisitely selective and sensitive HClO/ClO^(-)sensor in living system is of the utmost importance.To achieve near-infrared(NIR)-responsive detection of HClO/ClO^(-),a new nanoprobe(csUCNP-Cy820) is co...Development of exquisitely selective and sensitive HClO/ClO^(-)sensor in living system is of the utmost importance.To achieve near-infrared(NIR)-responsive detection of HClO/ClO^(-),a new nanoprobe(csUCNP-Cy820) is composed of the ClO^(-)sensitive Cy820(energy acceptor),and NaLuF4:20%Yb,1%Tm@NaLuF4core@shell upconversion nanoparticles(csUCNP,energy donor) capable of emitting NIR upconversion luminescence(UCL) of Tm^(3+)(800 nm).Through the mechanism of F?rster resonance energy transfer(FRET),the UCL emission can be recovered in the presence of HClO/CIO^(-).The csUCNP-Cy820 nanoprobe is effectively adapted as a precise ClO^(-)detection sensor with a low limit of detection(LoD) of 58 nmol/L in vitro.Moreover,owing to excitation and emission wavelengths both falling within the NIR region,the nanoprobe facilitates high quality imaging in mice models of peritonitis and arthritis,thereby enabling deeper penetration depth for imaging detection in vivo.展开更多
Photodetectors with weak-light detection capabilities play an indispensable role in various crucial fields such as health monitors,imaging,optical communication,and etc.Nevertheless,the detection of weak light signals...Photodetectors with weak-light detection capabilities play an indispensable role in various crucial fields such as health monitors,imaging,optical communication,and etc.Nevertheless,the detection of weak light signals is often severely interfered by multiple factors such as background light,dark noise and circuit noise,making it difficult to accurately capture signals.While traditional technologies like silicon photomultiplier tubes excel in sensitivity,their high cost and inherent fragility restrict their widespread application.Against this background,perovskite materials have rapidly emerged as a research focus in the field of photodetection due to their simple preparation processes and exceptional optoelectronic properties.Not only are the preparation processes of perovskite materials straightforward and cost-effective,but more importantly,they can be flexibly integrated into flexible and stretchable substrates.This characteristic significantly compensates for the shortcomings of traditional rigid electronic devices in specific application scenarios,opening up entirely new possibilities for photodetection technology.Herein,recent advances in perovskite light detection technology are reviewed.Firstly,the chemical and physical properties of perovskite materials are discussed,highlighting their remarkable advantages in weak-light detection.Subsequently,the review systematically organizes various preparation techniques of perovskite materials and analyses their advantages in different application scenarios.Meanwhile,from the two core dimensions of performance improvement and light absorption enhancement,the key strategies of improving the performance of perovskite weak-light photodetectors are explored.Finally,the review concludes with a brief summary and a discussion on the potential challenges that may arise in the further development of perovskite devices.展开更多
The in-flight calibration and performance of the Solar Disk Imager(SDI),which is a pivotal instrument of the LyαSolar Telescope onboard the Advanced Space-based Solar Observatory mission,suggested a much lower spatia...The in-flight calibration and performance of the Solar Disk Imager(SDI),which is a pivotal instrument of the LyαSolar Telescope onboard the Advanced Space-based Solar Observatory mission,suggested a much lower spatial resolution than expected.In this paper,we developed the SDI point-spread function(PSF)and Image Bivariate Optimization Algorithm(SPIBOA)to improve the quality of SDI images.The bivariate optimization method smartly combines deep learning with optical system modeling.Despite the lack of information about the real image taken by SDI and the optical system function,this algorithm effectively estimates the PSF of the SDI imaging system directly from a large sample of observational data.We use the estimated PSF to conduct deconvolution correction to observed SDI images,and the resulting images show that the spatial resolution after correction has increased by a factor of more than three with respect to the observed ones.Meanwhile,our method also significantly reduces the inherent noise in the observed SDI images.The SPIBOA has now been successfully integrated into the routine SDI data processing,providing important support for the scientific studies based on the data.The development and application of SPIBOA also paves new ways to identify astronomical telescope systems and enhance observational image quality.Some essential factors and precautions in applying the SPIBOA method are also discussed.展开更多
This study assessed the feasibility of developing a machine vision system equipped with ultraviolet (UV) light, using changes in fish-surface color to predict aerobic plate count (APC, a standard freshness indicator) ...This study assessed the feasibility of developing a machine vision system equipped with ultraviolet (UV) light, using changes in fish-surface color to predict aerobic plate count (APC, a standard freshness indicator) during storage. The APC values were tested and images of the fish surface were taken when fish were stored at room temperature. Then, images</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">’</span></span></span><span><span><span><span> color-space conversion among RGB, HSV, and L*a*b* color spaces was carried out and analyzed. The results revealed that a* and b* values from the UV-light image decreased linearly during storage. A further regression analysis of these two parameters with APC value demonstrated a good exponential relationship between the a* value and the APC value (R</span><sup><span>2</span></sup><span> = 0.97), followed by the b* (R</span><sup><span>2</span></sup><span> = 0.85). Therefore, our results suggest that the change in color of the fish surface under UV light can be used to assess fish freshness during storage.展开更多
Clostridium difficile infection(CDI)is a major global public health concern,accounting for 15%-25%of antibiotic-associated diarrhea,50%-75%of antibiotic-associated colitis,and nearly all cases of pseudomembranous coli...Clostridium difficile infection(CDI)is a major global public health concern,accounting for 15%-25%of antibiotic-associated diarrhea,50%-75%of antibiotic-associated colitis,and nearly all cases of pseudomembranous colitis.Over the past decade,CDI outbreaks have become increasingly prevalent in North America and Europe,with rising incidence and mortality rates.In 2019,the Centers for Disease Control and Prevention(CDC)in the United States classified CDI as a“critical”public health threat in their report on antibiotic resistance threats[1].CDI incidence varies widely across countries,healthcare settings,and age groups,with cumulative incidence rates ranging from 1.12 to 631.80 per 100,000 people annually[2].As the epidemiology of CDI continues to evolve and our understanding of the disease advances,reassessing its burden remains essential.The Global Burden of Disease,Injury,and Risk Factors Study(GBD 2021)database offers new insights into this issue.展开更多
The Southern Ocean is a critical component in the Earth system by dominating the global heat and anthropogenic carbon uptake and supplying heat to melt the largest ice sheet.Variability and changes in the water masses...The Southern Ocean is a critical component in the Earth system by dominating the global heat and anthropogenic carbon uptake and supplying heat to melt the largest ice sheet.Variability and changes in the water masses of the Southern Ocean are thus important to the global energy and water cycles,carbon cycling,and sea-level change.In this article,we review the recent progress on understanding the variability and changes in the four major water masses in the Southern Ocean,including Subantarctic Mode Water,Antarctic Intermediate Water,Circumpolar Deep Water and Antarctic Bottom Water.Subantarctic Mode Water and Antarctic Intermediate Water show statistically significant strong circumpolar shoaling,warming,and density reductions since 1970s,indicating that signals of global warming have entered the interior ocean.Meanwhile,strong regional variability of Subantarctic Mode Water and Antarctic Intermediate Water responding to surface buoyancy forcing and westerly winds is attracting more attention.Circumpolar Deep Water is an important modulator of heat content and nutrient concentrations on continental shelves around Antarctica and has made significant contributions to the basal melting of Antarctic ice shelves.Since the late 1950s,a long-term freshening trend in Antarctic Bottom Water in the Ross Sea and its downstream region has been observed and is mainly attributed to the accelerated basal melting of ice shelves in West Antarctica.The shrinking of Antarctic Bottom Water in the Weddell Sea during 1992–2020 has also been revealed and is attributed to reduced sea ice production over the southern Weddell continental shelf related to the Interdecadal Pacific Oscillation and the variability in the Amundsen Sea Low.Though significant advances have been achieved,there is an urgent need to enhance and improve both observations and model performances for better understandings and projections of the formation,transformation,and transport of the water masses in the Southern Ocean.展开更多
Hydrogen peroxide(H_(2)O_(2))is highly required in various applications.The development of catalysts exhibiting elevated catalytic activity,selectivity,and stability is essential for H_(2)O_(2)production technology.Me...Hydrogen peroxide(H_(2)O_(2))is highly required in various applications.The development of catalysts exhibiting elevated catalytic activity,selectivity,and stability is essential for H_(2)O_(2)production technology.Metalbased catalysts are widely used for 2e^(-)ORR(oxygen reduction reaction)because of their adjustable structure,chemical stability,and availability.However,due to competition with the 4e^(-)ORR,modifications are often conducted to balance activity and selectivity.Common techniques include altering the surface electronic structure of catalysts and the interaction between active sites and intermediates.This review discusses diverse catalyst types(including precious and transition metals,single-atom catalysts,and MOFs/COFs)along with modification strategies(such as morphological control,electronic structure tuning,conductivity enhancement,and wettability improvement).The objective is to elucidate catalyst design and associated reaction mechanisms,as well as the relationship between catalyst structure and activity,in order to provide an insight for producing H_(2)O_(2)in an efficient,highly selective,and stable manner.展开更多
Objective:To explore the obstructive factors in the behavior of medical staff during the implementation of respiratory rehabilitation process,and to provide a basis for the rehabilitation management intervention of CO...Objective:To explore the obstructive factors in the behavior of medical staff during the implementation of respiratory rehabilitation process,and to provide a basis for the rehabilitation management intervention of COPD.Methods:A descriptive nature research method was adopted.An interview outline was formulated based on the theoretical domain framework.From October to December 2024,15 medical staff from the respiratory department of a tertiary hospital in Shaanxi Province were selected for semi-structured interviews.The interview data were analyzed using the Colaizzi 7-step analysis method.Result:The analysis of this study found that the obstructive factors for medical staff to implement respiratory rehabilitation include five theoretical domains.The problems are respectively the lack of knowledge about respiratory rehabilitation and insufficient training intensity,the insufficient self-recognition of implementing respiratory rehabilitation,the low awareness rate of patients and the low cooperation degree,the insufficient provision of instruments and facilities,the lack of rehabilitation training venues and respiratory rehabilitation clinics,and the lack of scientific and standardized respiratory rehabilitation management processes.Conclusion:There are many obstructive factors affecting the implementation of respiratory rehabilitation by medical staff.Clinical managers should take corresponding measures,continuously improve the rehabilitation management strategies for COPD,and promote the clinical application of the best evidence for respiratory rehabilitation.展开更多
BACKGROUND Sepsis is a life-threatening condition defined by organ dysfunction,triggered by a dysregulated host response to infection.there is limited published literature combining cognitive impairment with topologic...BACKGROUND Sepsis is a life-threatening condition defined by organ dysfunction,triggered by a dysregulated host response to infection.there is limited published literature combining cognitive impairment with topological property alterations in brain networks in sepsis survivors.Therefore,we employed graph theory and Granger causality analysis(GCA)methods to analyze resting-state functional magnetic resonance imaging(rs-fMRI)data,aiming to explore the topological alterations in the brain networks of intensive care unit(ICU)sepsis survivors.Using correlation analysis,the interplay between topological property alterations and cognitive impairment was also investigated.AIM To explore the topological alterations of the brain networks of sepsis survivors and their correlation with cognitive impairment.METHODS Sixteen sepsis survivors and nineteen healthy controls from the community were recruited.Within one month after discharge,neurocognitive tests were administered to assess cognitive performance.Rs-fMRI was acquired and the topological properties of brain networks were measured based on graph theory approaches.GCA was conducted to quantify effective connectivity(EC)between brain regions showing positive topological alterations and other regions in the brain.The correlations between topological properties and cognitive were analyzed.RESULTS Sepsis survivors exhibited significant cognitive impairment.At the global level,sepsis survivors showed lower normalized clustering coefficient(γ)and small-worldness(σ)than healthy controls.At the local level,degree centrality(DC)and nodal efficiency(NE)decreased in the right orbital part of inferior frontal gyrus(ORBinf.R),NE decreased in the left temporal pole of superior temporal gyrus(TPOsup.L)whereas DC and NE increased in the right cerebellum Crus 2(CRBLCrus2.R).Regarding directional connection alterations,EC from left cerebellum 6(CRBL6.L)to ORBinf.R and EC from TPOsup.L to right cerebellum 1(CRBLCrus1.R)decreased,whereas EC from right lingual gyrus(LING.R)to TPOsup.L increased.The implementation of correlation analysis revealed a negative correlation between DC in CRBLCrus2.R and both Mini-mental state examination(r=-0.572,P=0.041)and Montreal cognitive assessment(MoCA)scores(r=-0.629,P=0.021)at the local level.In the CRBLCrus2.R cohort,a negative correlation was identified between NE and MoCA scores,with a statistically significant result of r=-0.633 and P=0.020.CONCLUSION Frontal,temporal and cerebellar topological property alterations are possibly associated with cognitive impairment of ICU sepsis survivors and may serve as biomarkers for early diagnosis.展开更多
The development of bifunctional electrocatalysts for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)at high current density under industrial temperatures is crucial for large-scale industrial hydrog...The development of bifunctional electrocatalysts for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)at high current density under industrial temperatures is crucial for large-scale industrial hydrogen production from water splitting.In this work,M-MnO_(2)@TNTA composite electrodes were prepared by depositing various metal ion-doped manganese oxide nanoparticles on the titania nanotube array(TNTA)by successive ionic layer adsorption reaction(SILAR)method,and their HER and OER electrocatalytic performances were investigated in 1 M KOH.Results show that the CoFe-MnO_(2)@TNTA composite electrode prepared by simultaneous doping of Co^(3+)and Fe^(3+)in MnO_(2) exhibits optimal catalytic performance.Compared with MnO_(2)@TNTA without ion doping,the overpotentials of CoFe-MnO_(2)@TNTA at 10 mA cm^(-2)(η_(10))for HER and OER are reduced by 571 and 665 mV.In addition,the electrode perfor-mance can be significantly enhanced by increasing the test temperature,and the porous array structure enables CoFe-MnO_(2)@TNTA to exhibit better performance at high current densities.At 50℃,which is the common industrial electrolytic water temperature,the η_(10) of CoFe-MnO_(2)@TNTA for HER is almost equal to that of the Pt/C electrode.The η_(100) of CoFe-MnO_(2)@TNTA for HER is reduced by 35 mV compared with the Pt/C electrode.Moreover,η_(200) of CoFe-MnO_(2)@TNTA for OER is significantly lowered by 111 and 184 mV compared with IrO_(2) and RuO_(2) electrodes.Utilizing CoFe-MnO_(2)@TNTA as both the cathode and anode for overall water splitting,the electrolysis voltage is merely 2.33 V under the current density of 200 mA cm^(-2),much lower than that of IrO_(2)(+)||Pt/C(-)(2.68 V).The present work may provide a valuable reference for the development of self-supporting bifunctional electrodes suitable for high-current-density water splitting at industrial temperatures.展开更多
Background:Multiple myeloma(MM)remains a formidable clinical challenge due to its high relapse rate and resistance to existing therapies.Estrogen-related receptor gamma(ERRγ),a nuclear receptor critical for cellular ...Background:Multiple myeloma(MM)remains a formidable clinical challenge due to its high relapse rate and resistance to existing therapies.Estrogen-related receptor gamma(ERRγ),a nuclear receptor critical for cellular energy metabolism,has been implicated in various cancers.but its role in MM remains unclear.Methods:ERRγexpres-sion was assessed using bioinformatics and RT-qPCR.Functional studies were conducted through siRNA-mediated ERRγknockdown and treatment with the inverse agonist GSK5182 to examine their effects on MM cell proliferation and apoptosis.Results:ERRγwas significantly upregulated in the bone marrow of MM patients,correlating with advanced clinical stages and pathological fractures.Inhibition of ERRγreduced MM cell expansion both in vitro and in vivo,while promoting mitochondrial-dependent apoptosis.Co-immunoprecipitation assays demonstrated a physical association between ERRγand P65.Inhibition of ERRγattenuated canonical nuclear factor-kappa B(NF-κB)signaling by blocking the nuclear translocation of its key effector p65.Additionally,modulation of ERRγaltered receptor activator of nuclear factor-κB ligand(RANKL)levels,implying a potential role in bone degradation observed in MM cases.Conclusion:Collectively,the data broaden understanding of ERRγ’s contribution to MM development and propose it as a viable target for therapeutic intervention.展开更多
Red tide is an ecological disaster caused by the excessive proliferation of photosynthetic algae in the ocean.The frequent occurrences of red tide have brought serious harms to the marine aquaculture and caused signif...Red tide is an ecological disaster caused by the excessive proliferation of photosynthetic algae in the ocean.The frequent occurrences of red tide have brought serious harms to the marine aquaculture and caused significant economic losses to the marine industry.Red tide prediction can alleviate and even stop the long-term damages to marine ecosystems,which helps maintain the ecological balance of the ocean environment and contributes to the Sustainable Development Goal of“life below water”formulated by the United Nations.Aiming at red tide prediction using remote sensing technology,this study proposed a novel approach of red tide prediction using time-series hyperspectral observations,and examined the proposed method in the Xinghai Bay,China.Three spectral indices,namely the twoband ratio(TBR),the three-band spectral index(TBSI),and the fluorescence baseline height(FLH),were used to reduce the dimensionality of hyperspectral data and extract spectral features.Two machine learning models including the random forest(RF)and the support vector machine(SVM)were employed to predict whether red tide would occur on a target day based on the time-series spectral indices obtained in the previous days.By comparing and analyzing the prediction results of multiple machine learning models trained with different spectral indices and temporal lengths,it is found that both the RF and the SVM models can predict the red tide outbreaks at the accuracies over 0.9 using adequate temporal lengths of input data.When the temporal length of input data is limited,however,it is suggested to use the RF model,which accurately predicts red tide outbreaks using the temporal input of the 2-d TBSI.The proposed method is expected to provide oceanic and maritime agencies with early warnings on red tide outbreaks and ensure the safety of the coastal environment in large spatial scales using optical remote sensing technology.展开更多
Objective: To investigate the current beliefs and attitudes of nurses in Yunnan Province toward prescriptive authority, analyze the influencing factors, and provide evidence for future research and policy formulation ...Objective: To investigate the current beliefs and attitudes of nurses in Yunnan Province toward prescriptive authority, analyze the influencing factors, and provide evidence for future research and policy formulation to support the establishment of nurses’ prescriptive authority in China. Method: A cross-sectional survey was conducted among 937 nurses in Yunnan Province using the Beliefs and Attitudes Scale on Nurses’ Prescriptive Authority. The scale assessed four dimensions: perceived need, self-efficacy, perceived benefits, and perceived barriers. Multiple linear regression analysis was used to identify factors influencing the overall score and each dimension. Results: The total score of the Beliefs and Attitudes Scale was 89.17 ± 17.69, indicating a moderate level of awareness and positive attitude among nurses. The highest-scoring dimension was perceived benefits (34.94 ± 8.04), while the lowest was perceived barriers (15.23 ± 3.5). Age was identified as a significant factor influencing the overall score and self-efficacy dimension (P < 0.05). Years of practice influenced the perceived benefits dimension (P = 0.051), while gender, age, and professional title were key factors affecting the perceived barriers dimension (P < 0.05). Male nurses and senior nurses demonstrated more caution toward potential risks associated with prescriptive authority. Conclusion: Nurses in Yunnan Province exhibit moderate levels of belief in and attitudes toward prescriptive authority, with age being the most significant influencing factor. Tailored training programs, policy promotion, and practical guidance are recommended to enhance nurses’ understanding and support for prescriptive authority, thereby improving nursing practices and addressing regional healthcare challenges.展开更多
Due to the wide and adjustable emission range,Ce^(3+)is an indispensable luminous center for full spectrum lighting.However,it needs to be sintered at high temperature in a reducing atmosphere,resulting in difficulty ...Due to the wide and adjustable emission range,Ce^(3+)is an indispensable luminous center for full spectrum lighting.However,it needs to be sintered at high temperature in a reducing atmosphere,resulting in difficulty to coexisting with other multivalent activated ions(such as Eu^(3+),Tm^(3+)),which greatly hinders the formation of full spectrum.In this study,a calcium vacancy enhanced self-reduction of Ce^(4+)is realized in CaNaSb_(2)O_(6)F(CNSOF)host under air atmosphere sintering,through which Ce^(3+),Tm^(3+)and Eu^(3+)coexisting in a single-phase full spectrum phosphor was prepared.Notably,the artificial introduction of a calcium vacancy was designed to verify this self-reduction mechanism.Moreover,the energy transfer kinetics among Tm^(3+),Ce^(3+)and Eu^(3+)were explored.Finally,combined with a 340 nm UV chip,a full spectrum phosphor-converted light-emitting diode(pc-LED)was fabricated,showing a broad emission range from 400 to 750 nm,Commission Internationale de I'Edairage(CIE)of(0.3485,0.3673),Ra of 92 and correlated color temperature(CCT)of 4933 K.Utilizing the variation in emission colors of this phosphor under different UV wavelengths,a dual encryption method combining point character code and fluorescent encryption technique is proposed.This work provides an effective path for Ce^(4+)self-reduction to apply in full spectrum pc-LED and information encryption.展开更多
Metabonomics,a key aspect of systems biology,offers novel approaches for early diagnosis,pharmacotherapy,and health management in Traditional Chinese Medicine(TCM).This paper summarizes its applications in establishin...Metabonomics,a key aspect of systems biology,offers novel approaches for early diagnosis,pharmacotherapy,and health management in Traditional Chinese Medicine(TCM).This paper summarizes its applications in establishing TCM quality standards,exploring material basis,clarifying mechanism,and assessing toxicity.By profiling TCM and its metabolites,metabonomics comprehensively captures chemical traits,enhancing quality evaluation precision.It also tracks metabolic dynamics to understand TCM’s absorption,distribution,metabolism,excretion,thereby facilitating the identification of active components and their underlying mechanisms.In toxicity assessment,metabonomics uncovers hepatic and renal toxicity while elucidating potential mechanisms.In summary,metabonomics fosters TCM modernization and globalization,serving as a pivotal tool for advancing research and development.展开更多
Magnesium(Mg)-based materials are promising for lightweight structural applications.However,their widespread adoption is significantly constrained by inherent limitations in mechanical properties.To address this chall...Magnesium(Mg)-based materials are promising for lightweight structural applications.However,their widespread adoption is significantly constrained by inherent limitations in mechanical properties.To address this challenge,this study introduces a novel Mg-based interpenetratingphase composite reinforced with a nickel-titanium(NiTi)scaffold featuring a triply periodic minimal surface(TPMS)configuration.By combining experimental investigations with finite element simulations,we systematically elucidate the dual impact of the scaffold’s unit cell size(a)on manufacturing viability and mechanical enhancement.To compensate for compromised infiltration dynamics induced by decreasing a,a critical permeability threshold of 1×10^(-8) m^(2) is proposed for achieving successful composite fabrication.Mechanically,reducing a strengthens the interaction between the scaffold and matrix:the TPMS-configured NiTi scaffolds improve stress transfer,deflect crack propagation,and facilitate damage delocalization,whereas the Mg matrix preserves structural integrity and enables load redistribution.Consequently,the composites significantly outperform pure Mg,and lowering a leads to more substantial enhancements in compressive strength,energy dissipation,and deformation recoverability.This study offers valuable insight into the design and fabrication of highperformance Mg-based materials for structural and biomedical applications.展开更多
Diabetic wound healing is often complicated due to bacterial infections that intensify inflammation.Employing hydrogel dressings with inherent antibacterial properties can significantly reduce reliance on antibiotics ...Diabetic wound healing is often complicated due to bacterial infections that intensify inflammation.Employing hydrogel dressings with inherent antibacterial properties can significantly reduce reliance on antibiotics for treating infected wounds in diabetics.Traditional hydrogels typically rely on the infiltration of bacteria into their porous structure to manifest antibacterial effects.However,this infiltration process is not only prolonged but can also exacerbate inflammation,further delaying the healing of the wound.Thus,promptly capturing and eliminating bacteria is crucial for enhancing the antibacterial efficiency of the hydrogel.In this context,we present a multifunctional hydrogel dressing,termed SIP,designed to tackle drug-resistant bacterial infections in diabetic wounds.This dressing integrates ionic liquid functional groups into a sericin-based matrix:phenylboronic acid for the immobilization of bacteria and imidazole for their subsequent annihilation.Expectedly,the SIP system demonstrates potent antibacterial activity against methicillin-resistant Staphylococcus aureus,verified through in vitro and in vivo experiments.As a result,SIP emerges as a promising candidate in the realm of hydrogel dressings with innate antibacterial properties,showcasing considerable potential for addressing diabetic wounds plagued by drug-resistant bacterial infections.展开更多
The advancement of functional adhesives featuring recyclable and repairable properties is of great significance in interfacial science and engineering.Herein,a series of high-strength,recyclable fluorine-containing ad...The advancement of functional adhesives featuring recyclable and repairable properties is of great significance in interfacial science and engineering.Herein,a series of high-strength,recyclable fluorine-containing adhesives(ESOx-FPF)were designed and synthesized by crosslinking two prepolymers,FPF-B(derived from side-chain fluorinated diol,isocyanate,and aminoboric acid)and ESO-B(synthesized from biobased epoxy soybean oil and aminoboric acid),through dynamic boro-oxygen bonds.The resulting adhesive exhibited an optimal tensile strength of 42 MPa and the shear strength on steel plates reached as high as 3.89 MPa.More importantly,benefiting from the dynamic reversibility of the boron-oxygen bonds along with the hydrogen bonds interaction,ESOx-FPF can be welded with the assistance of solvents and recycled for multiple cycles.The outstanding healing efficiency and excellent reprocessability of these functional adhesives were confirmed by mechanical testing.Moreover,the as-prepared adhesives demonstrated universal and remarkable adhesion to various substrates,such as aromatic polyamide,aluminum plates and polycarbonate,meanwhile,they could be easily disassembled and recycled using ethanol without damaging the substrates surface.This study not only provides a simple strategy for the synthesis of eco-friendly adhesives with weldable and recyclable properties,but also sheds light on the development of other functional materials utilizing dynamic covalent chemistry.展开更多
基金supported by the National Natural Science Foundation of China(Nos.92371110 and 52373281)Weiqiao Science Foundation(H2872302 and H2872303)the Scientific Research Innovation Capability Support Project for Young Faculty.
文摘Ceramic aerogels(CAs)have emerged as a significant research frontier across various applications due to their lightweight,high porosity,and easily tunable structural characteristics.However,the intrinsic weak interactions among the constituent nanoparticles,coupled with the limited toughness of traditional CAs,make them susceptible to structural collapse or even catastrophic failure when exposed to complex mechanical external forces.Unlike 0D building units,1D ceramic nanofibers(CNFs)possess a high aspect ratio and exceptional flexibility simultaneously,which are desirable building blocks for elastic CAs.This review presents the recent progress in electrospun ceramic nanofibrous aerogels(ECNFAs)that are constructed using ECNFs as building blocks,focusing on the various preparation methods and corresponding structural characteristics,strategies for optimizing mechanical performance,and a wide range of applications.The methods for preparing ECNFs and ECNFAs with diverse structures were initially explored,followed by the implementation of optimization strategies for enhancing ECNFAs,emphasizing the improvement of reinforcing the ECNFs,establishing the bonding effects between ECNFs,and designing the aggregate structures of the aerogels.Moreover,the applications of ECNFAs across various fields are also discussed.Finally,it highlights the existing challenges and potential opportunities for ECNFAs to achieve superior properties and realize promising prospects.
文摘A modified electrospraying process is exploited to enhance the dissolution profiles of a poorly water-soluble drug. With polyvinylpyrrolidone (PVP) as a hydrophilic polymer matrix and ketoprofen (KET) as a model drug, polymer-drug composites in the form of nanoparticles were prepared and characterized. The surface morphologies, the physical status of the drug, and the drug-polymer interactions were studied using FESEM, DSC, XRD, and ATR-FTIR. FESEM observations demonstrated that the nanoparticles gradually decreased in size from 640 ± 350, to 530 ± 320, 460 ± 200 and 320 ± 160 nm as the KET content increased from 0, to 9.1%, 16.7% and 33.3% w/w, respectively. Results from DSC and XRD suggested that KET was distributed in the PVP matrix in an amorphous manner at the molecular level. This is thought to be due to their compatibility, arising through hydrogen bonding as demonstrated by ATR- FTIR spectra. In vitro dissolution tests showed that the nanoparticles released the incorporated KET within 1 min, evidencing markedly improved dissolution over pure KET and a KET-PVP physical mixture. Electrospraying can hence offer a facile route to develop new polymer composites for biomedical applications, in particular for improving dissolution rate of poorly water-soluble drugs.
基金Project supported by the National Key R&D Program of China (2022YFF0710000)。
文摘Development of exquisitely selective and sensitive HClO/ClO^(-)sensor in living system is of the utmost importance.To achieve near-infrared(NIR)-responsive detection of HClO/ClO^(-),a new nanoprobe(csUCNP-Cy820) is composed of the ClO^(-)sensitive Cy820(energy acceptor),and NaLuF4:20%Yb,1%Tm@NaLuF4core@shell upconversion nanoparticles(csUCNP,energy donor) capable of emitting NIR upconversion luminescence(UCL) of Tm^(3+)(800 nm).Through the mechanism of F?rster resonance energy transfer(FRET),the UCL emission can be recovered in the presence of HClO/CIO^(-).The csUCNP-Cy820 nanoprobe is effectively adapted as a precise ClO^(-)detection sensor with a low limit of detection(LoD) of 58 nmol/L in vitro.Moreover,owing to excitation and emission wavelengths both falling within the NIR region,the nanoprobe facilitates high quality imaging in mice models of peritonitis and arthritis,thereby enabling deeper penetration depth for imaging detection in vivo.
文摘Photodetectors with weak-light detection capabilities play an indispensable role in various crucial fields such as health monitors,imaging,optical communication,and etc.Nevertheless,the detection of weak light signals is often severely interfered by multiple factors such as background light,dark noise and circuit noise,making it difficult to accurately capture signals.While traditional technologies like silicon photomultiplier tubes excel in sensitivity,their high cost and inherent fragility restrict their widespread application.Against this background,perovskite materials have rapidly emerged as a research focus in the field of photodetection due to their simple preparation processes and exceptional optoelectronic properties.Not only are the preparation processes of perovskite materials straightforward and cost-effective,but more importantly,they can be flexibly integrated into flexible and stretchable substrates.This characteristic significantly compensates for the shortcomings of traditional rigid electronic devices in specific application scenarios,opening up entirely new possibilities for photodetection technology.Herein,recent advances in perovskite light detection technology are reviewed.Firstly,the chemical and physical properties of perovskite materials are discussed,highlighting their remarkable advantages in weak-light detection.Subsequently,the review systematically organizes various preparation techniques of perovskite materials and analyses their advantages in different application scenarios.Meanwhile,from the two core dimensions of performance improvement and light absorption enhancement,the key strategies of improving the performance of perovskite weak-light photodetectors are explored.Finally,the review concludes with a brief summary and a discussion on the potential challenges that may arise in the further development of perovskite devices.
基金supported by the National Natural Science Foundation of China(NSFC)under grant No.12233012,the Strategic Priority Research Program of the Chinese Academy of Sciences,grant No.XDB0560102the National Key R&D Program of China 2022YFF0503003(2022YFF0503000)。
文摘The in-flight calibration and performance of the Solar Disk Imager(SDI),which is a pivotal instrument of the LyαSolar Telescope onboard the Advanced Space-based Solar Observatory mission,suggested a much lower spatial resolution than expected.In this paper,we developed the SDI point-spread function(PSF)and Image Bivariate Optimization Algorithm(SPIBOA)to improve the quality of SDI images.The bivariate optimization method smartly combines deep learning with optical system modeling.Despite the lack of information about the real image taken by SDI and the optical system function,this algorithm effectively estimates the PSF of the SDI imaging system directly from a large sample of observational data.We use the estimated PSF to conduct deconvolution correction to observed SDI images,and the resulting images show that the spatial resolution after correction has increased by a factor of more than three with respect to the observed ones.Meanwhile,our method also significantly reduces the inherent noise in the observed SDI images.The SPIBOA has now been successfully integrated into the routine SDI data processing,providing important support for the scientific studies based on the data.The development and application of SPIBOA also paves new ways to identify astronomical telescope systems and enhance observational image quality.Some essential factors and precautions in applying the SPIBOA method are also discussed.
文摘This study assessed the feasibility of developing a machine vision system equipped with ultraviolet (UV) light, using changes in fish-surface color to predict aerobic plate count (APC, a standard freshness indicator) during storage. The APC values were tested and images of the fish surface were taken when fish were stored at room temperature. Then, images</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">’</span></span></span><span><span><span><span> color-space conversion among RGB, HSV, and L*a*b* color spaces was carried out and analyzed. The results revealed that a* and b* values from the UV-light image decreased linearly during storage. A further regression analysis of these two parameters with APC value demonstrated a good exponential relationship between the a* value and the APC value (R</span><sup><span>2</span></sup><span> = 0.97), followed by the b* (R</span><sup><span>2</span></sup><span> = 0.85). Therefore, our results suggest that the change in color of the fish surface under UV light can be used to assess fish freshness during storage.
基金supported by the Beijing Natural Science Foundation(No.L202008)the Chinese Center for Disease Control and Prevention Foundation(No.201833).
文摘Clostridium difficile infection(CDI)is a major global public health concern,accounting for 15%-25%of antibiotic-associated diarrhea,50%-75%of antibiotic-associated colitis,and nearly all cases of pseudomembranous colitis.Over the past decade,CDI outbreaks have become increasingly prevalent in North America and Europe,with rising incidence and mortality rates.In 2019,the Centers for Disease Control and Prevention(CDC)in the United States classified CDI as a“critical”public health threat in their report on antibiotic resistance threats[1].CDI incidence varies widely across countries,healthcare settings,and age groups,with cumulative incidence rates ranging from 1.12 to 631.80 per 100,000 people annually[2].As the epidemiology of CDI continues to evolve and our understanding of the disease advances,reassessing its burden remains essential.The Global Burden of Disease,Injury,and Risk Factors Study(GBD 2021)database offers new insights into this issue.
基金The Independent Research Foundation of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)under contract Nos SML2023SP201 and SML2021SP306the Natural Science Foundation of Guangdong Province of China under contract No.2024A1515012717+5 种基金the Initial Research Foundation of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)under contract Nos 313021004,313022009,and 313022001the National Natural Science Foundation of China under contract No.41706225the National Key R&D Program of China under contract No.2018YFA0605701the Impact and Response of Antarctic Seas to Climate Change under contract No.IRASCC 1-02-01Bthe Shenlan Program funded by Shanghai Jiao Tong University under contract No.SL2020MS021the fund from Shanghai Frontiers Science Center of Polar Research.
文摘The Southern Ocean is a critical component in the Earth system by dominating the global heat and anthropogenic carbon uptake and supplying heat to melt the largest ice sheet.Variability and changes in the water masses of the Southern Ocean are thus important to the global energy and water cycles,carbon cycling,and sea-level change.In this article,we review the recent progress on understanding the variability and changes in the four major water masses in the Southern Ocean,including Subantarctic Mode Water,Antarctic Intermediate Water,Circumpolar Deep Water and Antarctic Bottom Water.Subantarctic Mode Water and Antarctic Intermediate Water show statistically significant strong circumpolar shoaling,warming,and density reductions since 1970s,indicating that signals of global warming have entered the interior ocean.Meanwhile,strong regional variability of Subantarctic Mode Water and Antarctic Intermediate Water responding to surface buoyancy forcing and westerly winds is attracting more attention.Circumpolar Deep Water is an important modulator of heat content and nutrient concentrations on continental shelves around Antarctica and has made significant contributions to the basal melting of Antarctic ice shelves.Since the late 1950s,a long-term freshening trend in Antarctic Bottom Water in the Ross Sea and its downstream region has been observed and is mainly attributed to the accelerated basal melting of ice shelves in West Antarctica.The shrinking of Antarctic Bottom Water in the Weddell Sea during 1992–2020 has also been revealed and is attributed to reduced sea ice production over the southern Weddell continental shelf related to the Interdecadal Pacific Oscillation and the variability in the Amundsen Sea Low.Though significant advances have been achieved,there is an urgent need to enhance and improve both observations and model performances for better understandings and projections of the formation,transformation,and transport of the water masses in the Southern Ocean.
基金financially supported by the National Natural Science Foundation of China(Nos.22466011 and 22165004)the Innovative Research Team for Science and Technology of Shanxi Province(No.2022TD-04)。
文摘Hydrogen peroxide(H_(2)O_(2))is highly required in various applications.The development of catalysts exhibiting elevated catalytic activity,selectivity,and stability is essential for H_(2)O_(2)production technology.Metalbased catalysts are widely used for 2e^(-)ORR(oxygen reduction reaction)because of their adjustable structure,chemical stability,and availability.However,due to competition with the 4e^(-)ORR,modifications are often conducted to balance activity and selectivity.Common techniques include altering the surface electronic structure of catalysts and the interaction between active sites and intermediates.This review discusses diverse catalyst types(including precious and transition metals,single-atom catalysts,and MOFs/COFs)along with modification strategies(such as morphological control,electronic structure tuning,conductivity enhancement,and wettability improvement).The objective is to elucidate catalyst design and associated reaction mechanisms,as well as the relationship between catalyst structure and activity,in order to provide an insight for producing H_(2)O_(2)in an efficient,highly selective,and stable manner.
基金Shaanxi Provincial People’s Hospital Science and Technology Development Incubation Fund Program 2023(Project No.:2023HL-12)。
文摘Objective:To explore the obstructive factors in the behavior of medical staff during the implementation of respiratory rehabilitation process,and to provide a basis for the rehabilitation management intervention of COPD.Methods:A descriptive nature research method was adopted.An interview outline was formulated based on the theoretical domain framework.From October to December 2024,15 medical staff from the respiratory department of a tertiary hospital in Shaanxi Province were selected for semi-structured interviews.The interview data were analyzed using the Colaizzi 7-step analysis method.Result:The analysis of this study found that the obstructive factors for medical staff to implement respiratory rehabilitation include five theoretical domains.The problems are respectively the lack of knowledge about respiratory rehabilitation and insufficient training intensity,the insufficient self-recognition of implementing respiratory rehabilitation,the low awareness rate of patients and the low cooperation degree,the insufficient provision of instruments and facilities,the lack of rehabilitation training venues and respiratory rehabilitation clinics,and the lack of scientific and standardized respiratory rehabilitation management processes.Conclusion:There are many obstructive factors affecting the implementation of respiratory rehabilitation by medical staff.Clinical managers should take corresponding measures,continuously improve the rehabilitation management strategies for COPD,and promote the clinical application of the best evidence for respiratory rehabilitation.
基金Supported by National Natural Science Foundation of China,No.82372182,No.82172131,and No.U23A20421Training Project of the Leading Expert Team:"Jiyang Medical Elites",No.RC2023-004.
文摘BACKGROUND Sepsis is a life-threatening condition defined by organ dysfunction,triggered by a dysregulated host response to infection.there is limited published literature combining cognitive impairment with topological property alterations in brain networks in sepsis survivors.Therefore,we employed graph theory and Granger causality analysis(GCA)methods to analyze resting-state functional magnetic resonance imaging(rs-fMRI)data,aiming to explore the topological alterations in the brain networks of intensive care unit(ICU)sepsis survivors.Using correlation analysis,the interplay between topological property alterations and cognitive impairment was also investigated.AIM To explore the topological alterations of the brain networks of sepsis survivors and their correlation with cognitive impairment.METHODS Sixteen sepsis survivors and nineteen healthy controls from the community were recruited.Within one month after discharge,neurocognitive tests were administered to assess cognitive performance.Rs-fMRI was acquired and the topological properties of brain networks were measured based on graph theory approaches.GCA was conducted to quantify effective connectivity(EC)between brain regions showing positive topological alterations and other regions in the brain.The correlations between topological properties and cognitive were analyzed.RESULTS Sepsis survivors exhibited significant cognitive impairment.At the global level,sepsis survivors showed lower normalized clustering coefficient(γ)and small-worldness(σ)than healthy controls.At the local level,degree centrality(DC)and nodal efficiency(NE)decreased in the right orbital part of inferior frontal gyrus(ORBinf.R),NE decreased in the left temporal pole of superior temporal gyrus(TPOsup.L)whereas DC and NE increased in the right cerebellum Crus 2(CRBLCrus2.R).Regarding directional connection alterations,EC from left cerebellum 6(CRBL6.L)to ORBinf.R and EC from TPOsup.L to right cerebellum 1(CRBLCrus1.R)decreased,whereas EC from right lingual gyrus(LING.R)to TPOsup.L increased.The implementation of correlation analysis revealed a negative correlation between DC in CRBLCrus2.R and both Mini-mental state examination(r=-0.572,P=0.041)and Montreal cognitive assessment(MoCA)scores(r=-0.629,P=0.021)at the local level.In the CRBLCrus2.R cohort,a negative correlation was identified between NE and MoCA scores,with a statistically significant result of r=-0.633 and P=0.020.CONCLUSION Frontal,temporal and cerebellar topological property alterations are possibly associated with cognitive impairment of ICU sepsis survivors and may serve as biomarkers for early diagnosis.
基金financially supported by the National Natural Science Foundation of China(No.51972095).
文摘The development of bifunctional electrocatalysts for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)at high current density under industrial temperatures is crucial for large-scale industrial hydrogen production from water splitting.In this work,M-MnO_(2)@TNTA composite electrodes were prepared by depositing various metal ion-doped manganese oxide nanoparticles on the titania nanotube array(TNTA)by successive ionic layer adsorption reaction(SILAR)method,and their HER and OER electrocatalytic performances were investigated in 1 M KOH.Results show that the CoFe-MnO_(2)@TNTA composite electrode prepared by simultaneous doping of Co^(3+)and Fe^(3+)in MnO_(2) exhibits optimal catalytic performance.Compared with MnO_(2)@TNTA without ion doping,the overpotentials of CoFe-MnO_(2)@TNTA at 10 mA cm^(-2)(η_(10))for HER and OER are reduced by 571 and 665 mV.In addition,the electrode perfor-mance can be significantly enhanced by increasing the test temperature,and the porous array structure enables CoFe-MnO_(2)@TNTA to exhibit better performance at high current densities.At 50℃,which is the common industrial electrolytic water temperature,the η_(10) of CoFe-MnO_(2)@TNTA for HER is almost equal to that of the Pt/C electrode.The η_(100) of CoFe-MnO_(2)@TNTA for HER is reduced by 35 mV compared with the Pt/C electrode.Moreover,η_(200) of CoFe-MnO_(2)@TNTA for OER is significantly lowered by 111 and 184 mV compared with IrO_(2) and RuO_(2) electrodes.Utilizing CoFe-MnO_(2)@TNTA as both the cathode and anode for overall water splitting,the electrolysis voltage is merely 2.33 V under the current density of 200 mA cm^(-2),much lower than that of IrO_(2)(+)||Pt/C(-)(2.68 V).The present work may provide a valuable reference for the development of self-supporting bifunctional electrodes suitable for high-current-density water splitting at industrial temperatures.
文摘Background:Multiple myeloma(MM)remains a formidable clinical challenge due to its high relapse rate and resistance to existing therapies.Estrogen-related receptor gamma(ERRγ),a nuclear receptor critical for cellular energy metabolism,has been implicated in various cancers.but its role in MM remains unclear.Methods:ERRγexpres-sion was assessed using bioinformatics and RT-qPCR.Functional studies were conducted through siRNA-mediated ERRγknockdown and treatment with the inverse agonist GSK5182 to examine their effects on MM cell proliferation and apoptosis.Results:ERRγwas significantly upregulated in the bone marrow of MM patients,correlating with advanced clinical stages and pathological fractures.Inhibition of ERRγreduced MM cell expansion both in vitro and in vivo,while promoting mitochondrial-dependent apoptosis.Co-immunoprecipitation assays demonstrated a physical association between ERRγand P65.Inhibition of ERRγattenuated canonical nuclear factor-kappa B(NF-κB)signaling by blocking the nuclear translocation of its key effector p65.Additionally,modulation of ERRγaltered receptor activator of nuclear factor-κB ligand(RANKL)levels,implying a potential role in bone degradation observed in MM cases.Conclusion:Collectively,the data broaden understanding of ERRγ’s contribution to MM development and propose it as a viable target for therapeutic intervention.
基金The National Natural Science Foundation of China under contract No.42406188the Natural Science Foundation of Liaoning Province under contract No.2024-BS-022+1 种基金the Dalian High-Level Talent Innovation Program under contract No.2022RG02the Fundamental Research Funds for the Central Universities under contract No.3132025107.
文摘Red tide is an ecological disaster caused by the excessive proliferation of photosynthetic algae in the ocean.The frequent occurrences of red tide have brought serious harms to the marine aquaculture and caused significant economic losses to the marine industry.Red tide prediction can alleviate and even stop the long-term damages to marine ecosystems,which helps maintain the ecological balance of the ocean environment and contributes to the Sustainable Development Goal of“life below water”formulated by the United Nations.Aiming at red tide prediction using remote sensing technology,this study proposed a novel approach of red tide prediction using time-series hyperspectral observations,and examined the proposed method in the Xinghai Bay,China.Three spectral indices,namely the twoband ratio(TBR),the three-band spectral index(TBSI),and the fluorescence baseline height(FLH),were used to reduce the dimensionality of hyperspectral data and extract spectral features.Two machine learning models including the random forest(RF)and the support vector machine(SVM)were employed to predict whether red tide would occur on a target day based on the time-series spectral indices obtained in the previous days.By comparing and analyzing the prediction results of multiple machine learning models trained with different spectral indices and temporal lengths,it is found that both the RF and the SVM models can predict the red tide outbreaks at the accuracies over 0.9 using adequate temporal lengths of input data.When the temporal length of input data is limited,however,it is suggested to use the RF model,which accurately predicts red tide outbreaks using the temporal input of the 2-d TBSI.The proposed method is expected to provide oceanic and maritime agencies with early warnings on red tide outbreaks and ensure the safety of the coastal environment in large spatial scales using optical remote sensing technology.
文摘Objective: To investigate the current beliefs and attitudes of nurses in Yunnan Province toward prescriptive authority, analyze the influencing factors, and provide evidence for future research and policy formulation to support the establishment of nurses’ prescriptive authority in China. Method: A cross-sectional survey was conducted among 937 nurses in Yunnan Province using the Beliefs and Attitudes Scale on Nurses’ Prescriptive Authority. The scale assessed four dimensions: perceived need, self-efficacy, perceived benefits, and perceived barriers. Multiple linear regression analysis was used to identify factors influencing the overall score and each dimension. Results: The total score of the Beliefs and Attitudes Scale was 89.17 ± 17.69, indicating a moderate level of awareness and positive attitude among nurses. The highest-scoring dimension was perceived benefits (34.94 ± 8.04), while the lowest was perceived barriers (15.23 ± 3.5). Age was identified as a significant factor influencing the overall score and self-efficacy dimension (P < 0.05). Years of practice influenced the perceived benefits dimension (P = 0.051), while gender, age, and professional title were key factors affecting the perceived barriers dimension (P < 0.05). Male nurses and senior nurses demonstrated more caution toward potential risks associated with prescriptive authority. Conclusion: Nurses in Yunnan Province exhibit moderate levels of belief in and attitudes toward prescriptive authority, with age being the most significant influencing factor. Tailored training programs, policy promotion, and practical guidance are recommended to enhance nurses’ understanding and support for prescriptive authority, thereby improving nursing practices and addressing regional healthcare challenges.
基金Project supported by National Natural Science Foundation of China(62075203,12304460)Zhejiang Provincial Natural Science Foundation of China(LQ23A040007)Basic Public Welfare Research Program of Zhejiang Province(LDT23F05013F05)。
文摘Due to the wide and adjustable emission range,Ce^(3+)is an indispensable luminous center for full spectrum lighting.However,it needs to be sintered at high temperature in a reducing atmosphere,resulting in difficulty to coexisting with other multivalent activated ions(such as Eu^(3+),Tm^(3+)),which greatly hinders the formation of full spectrum.In this study,a calcium vacancy enhanced self-reduction of Ce^(4+)is realized in CaNaSb_(2)O_(6)F(CNSOF)host under air atmosphere sintering,through which Ce^(3+),Tm^(3+)and Eu^(3+)coexisting in a single-phase full spectrum phosphor was prepared.Notably,the artificial introduction of a calcium vacancy was designed to verify this self-reduction mechanism.Moreover,the energy transfer kinetics among Tm^(3+),Ce^(3+)and Eu^(3+)were explored.Finally,combined with a 340 nm UV chip,a full spectrum phosphor-converted light-emitting diode(pc-LED)was fabricated,showing a broad emission range from 400 to 750 nm,Commission Internationale de I'Edairage(CIE)of(0.3485,0.3673),Ra of 92 and correlated color temperature(CCT)of 4933 K.Utilizing the variation in emission colors of this phosphor under different UV wavelengths,a dual encryption method combining point character code and fluorescent encryption technique is proposed.This work provides an effective path for Ce^(4+)self-reduction to apply in full spectrum pc-LED and information encryption.
文摘Metabonomics,a key aspect of systems biology,offers novel approaches for early diagnosis,pharmacotherapy,and health management in Traditional Chinese Medicine(TCM).This paper summarizes its applications in establishing TCM quality standards,exploring material basis,clarifying mechanism,and assessing toxicity.By profiling TCM and its metabolites,metabonomics comprehensively captures chemical traits,enhancing quality evaluation precision.It also tracks metabolic dynamics to understand TCM’s absorption,distribution,metabolism,excretion,thereby facilitating the identification of active components and their underlying mechanisms.In toxicity assessment,metabonomics uncovers hepatic and renal toxicity while elucidating potential mechanisms.In summary,metabonomics fosters TCM modernization and globalization,serving as a pivotal tool for advancing research and development.
基金supported by the Mainland-Hong Kong Joint Funding Scheme(MHKJFS)(Project No:MHP/040/22)RGC Theme-based Research Scheme AoE/M-402/20+1 种基金National Natural Science Foundation of China/Hong Kong Research Grants Council Joint Research Scheme(Project No:N_CityU151/23)Hong Kong Innovation and Technology Commission via the Hong Kong Branch of National Precious Metals Materials Engineering Research Center.
文摘Magnesium(Mg)-based materials are promising for lightweight structural applications.However,their widespread adoption is significantly constrained by inherent limitations in mechanical properties.To address this challenge,this study introduces a novel Mg-based interpenetratingphase composite reinforced with a nickel-titanium(NiTi)scaffold featuring a triply periodic minimal surface(TPMS)configuration.By combining experimental investigations with finite element simulations,we systematically elucidate the dual impact of the scaffold’s unit cell size(a)on manufacturing viability and mechanical enhancement.To compensate for compromised infiltration dynamics induced by decreasing a,a critical permeability threshold of 1×10^(-8) m^(2) is proposed for achieving successful composite fabrication.Mechanically,reducing a strengthens the interaction between the scaffold and matrix:the TPMS-configured NiTi scaffolds improve stress transfer,deflect crack propagation,and facilitate damage delocalization,whereas the Mg matrix preserves structural integrity and enables load redistribution.Consequently,the composites significantly outperform pure Mg,and lowering a leads to more substantial enhancements in compressive strength,energy dissipation,and deformation recoverability.This study offers valuable insight into the design and fabrication of highperformance Mg-based materials for structural and biomedical applications.
基金supported by the National Natural Science Foundation of China(No.82372551)。
文摘Diabetic wound healing is often complicated due to bacterial infections that intensify inflammation.Employing hydrogel dressings with inherent antibacterial properties can significantly reduce reliance on antibiotics for treating infected wounds in diabetics.Traditional hydrogels typically rely on the infiltration of bacteria into their porous structure to manifest antibacterial effects.However,this infiltration process is not only prolonged but can also exacerbate inflammation,further delaying the healing of the wound.Thus,promptly capturing and eliminating bacteria is crucial for enhancing the antibacterial efficiency of the hydrogel.In this context,we present a multifunctional hydrogel dressing,termed SIP,designed to tackle drug-resistant bacterial infections in diabetic wounds.This dressing integrates ionic liquid functional groups into a sericin-based matrix:phenylboronic acid for the immobilization of bacteria and imidazole for their subsequent annihilation.Expectedly,the SIP system demonstrates potent antibacterial activity against methicillin-resistant Staphylococcus aureus,verified through in vitro and in vivo experiments.As a result,SIP emerges as a promising candidate in the realm of hydrogel dressings with innate antibacterial properties,showcasing considerable potential for addressing diabetic wounds plagued by drug-resistant bacterial infections.
基金financially supported by the Natural Science Foundation of Shandong Province(No.ZR2022MB034)。
文摘The advancement of functional adhesives featuring recyclable and repairable properties is of great significance in interfacial science and engineering.Herein,a series of high-strength,recyclable fluorine-containing adhesives(ESOx-FPF)were designed and synthesized by crosslinking two prepolymers,FPF-B(derived from side-chain fluorinated diol,isocyanate,and aminoboric acid)and ESO-B(synthesized from biobased epoxy soybean oil and aminoboric acid),through dynamic boro-oxygen bonds.The resulting adhesive exhibited an optimal tensile strength of 42 MPa and the shear strength on steel plates reached as high as 3.89 MPa.More importantly,benefiting from the dynamic reversibility of the boron-oxygen bonds along with the hydrogen bonds interaction,ESOx-FPF can be welded with the assistance of solvents and recycled for multiple cycles.The outstanding healing efficiency and excellent reprocessability of these functional adhesives were confirmed by mechanical testing.Moreover,the as-prepared adhesives demonstrated universal and remarkable adhesion to various substrates,such as aromatic polyamide,aluminum plates and polycarbonate,meanwhile,they could be easily disassembled and recycled using ethanol without damaging the substrates surface.This study not only provides a simple strategy for the synthesis of eco-friendly adhesives with weldable and recyclable properties,but also sheds light on the development of other functional materials utilizing dynamic covalent chemistry.
